Genomes and Genes
Experts and Doctors on synapses in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Publications107 found, 100 shown here
- Thanawala M, Regehr W. Determining synaptic parameters using high-frequency activation. J Neurosci Methods. 2016;264:136-152 pubmed publisher..Careful application of appropriate methods can greatly improve estimates of synaptic parameters. ..
- Seo J, Kritskiy O, Watson L, Barker S, Dey D, Raja W, et al. Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia. J Neurosci. 2017;37:9917-9924 pubmed publisher..Our data suggest that p25/Cdk5 plays an important role in tauopathy in both mouse and human model systems. ..
- Kazama H, Wilson R. Origins of correlated activity in an olfactory circuit. Nat Neurosci. 2009;12:1136-44 pubmed publisher..PN axons from the same glomerulus reconverge in the lateral horn, where pooling redundant signals may allow lateral horn neurons to average out noise that arises independently in these PNs...
- Murthy V, Taranda J, Elgoyhen A, Vetter D. Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs. Dev Neurobiol. 2009;69:931-49 pubmed publisher..Finally, by using mice expressing the nondesensitizing alpha9 L9'T point mutant nAChR subunit, we show that increased nAChR activity drives synaptic hyperinnervation. ..
- Schratt G, Nigh E, Chen W, Hu L, Greenberg M. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. J Neurosci. 2004;24:7366-77 pubmed..The local translation of the cytoskeleton-associated protein Homer2 in particular might have important implications for growth cone dynamics and dendritic spine development. ..
- Jo S, Zhu X, Marchionni M, Burden S. Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature. 1995;373:158-61 pubmed
- Beierlein M, Regehr W. Local interneurons regulate synaptic strength by retrograde release of endocannabinoids. J Neurosci. 2006;26:9935-43 pubmed..Thus, local interneurons within the cerebellum can release endocannabinoids through metabotropic glutamate receptor- and NMDAR-dependent mechanisms and contribute to use-dependent modulation of circuit properties. ..
- Kubilus J, Linsenmayer T. Developmental corneal innervation: interactions between nerves and specialized apical corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:782-9 pubmed publisher..During avian corneal development the nerves make close associations with a specialized type of ACE cell. There they form synapse-like structures, suggesting that not all nerves within the CE terminate as free nerve endings. ..
- Contini M, Lin B, Kobayashi K, Okano H, Masland R, Raviola E. Synaptic input of ON-bipolar cells onto the dopaminergic neurons of the mouse retina. J Comp Neurol. 2010;518:2035-50 pubmed publisher..The presynaptic ON-bipolar cells most likely belonged to the CB3 (type 5) variety. ..
- Kantardzhieva A, Peppi M, Lane W, Sewell W. Protein composition of immunoprecipitated synaptic ribbons. J Proteome Res. 2012;11:1163-74 pubmed publisher..The ribbon appears to comprise a concentrated cluster of proteins dealing with vesicle creation, retention and distribution, and consequent exocytosis. ..
- Tsai P, Hull C, Chu Y, Greene Colozzi E, Sadowski A, Leech J, et al. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012;488:647-51 pubmed publisher..These findings demonstrate new roles for Tsc1 in PC function and define a molecular basis for a cerebellar contribution to cognitive disorders such as autism. ..
- Litvina E, Chen C. Functional Convergence at the Retinogeniculate Synapse. Neuron. 2017;96:330-338.e5 pubmed publisher..These results signify a greater role for the thalamus in visual processing and provide a functional perspective of anatomical connectivity data. ..
- Fricker Gates R, Shin J, Tai C, Catapano L, Macklis J. Late-stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing targeted neurodegeneration. J Neurosci. 2002;22:4045-56 pubmed
- McGann J, Pírez N, Gainey M, Muratore C, Elias A, Wachowiak M. Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons. Neuron. 2005;48:1039-53 pubmed..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity. ..
- Zikopoulos B, Barbas H. Prefrontal projections to the thalamic reticular nucleus form a unique circuit for attentional mechanisms. J Neurosci. 2006;26:7348-61 pubmed..The targeting of sensory tiers of TRN by specific prefrontal areas may underlie attentional regulation for the selection of relevant sensory signals and suppression of distractors. ..
- Fried S, Masland R. Image processing: how the retina detects the direction of image motion. Curr Biol. 2007;17:R63-6 pubmed..This computation, occurring in a retinal interneuron, is a foundation of the directional signals transmitted by the retina to the brain. ..
- Chen Y, Sabatini B. Signaling in dendritic spines and spine microdomains. Curr Opin Neurobiol. 2012;22:389-96 pubmed publisher..Here we review these findings as well as the developments in fluorescence microscopy that are making possible direct monitoring of signaling within spines and, in the future, within sub-spine microdomains. ..
- Nagel K, Wilson R. Mechanisms Underlying Population Response Dynamics in Inhibitory Interneurons of the Drosophila Antennal Lobe. J Neurosci. 2016;36:4325-38 pubmed publisher..As a result, inhibition is recruited over a range of conditions, and there is the potential to tune the timing of inhibition as the environment changes. ..
- Jarzylo L, Man H. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci. 2012;32:2552-63 pubmed publisher..These results indicate a role for neuron-specific glutamate transporters in AMPAR synaptic localization and stability. ..
- Kinney H, Rava L, Benowitz L. Anatomic distribution of the growth-associated protein GAP-43 in the developing human brainstem. J Neuropathol Exp Neurol. 1993;52:39-54 pubmed..This study provides baseline information relevant to understanding developmental brainstem disorders in early human life. ..
- Roberts R, Sheng M. Association of dystrophin-related protein 2 (DRP2) with postsynaptic densities in rat brain. Mol Cell Neurosci. 2000;16:674-85 pubmed
- Chen C, Regehr W. Presynaptic modulation of the retinogeniculate synapse. J Neurosci. 2003;23:3130-5 pubmed..Taken together, our data indicate that serotonin and GABA can act presynaptically to decrease calcium influx at the retinogeniculate synapse and modify transmission of visual information in the LGN. ..
- Escobar G, Fares T, Stepanyants A. Structural plasticity of circuits in cortical neuropil. J Neurosci. 2008;28:8477-88 pubmed publisher..Primate neurons appear to be more selective, making synaptic connections with >7-15% of encountered axons. ..
- Tong Q, Ye C, Jones J, Elmquist J, Lowell B. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008;11:998-1000 pubmed publisher..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance. ..
- Kato G, Kawasaki Y, Koga K, Uta D, Kosugi M, Yasaka T, et al. Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn. J Neurosci. 2009;29:5088-99 pubmed publisher..These results reveal a specific three-dimensional organization in the local patterns of excitatory and inhibitory connectivity that has implications for the processing of information related to both somatotopy and sensory modality. ..
- Mosca T, Schwarz T. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci. 2010;13:935-43 pubmed publisher..Thus, Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway. ..
- Tai H, Serrano Pozo A, Hashimoto T, Frosch M, Spires Jones T, Hyman B. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol. 2012;181:1426-35 pubmed publisher..Our findings suggest that synaptic hyperphosphorylated tau oligomers may be an important mediator of the proteotoxicity that disrupts synapses in AD. ..
- Ha S, Baver S, Huo L, Gata A, Hairston J, Huntoon N, et al. Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons. PLoS ONE. 2013;8:e77622 pubmed publisher..Dendritic LepRb signaling may therefore play an important role in leptin's central effects on energy balance, possibly through modulation of synaptic activity via post-synaptic mechanisms. ..
- TIMBIE C, Barbas H. Specialized pathways from the primate amygdala to posterior orbitofrontal cortex. J Neurosci. 2014;34:8106-18 pubmed publisher..These features provide a circuit mechanism for flexibly shifting focus and adjusting emotional drive in processes disrupted in psychiatric disorders, such as phobias and obsessive-compulsive disorder. ..
- BEIER K, Mundell N, Pan Y, Cepko C. Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors. Curr Protoc Neurosci. 2016;74:1.26.1-27 pubmed publisher..Here, we detail the use of these vectors and provide protocols for propagating virus, changing the surface glycoprotein, and infecting multiple organisms using several injection strategies. ..
- Biederer T, Kaeser P, Blanpied T. Transcellular Nanoalignment of Synaptic Function. Neuron. 2017;96:680-696 pubmed publisher..We propose that this architecture may allow for precise synaptic information exchange and may be modulated to contribute to the remarkable plasticity of brain function. ..
- Tamm S, Tamm S. Novel bridge of axon-like processes of epithelial cells in the aboral sense organ of ctenophores. J Morphol. 2002;254:99-120 pubmed..We discuss the possibility that the bridge is an electrical conduction pathway to balancers that coordinates tentacle-evoked swimming responses of ctenophores, such as global ciliary excitation...
- Ch ng Q, Sieburth D, Kaplan J. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008;4:e1000283 pubmed publisher..Using this strategy, we identified several genes that regulate secretion of insulin-like growth factors (IGFs) and influence lifespan in a manner dependent on insulin/IGF signaling. ..
- Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher..These findings reveal that dopamine regulates spine Ca2+ by multiple pathways and that competitive modulation of PKA controls NMDAR-mediated Ca2+ signaling in the striatum. ..
- Fluharty B, Biasini E, Stravalaci M, Sclip A, Diomede L, Balducci C, et al. An N-terminal fragment of the prion protein binds to amyloid-? oligomers and inhibits their neurotoxicity in vivo. J Biol Chem. 2013;288:7857-66 pubmed publisher..These data suggest that N1, or small peptides derived from it, could be potent inhibitors of A? oligomer toxicity and represent an entirely new class of therapeutic agents for AD. ..
- Suzuki R, Ferris H, Chee M, Maratos Flier E, Kahn C. Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. PLoS Biol. 2013;11:e1001532 pubmed publisher..Thus, reduction of SCAP and the consequent suppression of cholesterol synthesis in the brain may play an important role in the increased rates of cognitive decline and Alzheimer disease observed in diabetic states. ..
- Xu Friedman M, Harris K, Regehr W. Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neurosci. 2001;21:6666-72 pubmed..Similarities in the number of docked vesicles for PF and CF synapses indicate that differences in probability of release are unrelated to the number of anatomically docked vesicles at these synapses...
- Bateup H, Takasaki K, Saulnier J, Denefrio C, Sabatini B. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci. 2011;31:8862-9 pubmed publisher..Furthermore, these data suggest that perturbations of synaptic signaling may contribute to the pathogenesis of TSC. ..
- Li J, Zhang W, Yang H, Howrigan D, Wilkinson B, Souaiaia T, et al. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nat Neurosci. 2017;20:1150-1161 pubmed publisher..These results were integrated into a software platform, Synaptic Protein/Pathways Resource (SyPPRes), enabling the prioritization of disease risk factors and their placement within synaptic protein interaction networks. ..
- Carter A, Chen C, Schwartz P, Segal R. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci. 2002;22:1316-27 pubmed..These data suggest that BDNF regulates both the mechanisms that underlie short-term synaptic plasticity and the steady-state relationship between different vesicle pools within the terminal. ..
- Safo P, Regehr W. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005;48:647-59 pubmed..This indicates that Purkinje cells release 2-AG that activates CB1Rs to both transiently inhibit release and induce a postsynaptic form of LTD. ..
- Zhou Y, Lee S, Jin Z, Wright M, Smith S, Anderson M. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009;15:1208-14 pubmed publisher..Thus, LGI1 represents a human gene mutated to promote epilepsy through impaired postnatal development of glutamatergic circuits. ..
- Chu Y, Fioravante D, Thanawala M, Leitges M, Regehr W. Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci. 2012;32:13796-804 pubmed publisher..Our results reveal that PKC(Ca) can enhance evoked neurotransmitter release in response to calcium increases caused by small presynaptic depolarizations. ..
- Kwon H, Kozorovitskiy Y, Oh W, Peixoto R, Akhtar N, Saulnier J, et al. Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat Neurosci. 2012;15:1667-74 pubmed publisher..Our data indicate that transcellular competitive processes govern synapse formation and number in developing cortex and that NL1 has a central function in these processes. ..
- Umezu K, Kolodner R. Protein interactions in genetic recombination in Escherichia coli. Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA-binding protein. J Biol Chem. 1994;269:30005-13 pubmed..ssDNA complexes and modify their structure to allow RecA to nucleate on them efficiently. Second, RecO and RecR are retained in RecA presynaptic filaments and play a role in the subsequent homologous pairing process promoted by RecA. ..
- Fischer A, Sananbenesi F, Pang P, Lu B, Tsai L. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron. 2005;48:825-38 pubmed..Our data suggest a role for p25 in synaptic plasticity, synaptogenesis, learning, and memory and provide a model whereby deregulation of a plasticity factor can contribute to neurodegeneration. ..
- Kujawa S, Liberman M. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss. J Neurosci. 2009;29:14077-85 pubmed publisher..This primary neurodegeneration should add to difficulties hearing in noisy environments, and could contribute to tinnitus, hyperacusis, and other perceptual anomalies commonly associated with inner ear damage. ..
- Loya C, Van Vactor D, Fulga T. Understanding neuronal connectivity through the post-transcriptional toolkit. Genes Dev. 2010;24:625-35 pubmed publisher..In this review, we describe recent advances in understanding how post-transcriptional regulatory mechanisms refine the proteomic complexity required for the assembly of intricate and specific neural networks. ..
- Li S, Jin M, Koeglsperger T, Shepardson N, Shankar G, Selkoe D. Soluble A? oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci. 2011;31:6627-38 pubmed publisher..Thus, soluble A? oligomers at low nanomolar levels present in AD brain increase activation of extrasynaptic NR2B-containing receptors, thereby impairing synaptic plasticity. ..
- Kozorovitskiy Y, Saunders A, Johnson C, Lowell B, Sabatini B. Recurrent network activity drives striatal synaptogenesis. Nature. 2012;485:646-50 pubmed publisher..These effects indicate that the propagation of activity through a multi-stage network regulates the wiring of the basal ganglia, revealing an important role of positive feedback in driving network maturation. ..
- Miller K, DeProto J, Kaufmann N, Patel B, Duckworth A, Van Vactor D. Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles. Curr Biol. 2005;15:684-9 pubmed..It suggests the synaptic strength and morphology defects linked to Liprin-alpha may in part be due to a failure in the delivery of synaptic-vesicle precursors. ..
- Shalizi A, Bilimoria P, Stegmuller J, Gaudilliere B, Yang Y, Shuai K, et al. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. J Neurosci. 2007;27:10037-46 pubmed
- Higashi Kovtun M, Mosca T, Dickman D, Meinertzhagen I, Schwarz T. Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J Neurosci. 2010;30:5253-68 pubmed publisher..Thus, importin-beta11 function interacts with the BMP pathway to regulate a pool of pMAD that must be present at the presynapse for its proper development and function. ..
- Rosenberg M, Yang F, Mohn J, Storer E, Jacob M. The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. J Neurosci. 2010;30:11073-85 pubmed publisher..APC human gene mutations correlate with autism spectrum disorders, providing strong support for the importance of the association, demonstrated here, between APC, neuroligin and neurexin. ..
- Benson T, Lee D, Brown M. Tensor tympani motoneurons receive mostly excitatory synaptic inputs. Anat Rec (Hoboken). 2013;296:133-45 pubmed publisher..Having a high proportion of excitatory inputs, the TTMN innervation is like that of stapedius motoneurons but proportionately different from other types of motoneurons...
- Muresan V, Lyass A, Schnapp B. The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors. J Neurosci. 1999;19:1027-37 pubmed..These findings suggest that within a single cell, the photoreceptor, one kinesin polypeptide, KIF3A, can serve two distinct functions, one specific for ribbon synapses. ..
- Olsen D, Dunlap K, Jacob M. Kainate receptors and RNA editing in cholinergic neurons. J Neurochem. 2007;101:327-41 pubmed..Our data suggest that glutamatergic signaling may function as a local circuit mechanism to modulate excitability and calcium signaling during synapse formation and maturation in the CG in vivo. ..
- Ding J, Oh W, Sabatini B, Gu C. Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nat Neurosci. 2011;15:215-23 pubmed publisher..Thus, our results demonstrate that Sema3E and Plexin-D1 specify the degree of glutamatergic connectivity between a specific source and target in the complex circuitry of the basal ganglia. ..
- Bialas A, Stevens B. TGF-? signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2013;16:1773-82 pubmed publisher..These data implicate TGF-? in regulating neuronal C1q expression to initiate complement- and microglia-mediated synaptic pruning. ..
- Passafaro M, Sala C, Niethammer M, Sheng M. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. Nat Neurosci. 1999;2:1063-9 pubmed..However, the number of synapses and the synaptic clustering of NMDA receptors were unaffected, suggesting that PSD-95-family proteins are not essential for the maintenance of synapses and the synaptic localization of NMDA receptors. ..
- Li S, Tian X, Hartley D, Feig L. The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity. Curr Biol. 2006;16:2303-13 pubmed..The suppression of this gating mechanism in mature animals represents a new form of age-dependent decline in brain plasticity. ..
- Shankar G, Li S, Mehta T, Garcia Munoz A, Shepardson N, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008;14:837-42 pubmed publisher..We conclude that soluble Abeta oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species. ..
- Liberman L, Wang H, Liberman M. Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses. J Neurosci. 2011;31:801-8 pubmed publisher..2010). ..
- Hong Y, Chen C. Wiring and rewiring of the retinogeniculate synapse. Curr Opin Neurobiol. 2011;21:228-37 pubmed publisher..Today, with the advent of new technologies to map and monitor neuronal circuits, it is worthwhile to revisit a powerful experimental model for examining the development and plasticity of synaptic circuits--the retinogeniculate synapse. ..
- Niethammer M, Kim E, Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996;16:2157-63 pubmed..Members of the PSD-95 family might serve to anchor NMDA receptors to the submembrane cytoskeleton and aid in the assembly of signal transduction complexes at postsynaptic sites. ..
- Tsen G, Williams B, Allaire P, Zhou Y, Ikonomov O, Kondova I, et al. Receptors with opposing functions are in postsynaptic microdomains under one presynaptic terminal. Nat Neurosci. 2000;3:126-32 pubmed..Coexistence of separate clusters of receptors with opposing functions under one terminal contradicts Dale's principle and provides a new mechanism for modulating synaptic activity in vivo. ..
- Kass J, Jacob T, Kim P, Kaplan J. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J Neurosci. 2001;21:9265-72 pubmed..Taken together, these results suggest that egl-3 PC2-processed peptides normally regulate the responsiveness of C. elegans to mechanical stimuli. ..
- Lenz G, Avruch J. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem. 2005;280:38121-4 pubmed
- Johnson K, Tenney A, Ghose A, Duckworth A, Higashi M, Parfitt K, et al. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron. 2006;49:517-31 pubmed
- Gaudry Q, Hong E, Kain J, de Bivort B, Wilson R. Asymmetric neurotransmitter release enables rapid odour lateralization in Drosophila. Nature. 2013;493:424-8 pubmed publisher..Our data also show that small differences in spike timing and spike rate can produce reliable differences in olfactory behaviour. ..
- Olivares A, Han Y, Soto D, Flattery K, Marini J, Mollema N, et al. The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017;429:343-355 pubmed publisher..This study supports a role for Nr2c1 in defining the biphasic period of retinal development and specifically influencing the early phase of retinal cell fate. ..
- Wang Z, Li L, Taylor M, Wright D, Frank E. Prenatal exposure to elevated NT3 disrupts synaptic selectivity in the spinal cord. J Neurosci. 2007;27:3686-94 pubmed..These results indicate that prenatal exposure to elevated levels of NT3 disrupts the normal mechanisms responsible for synaptic selectivity in the stretch reflex circuit. ..
- Mosca T, Schwarz T. Drosophila Importin-?2 is involved in synapse, axon and muscle development. PLoS ONE. 2010;5:e15223 pubmed publisher..Thus, Importin-?2 is needed for some processes in the development of both the nervous system and the larval musculature. ..
- Loerch P, Lu T, Dakin K, Vann J, Isaacs A, Geula C, et al. Evolution of the aging brain transcriptome and synaptic regulation. PLoS ONE. 2008;3:e3329 pubmed publisher..Thus, repression of neuronal gene expression is a prominent and recently evolved feature of brain aging in humans and rhesus macaques that may alter neural networks and contribute to age-related cognitive changes. ..
- Hsueh Y, Sheng M. Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J Neurosci. 1999;19:7415-25 pubmed..Moreover, CASK is appropriately expressed and localized to interact with both syndecan-2 and -3 in different compartments of the neuron throughout postnatal development. ..
- BEIER K, Borghuis B, El Danaf R, Huberman A, Demb J, Cepko C. Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry. J Neurosci. 2013;33:35-51 pubmed publisher..VSV transsynaptic tracing enables cell type-specific dissection of neural circuitry and can reveal synaptic relationships among neurons that are otherwise obscured due to the complexity and density of neuropil. ..
- Hsueh Y, Yang F, Kharazia V, Naisbitt S, Cohen A, Weinberg R, et al. Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J Cell Biol. 1998;142:139-51 pubmed..The synaptic localization of CASK and syndecan suggests a potential role for these proteins in adhesion and signaling at neuronal synapses. ..
- Naisbitt S, Valtschanoff J, Allison D, Sala C, Kim E, Craig A, et al. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci. 2000;20:4524-34 pubmed..We discuss the possibility that the GKAP/DLC interaction may be involved in trafficking of the PSD-95 complex by motor proteins. ..
- Nakagawa T, Sheng M. Neurobiology. A stargazer foretells the way to the synapse. Science. 2000;290:2270-1 pubmed
- Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
- Dickman D, Horne J, Meinertzhagen I, Schwarz T. A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin. Cell. 2005;123:521-33 pubmed..Therefore, no genetic evidence remains to indicate that synaptic vesicles undergo kiss-and-run. ..
- Shankar G, Bloodgood B, Townsend M, Walsh D, Selkoe D, Sabatini B. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007;27:2866-75 pubmed..Our approach provides a quantitative cellular model for elucidating the molecular basis of Abeta-induced neuronal dysfunction. ..
- Zhou Y, Zhang D, Ozkaynak E, Wang X, Kasper E, LeGuern E, et al. Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses. J Neurosci. 2012;32:903-10 pubmed publisher..The results identify sensory axon remodeling defects in a sensory aura-associated human epilepsy disorder. ..