Experts and Doctors on spectrin in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Beggs A, Byers T, Knoll J, Boyce F, Bruns G, Kunkel L. Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11. J Biol Chem. 1992;267:9281-8 pubmed
..These results demonstrate that some of the isoform diversity of alpha-actinins is the result of transcription from different genetic loci. ..
Platt O, Falcone J. Membrane protein lesions in erythrocytes with Heinz bodies. J Clin Invest. 1988;82:1051-8 pubmed
Hassoun H, Vassiliadis J, Murray J, Yi S, Hanspal M, Ware R, et al
. Molecular basis of spectrin deficiency in beta spectrin Durham. A deletion within beta spectrin adjacent to the ankyrin-binding site precludes spectrin attachment to the membrane in hereditary spherocytosis. J Clin Invest. 1995;96:2623-9 pubmed
Tse W, Tang J, Jin O, Korsgren C, John K, Kung A, et al
. A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. J Biol Chem. 2001;276:23974-85 pubmed
..Spectrin betaIV is the first beta-spectrin associated with a subnuclear structure and may be part of a nuclear scaffold to which gene regulatory machinery binds. ..
Korsgren C, Peters L, Lux S. Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. J Biol Chem. 2010;285:4757-70 pubmed publisher
Brown J, McKnight C. Molecular model of the microvillar cytoskeleton and organization of the brush border. PLoS ONE. 2010;5:e9406 pubmed publisher
..Here, we present a molecular model of the protein cytoskeleton responsible for this dramatic cellular morphology...
Hoock T, Peters L, Lux S. Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J Cell Biol. 1997;136:1059-70 pubmed
..This is the first evidence for the association of an ankyrin with lysosomes and is an example of two ankyrins present in the same cell that segregate to different locations. ..