Experts and Doctors on rho gtp binding proteins in Boston, Massachusetts, United States


Locale: Boston, Massachusetts, United States
Topic: rho gtp binding proteins

Top Publications

  1. Bateman J, Shu H, Van Vactor D. The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron. 2000;26:93-106 pubmed
    ..Moreover, reduction of trio activity potentiates the phenotype of mutations in the LAR homolog Dlar, suggesting that these proteins collaborate in orchestrating the cytoskeletal events that underlie normal axonogenesis. ..
  2. Wong K, Mohammadi S, Isberg R. Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant. J Biol Chem. 2006;281:40379-88 pubmed
    ..We conclude that RhoGDI allows cross-talk between Rho family members that promote potentially antagonistic processes, and disruption of this cross-talk can interfere with invasin-promoted uptake. ..
  3. Lin M, Greenberg M. Orchestral maneuvers in the axon: trio and the control of axon guidance. Cell. 2000;101:239-42 pubmed
  4. Sagot I, Klee S, Pellman D. Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nat Cell Biol. 2002;4:42-50 pubmed
    ..A requirement for formins in constructing specific actin structures might be the basis for the diverse activities of formins in development. ..
  5. Sahin M, Greer P, Lin M, Poucher H, Eberhart J, Schmidt S, et al. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005;46:191-204 pubmed
    ..These findings reveal that ephexin1 plays a role in axon guidance and is regulated by a switch mechanism that is specifically tailored to control Eph-mediated growth cone collapse. ..
  6. Nezami A, Poy F, Eck M. Structure of the autoinhibitory switch in formin mDia1. Structure. 2006;14:257-63 pubmed
  7. Stuart J, Gonzalez F, Kawai H, Yuan Z. c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem. 2006;281:31290-7 pubmed
    ..Together, these data show that c-Abl activates WAVE2 via tyrosine phosphorylation to promote actin remodeling in vivo and that Abi-1 forms the crucial link between these two factors. ..
  8. Weihofen A, Thomas K, Ostaszewski B, Cookson M, Selkoe D. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry. 2009;48:2045-52 pubmed publisher
    ..Finally, we find that Miro and Milton expression suppresses altered mitochondrial morphology induced by loss of Pink1 function in cell culture. Our findings suggest that Pink1 functions in the trafficking of mitochondria in cells. ..
  9. Yoshida S, Bartolini S, Pellman D. Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev. 2009;23:810-23 pubmed publisher
    ..These findings comprehensively define the targeting mechanisms of Rho1 essential for cytokinesis in yeast, and are likely to be relevant to cytokinesis in other organisms. ..

More Information


  1. Li X, Bu X, Lu B, Avraham H, Flavell R, Lim B. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol. 2002;22:1158-71 pubmed
    ..The inhibitory function of RhoH supports a model in which Rho GTPases with opposing functions may compete to modulate the final outcome of a particular GTPase-activated pathway. ..
  2. Cherry L, Li X, Schwab P, Lim B, Klickstein L. RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes. Nat Immunol. 2004;5:961-7 pubmed
    ..We obtained similar results using RNA interference in peripheral blood lymphocytes. These data demonstrate that RhoH is required for maintenance of lymphocyte LFA-1 in a nonadhesive state. ..
  3. Cowan C, Shao Y, Sahin M, Shamah S, Lin M, Greer P, et al. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005;46:205-17 pubmed
    ..These findings suggest an important role for Vav family GEFs as regulators of ligand-receptor endocytosis and determinants of repulsive signaling during axon guidance. ..
  4. Hall A, Gakidis M, Glogauer M, Wilsbacher J, Gao S, Swat W, et al. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006;24:305-16 pubmed
    ..In contrast, Vav is specifically required for complement-mediated phagocytosis, suggesting that Rac is regulated by GEFs other than Vav downstream of the FcgammaR. ..