Genomes and Genes
Experts and Doctors on rho gtp binding proteins in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: rho gtp binding proteins
- Li X, Bu X, Lu B, Avraham H, Flavell R, Lim B. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol. 2002;22:1158-71 pubmed..The inhibitory function of RhoH supports a model in which Rho GTPases with opposing functions may compete to modulate the final outcome of a particular GTPase-activated pathway. ..
- Cherry L, Li X, Schwab P, Lim B, Klickstein L. RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes. Nat Immunol. 2004;5:961-7 pubmed..We obtained similar results using RNA interference in peripheral blood lymphocytes. These data demonstrate that RhoH is required for maintenance of lymphocyte LFA-1 in a nonadhesive state. ..
- Cowan C, Shao Y, Sahin M, Shamah S, Lin M, Greer P, et al. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005;46:205-17 pubmed..These findings suggest an important role for Vav family GEFs as regulators of ligand-receptor endocytosis and determinants of repulsive signaling during axon guidance. ..
- Hall A, Gakidis M, Glogauer M, Wilsbacher J, Gao S, Swat W, et al. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006;24:305-16 pubmed..In contrast, Vav is specifically required for complement-mediated phagocytosis, suggesting that Rac is regulated by GEFs other than Vav downstream of the FcgammaR. ..