Genomes and Genes
Experts and Doctors on neuropeptides in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
- Pradhan L, Cai X, Wu S, Andersen N, Martin M, Malek J, et al. Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing. J Surg Res. 2011;167:336-42 pubmed publisher..This suggests that the chronic inflammation in the skin of diabetic rabbits inhibits the acute inflammation much needed for wound healing. ..
- Scammell T, Winrow C. Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. 2011;51:243-66 pubmed publisher..As the orexin system mainly promotes arousal, these new compounds will likely improve insomnia without incurring many of the side effects encountered with current medications. ..
- Chou T, Bjorkum A, Gaus S, Lu J, Scammell T, Saper C. Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002;22:977-90 pubmed..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions. ..
- Furuta G, Turner J, Taylor C, Hershberg R, Comerford K, Narravula S, et al. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med. 2001;193:1027-34 pubmed..HIF-1-dependent induction of ITF may provide an adaptive link for maintenance of barrier function during hypoxia. ..
- Puopolo M, Hochstetler S, Gustincich S, Wightman R, Raviola E. Extrasynaptic release of dopamine in a retinal neuron: activity dependence and transmitter modulation. Neuron. 2001;30:211-25 pubmed..Since the somatic receptors for these ligands are extrasynaptic, we suggest that the composition of the extracellular fluid directly modulates extrasynaptic release. ..
- Kalwa H, Sartoretto J, Sartoretto S, Michel T. Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium. J Biol Chem. 2012;287:29147-58 pubmed publisher..These studies establish a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl. ..
- Feng Y, Walsh C. Protein-protein interactions, cytoskeletal regulation and neuronal migration. Nat Rev Neurosci. 2001;2:408-16 pubmed
- Kim A, Van Huffel C, Lutchman M, Chishti A. Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12. Genomics. 1998;49:165-6 pubmed
- Cole L, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, et al. Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab. 2008;93:3551-9 pubmed publisher..Mice deficient in prokineticin 2(PROK2) and prokineticin receptor2 (PROKR2) exhibit variable olfactory bulb dysgenesis and GnRH neuronal migration defects reminiscent of human GnRH deficiency...
- Marfatia S, Leu R, Branton D, Chishti A. Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein. J Biol Chem. 1995;270:715-9 pubmed..Our data provide new insights into how protein 4.1, glycophorin C, p55, and their non-erythroid homologues, interact with the cytoskeleton to exert their physiological effects. ..
- Gleeson J, Allen K, Fox J, Lamperti E, Berkovic S, Scheffer I, et al. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell. 1998;92:63-72 pubmed..Doublecortin, along with the newly characterized mDab1, may define an Abl-dependent pathway regulating neuronal migration. ..
- Wang T, Goldenring J, Dangler C, Ito S, Mueller A, Jeon W, et al. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology. 1998;114:675-89 pubmed..Because sPLA2 has been identified recently as the MOM1 (modifier of MIN) locus that influences polyp formation in the colon, these studies suggest that sPLA2 may also influence the gastric epithelial response to Helicobacter infection. ..
- Hao Y, Hu Z, Sieburth D, Kaplan J. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012;8:e1002464 pubmed publisher..These results suggest that RIC-7 promotes DCV-mediated secretion. ..
- John M, Arai M, Rubin D, Jonsson K, Juppner H. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002;143:1047-57 pubmed..Because PTH2 receptor expression was previously shown to be highest in brain, pancreas, and testis, our findings are consistent with the notion that TIP39 is a neuropeptide which may also have a role in spermatogenesis. ..
- Tischler A. Chromaffin cells as models of endocrine cells and neurons. Ann N Y Acad Sci. 2002;971:366-70 pubmed
- Dalkilic I, Kunkel L. Muscular dystrophies: genes to pathogenesis. Curr Opin Genet Dev. 2003;13:231-8 pubmed..The number of genes identified increases each year, adding to our understanding as well as revealing the overall complexity of the pathogenesis of these diseases. ..
- Kim T, Lim J, Ota S, Raja S, Rogers R, Rivnay B, et al. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J Cell Biol. 1998;141:553-66 pubmed..Our studies indicate that NRP/B is a novel nuclear matrix protein, specifically expressed in primary neurons, that interacts with p110(RB) and participates in the regulation of neuronal process formation. ..
- Seng S, Avraham H, Birrane G, Jiang S, Avraham S. Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem. 2010;285:26190-8 pubmed publisher..Thus, the interaction of NRP/B with the Neh4/Neh5 domains of NRF2 is indispensable for activation of NRF2-mediated ARE-driven antioxidant and detoxifying genes that confer cellular defense against oxidative stress-induced damage. ..
- Deuel T, Liu J, Corbo J, Yoo S, Rorke Adams L, Walsh C. Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006;49:41-53 pubmed..Dcx and Dclk may directly or indirectly regulate microtubule-based vesicle transport, a process critical to both neuronal migration and axon outgrowth. ..
- Nie D, Di Nardo A, Han J, Baharanyi H, Kramvis I, Huynh T, et al. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci. 2010;13:163-72 pubmed publisher..Our results indicate that TSC2-Rheb-mTOR signaling cooperates with the ephrin-Eph receptor system to control axon guidance in the visual system. ..
- Chee M, Pissios P, Maratos Flier E. Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus. J Comp Neurol. 2013;521:2208-34 pubmed publisher..Taken together, this study supports the use of the Mchr1-cre mouse for outlining the neuroanatomical distribution and neurochemical phenotype of MCHR1 neurons. ..
- Zhang X, McNeil G, Hilderbrand Chae M, Franklin T, Schroeder A, Jackson F. Circadian regulation of the lark RNA-binding protein within identifiable neurosecretory cells. J Neurobiol. 2000;45:14-29 pubmed
- Qin W, Bajaj V, Malinowska I, Lu X, MacConaill L, Wu C, et al. Angiomyolipoma have common mutations in TSC2 but no other common genetic events. PLoS ONE. 2011;6:e24919 pubmed publisher..However, chromosomal translocations and gene fusion events were not assessed here. TSC2 inactivation by mutation is a consistent and likely necessary genetic event in the pathogenesis of most angiomyolipoma...
- Saper C, Cano G, Scammell T. Homeostatic, circadian, and emotional regulation of sleep. J Comp Neurol. 2005;493:92-8 pubmed..Understanding the pathways that underlie the regulation of sleep and wakefulness may provide important insights into how the cognitive and emotional systems interact with basic homeostatic and circadian drives for sleep. ..
- Yew J, Wang Y, Barteneva N, Dikler S, Kutz Naber K, Li L, et al. Analysis of neuropeptide expression and localization in adult drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry. J Proteome Res. 2009;8:1271-84 pubmed publisher..Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker. ..
- Flier J, Maratos Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell. 1998;92:437-40 pubmed
- Shimada M, Tritos N, Lowell B, Flier J, Maratos Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998;396:670-4 pubmed..Our results show that MCH is a critical regulator of feeding and energy balance which acts downstream of leptin and the melanocortin system, and that deletion of a gene encoding a single orexigenic peptide can result in leanness. ..
- Gleeson J, Lin P, Flanagan L, Walsh C. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron. 1999;23:257-71 pubmed..Therefore, DCX likely directs neuronal migration by regulating the organization and stability of microtubules. ..
- Farrell J, Taupin D, Koh T, Chen D, Zhao C, Podolsky D, et al. TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest. 2002;109:193-204 pubmed..Taken together, these results suggest a physiologic role for TFF2 to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion. ..
- Mochizuki T, Klerman E, Sakurai T, Scammell T. Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol. 2006;291:R533-40 pubmed..In addition, because heat loss is an essential aspect of sleep, the blunted fall in Tb of orexin KO mice may provide an explanation for the fragmented sleep of narcolepsy. ..
- Corbo J, Deuel T, Long J, LaPorte P, Tsai E, Wynshaw Boris A, et al. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002;22:7548-57 pubmed..Behavioral tests show defects in context and cued conditioned fear tests, suggesting that deficits in hippocampal learning accompany the abnormal cytoarchitecture. ..
- Xu Y, Lopes C, Qian Y, Liu Y, Cheng L, Goulding M, et al. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci. 2008;28:4037-46 pubmed publisher..These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons. ..
- Seng S, Avraham H, Jiang S, Yang S, Sekine M, Kimelman N, et al. The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. Cancer Res. 2007;67:8596-604 pubmed..Thus, this study reveals that NRP/B enhances oxidative stress responses in breast cancer cells via the Nrf2 pathway, identifying a novel role of nuclear matrix protein(s) in oxidative stress responses. ..
- Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
- Sofer A, Lei K, Johannessen C, Ellisen L. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. 2005;25:5834-45 pubmed..These results define REDD1 as a critical transducer of the cellular response to energy depletion through the TSC-mTOR pathway. ..
- Hanada T, Takeuchi A, Sondarva G, Chishti A. Protein 4.1-mediated membrane targeting of human discs large in epithelial cells. J Biol Chem. 2003;278:34445-50 pubmed..1r. ..
- Bilder D. Cell polarity: squaring the circle. Curr Biol. 2001;11:R132-5 pubmed..The results illustrate the reiterated use of groups of proteins to dictate cell polarity in epithelial and non-epithelial cells. ..
- Krane I, Naylor S, Helin Davis D, Chin W, Spindel E. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. J Biol Chem. 1988;263:13317-23 pubmed..Since the gene for human gastrin-releasing peptide is on chromosome 18, this analysis demonstrates that the bombesin-like peptide genes are not clustered. ..
- Chakrabarti P, Anno T, Manning B, Luo Z, Kandror K. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. Mol Endocrinol. 2008;22:2260-7 pubmed publisher..It appears, therefore, that mTORC1 controls translation of leptin mRNA via a novel mechanism that does not require the presence of either the 5'-terminal oligopyrimidine tract or the 5'-UTR. ..
- Oishi Y, Williams R, Agostinelli L, Arrigoni E, Fuller P, Mochizuki T, et al. Role of the medial prefrontal cortex in cataplexy. J Neurosci. 2013;33:9743-51 pubmed publisher..These observations indicate that the mPFC is a critical site through which positive emotions trigger cataplexy. ..
- McNeil G, Zhang X, Genova G, Jackson F. A molecular rhythm mediating circadian clock output in Drosophila. Neuron. 1998;20:297-303 pubmed
- Tani T, Mercurio A. PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. J Biol Chem. 2001;276:36535-42 pubmed..The binding site in alpha(6)B defines a new subclass of type I PDZ interaction site, characterized by a non-aliphatic residue at position 0. ..
- Abreu A, Noel S, Xu S, Carroll R, Latronico A, Kaiser U. Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol. 2012;26:1417-27 pubmed publisher..In summary, we have shown the importance of Arg80 in ICL1 for PROKR2 expression and demonstrate that R80C PROKR2 exerts a dominant negative effect on WT PROKR2. ..
- Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell T. Behavioral state instability in orexin knock-out mice. J Neurosci. 2004;24:6291-300 pubmed..Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states. ..
- Hawley R, Scheibe R, Wagner J. NGF induces the expression of the VGF gene through a cAMP response element. J Neurosci. 1992;12:2573-81 pubmed..Sequence comparisons and hybridization studies indicate that there are at least two alternatively spliced forms of VGF mRNA, and the accumulation of both of these forms is similarly regulated by NGF and cAMP. ..
- Sieburth D, Madison J, Kaplan J. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007;10:49-57 pubmed..Similar neuropeptide secretion defects were found in mutants lacking unc-31 (encoding the protein CAPS) or unc-13 (encoding Munc13). These results suggest that PKC-1 selectively regulates DCV release from neurons...