Genomes and Genes
Experts and Doctors on neurons in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Publications484 found, 100 shown here
- Huang Y, Ainsley J, Reijmers L, Jackson F. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. PLoS Biol. 2013;11:e1001703 pubmed publisher..This includes Tdc2, encoding a neurotransmitter synthetic enzyme, which we demonstrate is required within clock neurons for normal circadian locomotor activity. ..
- Patten B, Peyrin J, Weinmaster G, Corfas G. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. J Neurosci. 2003;23:6132-40 pubmed..Thus, these results unveil some of the mechanisms underlying radial glia formation. ..
- Soiza Reilly M, Commons K. Glutamatergic drive of the dorsal raphe nucleus. J Chem Neuroanat. 2011;41:247-55 pubmed publisher..Understanding the intricacies of these local networks and their checks and balances, may help identify how potential imbalances could cause psychopathology and illuminate strategies for therapeutic manipulation. ..
- Gupta A, Sanada K, Miyamoto D, Rovelstad S, Nadarajah B, Pearlman A, et al. Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. Nat Neurosci. 2003;6:1284-91 pubmed..Hence, our findings suggest that inside-out layering requires distinct functions of Reelin and p35/Cdk5 signaling, with the latter being important for proper glia-guided migration. ..
- Huo L, Munzberg H, Nillni E, Bjørbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin. Endocrinology. 2004;145:2516-23 pubmed
- Putrino D, Brown E, Mastaglia F, Ghosh S. Differential involvement of excitatory and inhibitory neurons of cat motor cortex in coincident spike activity related to behavioral context. J Neurosci. 2010;30:8048-56 pubmed publisher..Different populations of excitatory and inhibitory neurons appear to be synchronized during skilled movement and quiet sitting...
- Biasini E, Unterberger U, Solomon I, Massignan T, Senatore A, Bian H, et al. A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity. J Neurosci. 2013;33:2408-18 pubmed publisher..A similar mechanism may operate in other neurodegenerative disorders attributable to toxic, ?-rich oligomers that bind to PrP(C). ..
- Meehan W, Zhang J, Mannix R, Whalen M. Increasing recovery time between injuries improves cognitive outcome after repetitive mild concussive brain injuries in mice. Neurosurgery. 2012;71:885-91 pubmed..Increasing the time interval between concussions attenuates the effects on cognition. When multiple concussions are sustained by mice daily, the effects on cognition are long term. ..
- Johnson W, McCormick C, Bray S, Hirsh J. A neuron-specific enhancer of the Drosophila dopa decarboxylase gene. Genes Dev. 1989;3:676-86 pubmed..These results suggest that the neuron-specific expression of Ddc results from the combined action of several factors binding within this distal enhancer region. ..
- Tsen G, Williams B, Allaire P, Zhou Y, Ikonomov O, Kondova I, et al. Receptors with opposing functions are in postsynaptic microdomains under one presynaptic terminal. Nat Neurosci. 2000;3:126-32 pubmed..Coexistence of separate clusters of receptors with opposing functions under one terminal contradicts Dale's principle and provides a new mechanism for modulating synaptic activity in vivo. ..
- Escobar G, Fares T, Stepanyants A. Structural plasticity of circuits in cortical neuropil. J Neurosci. 2008;28:8477-88 pubmed publisher..Primate neurons appear to be more selective, making synaptic connections with >7-15% of encountered axons. ..
- Heys J, Giocomo L, Hasselmo M. Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex. J Neurophysiol. 2010;104:258-70 pubmed publisher..Furthermore, our data suggest that these changes in resonance properties are mediated through modulation of h-current and m-current. ..
- Rosene D, Lister J, Schwagerl A, Tonkiss J, McCormick C, Galler J. Prenatal protein malnutrition in rats alters the c-Fos response of neurons in the anterior cingulate and medial prefrontal region to behavioral stress. Nutr Neurosci. 2004;7:281-9 pubmed..These results suggest that neurons in anterior cingulate and medial prefrontal regions respond excessively to restraint stress in prenatally malnourished rats. ..
- Kinney H, Broadbelt K, Haynes R, Rognum I, Paterson D. The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis. J Chem Neuroanat. 2011;41:182-99 pubmed publisher..The delineation of the development and organization of the human caudal 5-HT system provides the critical foundation for the neuropathologic elucidation of its disorders directly in the human brain. ..
- Yang J, Caligioni C, Chan Y, Seminara S. Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. Endocrinology. 2012;153:1498-508 pubmed publisher..Tacr3 mice are a useful model to examine the mechanisms by which neurokinin B signaling modulates GnRH release. ..
- Patel S, Sheth S, Martínez Rubio C, Mian M, Asaad W, Gerrard J, et al. Studying task-related activity of individual neurons in the human brain. Nat Protoc. 2013;8:949-57 pubmed publisher..We describe the protocol in detail and provide two examples of expected results. In addition, we discuss the potential difficulties and pitfalls related to intraoperative studies. This protocol takes ?1.5 h to complete. ..
- Glickfeld L, Histed M, Maunsell J. Mouse primary visual cortex is used to detect both orientation and contrast changes. J Neurosci. 2013;33:19416-22 pubmed publisher..Thus, detection of changes in either orientation or contrast is dependent on, and highly sensitive to, the activity of neurons in V1. ..
- Bjørbaek C, Elmquist J, Frantz J, Shoelson S, Flier J. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1998;1:619-25 pubmed..In conclusion, SOCS-3 is a leptin-inducible inhibitor of leptin signaling, and a potential mediator of leptin resistance in obesity. ..
- Elmquist J. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Int J Obes Relat Metab Disord. 2001;25 Suppl 5:S78-82 pubmed..These results provide a neuroanatomic framework explaining the endocrine, autonomic and behavioral effects of leptin. ..
- Kosik K. Beyond phrenology, at last. Nat Rev Neurosci. 2003;4:234-9 pubmed
- Munzberg H, Huo L, Nillni E, Hollenberg A, Bjørbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology. 2003;144:2121-31 pubmed..We speculate that STAT3 is critical for leptin-dependent effects on energy homeostasis that are mediated by the central melanocortin system. ..
- Xu H, Blair N, Clapham D. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci. 2005;25:8924-37 pubmed..We also found that camphor inhibited several other related TRP channels, including ankyrin-repeat TRP 1 (TRPA1). The camphor-induced desensitization of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor. ..
- Schnitzler A, Mellott T, Lopez Coviella I, Tallini Y, Kotlikoff M, Follettie M, et al. BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. J Neurosci. 2010;30:8221-8 pubmed publisher..The data suggest an autocrine/paracrine role for NGF in the development and/or maintenance of BFCN and imply that the stimulation of NGF production and release contributes to the cholinergic-supportive properties of BMP9. ..
- Fekete C, Singru P, Sanchez E, Sarkar S, Christoffolete M, Riberio R, et al. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology. 2006;147:520-9 pubmed..We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting. ..
- Siddiq A, Ayoub I, Chavez J, Aminova L, Shah S, Lamanna J, et al. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem. 2005;280:41732-43 pubmed..Taken together these findings identified low molecular weight and peptide HIF prolyl 4-hydroxylase inhibitors as novel neurological therapeutics for stroke as well as other diseases associated with oxidative stress. ..
- Sheen V, Ganesh V, Topcu M, Sebire G, Bodell A, Hill R, et al. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet. 2004;36:69-76 pubmed..Our findings show that vesicle trafficking is an important regulator of proliferation and migration during human cerebral cortical development. ..
- Xia Z, Dudek H, Miranti C, Greenberg M. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci. 1996;16:5425-36 pubmed..Taken together, these findings suggest that SRF, Elk, and ERKs may have important roles in neuroplasticity. ..
- Funari V, Crandall J, Tolan D. Fructose metabolism in the cerebellum. Cerebellum. 2007;6:130-40 pubmed..This review will discuss the status of fructose metabolism in the brain with special reference to the cerebellum and the physiological roles of the different pathways. ..
- Gao Y, Ferguson D, Xie W, Manis J, Sekiguchi J, Frank K, et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 2000;404:897-900 pubmed..Our findings support a crucial role for the non-homologous end-joining pathway as a caretaker of the mammalian genome, a role required both for normal development and for suppression of tumours. ..
- Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed publisher..Thus, Pin1 has opposite effects on the tauopathy phenotype depending on whether the tau is WT or a P301L mutant, indicating the need for disease-specific therapies for tauopathies. ..
- Peters L, John K, Lu F, Eicher E, Higgins A, Yialamas M, et al. Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. J Cell Biol. 1995;130:313-30 pubmed..We conclude that Ank3 is a broadly distributed epithelial ankyrin and is the major ankyrin in the kidney and other tissues, where it plays an important role in the polarized distribution of many integral membrane proteins. ..
- Vekrellis K, Ye Z, Qiu W, Walsh D, Hartley D, Chesneau V, et al. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000;20:1657-65 pubmed..Our results support a principal role for membrane-associated and secreted IDE isoforms in the degradation and clearance of naturally secreted Abeta by neurons and microglia. ..
- Giannaris E, Rosene D. A stereological study of the numbers of neurons and glia in the primary visual cortex across the lifespan of male and female rhesus monkeys. J Comp Neurol. 2012;520:3492-508 pubmed publisher..This study provides further evidence that in normal aging neurons are not lost and hence cannot account for age-related dysfunction. ..
- Corbo J, Deuel T, Long J, LaPorte P, Tsai E, Wynshaw Boris A, et al. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002;22:7548-57 pubmed..Behavioral tests show defects in context and cued conditioned fear tests, suggesting that deficits in hippocampal learning accompany the abnormal cytoarchitecture. ..
- Li H, Liu H, Sage C, Huang M, Chen Z, Heller S. Islet-1 expression in the developing chicken inner ear. J Comp Neurol. 2004;477:1-10 pubmed..Our data is consistent with a role for islet-1 in differentiating inner ear neurons and sensory epithelia cells, perhaps in the specification of cellular subtypes in conjunction with other LIM/homeodomain proteins. ..
- Zhang Y, Klassen H, Tucker B, Perez M, Young M. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci. 2007;27:4499-506 pubmed..This suggests a novel therapeutic role for progenitor cells in the treatment of CNS degenerative diseases. ..
- Lazarus M, Yoshida K, Coppari R, Bass C, Mochizuki T, Lowell B, et al. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007;10:1131-3 pubmed..These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses. ..
- Sheth S, Abuelem T, Gale J, Eskandar E. Basal ganglia neurons dynamically facilitate exploration during associative learning. J Neurosci. 2011;31:4878-85 pubmed publisher..Once a profitable response is identified, increased GPi activity suppresses alternative responses, sharpening the response profile and encouraging exploitation of the profitable learned behavior. ..
- Schratt G, Nigh E, Chen W, Hu L, Greenberg M. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. J Neurosci. 2004;24:7366-77 pubmed..The local translation of the cytoskeleton-associated protein Homer2 in particular might have important implications for growth cone dynamics and dendritic spine development. ..
- Dreier L, Burbea M, Kaplan J. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron. 2005;46:51-64 pubmed..We hypothesize that LIN-23-mediated degradation of BAR-1 beta-catenin regulates the transcription of Wnt target genes, which in turn alter postsynaptic properties. ..
- Jensen P, Farago A, Awatramani R, Scott M, Deneris E, Dymecki S. Redefining the serotonergic system by genetic lineage. Nat Neurosci. 2008;11:417-9 pubmed publisher..We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation. ..
- Ngwenya L, Peters A, Rosene D. Maturational sequence of newly generated neurons in the dentate gyrus of the young adult rhesus monkey. J Comp Neurol. 2006;498:204-16 pubmed
- Dittman J, Kaplan J. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008;28:7104-12 pubmed publisher..Thus, conserved GPCRs act in the nematode motor circuit to provide negative feedback and to regulate locomotory behaviors that underlie navigation...
- Li S, Jin M, Koeglsperger T, Shepardson N, Shankar G, Selkoe D. Soluble A? oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci. 2011;31:6627-38 pubmed publisher..Thus, soluble A? oligomers at low nanomolar levels present in AD brain increase activation of extrasynaptic NR2B-containing receptors, thereby impairing synaptic plasticity. ..
- Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher..Finally, REST levels during ageing are closely correlated with cognitive preservation and longevity. Thus, the activation state of REST may distinguish neuroprotection from neurodegeneration in the ageing brain. ..
- Kwon Y, Tsai L. A novel disruption of cortical development in p35(-/-) mice distinct from reeler. J Comp Neurol. 1998;395:510-22 pubmed..These data suggest that the p35/cdk5 kinase is required for cortical plate neurons to migrate past preexisting neurons and take up superficial positions to constitute the inside-outside layering order of cortical lamination. ..
- Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, et al. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci. 2001;21:7551-60 pubmed..These findings raise the possibility that the JNK pathway may also contribute to Abeta-dependent death in AD patients. ..
- Duggan A, Garcia Anoveros J, Corey D. The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem. 2002;277:5203-8 pubmed..Therefore, PICK1 interacts with BNaC/ASIC channels and may regulate their subcellular distribution or function in both peripheral and central neurons. ..
- Sheen V, Feng Y, Graham D, Takafuta T, Shapiro S, Walsh C. Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002;11:2845-54 pubmed..These results suggest that FLNA and FLNB may form both homodimers and heterodimers and that their interaction could potentially compensate for the loss of FLNA function during cortical development within PH individuals. ..
- Mills K, Ferguson D, Essers J, Eckersdorff M, Kanaar R, Alt F. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev. 2004;18:1283-92 pubmed..These findings demonstrate a role for NHEJ in the repair of DSBs that occur spontaneously during or after DNA replication, and reveal overlapping functions for NHEJ and Rad54-dependent HR in the repair of such DSBs. ..
- Walker K, Kang E, Whalen M, Shen Y, Tesco G. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 2012;32:10423-37 pubmed publisher..However, the efficient disposal of the acutely accumulated BACE1 solely depends on GGA3 levels in the subacute phase of injury. ..
- Krishnan V, Stoppel D, Nong Y, Johnson M, Nadler M, Ozkaynak E, et al. Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Nature. 2017;543:507-512 pubmed publisher..Our results suggest that gene and seizure interactions in VTA glutamatergic neurons impair sociability by downregulating Cbln1, a key node in the expanding protein interaction network of autism genes. ..
- Tischler A. Chromaffin cells as models of endocrine cells and neurons. Ann N Y Acad Sci. 2002;971:366-70 pubmed
- Ho A, Jain J, Rao A, Hogan P. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J Biol Chem. 1994;269:28181-6 pubmed..The presence of NFATp in the nervous system suggests that it has a role in the transcription of specific neuronal genes in response to increases in cytosolic calcium. ..
- Brown M. Response adaptation of medial olivocochlear neurons is minimal. J Neurophysiol. 2001;86:2381-92 pubmed..Such sustained responses may enable the MOC system to produce sustained effects in the periphery, supporting a role for this efferent system during ongoing stimuli of long duration...
- Yaar M, Zhai S, Fine R, Eisenhauer P, Arble B, Stewart K, et al. Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem. 2002;277:7720-5 pubmed..Our data suggest that p75(NTR) may be present as a preformed trimer that binds amyloid beta to induce receptor activation, and support the hypothesis that p75(NTR) activation by amyloid beta is causally related to Alzheimer's disease. ..
- Benedito A, Lehtinen M, Massol R, Lopes U, Kirchhausen T, Rao A, et al. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005;280:2818-25 pubmed..Taken together, these results reveal an essential function for NFAT3-mediated transcription in neuronal survival that may play important roles in the developing and mature brain. ..
- Dorval A, White J. Channel noise is essential for perithreshold oscillations in entorhinal stellate neurons. J Neurosci. 2005;25:10025-8 pubmed..These results provide the first direct demonstration that physiological levels of channel noise can produce qualitative changes in the integrative properties of neurons. ..
- Dhillon H, Zigman J, Ye C, Lee C, McGovern R, Tang V, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49:191-203 pubmed..These results reveal a critical role for leptin action on VMH neurons. ..
- Periquet M, Fulga T, Myllykangas L, Schlossmacher M, Feany M. Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo. J Neurosci. 2007;27:3338-46 pubmed
- Suter B, Nowakowski R, Bhide P, Caviness V. Navigating neocortical neurogenesis and neuronal specification: a positional information system encoded by neurogenetic gradients. J Neurosci. 2007;27:10777-84 pubmed..This mapping system consisting of a combination of signals from two different sources is a novel perspective on the source of positional information for neuronal specification in the developing CNS. ..
- Zilli E, Yoshida M, Tahvildari B, Giocomo L, Hasselmo M. Evaluation of the oscillatory interference model of grid cell firing through analysis and measured period variance of some biological oscillators. PLoS Comput Biol. 2009;5:e1000573 pubmed publisher..However, oscillatory interference models can tolerate small amounts of noise, suggesting the utility of circuit level effects which might reduce oscillator variability. Further implications for grid cell models are discussed. ..
- Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed publisher..Thus, caspase cleavage of tau may be a molecular mechanism through which lysosomal dysfunction and neurodegeneration are causally linked in Alzheimer's disease. ..
- Li Y, Radner S, French M, Pinzon Duarte G, Daly G, Burgeson R, et al. The ?3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies. Matrix Biol. 2012;31:120-34 pubmed publisher..These data support the suggestion that the ?3 chain is deposited in BMs and contributes some unique properties to their function, particularly in the nervous system...
- Fluharty B, Biasini E, Stravalaci M, Sclip A, Diomede L, Balducci C, et al. An N-terminal fragment of the prion protein binds to amyloid-? oligomers and inhibits their neurotoxicity in vivo. J Biol Chem. 2013;288:7857-66 pubmed publisher..These data suggest that N1, or small peptides derived from it, could be potent inhibitors of A? oligomer toxicity and represent an entirely new class of therapeutic agents for AD. ..
- Garcia J, Guerriero K, Keen K, Kenealy B, Seminara S, Terasawa E. Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys. Endocrinology. 2017;158:3269-3280 pubmed publisher..We speculate that this cooperative mechanism by the kisspeptin and NKB network underlies the pubertal increase in GnRH release in female monkeys. ..
- Kim T, Lim J, Ota S, Raja S, Rogers R, Rivnay B, et al. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J Cell Biol. 1998;141:553-66 pubmed..Our studies indicate that NRP/B is a novel nuclear matrix protein, specifically expressed in primary neurons, that interacts with p110(RB) and participates in the regulation of neuronal process formation. ..
- Kondoh K, Lu Z, Ye X, Olson D, Lowell B, Buck L. A specific area of olfactory cortex involved in stress hormone responses to predator odours. Nature. 2016;532:103-6 pubmed publisher..These findings suggest that AmPir, a small area comprising <5% of the olfactory cortex, plays a key part in the hormonal component of the instinctive fear response to volatile predator scents. ..
- Elmquist J, Saper C. Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide. J Comp Neurol. 1996;374:315-31 pubmed..Our results are consistent with the hypothesis that the PVH plays a key role in integrating diverse physiological cues into the varied manifestations that constitute the cerebral component of the acute phase response. ..
- Hsueh Y, Yang F, Kharazia V, Naisbitt S, Cohen A, Weinberg R, et al. Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J Cell Biol. 1998;142:139-51 pubmed..The synaptic localization of CASK and syndecan suggests a potential role for these proteins in adhesion and signaling at neuronal synapses. ..
- Heisler L, Cowley M, Kishi T, Tecott L, Fan W, Low M, et al. Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci. 2003;994:169-74 pubmed..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus. ..
- Ahn J, Radhakrishnan M, Mapelli M, Choi S, Tidor B, Cuny G, et al. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol. 2005;12:811-23 pubmed..These leads could be a starting point for structure-based drug design of more potent and selective inhibitors. ..
- Molyneaux B, Arlotta P, Menezes J, Macklis J. Neuronal subtype specification in the cerebral cortex. Nat Rev Neurosci. 2007;8:427-37 pubmed..Here, we assess recent data regarding the nature of neocortical progenitors, review the roles of individual genes in projection neuron specification and discuss the implications for progenitor plasticity. ..
- Zhu J, Lee K, Jewett K, Man H, Chung H, Tsai N. Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLoS Genet. 2017;13:e1006634 pubmed publisher..Our findings provide critical information to the future development of therapeutic strategies for patients who carry mutations of Nedd4-2. ..
- Azevedo A, Wilson R. Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons. Neuron. 2017;96:446-460.e9 pubmed publisher..These results illustrate how membrane properties and voltage-gated conductances can extract distinct stimulus features into parallel channels. ..
- Chae T, Kwon Y, Bronson R, Dikkes P, Li E, Tsai L. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 1997;18:29-42 pubmed..The phenotype of p35 mutant mice thus demonstrates that the formation of cortical laminar structure depends on the action of the p35/cdk5 kinase. ..
- Lin J, Ju W, Foster K, Lee S, Ahmadian G, Wyszynski M, et al. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat Neurosci. 2000;3:1282-90 pubmed..Thus, the molecular mechanisms and intracellular sorting of AMPA receptors are diverse, and depend on the internalizing stimulus. ..
- Wray S, Dalmau J, Chen A, King S, Leigh R. Paraneoplastic disorders of eye movements. Ann N Y Acad Sci. 2011;1233:279-84 pubmed publisher..Abnormal eye movements in paraneoplastic syndromes offer insights into the pathogenesis of these disorders and the opportunity to test potential therapies, such as new drugs with effects on neuronal channels. ..
- Samad T, Srinivasan A, Karchewski L, Jeong S, Campagna J, Ji R, et al. DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. J Neurosci. 2004;24:2027-36 pubmed..The dynamic expression, ordered spatial localization, and adhesive properties of the RGM-related family of membrane-associated proteins are compatible with specific roles in development. ..
- Belfort G, Bakirtzi K, Kandror K. Cellugyrin induces biogenesis of synaptic-like microvesicles in PC12 cells. J Biol Chem. 2005;280:7262-72 pubmed..We suggest that changing the length of this loop similar to disruption of the short hydrophobic hairpins alters the position of the vicinal transmembrane domains that may be crucial for protein function. ..
- Pellegrino D, Cicchetti F, Wang X, Zhu A, Yu M, Saint Pierre M, et al. Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats. J Nucl Med. 2007;48:1147-53 pubmed