Genomes and Genes
Experts and Doctors on molecular sequence data in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: molecular sequence data
Publications273 found, 100 shown here
- Li Z, Sacks D. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem. 2003;278:4347-52 pubmed..These results, which differ from the conventional model of Ca(2+)-independent binding of calmodulin to IQ motifs, provide insight into the complexity of the molecular interactions between calmodulin and IQ motifs. ..
- Tsujikawa M, Malicki J. Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron. 2004;42:703-16 pubmed..These studies reveal an essential role for IFT genes in vertebrate sensory neurons and implicate the molecular components of intraflagellar transport in degenerative disorders of these cells. ..
- Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell. 2005;7:167-78 pubmed..These findings indicate that MUC1 regulates p53-responsive genes and thereby cell fate in the genotoxic stress response. ..
- Ichida J, Zou K, Horhota A, Yu B, McLaughlin L, Szostak J. An in vitro selection system for TNA. J Am Chem Soc. 2005;127:2802-3 pubmed..We have also developed a method of covalently linking a DNA template to the TNA strand that it encodes, thus obviating the need for a TNA-dependent DNA polymerase during cycles of selection. ..
- Shaw G, Cope J, Li L, Corson K, Hersey C, Ackermann G, et al. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006;440:96-100 pubmed..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
- Pissios P, Bradley R, Maratos Flier E. Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions. Endocr Rev. 2006;27:606-20 pubmed
- Sheen J. Molecular mechanisms underlying the differential expression of maize pyruvate, orthophosphate dikinase genes. Plant Cell. 1991;3:225-45 pubmed..The low expression of cyppdkZm2 can be attributed to an absence of upstream positive elements and weak activity of the TATA promoter element. ..
- Klickstein L, Bartow T, Miletic V, Rabson L, Smith J, Fearon D. Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis. J Exp Med. 1988;168:1699-717 pubmed..The presence of these three distinct sites in CR1 may enable the receptor to interact multivalently with C4b/C3b and C3b/C3b complexes generated during activation of the classical and alternative pathways. ..
- Robinson L, Weremowicz S, Morton C, Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics. 1994;19:350-7 pubmed..abstract truncated at 250 words) ..
- Tontonoz P, Hu E, Spiegelman B. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-56 pubmed
- Saiz M, Llanos Cuentas A, Echevarria J, Roncal N, Cruz M, Muniz M, et al. Short report: detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru. Am J Trop Med Hyg. 1998;58:192-4 pubmed..This study demonstrates, through the reverse transcription-polymerase chain reaction, that Leishmaniavirus exists in human biopsy samples of leishmaniasis prior to manipulation in culture...
- Robertson N, Lu L, Heller S, Merchant S, Eavey R, McKenna M, et al. Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nat Genet. 1998;20:299-303 pubmed..These areas correspond to human inner ear structures which show histopathological findings of acidophilic ground substance in DFNA9 patients. ..
- Zhang X, Tsao H, Tsuji T, Minoshima S, McBride J, Majewski P, et al. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. Biochem Biophys Res Commun. 1999;255:59-63 pubmed..RT-PCR-SSCP analysis failed to detect deleterious mutations of the DOC-1R transcript in four premalignant oral keratinocyte lines and 20 different cancer cell lines from tumor types which frequently harbor LOH at chromosome 11q13. ..
- Membrillo Hernandez J, Echave P, Cabiscol E, Tamarit J, Ros J, Lin E. Evolution of the adhE gene product of Escherichia coli from a functional reductase to a dehydrogenase. Genetic and biochemical studies of the mutant proteins. J Biol Chem. 2000;275:33869-75 pubmed..Since both mutant enzymes exhibited similar kinetic properties, the second mutation probably conferred an increased growth rate on ethanol by stabilizing AdhE(A267T). ..
- Riggle P, Kumamoto C. Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. J Bacteriol. 2000;182:4899-905 pubmed..Crd1p is the first example of a eukaryotic copper pump that provides the primary source of cellular copper resistance, and its ability to confer silver resistance may enhance the prevalence of C. albicans as a nosocomial pathogen. ..
- Johnson B, Stehn J, Yaffe M, Blackwell T. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002;277:18029-36 pubmed..They also suggest that 14-3-3 binding is part of a complex network of stimuli and interactions that regulate TTP function. ..
- Rankin S, Ayad N, Kirschner M. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 2005;18:185-200 pubmed..We speculate that the protein, which we have named sororin, regulates the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes. ..
- Meijers R, Puettmann Holgado R, Skiniotis G, Liu J, Walz T, Wang J, et al. Structural basis of Dscam isoform specificity. Nature. 2007;449:487-91 pubmed..Phylogenetic analysis shows strong selection of matching peptide sequences only for epitope I. We propose that peptide complementarity of variable residues in epitope I of Dscam is essential for homophilic binding specificity. ..
- Alekseyenko A, Ellison C, Gorchakov A, Zhou Q, Kaiser V, Toda N, et al. Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila. Genes Dev. 2013;27:853-8 pubmed publisher..We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation. ..
- Chen X, Raab G, Deutsch U, Zhang J, Ezzell R, Klagsbrun M. Induction of heparin-binding EGF-like growth factor expression during myogenesis. Activation of the gene by MyoD and localization of the transmembrane form of the protein on the myotube surface. J Biol Chem. 1995;270:18285-94 pubmed
- Busconi L, Michel T. Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem. 1993;268:8410-3 pubmed..N-terminal myristoylation of the endothelial NO synthase may provide a potential point of regulation of the biological functions of endothelium-derived NO in situ. ..
- Bozic C, Gerard N, von Uexkull Guldenband C, Kolakowski L, Conklyn M, Breslow R, et al. The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization. J Biol Chem. 1994;269:29355-8 pubmed..Our data indicate that KC is the murine homologue of human Gro-alpha, and the KC receptor is an IL8 type B receptor homologue capable of binding both KC and macrophage inflammatory protein-2 with high affinity. ..
- Fath M, Zhang L, Rush J, Kolter R. Purification and characterization of colicin V from Escherichia coli culture supernatants. Biochemistry. 1994;33:6911-7 pubmed..0 amu, consistent with the mass of the unmodified 88 amino acid polypeptide. The purification scheme provides a rapid and simple way to obtain ColV for further biochemical analysis. ..
- Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, et al. Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus. J Biol Chem. 1996;271:8882-6 pubmed..These results suggest that Grb10 is a novel insulin receptor interactive protein and provide direct evidence for an insulin receptor substrate-1-independent function of the insulin receptor carboxyl terminus in protein binding. ..
- Wyszynski M, Lin J, Rao A, Nigh E, Beggs A, Craig A, et al. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature. 1997;385:439-42 pubmed..Intriguingly, NR1-alpha-actinin binding is directly antagonized by Ca2+/calmodulin. Thus alpha-actinin may play a role in both the localization of NMDA receptors and their modulation by Ca2+. ..
- Lee L, Klee S, Evangelista M, Boone C, Pellman D. Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. J Cell Biol. 1999;144:947-61 pubmed..Additionally, we present evidence that other bipolar bud site determinants together with cortical actin are also required for spindle orientation. ..
- Zhang Y, Moheban D, Conway B, Bhattacharyya A, Segal R. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J Neurosci. 2000;20:5671-8 pubmed..Thus, interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intracellular location of phosphorylated receptors. ..
- Monney L, Sabatos C, Gaglia J, Ryu A, Waldner H, Chernova T, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002;415:536-41 pubmed..Tim-3 may have an important role in the induction of autoimmune diseases by regulating macrophage activation and/or function. ..
- Izmailova E, Aldovini A. Functional analysis of the murine sarcoma virus RNA packaging sequence. J Virol. 2002;76:4643-8 pubmed..Our results reveal the extent to which each of the segments of the packaging sequence contribute to packaging efficiency...
- Krueger N, Reddy R, Johnson K, Bateman J, Kaufmann N, Scalice D, et al. Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol Cell Biol. 2003;23:6909-21 pubmed..These results indicate multiple roles for PTP-D2, perhaps by acting as a docking domain for downstream elements and as a regulator of PTP-D1. ..
- Cherepanov P, Sun Z, Rahman S, Maertens G, Wagner G, Engelman A. Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol. 2005;12:526-32 pubmed..The initial structure determination of a host cell factor that tightly binds to a retroviral enzyme lays the groundwork for understanding enzyme-host interactions important for viral replication. ..
- Mazzocca A, Coppari R, De Franco R, Cho J, Libermann T, Pinzani M, et al. A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Cancer Res. 2005;65:4728-38 pubmed..These results emphasize the importance of tumor-stromal interactions in invasion and suggest that ADAM9-S can be an important determinant in the ability of cancer cells to invade and colonize the liver. ..
- Wei R, Al Bassam J, Harrison S. The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol. 2007;14:54-9 pubmed..The less conserved, N-terminal segment of Ndc80p contributes to the interaction and may be a crucial regulatory element. We propose that the Ndc80 complex forms a direct link between kinetochore core components and spindle microtubules. ..
- Malia T, Wagner G. NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL. Biochemistry. 2007;46:514-25 pubmed..Our characterization of the VDAC/Bcl-xL complex offers initial structural insight into the role of antiapoptotic Bcl-xL in regulating apoptotic events in the mitochondrial outer membrane. ..
- Haseltine W. Molecular biology of the human immunodeficiency virus type 1. FASEB J. 1991;5:2349-60 pubmed..However, enough insight has been gained into the structure and function of each of these components to provide a firm basis for rational antiviral drug development. ..
- Lazar M, Hodin R, Darling D, Chin W. Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol. 1988;2:893-901 pubmed..r-erbA alpha-1 mRNA, unlike r-erbA alpha-2 mRNA, is undetectable in testis. Southern analyses suggest that the r-erbA alpha-1 and r-erbA alpha-2 mRNAs are derived from a single gene transcript. ..
- Koenig M, Monaco A, Kunkel L. The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Cell. 1988;53:219-28 pubmed..Dystrophin shares many features with the cytoskeletal protein spectrin and alpha-actinin and is a large structural protein that is likely to adopt a rod shape about 150 nm in length. ..
- Franc N, Dimarcq J, Lagueux M, Hoffmann J, Ezekowitz R. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. 1996;4:431-43 pubmed..Our findings support the idea that the primordial function of macrophages may have been in tissue modeling and that their adapted role is in host defense. ..
- Zhang M, Sheng S, Maass N, Sager R. mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility. Mol Med. 1997;3:49-59 pubmed..mMaspin has inhibitory properties similar to those of human maspin in cell culture, suggesting that the homologous proteins play similar physiological roles in vivo. ..
- Hunt J, Friend D, Gurish M, Feyfant E, Sali A, Huang C, et al. Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells. J Biol Chem. 1997;272:29158-66 pubmed..This finding suggests that each member of the chromosome 14 family of serine proteases evolved to degrade a distinct group of proteins. ..
- Cryns V, Byun Y, Rana A, Mellor H, Lustig K, Ghanem L, et al. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. J Biol Chem. 1997;272:29449-53 pubmed..Both of the major apoptotic cleavage sites of PRK2 in vivo lie within its regulatory domain, suggesting that its activity may be deregulated by proteolysis. ..
- Hu L, Pratt S, Perides G, Katz L, Rogers R, Klempner M. Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi. Infect Immun. 1997;65:4989-95 pubmed..coli (34% identity and 57% similarity), and, more generally, to the periplasmic oligopeptide binding family of proteins. ..
- Wang J, Smolyar A, Tan K, Liu J, Kim M, Sun Z, et al. Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell. 1999;97:791-803 pubmed..These features explain CD2-CD58 dynamic binding, offering insights into interactions of related immunoglobulin superfamily receptors. ..
- Vazquez F, Ramaswamy S, Nakamura N, Sellers W. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000;20:5010-8 pubmed..Therefore, the tail is likely to mediate the regulation of PTEN function through phosphorylation. ..
- Miyake S, Sellers W, Safran M, Li X, Zhao W, Grossman S, et al. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol. 2000;20:8889-902 pubmed..A pRB variant that can bind to EID1, but not MDM2, stabilizes EID-1 in cells. Thus, EID-1 may act at a nodal point that couples cell cycle exit to the transcriptional activation of genes required for differentiation. ..
- Tian J, Kim S, Heilig E, Ruderman J. Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation. Proc Natl Acad Sci U S A. 2000;97:14358-63 pubmed..These results argue that the conventional progesterone receptor also functions as the signaling receptor that is responsible for the rapid nontranscriptional activation of frog oocytes. ..
- Nishi T, Kawasaki Nishi S, Forgac M. The first putative transmembrane segment of subunit c" (Vma16p) of the yeast V-ATPase is not necessary for function. J Biol Chem. 2003;278:5821-7 pubmed..These results suggest that subunit c" contains four rather than five transmembrane segments with both the N and C terminus on the cytoplasmic side of the membrane. ..
- Fontebasso A, Papillon Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset P, et al. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Nat Genet. 2014;46:462-6 pubmed publisher..This work considerably expands the number of potential treatment targets and further justifies pretreatment biopsy in pediatric mHGA as a means to orient therapeutic efforts in this disease. ..
- Jimenez Li an M, Rubin B, King J. Examination of guinea pig luteinizing hormone-releasing hormone gene reveals a unique decapeptide and existence of two transcripts in the brain. Endocrinology. 1997;138:4123-30 pubmed publisher..Future studies will examine LHRH gene expression in guinea pigs, which like primates but unlike rats, have a true luteal phase as a component of their reproductive cycle...
- Reenan R, Kolodner R. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics. 1992;132:975-85 pubmed..26%) PMS events were observed. These results indicate that MSH1 plays a role in repair or stability of mtDNA and MSH2 plays a role in repair of 4-bp insertion/deletion mispairs in the nucleus. ..
- Mueller J, Sonenshein A. Role of the Bacillus subtilis gsiA gene in regulation of early sporulation gene expression. J Bacteriol. 1992;174:4374-83 pubmed..It apparently does so by inhibiting or counteracting the activity of KinA. ..
- Kaelin W, Krek W, Sellers W, DeCaprio J, Ajchenbaum F, Fuchs C, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 1992;70:351-64 pubmed..Therefore, RBAP-1 is a species of E2F and can bind specifically to the RB pocket. ..
- Coetzer T, Sahr K, Prchal J, Blacklock H, Peterson L, Koler R, et al. Four different mutations in codon 28 of alpha spectrin are associated with structurally and functionally abnormal spectrin alpha I/74 in hereditary elliptocytosis. J Clin Invest. 1991;88:743-9 pubmed..Our results imply that codon 28 of alpha Sp is a "hot spot" for mutations and also indicate that Arg 28 is critical for the conformational stability and functional self association of Sp heterodimers. ..
- Teixido J, Parker C, Kassner P, Hemler M. Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J Biol Chem. 1992;267:1786-91 pubmed..Thus, cleavage of the alpha 4 subunit in these transfectants did not alter any of the known VLA-4-mediated adhesion functions. ..
- Woo H, Lotz M, Jung J, Mercurio A. Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186. J Biol Chem. 1991;266:18419-22 pubmed..These results raise the possibility that homo- and heterodimeric forms of CBP35 contribute to its postulated functions in cell-matrix interactions and growth regulation. ..
- Hosler B, LaRosa G, Grippo J, Gudas L. Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol. 1989;9:5623-9 pubmed..The REX-1 gene is not identical to the previously reported murine genes that encode zinc finger-containing proteins. ..
- Bond M, Strydom D. Amino acid sequence of bovine angiogenin. Biochemistry. 1989;28:6110-3 pubmed..Two regions, 6-22 and 65-75, are highly conserved between the angiogenins but are significantly different from those of the ribonucleases, suggesting a possible role in the molecules' biological activity. ..
- Patarca R, Freeman G, Singh R, Wei F, Durfee T, Blattner F, et al. Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med. 1989;170:145-61 pubmed..Eta-1 gene expression appears to be part of a surprisingly rapid T cell-dependent response to bacterial infection that may precede classical forms of T cell-dependent immunity. ..
- Ho C, Conner D, Pollak M, Ladd D, Kifor O, Warren H, et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet. 1995;11:389-94 pubmed..Our findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface. ..
- Riddle R, Ensini M, Nelson C, Tsuchida T, Jessell T, Tabin C. Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell. 1995;83:631-40 pubmed..Ectopic expression of Lmx1 in the ventral mesenchyme is sufficient to generate double-dorsal limbs. Thus, the dorsalization of limb mesoderm appears to involve the WNT7a-mediated induction of Lmx1 in limb mesenchymal cells. ..
- Heginbotham L, Lu Z, Abramson T, MacKinnon R. Mutations in the K+ channel signature sequence. Biophys J. 1994;66:1061-7 pubmed..Furthermore, the results illustrate that the hydroxyl groups at the third and fourth positions, and the aromatic group at position seven, are not essential in determining K+ selectivity. ..
- Moller D, Xia C, Tang W, Zhu A, Jakubowski M. Human rsk isoforms: cloning and characterization of tissue-specific expression. Am J Physiol. 1994;266:C351-9 pubmed..These results indicate that the multiplicity of p90rsk isoforms is increased to at least three for humans and that marked tissue-/cell-specific differences in p90rsk isoform expression are present...
- Haass C, Hung A, Schlossmacher M, Teplow D, Selkoe D. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem. 1993;268:3021-4 pubmed..p3 appears to derive from the 10-kDa C-terminal stub of beta APP following secretion of APPs. ..
- Ranganathan R, Lewis J, MacKinnon R. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron. 1996;16:131-9 pubmed..These results reveal a shallow vestibule formed by the pore loops at the K+ channel entryway. The selectivity filter is located at the center of the vestibule close to (approximately 5 A) the extracellular solution. ..
- Zhu Y, Pless M, Inhorn R, Mathey Prevot B, D Andrea A. The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. Mol Cell Biol. 1996;16:4808-17 pubmed..Further analysis of the DUB-1 enhancer element may reveal specific determinants of a betac-specific signaling pathway. ..
- Zolotarev A, Chernova M, Yannoukakos D, Alper S. Proteolytic cleavage sites of native AE2 anion exchanger in gastric mucosal membranes. Biochemistry. 1996;35:10367-76 pubmed..These results provide experimental confirmation for some aspects of AE2 topography previously predicted from primary structure alone. ..
- Gisselbrecht S, Skeath J, Doe C, Michelson A. heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev. 1996;10:3003-17 pubmed..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer. ..
- Shih S, Claffey K. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem. 1999;274:1359-65 pubmed..Thus, we propose that specific association of hnRNP L with VEGF mRNA under hypoxia may play an important role in hypoxia-induced post-transcriptional regulation of VEGF mRNA expression. ..
- Beresford P, Zhang D, Oh D, Fan Z, Greer E, Russo M, et al. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem. 2001;276:43285-93 pubmed..Thus, GzmA activates a DNase (GzmA-activated DNase) within the SET complex to produce a novel form of DNA damage during cytotoxic T lymphocyte-mediated death. ..
- French C, Miyoshi I, Kubonishi I, Grier H, Perez Atayde A, Fletcher J. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003;63:304-7 pubmed..Very few fusion oncogenes have been identified in epithelial tumors, and BRD4-NUT is the first fusion oncogene mechanism identified in a highly lethal form of carcinoma. ..
- Keutmann H, Schneyer A, Sidis Y. The role of follistatin domains in follistatin biological action. Mol Endocrinol. 2004;18:228-40 pubmed..A continuous sequence comprising the N-terminal domain and followed by FS domains 1 and 2 fulfills the minimum structural requirement for activin binding and FS bioactivity. ..
- Moy L, Tsai L. Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem. 2004;279:54487-93 pubmed..Taken together, these data suggest that cdk5 phosphorylation of TH is an important regulator of TH activity through stabilization of TH protein levels. ..
- Djuretic I, Levanon D, Negreanu V, Groner Y, Rao A, Ansel K. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol. 2007;8:145-53 pubmed..Our data indicate that cytokine gene expression in T(H)1 cells may be controlled by a feed-forward regulatory circuit in which T-bet induces Runx3 and then 'partners' with Runx3 to direct lineage-specific gene activation and silencing. ..
- Cashman S, McCullough L, Kumar Singh R. Improved retinal transduction in vivo and photoreceptor-specific transgene expression using adenovirus vectors with modified penton base. Mol Ther. 2007;15:1640-6 pubmed..The use of these vectors in combination with a 4.7 kilobase (kb) rhodopsin promoter enabled transgene expression exclusively in PR cells in vivo. ..
- Roberts J, Chiche J, Kolpa E, Bloch D, Bloch K. cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein. Am J Physiol Lung Cell Mol Physiol. 2007;293:L903-12 pubmed
- Lopez Pajares V, Kim M, Yuan Z. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J Biol Chem. 2008;283:13707-13 pubmed publisher..Our data suggest that stabilization of MDMX by Akt may be an alternative mechanism by which Akt up-regulates MDM2 protein levels and exerts its oncogenic effects on p53 in tumor cells. ..
- Brumme Z, Brumme C, Carlson J, Streeck H, John M, Eichbaum Q, et al. Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection. J Virol. 2008;82:9216-27 pubmed publisher..Dramatic differences in escape and reversion rates across codons, genes, and HLA restrictions are observed, highlighting the complexity of viral adaptation to the host immune response. ..
- Wu N, Zheng B, SHAYWITZ A, Dagon Y, Tower C, Bellinger G, et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013;49:1167-75 pubmed publisher..The glucose influx through GLUT1 restores ATP-to-ADP ratios in the short run and ultimately induces TXNIP protein production to suppress glucose uptake once energy homeostasis is reestablished. ..
- Kanai Y, Hediger M. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 1992;360:467-71 pubmed..The abnormal glutamate transport that is associated with certain neurodegenerative diseases and which occurs during ischaemia and anoxia could be due to abnormalities in the function of this protein. ..
- Kochoyan M, Keutmann H, Weiss M. Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition. Biochemistry. 1991;30:7063-72 pubmed..Alternating surface architectures may have implications for the mechanism of DNA recognition by the ZFY two-finger repeat. ..
- Ezekowitz R, Sastry K, Bailly P, Warner A. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J Exp Med. 1990;172:1785-94 pubmed..Deletion of the cytoplasmic tail results in a mutant receptor that is able to bind but not ingest the ligated pathogens, suggesting that the signal for phagocytosis is contained in the cytoplasmic tail. ..
- Jain J, Burgeon E, Badalian T, Hogan P, Rao A. A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J Biol Chem. 1995;270:4138-45 pubmed..The results suggest that NFATp and Rel family proteins bind to DNA using similar structural motifs. ..
- Fiore S, Maddox J, Perez H, Serhan C. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J Exp Med. 1994;180:253-60 pubmed..Together, they suggest that the encoded protein is a candidate for a LXA4 receptor in myeloid cells. ..
- Jin S, Sonenshein A. Identification of two distinct Bacillus subtilis citrate synthase genes. J Bacteriol. 1994;176:4669-79 pubmed..A mutation in citZ caused a substantial loss of citrate synthase enzyme activity, glutamate auxotrophy, and a defect in sporulation. ..
- Mori Y, Matsubara H, Folco E, Siegel A, Koren G. The transcription of a mammalian voltage-gated potassium channel is regulated by cAMP in a cell-specific manner. J Biol Chem. 1993;268:26482-93 pubmed..We conclude that cAMP and depolarization play an important role in regulating K+ channel expression and thus may induce long term effects on the pattern of electrical activity of excitable cells. ..
- Silverman G, Kuo W, Taillon Miller P, Gray J. Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18. Genomics. 1993;15:442-5 pubmed..In addition, these YACs were found to contain another 18p11.32 gene, thymidylate synthase. These genes were less than 50 kb apart. Collectively, these data suggest that YES1 maps to 18p11.32 rather than to 18q21.3. ..
- Holmquist B, Moulis J, Engeland K, Vallee B. Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. Biochemistry. 1993;32:5139-44 pubmed..These results account in part for the unique specificity of chi chi-ADH relative to other human ADH isozymes. ..
- Gerecke D, Foley J, Castagnola P, Gennari M, Dublet B, Cancedda R, et al. Type XIV collagen is encoded by alternative transcripts with distinct 5' regions and is a multidomain protein with homologies to von Willebrand's factor, fibronectin, and other matrix proteins. J Biol Chem. 1993;268:12177-84 pubmed..We hypothesize therefore that the sequence in alpha 1(XIV) collagen may play a role in the control of alpha 1(XIV) protein synthesis. ..
- Brown W, Nobile V, Subramanian V, Shapiro R. The mouse angiogenin gene family: structures of an angiogenin-related protein gene and two pseudogenes. Genomics. 1995;29:200-6 pubmed..quot; Southern blotting of genomic DNA confirmed the presence of Ang, Angrp, and at least one of the pseudogenes in an individual mouse and suggested that the mouse Ang gene family may contain more than the four members identified here. ..
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