Experts and Doctors on knockout mice in Boston, Massachusetts, United States


Locale: Boston, Massachusetts, United States
Topic: knockout mice

Top Publications

  1. Kayyali U, Zhang W, Yee A, Seidman J, Potter H. Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. J Neurochem. 1997;68:1668-78 pubmed
    ..The CNA alpha -/- mice were found in a separate study to have deficits in learning and memory that may result in part from the cytoskeletal changes in the hippocampus. ..
  2. Ito M, Grujic D, Abel E, Vidal Puig A, Susulic V, Lawitts J, et al. Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. Diabetes. 1998;47:1464-71 pubmed
    ..These "humanized" mice should assist us in the development of drugs that may become effective anti-obesity agents in humans. ..
  3. White T, Paul D. Genetic diseases and gene knockouts reveal diverse connexin functions. Annu Rev Physiol. 1999;61:283-310 pubmed
    ..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity. ..
  4. Spergel J, Mizoguchi E, Oettgen H, Bhan A, Geha R. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest. 1999;103:1103-11 pubmed
    ..These results suggest that both the TH2 cytokines IL-4 and IL-5 and the TH1 cytokine IFN-gamma play important roles in the inflammation and hypertrophy of the skin in AD. ..
  5. Rengarajan J, Mittelstadt P, Mages H, Gerth A, Kroczek R, Ashwell J, et al. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity. 2000;12:293-300 pubmed
    ..Further, Egr3 expression is enriched in Th1 cells, suggesting a molecular basis for the known preferential expression of FasL in the Th1 versus Th2 subset. ..
  6. Alexander C, Reichsman F, Hinkes M, Lincecum J, Becker K, Cumberledge S, et al. Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Nat Genet. 2000;25:329-32 pubmed
    ..Our results provide both genetic and biochemical evidence that syndecan-1 can modulate Wnt signalling, and is critical for Wnt-1-induced tumorigenesis of the mouse mammary gland. ..
  7. Dufresne S, Bjørbaek C, El Haschimi K, Zhao Y, Aschenbach W, Moller D, et al. Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol. 2001;21:81-7 pubmed
    ..RSK2 knockout mice may be a good animal model for the study of Coffin-Lowry syndrome. ..
  8. Aikawa T, Segre G, Lee K. Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem. 2001;276:29347-52 pubmed
    ..Taken together, FGF's growth inhibitory effects of chondrocytes appear to be mediated at least partially through p21 induction and the subsequent inactivation of cyclin E-Cdk2 and activation of pRb. ..
  9. Yin Y, Stahl B, DeWolf W, Morgentaler A. P53 and Fas are sequential mechanisms of testicular germ cell apoptosis. J Androl. 2002;23:64-70 pubmed
    ..The cascade of testicular germ cell apoptosis in response to heat stress implies the existence of sequential quality control mechanisms in spermatogenesis. ..

More Information

Publications192 found, 100 shown here

  1. Lucey E, Keane J, Kuang P, Snider G, Goldstein R. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. Lab Invest. 2002;82:79-85 pubmed
  2. Morteau O, Castagliuolo I, Mykoniatis A, Zacks J, Wlk M, Lu B, et al. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology. 2002;122:725-33 pubmed
    ..C. difficile toxin A-induced murine enteritis involves CCR1 and its ligands MIP-1alpha and RANTES, which may be important mediators of the neutrophil recruitment characterizing acute, enterotoxin-mediated enteritis. ..
  3. Luo Y, Berman M, Zhai Q, Fischer F, Abromson Leeman S, Zhang Y, et al. RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes. Glia. 2002;39:19-30 pubmed
    ..Thus, after chemokine treatment, astrocytes release proinflammatory mediators and reprogram their surface molecules. The combined effects of RANTES may serve to amplify inflammatory responses within the central nervous system. ..
  4. Frossard J, Saluja A, Mach N, Lee H, Bhagat L, Hadenque A, et al. In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury. Am J Physiol Lung Cell Mol Physiol. 2002;283:L541-8 pubmed
    ..Our findings indicate that GM-CSF plays a critical role in coupling pancreatitis to ALI and suggest that GM-CSF may act indirectly by regulating the release of other proinflammatory factors including MIP-2. ..
  5. Cao C, Leng Y, Huang W, Liu X, Kufe D. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem. 2003;278:39609-14 pubmed
    ..Our findings provide the first evidence that GPx1 is regulated by a signaling pathway that is activated in the oxidative stress response. ..
  6. McMullen J, Shioi T, Huang W, Zhang L, Tarnavski O, Bisping E, et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem. 2004;279:4782-93 pubmed
    ..This study suggests that targeting the cardiac IGF1R-PI3K(p110alpha) pathway could be a potential therapeutic strategy for the treatment of heart failure. ..
  7. Nagle J, Ma Z, Byrne M, White M, Shaw L. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol. 2004;24:9726-35 pubmed
    ..In contrast, IRS-1(-/-) tumor cells, which express only IRS-2, were highly invasive and were resistant to apoptotic stimuli. Collectively, our findings reveal an important contribution of IRS-2 to breast cancer metastasis. ..
  8. Kwan K, Allchorne A, Vollrath M, Christensen A, Zhang D, Woolf C, et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006;50:277-89 pubmed
    ..TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons. ..
  9. Andersson C, Zaman M, Jones A, Freedman S. Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages. J Cyst Fibros. 2008;7:68-78 pubmed
    ..The effects of DHA could be reproduced by PPAR agonists and blocked by a PPARalpha antagonist. Impaired regulation of nuclear receptors may contribute to the abnormal LPS induced signaling in CF macrophages and is reversed by DHA. ..
  10. Tran P, Haycraft C, Besschetnova T, Turbe Doan A, Stottmann R, Herron B, et al. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet. 2008;40:403-410 pubmed publisher
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event. ..
  11. Grozovsky R, Ribich S, Rosene M, Mulcahey M, Huang S, Patti M, et al. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009;150:1976-83 pubmed publisher
  12. Xu Z, Zhang L, Liu T, Park J, Berta T, Yang R, et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med. 2010;16:592-7, 1p following 597 pubmed publisher
    ..Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain. ..
  13. Colvin R, Means T, Diefenbach T, Moita L, Friday R, Sever S, et al. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol. 2010;11:495-502 pubmed publisher
    ..Our data identify a molecular pathway required for chemotaxis that links chemoattractant-induced calcium flux to exocytosis and uropod release. ..
  14. Zhang D, Zhang C, Ho A, Kirkwood A, Sudhof T, Shen J. Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. J Neurochem. 2010;115:1215-21 pubmed publisher
  15. Young F, Mizoguchi E, Bhan A, Alt F. Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. Immunity. 1997;6:23-33 pubmed
  16. Borriello F, Sethna M, Boyd S, Schweitzer A, Tivol E, Jacoby D, et al. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity. 1997;6:303-13 pubmed
    ..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2. ..
  17. Westphal C, Leder P. Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice. Curr Biol. 1997;7:530-3 pubmed
    ..The results presented here indicate that this technique should also be applicable to the generation of gene fusion constructs [4-8], simplifying this technically demanding method. ..
  18. Lawler J, Sunday M, Thibert V, Duquette M, George E, Rayburn H, et al. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998;101:982-92 pubmed
    ..A thickening and ruffling of the epithelium of the airways results from increasing cell proliferation in TSP-1-deficient mice. These results indicate that TSP-1 is involved in normal lung homeostasis. ..
  19. Kulkarni R, Winnay J, Daniels M, Bruning J, Flier S, Hanahan D, et al. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest. 1999;104:R69-75 pubmed
    ..This article may have been published online in advance of the print edition. The date of publication is available from the JCI website, ..
  20. Chen B, Bronson R, Klaman L, Hampton T, Wang J, Green P, et al. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet. 2000;24:296-9 pubmed
  21. Chitnis T, Najafian N, Abdallah K, Dong V, Yagita H, Sayegh M, et al. CD28-independent induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;107:575-83 pubmed
    ..Our data show that EAE may develop in the absence of CD28 T-cell costimulation. These findings have implications for therapies aimed at blocking costimulatory signals in autoimmune diseases. ..
  22. Rodriguez Sosa M, Monteforte G, Satoskar A. Susceptibility to Leishmania mexicana infection is due to the inability to produce IL-12 rather than lack of IL-12 responsiveness. Immunol Cell Biol. 2001;79:320-2 pubmed
    ..Moreover, the data also demonstrate that the STAT4-mediated pathway is critical for the development of protective immunity against cutaneous leishmaniasis, regardless of the species of Leishmania and/or genetic background of the mice. ..
  23. Wang K, Kim J, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. 2002;420:74-8 pubmed
    ..Thus, interfering with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin. ..
  24. Wang X, Lee S, Arai K, Lee S, Tsuji K, Rebeck G, et al. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003;9:1313-7 pubmed
    ..Targeting the tPA-LRP signaling pathway in brain may offer new approaches for decreasing neurotoxicity and improving stroke therapy. ..
  25. Krauss S, Zhang C, Scorrano L, Dalgaard L, St Pierre J, Grey S, et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest. 2003;112:1831-42 pubmed
    ..Therefore, superoxide-mediated activation of UCP2 could play an important role in the pathogenesis of beta cell dysfunction and type 2 diabetes. ..
  26. Peng S, Townsend M, Hecht J, White I, Glimcher L. T-bet regulates metastasis rate in a murine model of primary prostate cancer. Cancer Res. 2004;64:452-5 pubmed
  27. Beglopoulos V, Sun X, Saura C, Lemere C, Kim R, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem. 2004;279:46907-14 pubmed
  28. Hass M, Yankner B. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005;280:36895-904 pubmed
    ..Thus, APP may signal to the nucleus by a gamma-secretase-independent mechanism that involves membrane sequestration and phosphorylation of Tip60. ..
  29. Handschin C, Lin J, Rhee J, Peyer A, Chin S, Wu P, et al. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005;122:505-15 pubmed
    ..These data show that PGC-1alpha links nutritional status to heme biosynthesis and acute hepatic porphyria. ..
  30. Tavazoie S, Alvarez V, Ridenour D, Kwiatkowski D, Sabatini B. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci. 2005;8:1727-34 pubmed
    ..Thus, the TSC pathway regulates growth and synapse function in neurons, and perturbations of neuronal structure and function are likely to contribute to the pathogenesis of the neurological symptoms of TSC. ..
  31. Pastorino L, Sun A, Lu P, Zhou X, Balastik M, Finn G, et al. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 2006;440:528-34 pubmed
    ..These findings provide new insight into the pathogenesis and treatment of Alzheimer's disease. ..
  32. Shinohara M, Lu L, Bu J, Werneck M, Kobayashi K, Glimcher L, et al. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol. 2006;7:498-506 pubmed
    ..The finding that Opn-i selectively coupled TLR9 signaling to expression of IFN-alpha but not to that of other proinflammatory cytokines provides new molecular insight into the biology of pDCs. ..
  33. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim Y, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12:642-9 pubmed
    ..Our results suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia. ..
  34. Holloway M, Cui Y, Laz E, Hosui A, Hennighausen L, Waxman D. Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology. 2007;148:1977-86 pubmed
    ..Thus, the major loss of liver sexual dimorphism in hepatocyte STAT5ab-deficient mice can primarily be attributed to the loss of STAT5b. ..
  35. Hou J, Shan Q, Wang T, Gomes A, Yan Q, Paul D, et al. Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J Biol Chem. 2007;282:17114-22 pubmed
    ..Furthermore, tight junction proteins could be major targets of drug development for electrolyte disorders. ..
  36. Sanchez Olea R, Ortiz S, Barreto O, Yang Q, Xu C, Zhu H, et al. Parcs is a dual regulator of cell proliferation and apaf-1 function. J Biol Chem. 2008;283:24400-5 pubmed publisher
    ..We conclude that Parcs may define a molecular checkpoint in the control of cell proliferation for normal cells that is lost in tumor cells. ..
  37. Kuraguchi M, Ohene Baah N, Sonkin D, Bronson R, Kucherlapati R. Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet. 2009;5:e1000367 pubmed publisher
  38. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, et al. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009;84:221-7 pubmed publisher
    ..These results indicate that the thrombotic diathesis of PNH patients could be due to a combination of increased complement-mediated platelet activation and reduced NO-bioavailability as a consequence of hemolysis. ..
  39. Martel K, Baum M. Adult testosterone treatment but not surgical disruption of vomeronasal function augments male-typical sexual behavior in female mice. J Neurosci. 2009;29:7658-66 pubmed publisher
    ..However, we failed to corroborate the recent claim that VNO signaling normally inhibits the activity of neural circuitry controlling the expression of male-typical mating behavior by female mice. ..
  40. Herman M, She P, Peroni O, Lynch C, Kahn B. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010;285:11348-56 pubmed publisher
    ..These results demonstrate for the first time the capacity of adipose tissue to catabolize circulating BCAAs in vivo and that coordinate regulation of adipose-tissue BCAA enzymes may modulate circulating BCAA levels. ..
  41. Hendrickson B, Conner D, Ladd D, Kendall D, Casanova J, Corthesy B, et al. Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J Exp Med. 1995;182:1905-11 pubmed
    ..Furthermore, the J chain is essential for efficient hepatic pIgR transport of IgA. ..
  42. Muglia L, Jacobson L, Weninger S, Luedke C, Bae D, Jeong K, et al. Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. J Clin Invest. 1997;99:2923-9 pubmed
    ..The presence of atrophic adrenals in CRH-deficient mice without an overt deficit in basal plasma ACTH concentration suggests that the diurnal increase in ACTH is essential to maintain normal adrenal function. ..
  43. Bozza M, Satoskar A, Lin G, Lu B, Humbles A, Gerard C, et al. Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med. 1999;189:341-6 pubmed
    ..Finally, the findings of enhanced resistance to P. aeruginosa and resistance to endotoxin-induced lethal shock suggest that the counteraction or neutralization of MIF may serve as an adjunct therapy in sepsis. ..
  44. Li Y, Chen W, Liang Y, Li E, Stashenko P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 1999;23:447-51 pubmed
    ..Atp6i-/- mice exhibit a normal acid-base balance in blood and urine. Our results demonstrate that Atp6i is unique and necessary for osteoclast-mediated extracellular acidification. ..
  45. Wenkel H, Streilein J. Evidence that retinal pigment epithelium functions as an immune-privileged tissue. Invest Ophthalmol Vis Sci. 2000;41:3467-73 pubmed
    ..Paradoxically, these grafts also display immunogenicity. Thus, neonatal RPE tissue owes its immune privilege to the capacity to prevent immune rejection rather than to inhibit sensitization. ..
  46. Carabatsos M, Sellitto C, Goodenough D, Albertini D. Oocyte-granulosa cell heterologous gap junctions are required for the coordination of nuclear and cytoplasmic meiotic competence. Dev Biol. 2000;226:167-79 pubmed
    ..This study demonstrates that heterologous gap-junctional communication is required for the completion of oocyte growth and the acquisition of cytoplasmic meiotic competence. ..
  47. Karas R, Schulten H, Pare G, Aronovitz M, Ohlsson C, Gustafsson J, et al. Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice. Circ Res. 2001;89:534-9 pubmed
    ..These possibilities may be resolved by studies of mice in which ERalpha has been fully disrupted (ERalphaKO(St)), which are in progress. ..
  48. Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, et al. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci. 2001;21:7551-60 pubmed
    ..These findings raise the possibility that the JNK pathway may also contribute to Abeta-dependent death in AD patients. ..
  49. Lawler J, Miao W, Duquette M, Bouck N, Bronson R, Hynes R. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am J Pathol. 2001;159:1949-56 pubmed
    ..Increased tumor growth is also observed in the absence of TSP1 on the 129Sv genetic background. These data indicate that endogenous host TSP1 functions as a modifier or landscaper gene to suppress tumor growth. ..
  50. Kawai H, Nie L, Yuan Z. Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Mol Cell Biol. 2002;22:6079-88 pubmed
    ..Using cells expressing the c-Abl(KA) protein under the control of an inducible promoter, we demonstrate inactivation of the NF-kappaB-dependent cell survival pathway as one of the mechanisms for c-Abl-mediated apoptosis. ..
  51. Chang S, Khoo C, Naylor M, Maser R, Depinho R. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev. 2003;17:88-100 pubmed
  52. Rosenbauer F, Wagner K, Kutok J, Iwasaki H, Le Beau M, Okuno Y, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet. 2004;36:624-30 pubmed
    ..1 expression rescued myeloid differentiation of mutant progenitors and AML blasts. These results suggest that tightly graded reduction, rather than complete loss, of a lineage-indispensable transcription factor can induce AML. ..
  53. Shaw R, Bardeesy N, Manning B, Lopez L, Kosmatka M, Depinho R, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004;6:91-9 pubmed
    ..These findings position aberrant mTOR activation at the nexus of these germline neoplastic conditions and suggest the use of mTOR inhibitors in the treatment of Peutz-Jeghers syndrome. ..
  54. Sharov A, Siebenhaar F, Sharova T, Botchkareva N, Gilchrest B, Botchkarev V. Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res. 2004;64:6266-70 pubmed
    ..These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy. ..
  55. Jepeal L, Fujitani Y, Boylan M, Wilson C, Wright C, Wolfe M. Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology. 2005;146:383-91 pubmed
    ..The results of these studies indicate that the transcription factor PDX-1 plays a critical role in the cell-specific expression of the GIP gene. ..
  56. Perez G, Jurisicova A, Matikainen T, Moriyama T, Kim M, Takai Y, et al. A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB J. 2005;19:860-2 pubmed
    ..Thus, the force driving the age-related increase in female germ cell death is multifactorial, but changes in the intercellular trafficking of ceramide, along with hypersensitivity of oocytes to ceramide, are key factors in this process. ..
  57. Maehr R, Mintern J, Herman A, Lennon Dumenil A, Mathis D, Benoist C, et al. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. J Clin Invest. 2005;115:2934-43 pubmed
    ..Our results identify Cat L as an enzyme whose activity is essential for the development of type I diabetes in the NOD mouse. ..
  58. Fredenburgh L, Baron R, Carvajal I, Mouded M, Macias A, Ith B, et al. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005;51:513-20 pubmed
    ..These findings have implications for our understanding of the pathophysiology of ARDS and may guide future therapeutic strategies. ..
  59. Keino H, Masli S, Sasaki S, Streilein J, Stein Streilein J. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci. 2006;47:1533-42 pubmed
    ..Thus, the necessity for CD103 emerges in the efferent CD8+ T-cell regulatory mechanisms in eye-derived tolerance. ..
  60. Simon D, Arikan M, Srisuma S, Bhattacharya S, Tsai L, Ingenito E, et al. Epithelial cell PPAR[gamma] contributes to normal lung maturation. FASEB J. 2006;20:1507-9 pubmed
    ..These data reveal airway epithelial cell PPARgamma is necessary for normal lung structure and function. ..
  61. Kim M, Gans J, Nogueira C, Wang A, Paik J, Feng B, et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 2006;125:1269-81 pubmed
    ..Thus, comparative oncogenomics has enabled the identification and facilitated the validation of a highly relevant cancer gene governing metastatic potential in human melanoma. ..
  62. Vianna C, Huntgeburth M, Coppari R, Choi C, Lin J, Krauss S, et al. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006;4:453-64 pubmed
    ..Importantly, these abnormalities do not cause insulin resistance in skeletal muscle but cause substantially reduced insulin action in the liver. ..
  63. Koh A, Priebe G, Ray C, Van Rooijen N, Pier G. Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect Immun. 2009;77:5300-10 pubmed publisher
    ..aeruginosa lung infection from extremely small bacterial doses. There is an inescapable requirement for local PMN recruitment and activation to mediate innate immunity to P. aeruginosa lung infection. ..
  64. Lee J, Greenwich J, Zhanel G, Han X, Cumming A, Saward L, et al. Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection. Infect Immun. 2010;78:4176-86 pubmed publisher
    ..We propose a novel role for a HABP as an innate immunomodulator in the treatment of MSSA and MRSA surgical wound infection through enhancement of the local CXC chemokine-driven neutrophil response. ..
  65. Yan N, Regalado Magdos A, Stiggelbout B, Lee Kirsch M, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol. 2010;11:1005-13 pubmed publisher
    ..HIV-stimulated interferon production in cells deficient in TREX1 did not involve known nucleic acid sensors. ..
  66. Rehm H, Zhang D, Brown M, Burgess B, Halpin C, Berger W, et al. Vascular defects and sensorineural deafness in a mouse model of Norrie disease. J Neurosci. 2002;22:4286-92 pubmed
    ..We propose that one of the principal functions of norrin in the ear is to regulate the interaction of the cochlea with its vasculature. ..
  67. Wu W, Heinrichs S, Xu D, Garrison S, Zambetti G, Adams J, et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell. 2005;123:641-53 pubmed
    ..Thus, Slug functions downstream of p53 in developing blood cells as a critical switch that prevents their apoptosis by antagonizing the trans-activation of puma by p53. ..
  68. Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B, Lin H, et al. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology. 2009;137:1489-97 pubmed publisher
    ..BMP6 induction of hepcidin expression was reduced in Hfe KO hepatocytes compared with WT hepatocytes. HFE is not involved in regulation of BMP6 by iron, but does regulate the downstream signals of BMP6 that are triggered by iron. ..
  69. Ranger A, Gerstenfeld L, Wang J, Kon T, Bae H, Gravallese E, et al. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med. 2000;191:9-22 pubmed
    ..Thus, NFATp is a repressor of cartilage cell growth and differentiation and also has the properties of a tumor suppressor. ..
  70. Sharon R, Bar Joseph I, Mirick G, Serhan C, Selkoe D. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J Biol Chem. 2003;278:49874-81 pubmed
    ..Together with our earlier observations, these results suggest that alphaS-PUFA interactions help regulate neuronal PUFA levels as well as the oligomerization state of alphaS, both normally and in human synucleinopathies. ..
  71. Laustsen P, Michael M, Crute B, Cohen S, Ueki K, Kulkarni R, et al. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev. 2002;16:3213-22 pubmed
    ..The results indicate that IRS-1 and IRS-3 play important complementary roles in adipogenesis and establish the Irs1(-/-)/Irs3(-/-) double knockout mouse as a novel model of lipoatrophic diabetes. ..
  72. Kim H, Rhee S, Pothoulakis C, LaMont J. Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand. Gastroenterology. 2007;133:875-86 pubmed
    ..Toxin A enteritis involves release of PGE(2), which activates the Fas/FasL system, causing enterocyte apoptosis and inflammation. ..
  73. Clodfelter K, Holloway M, Hodor P, Park S, Ray W, Waxman D. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol. 2006;20:1333-51 pubmed
    ..Several female-predominant repressors are elevated in STAT5b-deficient males; these may contribute to the major loss of male gene expression seen in the absence of STAT5b. ..
  74. Ren T, Zamboni D, Roy C, Dietrich W, Vance R. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog. 2006;2:e18 pubmed
    ..It thus appears that macrophages sense cytosolic flagellin via a TLR5-independent pathway that leads to rapid caspase-1-dependent cell death and provides defense against intracellular bacterial pathogens. ..
  75. Hettmann T, Barton K, Leiden J. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol. 2000;222:110-23 pubmed
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