Experts and Doctors on interferon regulatory factors in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: interferon regulatory factors
Lau D, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, et al
. Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection. Gastroenterology. 2013;144:402-413.e12 pubmed publisher
..Strategies to disrupt the virus-host interactions that induce innate immune tolerance should improve therapy. ..
Eguchi J, Kong X, Tenta M, Wang X, Kang S, Rosen E. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes. 2013;62:3394-403 pubmed publisher
..These findings indicate that IRF4 is a negative regulator of inflammation in diet-induced obesity, in part through regulation of macrophage polarization. ..
Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, et al
. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2014;63:1556-66 pubmed publisher
..05). This work identified a new therapeutic avenue to augment resolution of inflammation in healing infarcts by macrophage phenotype manipulation. This therapeutic concept may be used to attenuate post-MI remodeling and heart failure. ..
Kurachi M, Barnitz R, Yosef N, Odorizzi P, Diiorio M, Lemieux M, et al
. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol. 2014;15:373-83 pubmed publisher
..This checkpoint prevents irreversible commitment to an effector fate until a critical threshold of downstream transcriptional activity has been achieved. ..
HÃ©rault A, Binnewies M, Leong S, Calero Nieto F, Zhang S, Kang Y, et al
. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544:53-58 pubmed publisher
..Our results uncover a previously unrecognized dynamic behaviour of GMPs in situ, which tunes emergency myelopoiesis and is hijacked in leukaemia. ..
Li E, Truong D, Hallett S, Mukherjee K, Schutte B, Liao E. Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model. PLoS Genet. 2017;13:e1007009 pubmed publisher
..Furthermore, it unlocked the possibility for characterizing yet undiscovered human IRF6 missense gene variants from orofacial cleft patients, and illustrated a generalizable functional genomics paradigm in personalized medicine. ..
Han J, Kraft P, Nan H, Guo Q, Chen C, Qureshi A, et al
. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet. 2008;4:e1000074 pubmed publisher
..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. ..
Han J, Qureshi A, Nan H, Zhang J, Song Y, Guo Q, et al
. A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus. Cancer Res. 2011;71:1533-9 pubmed publisher
..6 × 10(-3)). Given that the T allele was shown previously to be associated with increased expression of IRF4 locus, further studies are warranted to elucidate the role of the IRF4 gene in human pigmentation and skin cancer development. ..
Fu W, Ergun A, Lu T, Hill J, Haxhinasto S, Fassett M, et al
. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol. 2012;13:972-80 pubmed publisher
..A redundant genetic switch thus 'locked in' the T(reg) cell phenotype, a model that would account for several aspects of T(reg) cell physiology, differentiation and stability. ..