Experts and Doctors on genetic transcription in Boston, Massachusetts, United States


Locale: Boston, Massachusetts, United States
Topic: genetic transcription

Top Publications

  1. Eisenmann D, Arndt K, Ricupero S, Rooney J, Winston F. SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae. Genes Dev. 1992;6:1319-31 pubmed
    ..Taken together, these results suggest that SPT3 is a TFIID-associated protein, required for TFIID to function at particular promoters in vivo. ..
  2. Demple B, Amábile Cuevas C. Redox redux: the control of oxidative stress responses. Cell. 1991;67:837-9 pubmed
  3. LuValle P, Ninomiya Y, Rosenblum N, Olsen B. The type X collagen gene. Intron sequences split the 5'-untranslated region and separate the coding regions for the non-collagenous amino-terminal and triple-helical domains. J Biol Chem. 1988;263:18378-85 pubmed
  4. Wieczorek D, Smith C, Nadal Ginard B. The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing. Mol Cell Biol. 1988;8:679-94 pubmed
  5. Eckner R, Ewen M, Newsome D, Gerdes M, DeCaprio J, Lawrence J, et al. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 1994;8:869-84 pubmed
    ..These results imply that p300 may function as a transcriptional adaptor protein for certain complex transcriptional regulatory elements. ..
  6. Sun Z, Yergeau D, Tuypens T, Tavernier J, Paul C, Baumann M, et al. Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene. J Biol Chem. 1995;270:1462-71 pubmed
    ..abstract truncated at 400 words) ..
  7. Girard J, Springer T. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. J Biol Chem. 1996;271:4511-7 pubmed
    ..Hevin-treated cells do not form focal adhesions and exhibit a rounded morphology. Together, these results suggest that hevin is an abundant extracellular protein that modulates high endothelial cell adhesion to the basement membrane. ..
  8. Lyons D, Mahanty S, Choi K, Manandhar M, Elion E. The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:4095-106 pubmed
    ..These and other results suggest that Bem1 may cross-link the Ste5-MAPK cascade complex to upstream activators and specific downstream substrates at the shmoo tip, thus enabling efficient circuitry for G1 arrest and mating. ..
  9. Kim A, Metzenberg A, Sahr K, Marfatia S, Chishti A. Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue. Genomics. 1996;31:223-9 pubmed

More Information

Publications146 found, 100 shown here

  1. Aster J, Robertson E, Hasserjian R, Turner J, Kieff E, Sklar J. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem. 1997;272:11336-43 pubmed
    ..These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites. ..
  2. Hetts S, Rosen K, Dikkes P, Villa Komaroff L, Mozell R. Expression and imprinting of the insulin-like growth factor II gene in neonatal mouse cerebellum. J Neurosci Res. 1997;50:958-66 pubmed
    ..In contrast, choroid plexus and leptomeninges express IGF-II mRNAs biallelically, indicating that cell type-specific regulation of genomic imprinting occurs within the mammalian CNS. ..
  3. Yao T, Oh S, Fuchs M, Zhou N, Ch Ng L, Newsome D, et al. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998;93:361-72 pubmed
    ..Our results provide genetic evidence that a coactivator endowed with histone acetyltransferase activity is essential for mammalian cell proliferation and development. ..
  4. Kadosh D, Struhl K. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol. 1998;18:5121-7 pubmed
    ..Taken together with previous observations, these results define a novel mechanism of transcriptional repression which involves targeted recruitment of a histone-modifying activity and localized perturbation of chromatin structure. ..
  5. Kasahara H, Izumo S. Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5. Mol Cell Biol. 1999;19:526-36 pubmed
    ..5 phosphorylation by CKII remains to be determined, it may play an important role, as this CKII phosphorylation site within the homeodomain is fully conserved in all known members of the NK2 family of the homeobox genes. ..
  6. Membrillo Hernandez J, Kwon O, De Wulf P, Finkel S, Lin E. Regulation of adhE (encoding ethanol oxidoreductase) by the Fis protein in Escherichia coli. J Bacteriol. 1999;181:7390-3 pubmed
    ..Sequence inspection of the adhE promoter revealed three potential Fis binding sites. Electrophoretic mobility shift analysis, using purified Fis protein and adhE promoter DNA, showed three different complexes. ..
  7. Roberts R, Sheng M. Association of dystrophin-related protein 2 (DRP2) with postsynaptic densities in rat brain. Mol Cell Neurosci. 2000;16:674-85 pubmed
  8. Jónsson Z, Dhar S, Narlikar G, Auty R, Wagle N, Pellman D, et al. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem. 2001;276:16279-88 pubmed
    ..Our findings show that Rvb1p and Rvb2p are essential components of a chromatin remodeling complex and determine genes regulated by the complex. ..
  9. Aikawa T, Segre G, Lee K. Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem. 2001;276:29347-52 pubmed
    ..Taken together, FGF's growth inhibitory effects of chondrocytes appear to be mediated at least partially through p21 induction and the subsequent inactivation of cyclin E-Cdk2 and activation of pRb. ..
  10. Masiello D, Cheng S, Bubley G, Lu M, Balk S. Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J Biol Chem. 2002;277:26321-6 pubmed
    ..These results demonstrate that bicalutamide stimulates the assembly of a transcriptionally inactive AR on DNA and support altered coactivator (or corepressor) expression as a mechanism of bicalutamide-resistant androgen-independent PCa. ..
  11. Cheng S, Brzostek S, Lee S, Hollenberg A, Balk S. Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol Endocrinol. 2002;16:1492-501 pubmed
    ..These results demonstrate that AR, in contrast to other SHRs, is regulated by NCoR and suggest the possibility of developing selective AR modulators that enhance this interaction. ..
  12. Wang X, Grammatikakis N, Siganou A, Calderwood S. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003;23:6013-26 pubmed
    ..Our experiments indicate a novel pathway for HSF1 regulation and suggest a mechanism for suppression of its activity during cellular proliferation. ..
  13. Keogh M, Podolny V, Buratowski S. Bur1 kinase is required for efficient transcription elongation by RNA polymerase II. Mol Cell Biol. 2003;23:7005-18 pubmed
    ..These results show that Bur1 functions in transcription elongation but may phosphorylate a substrate other than the CTD. ..
  14. Zukerberg L, DeBernardo R, Kirley S, D Apuzzo M, Lynch M, Littell R, et al. Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res. 2004;64:202-8 pubmed
    ..In addition, loss or suppression of Cables may be an early step in the development of endometrial cancer. ..
  15. Xu Y, Wang L, Buttice G, Sengupta P, Smith B. Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma). J Biol Chem. 2004;279:41319-32 pubmed
    ..Our data suggest that CIITA is a crucial member of a repressor complex responsible for mediating COL1A2 transcription repression by IFN-gamma. ..
  16. Margulis A, Zhang W, Alt Holland A, Crawford H, Fusenig N, Garlick J. E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res. 2005;65:1783-91 pubmed
  17. Sengupta P, Xu Y, Wang L, Widom R, Smith B. Collagen alpha1(I) gene (COL1A1) is repressed by RFX family. J Biol Chem. 2005;280:21004-14 pubmed
    ..Two dominant negative forms of RFX5 activate both collagen genes coordinately. Finally, CIITA RNA interference experiments indicate that CIITA induction is required for interferon gamma-mediated repression of both collagen type I genes. ..
  18. Martens J, Wu P, Winston F. Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae. Genes Dev. 2005;19:2695-704 pubmed
    ..Moreover, our results demonstrate a mechanism by which intergenic transcription allows activators to act indirectly as repressors. ..
  19. Dineen S, McBride S, Sonenshein A. Integration of metabolism and virulence by Clostridium difficile CodY. J Bacteriol. 2010;192:5350-62 pubmed publisher
    ..About 60% of the CodY-repressed transcription units were associated with binding regions. Several of these genes were confirmed to be direct targets of CodY by gel mobility shift and DNase I footprinting assays. ..
  20. Denker B, Neer E, Schmidt C. Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions. J Biol Chem. 1992;267:6272-7 pubmed
    ..Deletion of this region diminishes the ability of alpha o to interact with the beta gamma subunit, but substitutions at this position indicate that other amino acids can be tolerated without affecting subunit interaction. ..
  21. Slack F, Mueller J, Strauch M, Mathiopoulos C, Sonenshein A. Transcriptional regulation of a Bacillus subtilis dipeptide transport operon. Mol Microbiol. 1991;5:1915-25 pubmed
    ..Expression of dciA in growing cells was also repressed independently by glucose and by a mixture of amino acids; neither of these effects was mediated by AbrB. ..
  22. Dollard C, Ricupero Hovasse S, Natsoulis G, Boeke J, Winston F. SPT10 and SPT21 are required for transcription of particular histone genes in Saccharomyces cerevisiae. Mol Cell Biol. 1994;14:5223-8 pubmed
    ..These results suggest that under some conditions, S. cerevisiae may control the level of histone proteins by differential expression of its histone genes. ..
  23. Keates S, Keates A, Mizoguchi E, Bhan A, Kelly C. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol. 1997;273:G75-82 pubmed
    ..ENA-78 as an enterocyte-derived, neutrophil-activating chemokine may be especially important in neutrophil recruitment from the lamina propria into the epithelial layer. ..
  24. Monden T, Wondisford F, Hollenberg A. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. J Biol Chem. 1997;272:29834-41 pubmed
    ..When linked to the GAL4 DNA-binding domain, p120 is an activator of transcription alone. Thus, p120 satisfies a number of important criteria as a nuclear receptor coactivator. ..
  25. Forbes K, Humphrey T, Enoch T. Suppressors of cdc25p overexpression identify two pathways that influence the G2/M checkpoint in fission yeast. Genetics. 1998;150:1361-75 pubmed
    ..These results suggest that chk1(+) and rad24(+) may function redundantly with cds1(+) in the checkpoint response to unreplicated DNA. ..
  26. Zalieckas J, Wray L, Fisher S. Expression of the Bacillus subtilis acsA gene: position and sequence context affect cre-mediated carbon catabolite repression. J Bacteriol. 1998;180:6649-54 pubmed
    ..Examination of CCR of acsA expression revealed that this regulation required the Crh and seryl-phosphorylated form of the HPr proteins but not glucose kinase. ..
  27. Anrather J, Csizmadia V, Soares M, Winkler H. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. J Biol Chem. 1999;274:13594-603 pubmed
    ..Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation. ..
  28. Peters D, Mitchell Felton H, Kandarian S. Unloading induces transcriptional activation of the sarco(endo)plasmic reticulum Ca2+-ATPase 1 gene in muscle. Am J Physiol. 1999;276:C1218-25 pubmed
  29. Kim C, Nielsen H. Hoxa-5 in mouse developing lung: cell-specific expression and retinoic acid regulation. Am J Physiol Lung Cell Mol Physiol. 2000;279:L863-71 pubmed
    ..Cycloheximide and actinomycin D treatment studies suggested that the differences in RA effect on each cell type may involve the presence of a repressor that can be overcome by RA...
  30. Zannis V, Kan H, Kritis A, Zanni E, Kardassis D. Transcriptional regulation of the human apolipoprotein genes. Front Biosci. 2001;6:D456-504 pubmed
    ..Understanding the transcriptional regulatory mechanism of the apolipoprotein genes may allow, in the long run, selective increase of anti-atherogenic lipoproteins and thus reduce the risk of cardiovascular disease. ..
  31. Aguiar R, Cox G, Pomeroy S, Dahia P. Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas. J Clin Endocrinol Metab. 2001;86:2890-4 pubmed
    ..In conclusion, mutations of the SDHD gene are not a common event in this series of sporadic pheochromocytomas. The existence of SDHD pseudogenes should be considered when analyzing complementary DNA-based samples. ..
  32. Pani L, Horal M, Loeken M. Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis. Genes Dev. 2002;16:676-80 pubmed
    ..These results suggest that Pax-3 regulates neural tube closure by inhibiting p53-dependent apoptosis, rather than by inducing neural tube-specific gene expression. ..
  33. Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt F. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 2003;422:726-30 pubmed
    ..We conclude that transcription targets the DNA deamination activity of AID to dsDNA by generating secondary structures that provide ssDNA substrates. ..
  34. Kuang P, Goldstein R, Liu Y, Rishikof D, Jean J, Joyce Brady M. Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1147-52 pubmed
    ..Our results indicate that fibulin-5 is coordinately expressed and regulated with elastin in lung fibroblasts and may serve a key role during lung injury and repair. ..
  35. Merdek K, Nguyen N, Toksoz D. Distinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signaling. Mol Cell Biol. 2004;24:2410-22 pubmed
    ..These results suggest a novel function for alpha-catulin and imply that alpha-catenin and alpha-catulin have distinct activities that downregulate, respectively, beta-catenin and Ras signals converging on the cyclin D1 promoter. ..
  36. Baron R, Carvajal I, Fredenburgh L, Liu X, Porrata Y, Cullivan M, et al. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004;18:1276-8 pubmed
    ..This study demonstrates that expression of NOS2 in lung epithelial cells is critical for the development of lung injury and mediates surfactant dysfunction independent of NOS2 inflammatory cell expression and cytokine production...
  37. Davis K, Moldes M, Farmer S. The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation. J Biol Chem. 2004;279:42453-61 pubmed
    ..These data suggest that FoxC2 blocks adipogenesis by inhibiting the capacity of PPARgamma to promote the expression of a subset of adipogenic genes. ..
  38. Alikhani M, Alikhani Z, Graves D. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem. 2005;280:12096-102 pubmed
    ..siRNA silencing also blocked down-regulation of anti-apoptotic genes. These results indicate that TNF induces activation of the FOXO1 transcription factor, which acts as a master switch to control apoptosis. ..
  39. Schiekofer S, Shiojima I, Sato K, Galasso G, Oshima Y, Walsh K. Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. Physiol Genomics. 2006;27:156-70 pubmed
    ..These data define the gene regulatory programs downstream of Akt that control heart size and contribute to the transition from compensatory hypertrophy to heart failure. ..
  40. Eeckhoute J, Carroll J, Geistlinger T, Torres Arzayus M, Brown M. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes Dev. 2006;20:2513-26 pubmed
  41. Nickels B, Roberts C, Roberts J, Hochschild A. RNA-mediated destabilization of the sigma(70) region 4/beta flap interaction facilitates engagement of RNA polymerase by the Q antiterminator. Mol Cell. 2006;24:457-68 pubmed
    ..Our findings illustrate how a regulator can exploit the nascent RNA-mediated reconfiguration of the holoenzyme to gain access to the enzyme during early elongation. ..
  42. Mineva N, Rothstein T, Meyers J, Lerner A, Sonenshein G. CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis. J Biol Chem. 2007;282:17475-85 pubmed
    ..Thus, CD40 engagement of transformed B cells activates relB gene transcription via a process we have termed the de novo RelB synthesis pathway, which protects these cells from apoptosis. ..
  43. Jazwinska A, Badakov R, Keating M. Activin-betaA signaling is required for zebrafish fin regeneration. Curr Biol. 2007;17:1390-5 pubmed
    ..These findings reveal a role of Activin-betaA signaling in the tissue repair after injury and subsequent outgrowth formation during epigenetic regeneration of the vertebrate appendage. ..
  44. Chen Z, Luo H, Basran R, Hsu T, Mang D, Nuntakarn L, et al. A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F. Mol Cell Biol. 2008;28:4386-93 pubmed publisher
    ..The T-to-G mutation in this motif disrupts GATA-1 binding and the associated repressor complex, abolishing its silencing effect and resulting in the up-regulation of gamma-globin gene expression in adults. ..
  45. Silby M, Levy S. Overlapping protein-encoding genes in Pseudomonas fluorescens Pf0-1. PLoS Genet. 2008;4:e1000094 pubmed publisher
    ..We therefore designate iiv14 "cosA". These data suggest that, as is the case with eukaryotes, some bacterial genomes are more densely coded than currently recognized. ..
  46. Boucher J, Tseng Y, Kahn C. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem. 2010;285:17235-45 pubmed publisher
    ..Thus, IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction. ..
  47. Springhorn J, Ellingsen O, Berger H, Kelly R, Smith T. Transcriptional regulation in cardiac muscle. Coordinate expression of Id with a neonatal phenotype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro. J Biol Chem. 1992;267:14360-5 pubmed
  48. Keogh M, Cho E, Podolny V, Buratowski S. Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Mol Cell Biol. 2002;22:1288-97 pubmed
    ..Surprisingly, these phosphorylation site mutants appear to destabilize the association of the cyclin subunit within the context of TFIIH but not within the trimer complex. ..
  49. Seoh H, Weech M, Zhang N, Squires C. rRNA antitermination functions with heat shock promoters. J Bacteriol. 2003;185:6486-9 pubmed
  50. Hass M, Yankner B. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005;280:36895-904 pubmed
    ..Thus, APP may signal to the nucleus by a gamma-secretase-independent mechanism that involves membrane sequestration and phosphorylation of Tip60. ..
  51. Mueller J, Bukusoglu G, Sonenshein A. Transcriptional regulation of Bacillus subtilis glucose starvation-inducible genes: control of gsiA by the ComP-ComA signal transduction system. J Bacteriol. 1992;174:4361-73 pubmed
    ..We propose that gsiA and gsiB are members of an adaptive pathway of genes whose products are involved in responses to nutrient deprivation other than sporulation. ..
  52. Zervos A, Gyuris J, Brent R. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell. 1993;72:223-32 pubmed
  53. Lei E, Silver P. Intron status and 3'-end formation control cotranscriptional export of mRNA. Genes Dev. 2002;16:2761-6 pubmed
    ..Conversely, Yra1 recruitment to genes without introns is not dependent on splicing. Finally, 3'-end formation is required for Yra1 recruitment to genes regardless of intron status. ..
  54. Cheung K, Badarinarayana V, Selinger D, Janse D, Church G. A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli. Genome Res. 2003;13:206-15 pubmed
    ..In addition, these studies implicate 60 uncharacterized genes in the osmotic stress regulon, and offer evidence for a broader role for supercoiling in the control of stress-induced transcription. ..
  55. Morris J, Petrov D, Lee A, Wu C. Enhancer choice in cis and in trans in Drosophila melanogaster: role of the promoter. Genetics. 2004;167:1739-47 pubmed
    ..In fact, complete replacement of the yellow promoter with both TATA-containing and TATA-less heterologous promoters maintains enhancer action in cis. ..
  56. Kumar D, Shadrach J, Wagers A, Lassar A. Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells. Mol Biol Cell. 2009;20:3170-7 pubmed publisher
  57. Araki E, Sun X, Haag B, Chuang L, Zhang Y, Yang Feng T, et al. Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. Diabetes. 1993;42:1041-54 pubmed
    ..Thus, IRS-1 is widely expressed and highly conserved across species and tissues.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  58. Klose K, Mekalanos J. Differential regulation of multiple flagellins in Vibrio cholerae. J Bacteriol. 1998;180:303-16 pubmed
    ..These results reveal that the V. cholerae flagellum is a complex structure with multiple flagellin subunits including FlaA, which is essential for flagellar synthesis and is differentially regulated from the other flagellins...
  59. Rosenbaum S, Greenberg A. The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. Mol Endocrinol. 1998;12:1150-60 pubmed
    ..Since PPARgamma2 protein was more abundant at this time, these results suggest that the level of PPARgamma2 protein is not the sole factor that regulates the transcriptional control by BRL 49653. ..
  60. Datta K, Li J, Bhattacharya R, Gasparian L, Wang E, Mukhopadhyay D. Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. Cancer Res. 2004;64:456-62 pubmed
  61. Li Y, Kar A, Sodroski J. Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A. J Virol. 2009;83:10951-62 pubmed publisher
    ..In both cell types examined, decreased stability of the capsid was associated with a decrease in the efficiency of HIV-1 infection. ..
  62. Solanes G, Vidal Puig A, Grujic D, Flier J, Lowell B. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem. 1997;272:25433-6 pubmed
    ..Our study shows that UCP3 is also coincident with these quantitative trait loci raising the possibility that abnormalities in UCP3 are responsible for obesity in these models. ..
  63. Sibinga N, Wang H, Perrella M, Endege W, Patterson C, Yoshizumi M, et al. Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter. J Biol Chem. 1999;274:12139-46 pubmed
    ..We hypothesize that IFN-gamma inhibits cyclin A transcription by modifying co-activators or general transcription factors within the complex that drives transcription of the cyclin A gene. ..
  64. Kwon J, Keates S, Simeonidis S, Grall F, Libermann T, Keates A. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003;278:875-84 pubmed
  65. Luke M, Sui G, Liu H, Shi Y. Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription. J Biol Chem. 2006;281:33226-32 pubmed
    ..These findings not only provide a novel insight into YY1 function but also identify a new regulation of homeotic protein-mediated transcriptional regulation in general. ..
  66. Woychik R, Maas R, Zeller R, Vogt T, Leder P. 'Formins': proteins deduced from the alternative transcripts of the limb deformity gene. Nature. 1990;346:850-3 pubmed
    ..The observation of these different RNA transcripts in different tissues suggests that the formins play a part in the formation of several organ systems. ..
  67. Hosler B, Rogers M, Kozak C, Gudas L. An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells. Mol Cell Biol. 1993;13:2919-28 pubmed
  68. Bodor J, Habener J. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J Biol Chem. 1998;273:9544-51 pubmed
    ..These findings provide further insight into the mechanisms involved in cAMP-mediated transcriptional attenuation of cytokine expression. ..
  69. Larschan E, Winston F. The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4. Genes Dev. 2001;15:1946-56 pubmed
    ..These results, taken together with previous studies, demonstrate a dependent pathway for the recruitment of TBP to GAL gene promoters consisting of the recruitment of SAGA by Gal4 and the subsequent recruitment of TBP by SAGA. ..
  70. LaVoie M, Selkoe D. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem. 2003;278:34427-37 pubmed
    ..Thus, Notch and its cognate ligands are processed by the same molecular machinery and may antagonistically regulate each other's signaling. ..
  71. LU J, Izvolsky K, Qian J, Cardoso W. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem. 2005;280:4834-41 pubmed
    ..Our approach identifies Fgf10 targets that are common to multiple biological processes and provides insights into potential mechanisms by which Fgf signaling regulates epithelial cell behavior. ..
  72. Kiani A, Viola J, Lichtman A, Rao A. Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity. 1997;7:849-60 pubmed
    ..Consistent with this observation, NFAT1-/- mice are more susceptible to infection with Leishmania major. This report provides evidence that NFAT proteins regulate not only the initiation but also the termination of gene transcription. ..
  73. Kaneto H, Suzuma K, Sharma A, Bonner Weir S, King G, Weir G. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002;277:3680-5 pubmed
    ..These results suggest that at least some of the reduction of insulin gene transcription found in the diabetic state is mediated by PKC beta2 regulation of c-myc expression. ..
  74. Sikorski T, Buratowski S. The basal initiation machinery: beyond the general transcription factors. Curr Opin Cell Biol. 2009;21:344-51 pubmed publisher
    ..Recent studies are expanding our understanding of the roles of these factors, demonstrating that their functions are both broader and more context dependent than previously realized. ..
  75. Zhang Y, Moqtaderi Z, Rattner B, Euskirchen G, Snyder M, Kadonaga J, et al. Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo. Nat Struct Mol Biol. 2009;16:847-52 pubmed publisher
  76. Beggs A, Byers T, Knoll J, Boyce F, Bruns G, Kunkel L. Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11. J Biol Chem. 1992;267:9281-8 pubmed
    ..These results demonstrate that some of the isoform diversity of alpha-actinins is the result of transcription from different genetic loci. ..
  77. Ouellette A, Lualdi J. A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin. J Biol Chem. 1990;265:9831-7 pubmed
  78. Izumo S, Mahdavi V. Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription. Nature. 1988;334:539-42 pubmed
    ..Thus, alternative splicing can produce marked differences in the functional properties of a transcriptional factor. ..
  79. Boim M, Ho K, Shuck M, Bienkowski M, Block J, Slightom J, et al. ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms. Am J Physiol. 1995;268:F1132-40 pubmed
    ..Nondegenerate PCR primer pairs were designed to span at least one intron and to amplify specific alternatively spliced forms of ROMK.(ABSTRACT TRUNCATED AT 250 WORDS)..
  80. Hsieh C, Yoshizumi M, Endege W, Kho C, Jain M, Kashiki S, et al. APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem. 1996;271:17354-9 pubmed
    ..Taken together, these data indicate that APEG-1 is a novel marker for differentiated ASMC and may have a role in regulating growth and differentiation of this cell type. ..
  81. Cohen H, Bossone S, Zhu G, McDonald G, Sukhatme V. Sp1 is a critical regulator of the Wilms' tumor-1 gene. J Biol Chem. 1997;272:2901-13 pubmed
    ..This work suggests abundant Sp1 may be a prerequisite for WT1 expression, and that Sp1 may have a wider role in nephrogenesis. ..
  82. Kim Y, Glatt H, Xie W, Sinnett D, Lalande M. Human gamma-aminobutyric acid-type A receptor alpha5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region. Genomics. 1997;42:378-87 pubmed
    ..These findings suggest that the differential exon 1 usage of GABRA5 arises as a consequence of alternative promoter activation. ..
  83. Peng H, Tan L, Osaki M, Zhan Y, Ijiri K, Tsuchimochi K, et al. ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol. 2008;215:562-73 pubmed
    ..Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair. ..
  84. Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, Short S, et al. Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. Cancer Res. 2009;69:836-44 pubmed publisher
    ..These data will be instrumental in identifying novel early cancer biomarkers and could provide a rationale for development of dormancy-promoting tumor therapy strategies. ..
  85. Cohen S, Levy S, Foulds J, Rosner J. Salicylate induction of antibiotic resistance in Escherichia coli: activation of the mar operon and a mar-independent pathway. J Bacteriol. 1993;175:7856-62 pubmed
    ..However, salicylate can also activate an unidentified, mar-independent pathway(s) which engenders multiple antibiotic resistance. ..
  86. Mayadas T, Johnson R, Rayburn H, Hynes R, Wagner D. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 1993;74:541-54 pubmed
    ..These mutant mice should prove useful in deciphering the contributions of P selectin in various inflammatory responses as well as in platelet functions. ..
  87. Liu J, Rich C, Buczek Thomas J, Nugent M, Panchenko M, Foster J. Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1106-15 pubmed
    ..Furthermore, HB-EGF addition to pulmonary fibroblasts increases FGF-2 mRNA and protein levels. These data suggest that HB-EGF and FGF-2 act in concert to regulate the synthesis of elastin in injury/repair situations. ..
  88. Keeton E, Brown M. Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT. Mol Endocrinol. 2005;19:1543-54 pubmed
  89. Perkins L, Doctor J, Zhang K, Stinson L, Perrimon N, Craig E. Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster. Mol Cell Biol. 1990;10:3232-8 pubmed
    ..Developmental expression revealed that hsc4 transcripts are enriched in cells active in endocytosis and those undergoing rapid growth and changes in shape. ..
  90. Cook S, Matsui T, Li L, Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J Biol Chem. 2002;277:22528-33 pubmed
    ..Thus, microarray analysis reveals previously unappreciated Akt regulation of genes that could contribute to the effects of Akt on cardiomyocyte survival, metabolism, and growth. ..
  91. Bulyk M, McGuire A, Masuda N, Church G. A motif co-occurrence approach for genome-wide prediction of transcription-factor-binding sites in Escherichia coli. Genome Res. 2004;14:201-8 pubmed
    ..This approach may be useful in analyzing binding sites in a variety of organisms. ..
  92. Chen Y, Lu Z, Lin E. Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol. J Bacteriol. 1989;171:6097-105 pubmed
    ..The DNA of the fucAO operon and a part of the adjacent fucP was sequenced. ..