Genomes and Genes
Experts and Doctors on energy metabolism in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: energy metabolism
Publications120 found, 100 shown here
- Tong Q, Ye C, Jones J, Elmquist J, Lowell B. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008;11:998-1000 pubmed publisher..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance. ..
- Aronis K, Kilim H, Chamberland J, Breggia A, Rosen C, Mantzoros C. Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin. J Clin Endocrinol Metab. 2011;96:E1634-9 pubmed publisher..No previous studies exist on pref-1 in women with exercise-induced hypothalamic amenorrhea (HA), which similar to anorexia nervosa, is an energy-deficiency state associated with hypoleptinemia...
- Rajan A, Perrimon N. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell. 2012;151:123-37 pubmed publisher..Strikingly, we find that human Leptin can rescue the upd2 mutant phenotypes, suggesting that Upd2 is the functional homolog of Leptin. ..
- Bhasin M, Dusek J, Chang B, Joseph M, Denninger J, Fricchione G, et al. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS ONE. 2013;8:e62817 pubmed publisher..Mitochondrial resiliency might also be promoted by RR-induced downregulation of NF-?B-associated upstream and downstream targets that mitigates stress. ..
- Estrada J, Wong F, DePace A, Gunawardena J. Information Integration and Energy Expenditure in Gene Regulation. Cell. 2016;166:234-44 pubmed publisher..Our approach is grounded in fundamental physics, leads to testable experimental predictions, and suggests how a quantitative paradigm for eukaryotic gene regulation can be formulated. ..
- Shimada M, Tritos N, Lowell B, Flier J, Maratos Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998;396:670-4 pubmed..Our results show that MCH is a critical regulator of feeding and energy balance which acts downstream of leptin and the melanocortin system, and that deletion of a gene encoding a single orexigenic peptide can result in leanness. ..
- Vidal Puig A, Grujic D, Zhang C, Hagen T, Boss O, Ido Y, et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000;275:16258-66 pubmed..The consequence of increased mitochondrial coupling in UCP3 KO mice on metabolism and the possible role of yet unidentified compensatory mechanisms, remains to be determined. ..
- Mijailovich S, Butler J, Fredberg J. Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism. Biophys J. 2000;79:2667-81 pubmed..Although these results are specific to airway smooth muscle, the approach generalizes to other smooth muscles subjected to cyclic length fluctuations. ..
- Cheng A, Morrison S, Yang D, Hagen S. Energy dependence of restitution in the gastric mucosa. Am J Physiol Cell Physiol. 2001;281:C430-8 pubmed..Our results demonstrate that the glycolytic pathway is essential for restitution after injury in the bullfrog gastric mucosa and that all but complete repair of barrier function occurs in the absence of mitochondrial respiration. ..
- Chan J, Bullen J, Lee J, Yiannakouris N, Mantzoros C. Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. J Clin Endocrinol Metab. 2004;89:335-43 pubmed
- Minokoshi Y, Alquier T, Furukawa N, Kim Y, Lee A, Xue B, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004;428:569-74 pubmed..Thus, hypothalamic AMPK plays a critical role in hormonal and nutrient-derived anorexigenic and orexigenic signals and in energy balance. ..
- Banta S, Vemula M, Yokoyama T, Jayaraman A, Berthiaume F, Yarmush M. Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and cecal ligation and puncture in rats. Biotechnol Bioeng. 2007;97:118-37 pubmed..Overall, these data show that mRNA changes measured at a single time point by DNA microarray analysis do not reliably predict metabolic flux changes in perfused livers. ..
- Cataldo A, McPhie D, Lange N, Punzell S, Elmiligy S, Ye N, et al. Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol. 2010;177:575-85 pubmed publisher..The findings may have implications for diagnosis, if they are specific to BD, and for treatment, if they provide clues as to the underlying pathophysiology of BD. ..
- Magkos F. Exercise and fat accumulation in the human liver. Curr Opin Lipidol. 2010;21:507-17 pubmed publisher..Exercise does hold promise as an effective treatment for hepatic steatosis; this field of research is still in its infancy, and there is much more to be learned. ..
- Dibble C, Manning B. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol. 2013;15:555-64 pubmed publisher..Our expanding understanding of the regulatory network upstream of mTORC1 provides molecular insights into the integrated sensing mechanisms by which diverse cellular signals converge to control cell physiology. ..
- Chamberland J, Berman R, Aronis K, Mantzoros C. Chemerin is expressed mainly in pancreas and liver, is regulated by energy deprivation, and lacks day/night variation in humans. Eur J Endocrinol. 2013;169:453-62 pubmed publisher..Chemerin receptor showed increased expression in the lymph nodes and the spleen. We outline for the first time chemerin expression and physiology in humans, which are different from those in mice. ..
- Klaman L, Boss O, Peroni O, Kim J, Martino J, Zabolotny J, et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000;20:5479-89 pubmed..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo. ..
- Heisler L, Cowley M, Kishi T, Tecott L, Fan W, Low M, et al. Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci. 2003;994:169-74 pubmed..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus. ..
- Kotani K, Peroni O, Minokoshi Y, Boss O, Kahn B. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest. 2004;114:1666-75 pubmed..Genetic determinants limiting this "metabolic flexibility" may contribute to insulin resistance and type 2 diabetes in humans. ..
- Kokkotou E, Jeon J, Wang X, Marino F, Carlson M, Trombly D, et al. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol. 2005;289:R117-24 pubmed..These studies reinforce the important role of MCH in energy homeostasis and indicate that MCH is a plausible target for antiobesity therapy. ..
- Sofer A, Lei K, Johannessen C, Ellisen L. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. 2005;25:5834-45 pubmed..These results define REDD1 as a critical transducer of the cellular response to energy depletion through the TSC-mTOR pathway. ..
- Scapa E, Pocai A, Wu M, Gutierrez Juarez R, Glenz L, Kanno K, et al. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. FASEB J. 2008;22:2579-90 pubmed publisher..Collectively, these data support a key biological role for PC-TP in the regulation of energy substrate utilization. ..
- Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, et al. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008;57:2311-20 pubmed publisher..Extracellular nucleotides serve as "metabolokines," indicating further links between inflammation and associated metabolic derangements. ..
- Tseng Y, Kokkotou E, Schulz T, Huang T, Winnay J, Taniguchi C, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454:1000-4 pubmed publisher..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity. ..
- McNay D, Briancon N, Kokoeva M, Maratos Flier E, Flier J. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest. 2012;122:142-52 pubmed publisher..This insight has important implications for our understanding of nutritional regulation of energy balance and brain function. ..
- Kitajima S, Takahashi C. Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation. Cancer Sci. 2017;108:1726-1731 pubmed publisher..In this review, we highlight the consequences of RB inactivation during cancer progression, and discuss the biological and pathological significance of the interaction between RB and pro-inflammatory signaling. ..
- Trudeau K, Molina A, Roy S. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci. 2011;52:8657-64 pubmed publisher..The detrimental effects of HG on mitochondrial function and cellular metabolism could play a role in the accelerated apoptosis associated with the retinal pericytes in diabetic retinopathy. ..
- Puigserver P, Wu Z, Park C, Graves R, Wright M, Spiegelman B. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92:829-39 pubmed..These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis. ..
- Karagiannides I, Torres D, Tseng Y, Bowe C, Carvalho E, Espinoza D, et al. Substance P as a novel anti-obesity target. Gastroenterology. 2008;134:747-55 pubmed publisher..CJ reduces appetite and promotes weight loss in mice. We speculate that NK-1R antagonists, already tested in clinical trials for various diseases, may represent a potential target against obesity. ..
- Stanford K, Middelbeek R, Townsend K, An D, Nygaard E, Hitchcox K, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013;123:215-23 pubmed publisher..These findings reveal a previously under-appreciated role for BAT in glucose metabolism. ..
- Cespedes E, Bhupathiraju S, Li Y, Rosner B, Redline S, Hu F. Long-term changes in sleep duration, energy balance and risk of type 2 diabetes. Diabetologia. 2016;59:101-109 pubmed publisher..Increases in sleep duration among middle-aged and older women were modestly associated with risk of diabetes; changes in diet, physical activity and BMI did not explain associations. ..
- Martin C, Carey A, Fortune S. A bug's life in the granuloma. Semin Immunopathol. 2016;38:213-20 pubmed publisher..It is through better understanding of these complex interactions that we may begin to strategize novel approaches for tuberculosis treatments. ..
- Smallwood C, Martinez E, Mehta N. A Comparison of Carbon Dioxide Elimination Measurements Between a Portable Indirect Calorimeter and Volumetric Capnography Monitor: An In Vitro Simulation. Respir Care. 2016;61:354-8 pubmed publisher..Currently available portable gas exchange monitors demonstrated acceptable agreement with reference VÌ‡O2 and VÌ‡CO2 values in an in vitro simulation. The devices demonstrated good agreement with each other. ..
- Howard J, Cave B, Oksanen L, Tzameli I, Bjørbaek C, Flier J. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med. 2004;10:734-8 pubmed..The level of Socs3 expression is thus a critical determinant of leptin sensitivity and obesity susceptibility in vivo and this molecule is a potential target for therapeutic intervention. ..
- Cahill G. Fuel metabolism in starvation. Annu Rev Nutr. 2006;26:1-22 pubmed
- Lessard S, Rivas D, Alves Wagner A, Hirshman M, Gallagher I, Constantin Teodosiu D, et al. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes. 2013;62:2717-27 pubmed publisher..Using this powerful biological model system, we have discovered key pathways for low exercise training response that may represent novel targets for the treatment of metabolic disease. ..
- Kim B. Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. Thyroid. 2008;18:141-4 pubmed publisher..Nevertheless, more work must be done before it can be fully explained how thyroid hormone determines the metabolic rate. ..
- St Pierre J, Lin J, Krauss S, Tarr P, Yang R, Newgard C, et al. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem. 2003;278:26597-603 pubmed..Together, these data indicate that PGC-1alpha and PGC-1beta profoundly alter mitochondrial metabolism and suggest that these proteins are likely to play different physiological functions. ..
- Kang H, Ozdemir C, Kawano Y, Leclair K, Vernochet C, Kahn C, et al. Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. J Biol Chem. 2013;288:33376-86 pubmed publisher..At least in part by regulating intracellular fatty acid channeling, Them2 functions in brown adipose tissue to suppress adaptive increases in energy expenditure. ..
- Pierroz D, Ziotopoulou M, Ungsunan L, Moschos S, Flier J, Mantzoros C. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes. 2002;51:1337-45 pubmed..In conclusion, treatment with a melanocortin agonist is a promising therapeutic approach to DIO and associated insulin resistance. ..
- Roberts S, Hajduk C, Howarth N, Russell R, McCrory M. Dietary variety predicts low body mass index and inadequate macronutrient and micronutrient intakes in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2005;60:613-21 pubmed..These findings suggest that all adults need advice on the changing needs for dietary variety with aging to maintain health, and that older persons with low BMI are particularly vulnerable to dietary shortfalls. ..
- Dhillon H, Zigman J, Ye C, Lee C, McGovern R, Tang V, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49:191-203 pubmed..These results reveal a critical role for leptin action on VMH neurons. ..
- Pissios P, Bradley R, Maratos Flier E. Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions. Endocr Rev. 2006;27:606-20 pubmed
- Pissios P. Animals models of MCH function and what they can tell us about its role in energy balance. Peptides. 2009;30:2040-4 pubmed publisher..Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research. ..
- Itani S, Saha A, Kurowski T, Coffin H, Tornheim K, Ruderman N. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003;52:1635-40 pubmed
- Krashes M, Lowell B, Garfield A. Melanocortin-4 receptor-regulated energy homeostasis. Nat Neurosci. 2016;19:206-19 pubmed publisher..Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis. ..
- Long J, Svensson K, Bateman L, Lin H, Kamenecka T, Lokurkar I, et al. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. 2016;166:424-435 pubmed publisher..These data identify an enzymatic node and a family of metabolites that regulate energy homeostasis. This pathway might be useful for treating obesity and associated disorders. ..
- Schulz T, Huang P, Huang T, Xue R, McDougall L, Townsend K, et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature. 2013;495:379-83 pubmed publisher..This sophisticated regulatory mechanism of body temperature may participate in the control of energy balance and metabolic disease. ..
- Huang H, Lee S, Ye C, Lima I, Oh B, Lowell B, et al. ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice. Endocrinology. 2013;154:3660-70 pubmed publisher..These results further support previous work identifying ROCK1 as a key regulator of energy balance and suggest that targeting ROCK1 in the hypothalamus may lead to development of antiobesity therapeutics. ..
- Mak T, Grusdat M, Duncan G, Dostert C, Nonnenmacher Y, Cox M, et al. Glutathione Primes T Cell Metabolism for Inflammation. Immunity. 2017;46:675-689 pubmed publisher..The antioxidative GSH pathway thus plays an unexpected role in metabolic integration and reprogramming during inflammatory T cell responses. ..
- Willett W, Stampfer M, Manson J, Colditz G, Speizer F, Rosner B, et al. Intake of trans fatty acids and risk of coronary heart disease among women. Lancet. 1993;341:581-5 pubmed..These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD. ..
- Smith S, Montain S, Matott R, Zientara G, Jolesz F, Fielding R. Effects of creatine supplementation on the energy cost of muscle contraction: a 31P-MRS study. J Appl Physiol (1985). 1999;87:116-23 pubmed..DeltaATP/J and DeltaATP/N were greatest at the onset of the exercise protocol (P < 0.01). In summary, creatine supplementation increased muscle PCr concentration, which did not affect muscle ATP cost of contraction...
- Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 2010;468:701-4 pubmed publisher..Thus, Lkb1 serves as an essential regulator of HSCs and haematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem-cell homeostasis. ..
- Damrauer S, Studer P, da Silva C, Longo C, Ramsey H, Csizmadia E, et al. A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE. 2011;6:e17715 pubmed publisher..These findings support pursuit of A20-based therapies to improve patients' outcomes in the context of extreme liver injury and extensive LR for tumor treatment or donation. ..
- Roubenoff R, Grinspoon S, Skolnik P, Tchetgen E, Abad L, Spiegelman D, et al. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. Am J Physiol Endocrinol Metab. 2002;283:E138-45 pubmed..Even though weight loss was rare in this cohort of patients treated with highly active antiretroviral therapy, loss of LBM was common and was driven by catabolic cytokines and not by inadequate dietary intake or hypogonadism. ..
- Handschin C, Spiegelman B. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006;27:728-35 pubmed..Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration. ..
- Tsuji T, Del Monte F, Yoshikawa Y, Abe T, Shimizu J, Nakajima Takenaka C, et al. Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. Am J Physiol Heart Circ Physiol. 2009;296:H310-7 pubmed publisher..We conclude that SERCA2a function enhanced by adenoviral gene transfer of asPLB prevents Ca2+ overload-induced LV contractile dysfunction in terms of mechanical work and especially energetics. ..
- Ongur D, Prescot A, Jensen J, Cohen B, Renshaw P. Creatine abnormalities in schizophrenia and bipolar disorder. Psychiatry Res. 2009;172:44-8 pubmed publisher..They also add to the literature on bioenergetic abnormalities in schizophrenia. ..
- Gurumurthy S, Xie S, Alagesan B, Kim J, Yusuf R, Saez B, et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010;468:659-63 pubmed publisher..Instead, these data define a central role for Lkb1 in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in haematopoietic cells through a novel metabolic checkpoint. ..
- Pinz I, Tian R, Belke D, Swanson E, Dillmann W, Ingwall J. Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a. J Biol Chem. 2011;286:10163-8 pubmed publisher..Thus, strategies combining energetic support with increasing SERCA activity may improve the therapeutic effectiveness for heart failure. ..
- Blättler S, Verdeguer F, Liesa M, Cunningham J, Vogel R, Chim H, et al. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012;32:3333-46 pubmed publisher..These results underscore the important role of YY1 in the maintenance of mitochondrial function and explain how its inactivation might contribute to exercise intolerance and mitochondrial myopathies. ..
- Nieuwdorp M, Gilijamse P, Pai N, Kaplan L. Role of the microbiome in energy regulation and metabolism. Gastroenterology. 2014;146:1525-33 pubmed publisher..We discuss how controlled studies involving direct perturbations of microbial communities in human and animal models are required to identify effective therapeutic targets in the microbiota. ..
- Lynes M, Leiria L, Lundh M, Bartelt A, Shamsi F, Huang T, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017;23:631-637 pubmed publisher..These data suggest that 12,13-diHOME, or a functional analog, could be developed as a treatment for metabolic disorders. ..
- Zhang Y, Xie L, Gunasekar S, Tong D, Mishra A, Gibson W, et al. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017;19:504-517 pubmed publisher..These studies identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin sensitivity and glucose tolerance. ..
- Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman M, et al. Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J Biol Chem. 2003;278:28372-7 pubmed..Thus, AMPK alpha2 is necessary for maintaining myocardial energy homeostasis during ischemia. It is likely that the functional role of AMPK in myocardial energy metabolism resides both in energy supply and utilization. ..
- Lee J, Ivanova E, Seong I, Cashorali T, Kohane I, Gusella J, et al. Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism. PLoS Genet. 2007;3:e135 pubmed..Elucidation of this HD CAG-dependent pathway would spur efforts to achieve energy-based therapeutics in HD. ..
- Pinz I, Robbins J, Rajasekaran N, Benjamin I, Ingwall J. Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 2008;22:84-92 pubmed..5 +/- 0.8 kJ/mol compared with only approximately 3.3 kJ/mol in WT and mCryAB(Tg). Thus, CryAB and HSPB2 proteins play nonredundant roles in the heart, CryAB in structural remodeling and HSPB2 in maintaining energetic balance. ..
- Tseng Y, Cypess A, Kahn C. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov. 2010;9:465-82 pubmed publisher..In this article, we integrate these developments in relation to the classical understandings of cellular bioenergetics to explore the potential for developing novel anti-obesity therapies that target cellular energy expenditure. ..
- Spindler M, Saupe K, Christe M, Sweeney H, Seidman C, Seidman J, et al. Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. J Clin Invest. 1998;101:1775-83 pubmed..Changes in high-energy phosphate content suggest that an energy-requiring process may contribute to the observed diastolic dysfunction. ..
- Lowell B, Spiegelman B. Towards a molecular understanding of adaptive thermogenesis. Nature. 2000;404:652-60 pubmed..Here we explore these developments in relation to classical physiological views of adaptive thermogenesis. ..
- Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell B, Maratos Flier E, et al. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008;149:5654-61 pubmed publisher..These results suggest that Socs3 in SF1 neurons negatively regulates leptin signaling and plays important roles in mediating leptin sensitivity, glucose homeostasis, and energy expenditure. ..
- Dardeno T, Chou S, Moon H, Chamberland J, Fiorenza C, Mantzoros C. Leptin in human physiology and therapeutics. Front Neuroendocrinol. 2010;31:377-93 pubmed publisher..Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated...
- Gregor M, Hotamisligil G. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415-45 pubmed publisher..Finally, we examine anti-inflammatory therapies for their potential in the treatment of obesity-related insulin resistance and glucose intolerance. ..
- Boucher J, Mori M, Lee K, Smyth G, Liew C, Macotela Y, et al. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun. 2012;3:902 pubmed publisher..Thus, insulin/IGF-1 signalling has a crucial role in the control of brown and white fat development, and, when disrupted, leads to defective thermogenesis and a paradoxical increase in basal metabolic rate. ..
- Robertson L, Mitchell J. Benefits of short-term dietary restriction in mammals. Exp Gerontol. 2013;48:1043-8 pubmed publisher..The encouraging results obtained in these preclinical and clinical studies, and the general lack of mechanistic understanding, both strongly suggest the need for further research in this emerging area. ..
- Li Y, Wong K, Walsh K, Gao B, Zang M. Retinoic acid receptor ? stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem. 2013;288:10490-504 pubmed publisher..The hepatic RAR-FGF21 pathway may represent a potential drug target for treating metabolic disorders. ..
- Kraus D, Yang Q, Kong D, Banks A, Zhang L, Rodgers J, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508:258-62 pubmed publisher..Thus, NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes. ..
- Tien T, Zhang J, Muto T, Kim D, Sarthy V, Roy S. High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017;58:2915-2921 pubmed publisher..05). Findings indicate that HG-induced mitochondrial morphology changes and subsequent mitochondrial dysfunction may contribute to retinal Müller cell loss associated with diabetic retinopathy. ..
- Cabeen M, Russell J, Paulsson J, Losick R. Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis. PLoS Genet. 2017;13:e1006901 pubmed publisher..Whereas RsbRA-only cells mimicked the wild type, RsbRC-only cells displayed a slower but sustained overall response composed of repeated activation events in single cells. ..
- Pereira M, Ludwig D. Dietary fiber and body-weight regulation. Observations and mechanisms. Pediatr Clin North Am. 2001;48:969-80 pubmed..Such diets may have additional benefits, independent of changes in adiposity, in the prevention of cardiovascular disease and type 2 diabetes...
- Bates S, Dundon T, Seifert M, Carlson M, Maratos Flier E, Myers M. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes. 2004;53:3067-73 pubmed..Thus, the LRb-->STAT3 signal is central to both the control of energy expenditure by leptin and the neuroendocrine regulation of the SNS and the thyroid axis. ..
- Schonhoff S, Baggio L, Ratineau C, Ray S, Lindner J, Magnuson M, et al. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol Cell Biol. 2005;25:4189-99 pubmed..These observations suggest that targeted disruption of the peptide YY gene does not perturb terminal endocrine cell differentiation or the control of food intake and energy homeostasis. ..
- Pittas A, Harris S, Eliades M, Stark P, Dawson Hughes B. Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab. 2009;94:827-32 pubmed publisher..Our findings should be considered hypothesis generating, and they need to be replicated in human studies designed to test the hypothesis that osteocalcin affects metabolism. ..