Genomes and Genes
Experts and Doctors on drosophila proteins in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: drosophila proteins
Publications160 found, 100 shown here
- Diaz Cano S, De Miguel M, Blanes A, Tashjian R, Wolfe H. Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia. J Clin Endocrinol Metab. 2001;86:3948-57 pubmed
- Amar S, Oyaisu K, Li L, Van Dyke T. Moesin: a potential LPS receptor on human monocytes. J Endotoxin Res. 2001;7:281-6 pubmed..The data suggest that Moesin functions as an independent LPS receptor on human monocytes. ..
- Dickman D, Horne J, Meinertzhagen I, Schwarz T. A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin. Cell. 2005;123:521-33 pubmed..Therefore, no genetic evidence remains to indicate that synaptic vesicles undergo kiss-and-run. ..
- Johnson K, Tenney A, Ghose A, Duckworth A, Higashi M, Parfitt K, et al. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron. 2006;49:517-31 pubmed
- Patten B, Sardi S, Koirala S, Nakafuku M, Corfas G. Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms. J Neurosci. 2006;26:3102-8 pubmed..Together, these results show that Notch1 regulates radial glia formation through two distinct transcriptional mechanisms and that the outcomes of Notch1 signaling may depend on the relative expression levels of its coregulators. ..
- Gorchakov A, Alekseyenko A, Kharchenko P, Park P, Kuroda M. Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X. Genes Dev. 2009;23:2266-71 pubmed publisher..We conclude that a long-sought specific DNA sequence within X-linked genes is not obligatory for MSL binding. Instead, linkage and transcription play the pivotal roles in MSL targeting irrespective of gene origin and DNA sequence. ..
- Low S, Harney J, Berry M. Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis. J Biol Chem. 1995;270:21659-64 pubmed..Further analysis revealed that reduced selenium labeling was due to altered ATP binding properties of the mutant selenophosphate synthetases. ..
- Perrimon N. Hedgehog and beyond. Cell. 1995;80:517-20 pubmed
- Gisselbrecht S, Skeath J, Doe C, Michelson A. heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev. 1996;10:3003-17 pubmed..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer. ..
- Ghiglione C, Carraway K, Amundadottir L, Boswell R, Perrimon N, Duffy J. The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell. 1999;96:847-56 pubmed..We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism. ..
- Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000;10:964-73 pubmed..As CAP controls the spatial distribution of actin filaments and mRNA determinants in both yeast and Drosophila, we conclude that CAP has an evolutionarily conserved function in the genesis of eukaryotic cell polarity. ..
- Gindhart J, Chen J, Faulkner M, Gandhi R, Doerner K, Wisniewski T, et al. The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system. Mol Biol Cell. 2003;14:3356-65 pubmed..Given the interaction of FEZ1, the mammalian homolog of UNC-76, with protein kinase Czeta, and the role of FEZ1 in axon outgrowth, we propose that UNC-76 helps integrate kinesin activity in response to transport requirements in axons. ..
- Zeidler M, Tan C, Bellaiche Y, Cherry S, Häder S, Gayko U, et al. Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol. 2004;22:871-6 pubmed
- Draper I, Kurshan P, McBride E, Jackson F, Kopin A. Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis. Dev Neurobiol. 2007;67:378-93 pubmed..These results suggest Drosophila as a useful system for future studies aimed at identifying modifiers of dopaminergic signaling/locomotor function. ..
- Markstein M, Pitsouli C, Villalta C, Celniker S, Perrimon N. Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet. 2008;40:476-83 pubmed publisher..The generality of our approach makes it adaptable to other model systems to identify and modify loci for optimal transgene expression. ..
- Krishnamoorthy S. Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks. PLoS ONE. 2008;3:e2877 pubmed publisher..The novel pY events found in this study that are conserved on human proteins could potentially lead to the discovery of drug targets and biomarkers for the detection of various cancers and neurodegenerative diseases. ..
- Raffel G, Chu G, Jesneck J, Cullen D, Bronson R, Bernard O, et al. Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen. Mol Cell Biol. 2009;29:333-41 pubmed publisher..Thus, Ott1-dependent pathways, in addition to being implicated in leukemogenesis, may also be important for the pathogenesis of placental insufficiency and cardiac malformations. ..
- Kockel L, Kerr K, Melnick M, Brückner K, Hebrok M, Perrimon N. Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet. 2010;6:e1000990 pubmed publisher..These results illustrate how the Akt-TOR pathway dynamically adapts the routing of negative feedback in response to the activity load of its signaling circuit in vivo. ..
- Kharchenko P, Alekseyenko A, Schwartz Y, Minoda A, Riddle N, Ernst J, et al. Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature. 2011;471:480-5 pubmed publisher..This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function. ..
- Bergwitz C, Rasmussen M, Derobertis C, Wee M, Sinha S, Chen H, et al. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. PLoS ONE. 2012;7:e31730 pubmed publisher..Finally, while phosphate is essential for Drosophila larval development, loss of MFS13 activity is compatible with viability indicating redundancy at the levels of the transporters...
- Branco A, Hartl D, Lemos B. Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis. Genetics. 2013;194:609-18 pubmed publisher..The phenotypes that emerge in the context of wild-type levels of the HP1 and Mod(mdg4) proteins might be part of an adaptive response to the environment. ..
- Pease B, Borges A, Bender W. Noncoding RNAs of the Ultrabithorax domain of the Drosophila bithorax complex. Genetics. 2013;195:1253-64 pubmed publisher..The mutant flies look normal; the regulation of the bxd domain appears unaffected. Thus, the bxd noncoding RNA has no apparent function. ..
- Hacker U, Lin X, Perrimon N. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Development. 1997;124:3565-73 pubmed..We discuss the possibility that tissue-specific regulation of proteoglycans may be involved in regulating both Wingless short- or long-range effects. ..
- Bellaiche Y, The I, Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 1998;394:85-8 pubmed..These results show the existence of a new conserved mechanism required for diffusion of Hedgehog. ..
- Phelan S, Loeken M. Identification of a new binding motif for the paired domain of Pax-3 and unusual characteristics of spacing of bipartite recognition elements on binding and transcription activation. J Biol Chem. 1998;273:19153-9 pubmed..Because the Pax-3-responsive genes identified to date contain almost exclusively low affinity binding sequences, our analysis indicates that they may be responsive to Pax-3 only when cellular levels are high. ..
- Wills Z, Marr L, Zinn K, Goodman C, Van Vactor D. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron. 1999;22:291-9 pubmed..Moreover, the phenotype of a double mutant suggests that these components function together to control axonal outgrowth. ..
- Fitzgerald D, Bender W. Polycomb group repression reduces DNA accessibility. Mol Cell Biol. 2001;21:6585-97 pubmed..In contrast to SIR silencing, however, episomes excised from Polycomb-repressed chromosomal sites do not show an altered superhelix density. ..
- Wang W, Wang Y, Reginato A, Plotkina S, Gridley T, Olsen B. Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Dev Dyn. 2002;224:79-89 pubmed..We suggest that Grg5, a transcriptional coregulator, modulates the activities of transcription factors, such as Cbfa1/Runx2 in vivo to affect Ihh expression and the function of long bone growth plates. ..
- Kocks C, Cho J, Nehme N, Ulvila J, Pearson A, Meister M, et al. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell. 2005;123:335-46 pubmed..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo. ..
- Schlief M, Wilson R. Olfactory processing and behavior downstream from highly selective receptor neurons. Nat Neurosci. 2007;10:623-30 pubmed
- Farny N, Hurt J, Silver P. Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 2008;22:66-78 pubmed..Our results define the global network of factors involved in Drosophila mRNA export, reveal specificity in the export requirements of different transcripts, and expose new avenues for future work in mRNA export. ..
- Long J, Bagonis M, Lowery L, Lee H, Danuser G, Van Vactor D. Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Mol Cell Biol. 2013;33:1528-45 pubmed publisher..Using these data, we identify subnetworks of proteins with novel yet overlapping MT-regulatory roles and also uncover subtle distinctions between the functions of proteins previously thought to act via similar mechanisms...
- Peterson J, McCall K. Combined inhibition of autophagy and caspases fails to prevent developmental nurse cell death in the Drosophila melanogaster ovary. PLoS ONE. 2013;8:e76046 pubmed publisher..These findings suggest that there is another cell death mechanism functioning in the ovary to remove all nurse cell remnants from late stage egg chambers. ..
- Hou X, Chou T, Melnick M, Perrimon N. The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell. 1995;81:63-71 pubmed..Our study provides in vivo evidence that Raf can be activated by an RTK in a Ras-independent pathway. ..
- Goode S, Perrimon N. Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development. Cold Spring Harb Symp Quant Biol. 1997;62:177-84 pubmed
- Van Vactor D, Lorenz L. Neural development: The semantics of axon guidance. Curr Biol. 1999;9:R201-4 pubmed
- Blackwell T. Germ cells: finding programs of mass repression. Curr Biol. 2004;14:R229-30 pubmed..Why are these mechanisms so diverse and complex? ..
- Gorr T, Tomita T, Wappner P, Bunn H. Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells: identification of a hypoxia-induced variant isoform of the HIFalpha homolog gene similar. J Biol Chem. 2004;279:36048-58 pubmed..Tango)-stimulated reporter expression in a dose-dependent manner. Thus, svSima has the potential to regulate Drosophila HIF function under steady and hypoxic pO(2) by creating a cytosolic sink for the Sima partner protein Tango. ..
- Dickman D, Kurshan P, Schwarz T. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008;28:31-8 pubmed publisher..This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones. ..
- Bergwitz C, Wee M, Sinha S, Huang J, Derobertis C, Mensah L, et al. Genetic determinants of phosphate response in Drosophila. PLoS ONE. 2013;8:e56753 pubmed publisher..We identified a number of candidate genes potentially important for the cellular response to phosphate. Evaluation of 51 genes in live flies revealed some that affect larval development, adult life span and hemolymph phosphate levels. ..
- Alekseyenko A, Ellison C, Gorchakov A, Zhou Q, Kaiser V, Toda N, et al. Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila. Genes Dev. 2013;27:853-8 pubmed publisher..We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation. ..
- Nybakken K, Vokes S, Lin T, McMahon A, Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet. 2005;37:1323-32 pubmed..Finally, we showed that several of these genes have conserved roles in mammalian Hh signaling. ..
- Bateman J, Shu H, Van Vactor D. The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron. 2000;26:93-106 pubmed..Moreover, reduction of trio activity potentiates the phenotype of mutations in the LAR homolog Dlar, suggesting that these proteins collaborate in orchestrating the cytoskeletal events that underlie normal axonogenesis. ..
- Neufeld E, Skalnik D, Lievens P, Orkin S. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat Genet. 1992;1:50-5 pubmed..As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development. ..
- Krueger N, Reddy R, Johnson K, Bateman J, Kaufmann N, Scalice D, et al. Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol Cell Biol. 2003;23:6909-21 pubmed..These results indicate multiple roles for PTP-D2, perhaps by acting as a docking domain for downstream elements and as a regulator of PTP-D1. ..
- Dickman D, Lu Z, Meinertzhagen I, Schwarz T. Altered synaptic development and active zone spacing in endocytosis mutants. Curr Biol. 2006;16:591-8 pubmed..We propose that endocytosis plays a critical role in sculpting the structure of synapses, perhaps through the endocytosis of unknown regulatory signals that organize morphogenesis at synaptic terminals. ..
- ..This iab-8 RNA also encodes a miRNA, detected on Northern blots, derived from the hairpin complementary to the iab-4 precursor hairpin. Ultrabithorax is a target of both miRNAs, although its repression is subtle in both cases. ..
- Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions. ..
- Musacchio M, Perrimon N. The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. Dev Biol. 1996;178:63-76 pubmed..Genetic analysis reveals that deletion of the kek1 gene causes no obvious developmental defects. The coexpression of kek2 in the CNS leads us to suggest that Kek1 is part of a family of cell surface proteins with redundant function. ..
- Hou X, Goldstein E, Perrimon N. Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev. 1997;11:1728-37 pubmed..In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK. ..
- Lu C, Vihtelic T, Hyde D, Li T. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. J Neurosci. 1999;19:7317-25 pubmed..Because transgenic expression of M-RdgB2 does not restore the wild-type phenotype to rdgB2 mutant flies to the same extent as M-RdgB1, functional differences likely exist between the two M-RdgB homologs. ..
- Lai C, Parnell L, Arnett D, GarcÃa Bailo B, Tsai M, Kabagambe E, et al. WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. Obesity (Silver Spring). 2009;17:593-600 pubmed publisher..Given the high frequency of the major alleles in both populations, we suggest that WDTC1 variation may be an important risk factor contributing to obesity in these populations. ..
- Tanaka M, Schinke M, Liao H, Yamasaki N, Izumo S. Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol Cell Biol. 2001;21:4391-8 pubmed..Furthermore, the development of the atrium was less advanced in the double-mutant embryos, indicating that these two genes are essential for both pharyngeal and cardiac development. ..
- Chen L, Feany M. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci. 2005;8:657-63 pubmed..Because increased number of inclusion bodies correlates with reduced toxicity, inclusion bodies may protect neurons from alpha-synuclein toxicity. ..
- Grammatikakis N, Lin J, Grammatikakis A, Tsichlis P, Cochran B. p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol Cell Biol. 1999;19:1661-72 pubmed..These results provide the first biochemical evidence for the requirement of the p50(cdc37)-Hsp90 complex in protein kinase regulation and for Raf-1 function in particular. ..
- Anjum S, Xu W, Nikkholgh N, Basu S, Nie Y, Thomas M, et al. Regulation of Toll signaling and inflammation by ?-arrestin and the SUMO protease Ulp1. Genetics. 2013;195:1307-17 pubmed publisher..Our results demonstrate that ?-arrestin controls Toll signaling and systemic inflammation at the level of sumoylation. ..
- Laufer E, Dahn R, Orozco O, Yeo C, Pisenti J, Henrique D, et al. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. Nature. 1997;386:366-73 pubmed..Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm. ..
- Alekseyenko A, Ho J, Peng S, Gelbart M, Tolstorukov M, Plachetka A, et al. Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. PLoS Genet. 2012;8:e1002646 pubmed publisher..Our analysis can serve as a model for identifying chromatin and local sequence features that may contribute to selection of functional protein binding sites in the genome...
- Luo H, Rose P, Barber D, Hanratty W, Lee S, Roberts T, et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997;17:1562-71 pubmed..Finally, we propose a model for the role of the Hop-D-Stat pathway in Drosophila hematopoiesis. ..
- Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik K. Presenilin affects arm/beta-catenin localization and function in Drosophila. Dev Biol. 2000;227:450-64 pubmed..Our results suggest that Presenilin may regulate the delivery of a multiprotein complex that regulates Armadillo trafficking between the adherens junction and the proteasome. ..
- Re F, Strominger J. Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem. 2002;277:23427-32 pubmed..Remarkably, although the majority of recombinant MD-2 exists in multimeric form, monomeric MD-2 was found to preferentially bind TLR4 and to confer LPS responsiveness more efficiently than MD-2 multimers. ..
- Hamada F, Park P, Gordadze P, Kuroda M. Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster. Genes Dev. 2005;19:2289-94 pubmed..We found that expression of many genes from the X chromosome decreased, while expression from the autosomes was largely unchanged. We conclude that the primary role of the MSL complex is to up-regulate the male X chromosome. ..
- Zinyk D, McGonnigal B, Dearolf C. Drosophila awdK-pn, a homologue of the metastasis suppressor gene nm23, suppresses the Tum-1 haematopoietic oncogene. Nat Genet. 1993;4:195-201 pubmed..Tum-l lethality is also suppressed by pn mutations, indicating the existence of a haematopoietic regulatory pathway involving the Tum-l, AwdK-pn and Pn proteins. ..
- Moqtaderi Z, Keaveney M, Struhl K. The histone H3-like TAF is broadly required for transcription in yeast. Mol Cell. 1998;2:675-82 pubmed
- Ma M, Zhao H, Zhao H, Binari R, Perrimon N, Li Z. Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Dev Biol. 2016;411:207-216 pubmed publisher..Together, these data demonstrate that wildtype adult stem cells and tumor cells show dramatic differences in sensitivity to cellular damages, thus providing potential therapeutic implications targeting tumorigenesis. ..
- Veal E, Eisenstein M, Tseng Z, Gill G. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol Cell Biol. 1998;18:5032-41 pubmed
- Saurin A, Shao Z, Erdjument Bromage H, Tempst P, Kingston R. A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature. 2001;412:655-60 pubmed..Thus, in fly embryos, there is a direct physical connection between proteins that bind to specific regulatory sequences, PcG proteins, and proteins of the general transcription machinery. ..
- Kaplan C, Morris J, Wu C, Winston F. Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev. 2000;14:2623-34 pubmed..Furthermore, Spt5 and Spt6 do not colocalize widely with the unphosphorylated, nonelongating form of Pol II. These results strongly suggest that Spt5 and Spt6 play closely related roles associated with active transcription in vivo. ..
- Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith A, Megraw T, et al. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2011;2:359 pubmed publisher..In summary, PCM assembly begins in the cytosol where Sas-4 provides a scaffold for pre-assembled cytoplasmic complexes before tethering of the complexes in a centrosome. ..
- Wakabayashi Ito N, Doherty O, Moriyama H, Breakefield X, Gusella J, O Donnell J, et al. Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. PLoS ONE. 2011;6:e26183 pubmed publisher..This dtorsin mutant line will be valuable for understanding this relationship and potentially other novel torsin functions that could play a role in human dystonia. ..
- Jesaitis L, Goodenough D. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994;124:949-61 pubmed..Nagafuchi, S. Tsukita, and Sh. Tsukita. 1991. J. Cell Biol. 115:1449-1462). Thus it appears that ZO-2 is not a component of the fascia adherens, and that unlike ZO-1, this protein is restricted to the epithelial tight junction. ..
- Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996;10:3116-28 pubmed..We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts. ..
- Egan E, Franklin T, Hilderbrand Chae M, McNeil G, Roberts M, Schroeder A, et al. An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. J Neurosci. 1999;19:3665-73 pubmed..Finally, we show that changes in DCry gene dosage are associated predictably with alterations of the blue light resetting response for the circadian rhythm of adult locomotor activity. ..
- Chung Y, Kocks C. Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater. J Biol Chem. 2011;286:26524-32 pubmed publisher..These results suggest a previously unrecognized mechanism by which antimicrobial peptides cooperate with phagocytic receptors to extend the range of microbes that can be targeted by a single, germline-encoded receptor. ..
- Neumüller R, Wirtz Peitz F, Lee S, Kwon Y, BUCKNER M, Hoskins R, et al. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics. 2012;190:931-40 pubmed publisher..Finally, we show that fluorescent traps, paired with recombinant nanobodies and mass spectrometry, allow the study of endogenous protein complexes in Drosophila. ..
- Riddle R, Johnson R, Laufer E, Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 1993;75:1401-16 pubmed..Like the ZPA, Sonic hedgehog expression leads to the activation of Hox genes. Sonic hedgehog thus appears to function as the signal for antero-posterior patterning in the limb. ..
- Lu X, Chou T, Williams N, Roberts T, Perrimon N. Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes Dev. 1993;7:621-32 pubmed..p21ras/Ras1 operates upstream of the D-raf kinase in this signaling pathway. ..
- Ranganathan R, Lewis J, MacKinnon R. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron. 1996;16:131-9 pubmed..These results reveal a shallow vestibule formed by the pore loops at the K+ channel entryway. The selectivity filter is located at the center of the vestibule close to (approximately 5 A) the extracellular solution. ..
- Zhang S, Binari R, Zhou R, Perrimon N. A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics. 2010;184:1165-79 pubmed publisher..Thus, other aggregates regulators isolated in our screen may identify additional genes involved in the protein-folding pathway and neurotoxicity. ..
- Goodrich L, Strutt D. Principles of planar polarity in animal development. Development. 2011;138:1877-92 pubmed publisher..Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom. ..
- Sarraf S, Raman M, Guarani Pereira V, Sowa M, Huttlin E, Gygi S, et al. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013;496:372-6 pubmed publisher..These studies provide a resource for understanding how the PINK1-PARKIN pathway re-sculpts the proteome to support mitochondrial homeostasis. ..
- Huang Y, Ainsley J, Reijmers L, Jackson F. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. PLoS Biol. 2013;11:e1001703 pubmed publisher..This includes Tdc2, encoding a neurotransmitter synthetic enzyme, which we demonstrate is required within clock neurons for normal circadian locomotor activity. ..
- Periquet M, Fulga T, Myllykangas L, Schlossmacher M, Feany M. Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo. J Neurosci. 2007;27:3338-46 pubmed
- Siegfried E, Wilder E, Perrimon N. Components of wingless signalling in Drosophila. Nature. 1994;367:76-80 pubmed..Our results indicate that dsh and porc act upstream of zw3, and arm acts downstream of zw3. ..
- Jackson F, Banfi S, Guffanti A, Rossi E. A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans. Genomics. 1997;41:444-52 pubmed..These common sequence features and comparisons among a large collection of RRM proteins suggest that the human and mouse proteins represent homologues of Drosophila lark. ..
- Zhang X, McNeil G, Hilderbrand Chae M, Franklin T, Schroeder A, Jackson F. Circadian regulation of the lark RNA-binding protein within identifiable neurosecretory cells. J Neurobiol. 2000;45:14-29 pubmed