Experts and Doctors on drosophila melanogaster in Worcester, Massachusetts, United States


Locale: Worcester, Massachusetts, United States
Topic: drosophila melanogaster

Top Publications

  1. Meng X, Brodsky M, Wolfe S. A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nat Biotechnol. 2005;23:988-94 pubmed
    ..Regulatory targets of Odd-skipped were successfully predicted using this information, demonstrating that the data produced by the bacterial one-hybrid system are relevant to in vivo function. ..
  2. Brodsky M, Weinert B, Tsang G, Rong Y, McGinnis N, Golic K, et al. Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol Cell Biol. 2004;24:1219-31 pubmed
    ..Our results indicate that MNK/Chk2-dependent modification of Drosophila p53 activates a global transcriptional response to DNA damage that induces error-prone DNA repair as well as intrinsic and extrinsic apoptosis pathways. ..
  3. Gegear R, Casselman A, Waddell S, Reppert S. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008;454:1014-8 pubmed publisher
    ..Moreover, Cry-dependent magnetosensitivity does not require a functioning circadian clock. Our work provides, to our knowledge, the first genetic evidence for a Cry-based magnetosensitive system in any animal. ..
  4. Fan Y, Wang S, Hernandez J, Yenigun V, Hertlein G, Fogarty C, et al. Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila. PLoS Genet. 2014;10:e1004131 pubmed publisher
    ..These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation. ..
  5. Matranga C, Tomari Y, Shin C, Bartel D, Zamore P. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 2005;123:607-20 pubmed
    ..For siRNAs, virtually all RISC is assembled through this cleavage-assisted mechanism. In contrast, passenger-strand cleavage is not important for the incorporation of miRNAs that derive from mismatched duplexes. ..
  6. Dubruille R, Murad A, Rosbash M, Emery P. A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet. 2009;5:e1000787 pubmed publisher
    ..We therefore conclude that KIS is a key transcriptional regulator of genes that function in the CRY signaling cascade, and thus it plays an important role in the synchronization of circadian rhythms with the dayrationight cycle. ..
  7. Tasdemir Yilmaz O, Freeman M. Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons. Genes Dev. 2014;28:20-33 pubmed publisher
  8. Chang T, Shravage B, Hayes S, Powers C, Simin R, Wade Harper J, et al. Uba1 functions in Atg7- and Atg3-independent autophagy. Nat Cell Biol. 2013;15:1067-78 pubmed publisher
    ..Our data reveal that distinct autophagy programs are used by different cells within an animal, and disclose an unappreciated role for ubiquitin activation in autophagy. ..
  9. Burke C, Huetteroth W, Owald D, Perisse E, Krashes M, Das G, et al. Layered reward signalling through octopamine and dopamine in Drosophila. Nature. 2012;492:433-7 pubmed publisher
    ..In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought. ..

More Information


  1. Ziegenfuss J, Doherty J, Freeman M. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Nat Neurosci. 2012;15:979-87 pubmed publisher
  2. McPhee C, Logan M, Freeman M, Baehrecke E. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 2010;465:1093-6 pubmed publisher
    ..Further, Drpr is the first factor that distinguishes autophagy that is associated with cell death from autophagy associated with cell survival...
  3. Aggarwal K, Rus F, Vriesema Magnuson C, Erturk Hasdemir D, Paquette N, Silverman N. Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog. 2008;4:e1000120 pubmed publisher
    ..These results show that Rudra is a critical component in a negative feedback loop, whereby immune-induced gene expression rapidly produces a potent inhibitor that binds and inhibits pattern recognition receptors...
  4. Keene A, Krashes M, Leung B, Bernard J, Waddell S. Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation. Curr Biol. 2006;16:1524-30 pubmed
    ..Therefore, our results suggest that the fly employs the local DPM-MB circuit to stabilize punitive- and reward-odor memories and that stable aspects of both forms of memory may reside in mushroom body alpha' and beta' lobe neurons. ..
  5. Oikemus S, McGinnis N, Queiroz Machado J, Tukachinsky H, Takada S, Sunkel C, et al. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes Dev. 2004;18:1850-61 pubmed
    ..We propose that recognition of chromosome ends by ATM prevents telomere fusion and apoptosis by recruiting chromatin-modifying complexes to telomeres. ..
  6. Ashraf S, Ganguly A, Roote J, Ip Y. Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila. Dev Dyn. 2004;231:379-86 pubmed
    ..The results suggest that the loss of Worniu function within the neuroblasts ultimately causes the larval brainstem to fail to go through shortening during development. ..
  7. Oikemus S, Queiroz Machado J, Lai K, McGinnis N, Sunkel C, Brodsky M. Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet. 2006;2:e71 pubmed
    ..Given the conserved roles of DNA damage response proteins in telomere function, related mechanisms may act at the telomeres of other organisms. ..
  8. Forstemann K, Tomari Y, Du T, Vagin V, Denli A, Bratu D, et al. Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol. 2005;3:e236 pubmed
    ..Thus, every known Drosophila RNase-III endonuclease is paired with a dsRBD protein that facilitates its function in small RNA biogenesis. ..
  9. Gong P, Han J, Reddig K, Li H. A potential dimerization region of dCAMTA is critical for termination of fly visual response. J Biol Chem. 2007;282:21253-8 pubmed
    ..Our data suggest that dCAMTA may function as a dimer during fly visual regulation and that the CG-1 domain may mediate dimerization of CAMTA transcription factors. ..
  10. Bettencourt R, Asha H, Dearolf C, Ip Y. Hemolymph-dependent and -independent responses in Drosophila immune tissue. J Cell Biochem. 2004;92:849-63 pubmed
    ..We further show that Dorsal mutant larvae have much lower phenoloxidase activity, consistent with a more important role of Dorsal in innate immunity than previously shown. ..
  11. Lu Y, Zhang Z, Sun D, Sweeney S, Gao F. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell. 2013;52:264-71 pubmed publisher
    ..These results suggest that STX13 is a genetic modifier of ESCRT-III dysfunction and participates in the maturation of phagophores into closed autophagosomes. ..
  12. Ameres S, Hung J, Xu J, Weng Z, Zamore P. Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA. 2011;17:54-63 pubmed publisher
  13. Gegear R, Foley L, Casselman A, Reppert S. Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature. 2010;463:804-7 pubmed publisher
    ..This work emphasizes the utility of Drosophila transgenesis for elucidating the precise mechanisms of Cry-mediated magnetosensitivity in insects and also in vertebrates such as migrating birds. ..
  14. Khurana J, Xu J, Weng Z, Theurkauf W. Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection. PLoS Genet. 2010;6:e1001246 pubmed publisher
    ..However, the aub and armi genes have an additional function in assembly of the telomere protection complex. ..
  15. Koles K, Nunnari J, Korkut C, Barria R, Brewer C, Li Y, et al. Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons. J Biol Chem. 2012;287:16820-34 pubmed publisher
    ..Our studies revealed that secreted Evi vesicles show remarkable conservation with exosomes in other systems. In summary, our observations unravel some of the in vivo mechanisms required for Evi vesicle release. ..
  16. Radman Livaja M, Quan T, Valenzuela L, Armstrong J, van Welsem T, Kim T, et al. A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast. PLoS Genet. 2012;8:e1002811 pubmed publisher
    ..Taken together, our results emphasize a role for Chd1 in histone replacement in both budding yeast and Drosophila melanogaster, and surprisingly they show that the major effects of Chd1 on turnover occur at the 3' ends of genes. ..
  17. Flood T, Iguchi S, Gorczyca M, White B, Ito K, Yoshihara M. A single pair of interneurons commands the Drosophila feeding motor program. Nature. 2013;499:83-7 pubmed publisher
    ..Our results demonstrate that Fdg neurons operate firmly within the sensorimotor watershed, downstream of sensory and metabolic cues and at the top of the feeding motor hierarchy, to execute the decision to feed. ..
  18. Nirala N, Rahman M, Walls S, Singh A, Zhu L, Bamba T, et al. Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis. PLoS Genet. 2013;9:e1003556 pubmed publisher
    ..These data reveal novel glycolytic and non-autonomous lipolytic pathways in response to increased ceramide for sustenance of high energy demanding organ functions like the heart. ..
  19. Kaneko T, Yano T, Aggarwal K, Lim J, Ueda K, Oshima Y, et al. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol. 2006;7:715-23 pubmed
    ..These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition...
  20. Lin S, Huang Y, Lee T. Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons. PLoS ONE. 2009;4:e8392 pubmed publisher
    ..In sum, unf governs axonal morphogenesis of multiple MB neuron types, possibly through regulating neuronal subtype identity...
  21. Ashley J, Packard M, Ataman B, Budnik V. Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. J Neurosci. 2005;25:5943-55 pubmed
    ..These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development. ..
  22. Guce A, Mortimer S, Yoon T, Painter C, Jiang W, Mellins E, et al. HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol. 2013;20:90-8 pubmed publisher
    ..These results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation. ..
  23. Seitz H, Ghildiyal M, Zamore P. Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Curr Biol. 2008;18:147-51 pubmed publisher