Experts and Doctors on drosophila in Boston, Massachusetts, United States

Summary

Locale: Boston, Massachusetts, United States
Topic: drosophila

Top Publications

  1. Hou X, Chou T, Melnick M, Perrimon N. The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell. 1995;81:63-71 pubmed
    ..Our study provides in vivo evidence that Raf can be activated by an RTK in a Ras-independent pathway. ..
  2. Brand A, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 1993;118:401-15 pubmed
    ..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway. ..
  3. Wu C. Transvection, nuclear structure, and chromatin proteins. J Cell Biol. 1993;120:587-90 pubmed
  4. Ghiglione C, Carraway K, Amundadottir L, Boswell R, Perrimon N, Duffy J. The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell. 1999;96:847-56 pubmed
    ..We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism. ..
  5. Zeidler M, Perrimon N, Strutt D. Multiple roles for four-jointed in planar polarity and limb patterning. Dev Biol. 2000;228:181-96 pubmed
    ..The subtle phenotypes of mutant flies, and the diverse patterning processes in which it is involved, suggest that four-jointed may act as a modifier of the activity of multiple other signalling factors. ..
  6. Gorr T, Tomita T, Wappner P, Bunn H. Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells: identification of a hypoxia-induced variant isoform of the HIFalpha homolog gene similar. J Biol Chem. 2004;279:36048-58 pubmed
    ..Tango)-stimulated reporter expression in a dose-dependent manner. Thus, svSima has the potential to regulate Drosophila HIF function under steady and hypoxic pO(2) by creating a cytosolic sink for the Sima partner protein Tango. ..
  7. Wilson R, Laurent G. Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe. J Neurosci. 2005;25:9069-79 pubmed
  8. Johnson K, Tenney A, Ghose A, Duckworth A, Higashi M, Parfitt K, et al. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron. 2006;49:517-31 pubmed
  9. Friedman A, Perrimon N. A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature. 2006;444:230-4 pubmed
    ..Novel regulators that modulate specific pathway outputs may be selective targets for drug discovery. ..

More Information

Publications114 found, 100 shown here

  1. Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher
    ..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions. ..
  2. Logothetis D, Kammen B, Lindpaintner K, Bisbas D, Nadal Ginard B. Gating charge differences between two voltage-gated K+ channels are due to the specific charge content of their respective S4 regions. Neuron. 1993;10:1121-9 pubmed
    ..However, differences in residues inside the S4 region are not sufficient to account for each channel's characteristic voltage range of activation. ..
  3. Gerecke D, Foley J, Castagnola P, Gennari M, Dublet B, Cancedda R, et al. Type XIV collagen is encoded by alternative transcripts with distinct 5' regions and is a multidomain protein with homologies to von Willebrand's factor, fibronectin, and other matrix proteins. J Biol Chem. 1993;268:12177-84 pubmed
    ..We hypothesize therefore that the sequence in alpha 1(XIV) collagen may play a role in the control of alpha 1(XIV) protein synthesis. ..
  4. Perrimon N, Perkins L. There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor. Cell. 1997;89:13-6 pubmed
  5. Goode S, Perrimon N. Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development. Cold Spring Harb Symp Quant Biol. 1997;62:177-84 pubmed
  6. Kingston R, Narlikar G. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity. Genes Dev. 1999;13:2339-52 pubmed
  7. Tanaka M, Komuro I, Inagaki H, Jenkins N, Copeland N, Izumo S. Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev Dyn. 2000;219:248-60 pubmed
    ..However, we did not observe prostate cancer in homozygous mutant mice up to 2 years of age. Therefore, involvement of NKX3.1 in carcinogenesis in men needs to be carefully determined by further investigation. ..
  8. Hitchcock A, Krebber H, Frietze S, Lin A, Latterich M, Silver P. The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell. 2001;12:3226-41 pubmed
    ..Given the recent finding that NPL4 is allelic to the ERAD gene HRD4, we further propose that this NPL4 function extends to all endoplasmic reticulum-membrane-associated targets of the proteasome. ..
  9. Lee E, Salic A, Krüger R, Heinrich R, Kirschner M. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 2003;1:E10 pubmed
    ..By applying control analysis to our mathematical model, we demonstrate the modular design, sensitivity, and robustness of the Wnt pathway and derive an explicit expression for tumor suppression and oncogenicity. ..
  10. Blackwell T. Germ cells: finding programs of mass repression. Curr Biol. 2004;14:R229-30 pubmed
    ..Why are these mechanisms so diverse and complex? ..
  11. Chen L, Feany M. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci. 2005;8:657-63 pubmed
    ..Because increased number of inclusion bodies correlates with reduced toxicity, inclusion bodies may protect neurons from alpha-synuclein toxicity. ..
  12. Gibson M, Patel A, Nagpal R, Perrimon N. The emergence of geometric order in proliferating metazoan epithelia. Nature. 2006;442:1038-41 pubmed
  13. Periquet M, Fulga T, Myllykangas L, Schlossmacher M, Feany M. Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo. J Neurosci. 2007;27:3338-46 pubmed
  14. Pack Chung E, Kurshan P, Dickman D, Schwarz T. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci. 2007;10:980-9 pubmed
    ..Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting. ..
  15. Dickman D, Kurshan P, Schwarz T. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008;28:31-8 pubmed publisher
    ..This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones. ..
  16. Higashi Kovtun M, Mosca T, Dickman D, Meinertzhagen I, Schwarz T. Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J Neurosci. 2010;30:5253-68 pubmed publisher
    ..Thus, importin-beta11 function interacts with the BMP pathway to regulate a pool of pMAD that must be present at the presynapse for its proper development and function. ..
  17. Jodoin J, Coravos J, Chanet S, Vasquez C, Tworoger M, Kingston E, et al. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell. 2015;35:685-97 pubmed publisher
    ..Our work identifies a critical role for F-actin turnover in connecting actomyosin to intercellular junctions, defining a dynamic process required for the stability of force balance across intercellular contacts in tissues. ..
  18. Kang J, Shin S, Perrimon N, Shen J. An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain. Genetics. 2017;206:1479-1493 pubmed publisher
  19. Xu C, Luo J, He L, Montell C, Perrimon N. Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut. elife. 2017;6: pubmed publisher
    ..Our findings provide a link between redox regulation and Ca2+ signaling and reveal a novel mechanism by which ISCs detect stress signals. ..
  20. Azevedo A, Wilson R. Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons. Neuron. 2017;96:446-460.e9 pubmed publisher
    ..These results illustrate how membrane properties and voltage-gated conductances can extract distinct stimulus features into parallel channels. ..
  21. Finkelstein R, Smouse D, Capaci T, Spradling A, Perrimon N. The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev. 1990;4:1516-27 pubmed
    ..The predicted otd protein contains a well-conserved homeo domain and is therefore likely to be a transcriptional regulator involved in specifying cell fate both in the embryonic CNS and in the ocelli. ..
  22. Curtis D, Bender W. Gene conversion in Drosophila and the effects of the meiotic mutants mei-9 and mei-218. Genetics. 1991;127:739-46 pubmed
    ..Some unusual conversion events were found in the mei-218 and mei-9 samples, although most events were indistinguishable from wild-type tracts in their length and continuity. ..
  23. Klingensmith J, Noll E, Perrimon N. The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death. Dev Biol. 1989;134:130-45 pubmed
    ..We suggest that differential cell respecification, resulting in transformation or death, is involved in generating the segment polarity phenotype. ..
  24. Perrimon N. Hedgehog and beyond. Cell. 1995;80:517-20 pubmed
  25. Simon J, Chiang A, Bender W, Shimell M, O Connor M. Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev Biol. 1993;158:131-44 pubmed
    ..Instead, the results support the idea that Pc group products provide stable memory or imprinting of boundaries which are initially specified by gap and pair-rule regulators. ..
  26. Licht J, Hanna Rose W, Reddy J, English M, Ro M, Grossel M, et al. Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Krüppel protein. Mol Cell Biol. 1994;14:4057-66 pubmed
    ..This segment included a hydrophobic stretch of 11 consecutive alanine residues and a proline-rich region. ..
  27. Hanna Rose W, Licht J, Hansen U. Two evolutionarily conserved repression domains in the Drosophila Kruppel protein differ in activator specificity. Mol Cell Biol. 1997;17:4820-9 pubmed
    ..The different activator specificities of the two regions suggest that they repress transcription by different mechanisms and may play distinct biological roles during Drosophila development. ..
  28. Chin M, Pellacani A, Wang H, Lin S, Jain M, Perrella M, et al. Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). J Biol Chem. 1998;273:9755-60 pubmed
    ..Our observations suggest that members of the HMG-I family play an important role in SRF-dependent transcription and that their effect is mediated primarily by a protein-protein interaction. ..
  29. Eble J, Wucherpfennig K, Gauthier L, Dersch P, Krukonis E, Isberg R, et al. Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry. 1998;37:10945-55 pubmed
    ..In conclusion, studies of our recombinant alpha 3 beta 1 integrin have provided new insights into alpha 3 beta1 structure, ligand binding function, specificity, and regulation. ..
  30. Hobert O, Moerman D, Clark K, Beckerle M, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144:45-57 pubmed
    ..In addition to its localization to adherens junctions UNC-97 can also be detected in the nucleus, suggesting multiple functions for this LIM domain protein. ..
  31. Gayko U, Cleghon V, Copeland T, Morrison D, Perrimon N. Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. Proc Natl Acad Sci U S A. 1999;96:523-8 pubmed
  32. Van Vactor D, Flanagan J. The middle and the end: slit brings guidance and branching together in axon pathway selection. Neuron. 1999;22:649-52 pubmed
  33. Baeg G, Perrimon N. Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. Curr Opin Cell Biol. 2000;12:575-80 pubmed
  34. Callus B, Mathey Prevot B. SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. Oncogene. 2002;21:4812-21 pubmed
    ..These genetic interactions imply that SOCS36E can suppress activities of the JAK/STAT and EGF-R signalling pathways in the wing disc and suggest that SOCS36E interacts with multiple pathways in vivo. ..
  35. Krueger N, Reddy R, Johnson K, Bateman J, Kaufmann N, Scalice D, et al. Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol Cell Biol. 2003;23:6909-21 pubmed
    ..These results indicate multiple roles for PTP-D2, perhaps by acting as a docking domain for downstream elements and as a regulator of PTP-D1. ..
  36. Schwartz B, Ahmad K. Transcriptional activation triggers deposition and removal of the histone variant H3.3. Genes Dev. 2005;19:804-14 pubmed
    ..We conclude that H3.3 deposition is coupled to transcription, and continues while a gene is active. Repeated histone replacement suggests a mechanism to both maintain the structure of chromatin and access to DNA at active genes. ..
  37. Kocks C, Cho J, Nehme N, Ulvila J, Pearson A, Meister M, et al. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell. 2005;123:335-46 pubmed
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo. ..
  38. Draper I, Kurshan P, McBride E, Jackson F, Kopin A. Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis. Dev Neurobiol. 2007;67:378-93 pubmed
    ..These results suggest Drosophila as a useful system for future studies aimed at identifying modifiers of dopaminergic signaling/locomotor function. ..
  39. Krishnamoorthy S. Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks. PLoS ONE. 2008;3:e2877 pubmed publisher
    ..The novel pY events found in this study that are conserved on human proteins could potentially lead to the discovery of drug targets and biomarkers for the detection of various cancers and neurodegenerative diseases. ..
  40. Farny N, Kedersha N, Silver P. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA. 2009;15:1814-21 pubmed publisher
    ..These results suggest that mammals evolved alternative mechanisms for dealing with thermal stress. ..
  41. Kazama H, Wilson R. Origins of correlated activity in an olfactory circuit. Nat Neurosci. 2009;12:1136-44 pubmed publisher
    ..PN axons from the same glomerulus reconverge in the lateral horn, where pooling redundant signals may allow lateral horn neurons to average out noise that arises independently in these PNs...
  42. Kazama H, Yaksi E, Wilson R. Cell death triggers olfactory circuit plasticity via glial signaling in Drosophila. J Neurosci. 2011;31:7619-30 pubmed publisher
    ..By strengthening excitatory interactions between neurons in a deafferented brain region, this mechanism might help boost activity to compensate for lost sensory input. ..
  43. Gopalakrishnan J, Chim Y, Ha A, Basiri M, Lerit D, Rusan N, et al. Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. Nat Cell Biol. 2012;14:865-73 pubmed publisher
    ..On the basis of its guanine-bound state, tubulin can act as a molecular switch in PCM recruitment. ..
  44. Hsu J, Perrimon N. A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. Genes Dev. 1994;8:2176-87 pubmed
    ..In addition, we demonstrate that different RTK pathways respond differently to alteration in D-Mek activity. ..
  45. Bellaiche Y, The I, Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 1998;394:85-8 pubmed
    ..These results show the existence of a new conserved mechanism required for diffusion of Hedgehog. ..
  46. Egan E, Franklin T, Hilderbrand Chae M, McNeil G, Roberts M, Schroeder A, et al. An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. J Neurosci. 1999;19:3665-73 pubmed
    ..Finally, we show that changes in DCry gene dosage are associated predictably with alterations of the blue light resetting response for the circadian rhythm of adult locomotor activity. ..
  47. Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 2000;403:676-80 pubmed
    ..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions. ..
  48. Bateman J, Shu H, Van Vactor D. The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron. 2000;26:93-106 pubmed
    ..Moreover, reduction of trio activity potentiates the phenotype of mutations in the LAR homolog Dlar, suggesting that these proteins collaborate in orchestrating the cytoskeletal events that underlie normal axonogenesis. ..
  49. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000;10:964-73 pubmed
    ..As CAP controls the spatial distribution of actin filaments and mRNA determinants in both yeast and Drosophila, we conclude that CAP has an evolutionarily conserved function in the genesis of eukaryotic cell polarity. ..
  50. Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez Illasaca M, et al. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. Genome Res. 2006;16:1056-72 pubmed
    ..These results provide insight into the diverse roles of PDZ-ligand complexes in cellular signaling and provide a computational framework for the genome-wide evaluation of PDZ complexes. ..
  51. Khurana V, Elson Schwab I, Fulga T, Sharp K, Loewen C, Mulkearns E, et al. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010;6:e1001026 pubmed publisher
    ..Thus, caspase cleavage of tau may be a molecular mechanism through which lysosomal dysfunction and neurodegeneration are causally linked in Alzheimer's disease. ..
  52. Greer E, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012;13:343-57 pubmed publisher
    ..The importance of appropriately maintaining or reprogramming histone methylation is illustrated by its links to disease and ageing and possibly to transmission of traits across generations. ..
  53. Emerson M, Long J, Van Vactor D. Drosophila semaphorin2b is required for the axon guidance of a subset of embryonic neurons. Dev Dyn. 2013;242:861-73 pubmed publisher
  54. Lu X, Chou T, Williams N, Roberts T, Perrimon N. Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes Dev. 1993;7:621-32 pubmed
    ..p21ras/Ras1 operates upstream of the D-raf kinase in this signaling pathway. ..
  55. Wills Z, Bateman J, Korey C, Comer A, Van Vactor D. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron. 1999;22:301-12 pubmed
    ..These data suggest that Dlar, Abl, and Ena define a phosphorylation state-dependent switch that controls growth cone behavior by transmitting signals at the cell surface to the actin cytoskeleton. ..
  56. Medley Q, Buchbinder E, Tachibana K, Ngo H, Serra Pagès C, Streuli M. Signaling between focal adhesion kinase and trio. J Biol Chem. 2003;278:13265-70 pubmed
    ..These results suggest Trio may be involved in the regulation of focal adhesion dynamics in addition to effecting changes in the actin cytoskeleton through the activation of Rho family GTPases. ..
  57. Chou T, Noll E, Perrimon N. Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras. Development. 1993;119:1359-69 pubmed
    ..Specifically, we show that the Gap1 gene, which encodes a Drosophila homologue of mammalian GTPase-activating protein, is required in somatic follicle cells for embryonic dorsoventral polarity determination. ..
  58. Mohi M, Williams I, Dearolf C, Chan G, Kutok J, Cohen S, et al. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell. 2005;7:179-91 pubmed
    ..Shp2 mutants also cause myeloproliferation in Drosophila. Mek or Tor inhibitors potently inhibit transformation, suggesting new approaches to JMML therapy. ..
  59. Miech C, Pauer H, He X, Schwarz T. Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction. J Neurosci. 2008;28:10875-84 pubmed publisher
  60. Siegfried E, Chou T, Perrimon N. wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell. 1992;71:1167-79 pubmed
    ..Genetic epistasis experiments indicate that wg signaling operates by inactivating the zw3 repression of en autoactivation. In addition, we demonstrate that zw3 encodes the Drosophila homolog of mammalian glycogen synthase kinase-3. ..
  61. Finkelstein R, Perrimon N. The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature. 1990;346:485-8 pubmed
    ..We also show that otd expression responds to the activity of the maternal tor gene at the anterior pole of the embryo. ..
  62. Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, et al. Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev Genet. 1998;22:239-49 pubmed
    ..In this paper, we discuss molecular mechanisms of cardiovascular development with particular emphasis on roles of transcription factors. ..
  63. Halfon M, Carmena A, Gisselbrecht S, Sackerson C, Jimenez F, Baylies M, et al. Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell. 2000;103:63-74 pubmed
    ..The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development. ..
  64. Farny N, Hurt J, Silver P. Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 2008;22:66-78 pubmed
    ..Our results define the global network of factors involved in Drosophila mRNA export, reveal specificity in the export requirements of different transcripts, and expose new avenues for future work in mRNA export. ..
  65. Johnson R, Tabin C. The long and short of hedgehog signaling. Cell. 1995;81:313-6 pubmed
  66. Brand A, Perrimon N. Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev. 1994;8:629-39 pubmed
    ..In this assay, human and Drosophila Rafgof are functionally similar, in that either can induce ventral follicle cells to assume a dorsal fate. ..
  67. Hacker U, Lin X, Perrimon N. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Development. 1997;124:3565-73 pubmed
    ..We discuss the possibility that tissue-specific regulation of proteoglycans may be involved in regulating both Wingless short- or long-range effects. ..
  68. Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik K. Presenilin affects arm/beta-catenin localization and function in Drosophila. Dev Biol. 2000;227:450-64 pubmed
    ..Our results suggest that Presenilin may regulate the delivery of a multiprotein complex that regulates Armadillo trafficking between the adherens junction and the proteasome. ..
  69. See R, Calvo D, Kawa H, Luke M, Yuan Z, Shi Y. Stimulation of p300-mediated transcription by the kinase MEKK1. J Biol Chem. 2001;276:16310-7 pubmed
    ..Taken together, these results identify MEKK1 as a kinase that is likely to be involved in the regulation of the transactivation potential of p300 and support a role of p300 in MEKK1-induced apoptosis. ..
  70. Cherry S, Doukas T, Armknecht S, Whelan S, Wang H, Sarnow P, et al. Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev. 2005;19:445-52 pubmed
    ..Finally, this increased sensitivity to ribosome levels also holds true for poliovirus infection of human cells, demonstrating the generality of these findings. ..
  71. Dias Santagata D, Fulga T, Duttaroy A, Feany M. Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest. 2007;117:236-45 pubmed
    ..In summary, our study identifies oxidative stress as a causal factor in tau-induced neurodegeneration in Drosophila. ..
  72. Akten B, Tangredi M, Jauch E, Roberts M, Ng F, Raabe T, et al. Ribosomal s6 kinase cooperates with casein kinase 2 to modulate the Drosophila circadian molecular oscillator. J Neurosci. 2009;29:466-75 pubmed publisher
    ..We propose that the two kinases cooperate within clock neurons to fine-tune circadian period, improving the precision of the clock mechanism. ..
  73. Lake R, Grimm L, Veraksa A, Banos A, Artavanis Tsakonas S. In vivo analysis of the Notch receptor S1 cleavage. PLoS ONE. 2009;4:e6728 pubmed publisher
    ..Our results demonstrate a correlation between loss of cleavage and loss of in vivo function of the Notch receptor, supporting the notion that S1 cleavage is an in vivo mechanism of Notch signal control. ..
  74. Bai J, Sepp K, Perrimon N. Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening. Nat Protoc. 2009;4:1502-12 pubmed publisher
    ..The entire protocol takes approximately 14 d, whereas the preparation of primary cells from Drosophila embryos only requires 2-4 h...
  75. Castoreno A, Smurnyy Y, Torres A, Vokes M, Jones T, Carpenter A, et al. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010;6:457-63 pubmed publisher
    ..Rhodblocks differentially perturb Rho pathway proteins in cells and can be used to dissect the mechanism of the Rho pathway during cytokinesis. ..
  76. Smouse D, Perrimon N. Genetic dissection of a complex neurological mutant, polyhomeotic, in Drosophila. Dev Biol. 1990;139:169-85 pubmed
    ..Despite the apparent autonomy of the ph mutation, mutant neurons can influence the development of adjacent wild-type neurons, presumably by depriving them of their normal fasciculation partners. ..
  77. Zeidler M, Perrimon N, Strutt D. Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. Genes Dev. 1999;13:1342-53 pubmed
    ..A gradient of JAK/STAT activity across the DV axis of the eye regulates ommatidial polarity via an unidentified second signal. Additionally, localized Unpaired influences the position of the equator via repression of mirror. ..
  78. Vollrath B, Fitzgerald K, Leder P. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Mol Cell Biol. 2001;21:5688-97 pubmed
    ..Null embryos can be recovered as blastocysts but do not appear to implant, indicating that mouse Brainiac 1, likely a glycosyltransferase, is crucial for very early development of the mouse embryo. ..
  79. Marfatia S, Leu R, Branton D, Chishti A. Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein. J Biol Chem. 1995;270:715-9 pubmed
    ..Our data provide new insights into how protein 4.1, glycophorin C, p55, and their non-erythroid homologues, interact with the cytoskeleton to exert their physiological effects. ..
  80. Michelson A, Gisselbrecht S, Zhou Y, Baek K, Buff E. Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm. Dev Genet. 1998;22:212-29 pubmed
    ..Finally, parallels between requirements for FGFR signaling in Drosophila and vertebrate mesoderm development are considered. ..
  81. The I, Bellaiche Y, Perrimon N. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol Cell. 1999;4:633-9 pubmed
    ..This demonstrates an unexpected level of specificity in the regulation of the distribution of extracellular signals by HSPGs. ..
  82. Gorr T, Cahn J, Yamagata H, Bunn H. Hypoxia-induced synthesis of hemoglobin in the crustacean Daphnia magna is hypoxia-inducible factor-dependent. J Biol Chem. 2004;279:36038-47 pubmed
    ..In human cells, this -146 complex interferes with HIF occupancy at the adjacent -107 HRE and thus controls the extent of HIF-mediated hypoxic activation of the downstream target. ..
  83. Alekseyenko A, Larschan E, Lai W, Park P, Kuroda M. High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome. Genes Dev. 2006;20:848-57 pubmed
    ..Distinguishing expressed genes from the bulk of the genome is likely to be an important function common to many chromatin organizing and modifying activities. ..
  84. Schmidt C, Sladek T. A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. J Biol Chem. 1993;268:25681-6 pubmed
    ..A model is presented for the possible role of the R-esp1 protein in the negative regulation of Enhancer of split proteins containing WD-40 repeats. ..
  85. Feany M, Bender W. A Drosophila model of Parkinson's disease. Nature. 2000;404:394-8 pubmed
    ..Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease. ..
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    ..The csw gene encodes a putative nonreceptor protein tyrosine phosphatase covalently linked to two N-terminal SH2 domains, which is similar to the mammalian PTP1C protein. ..
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    ..Shh mapped to a position 0.6 cM distal to En2 and 1.9 cM proximal to Il6 on mouse chromosome 5. This location is closely linked but distinct from the murine limb mutation Hx and syntenic to human chromosome 7q36. ..
  88. Hou X, Melnick M, Perrimon N. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell. 1996;84:411-9 pubmed
    ..We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system. ..
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    ..We propose that binding to 14-3-3 by Raf is necessary but not sufficient for the activation of Raf and that overexpressed Drosophila 14-3-3 requires Ras1 to activate D-Raf. ..
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    ..The ability of HPV E7 to interact with a cellular DnaJ protein suggests that these two viral oncoproteins may target common regulatory pathways through J-domains...