Experts and Doctors on caveolin 1 in Boston, Massachusetts, United States


Locale: Boston, Massachusetts, United States
Topic: caveolin 1

Top Publications

  1. Igarashi J, Michel T. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 2000;275:32363-70 pubmed
    ..The agonist-modulated targeting of EDG-1 to caveolae and its dynamic inhibitory interactions with caveolin identify new points for regulation of sphingolipid-dependent signaling in the vascular wall. ..
  2. Vetterkind S, Saphirstein R, Morgan K. Stimulus-specific activation and actin dependency of distinct, spatially separated ERK1/2 fractions in A7r5 smooth muscle cells. PLoS ONE. 2012;7:e30409 pubmed publisher
    ..Our results show that (1) at least two ERK1/2 fractions are regulated separately by specific stimuli, and that (2) the association of ERK1/2 with the actin cytoskeleton regulates the outcome of ERK1/2 signaling. ..
  3. Wharton J, Meshulam T, Vallega G, Pilch P. Dissociation of insulin receptor expression and signaling from caveolin-1 expression. J Biol Chem. 2005;280:13483-6 pubmed
    ..We conclude that insulin receptor expression and ligand-dependent signaling is independent of caveolin-1 expression. ..
  4. Michel J, Feron O, Sacks D, Michel T. Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. J Biol Chem. 1997;272:15583-6 pubmed
    ..These findings may have broad implications for the regulation of Ca2+-dependent signal transduction in plasmalemmal caveolae. ..
  5. Badizadegan K, Dickinson B, Wheeler H, Blumberg R, Holmes R, Lencer W. Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1). Am J Physiol Gastrointest Liver Physiol. 2000;278:G895-904 pubmed
    ..We find direct evidence for the presence of caveolin-1 in DIGs from human intestinal epithelia but find that these membranes are heterogeneous and that caveolin-1 is not a structural component of apical membrane DIGs that contain CT...
  6. Takeuchi K, Morizane Y, Kamami Levy C, Suzuki J, Kayama M, Cai W, et al. AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells. J Biol Chem. 2013;288:20581-91 pubmed publisher
    ..Overall, our results suggest that activation of AMPK inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis, and this effect is mediated in part by stabilizing the interaction between c-Abl and Prdx-1. ..
  7. Kifor O, Kifor I, Moore F, Butters R, Brown E. m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR. J Biol Chem. 2003;278:31167-76 pubmed
    ..Our data suggest that localization of m-calpain within caveolae may contribute to maintenance of the enzyme in an inactive state and that m-calpain may also contribute to the regulation of CaR levels. ..
  8. Tang W, Hemler M. Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering. J Biol Chem. 2004;279:11112-8 pubmed
    ..In conclusion, caveolin-1 associates with CD147, in a complex distinct from CD147-alpha(3) integrin complexes, thereby diminishing both CD147 clustering and CD147-dependent MMP-1-inducing activity. ..
  9. Massol R, Larsen J, Fujinaga Y, Lencer W, Kirchhausen T. Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell. 2004;15:3631-41 pubmed
    ..These results are consistent with the existence of an additional retrograde pathway used by CT to reach the ER. ..

More Information


  1. Kathuria H, Cao Y, Hinds A, Ramirez M, Williams M. ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines. J Cell Biochem. 2007;102:13-27 pubmed
  2. Di Vizio D, Sotgia F, Williams T, Hassan G, Capozza F, Frank P, et al. Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Cancer Biol Ther. 2007;6:1263-8 pubmed
    ..In addition, our results provide the first molecular genetic evidence that Cav-1 functions upstream of FASN during prostate cancer progression. ..
  3. Di Vizio D, Adam R, Kim J, Kim R, Sotgia F, Williams T, et al. Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle. 2008;7:2257-67 pubmed
    ..These findings suggest that FASN and Cav-1 physically and functionally interact in PCa cells. They also imply that palmitoylation within this complex is involved in tumor growth and survival. ..
  4. Michel T, Feron O. Nitric oxide synthases: which, where, how, and why?. J Clin Invest. 1997;100:2146-52 pubmed
  5. Yousuf M, Zhou X, Mukherjee S, Chintakuntlawar A, Lee J, Ramke M, et al. Caveolin-1 associated adenovirus entry into human corneal cells. PLoS ONE. 2013;8:e77462 pubmed publisher
  6. Ricchiuti V, Lapointe N, Pojoga L, Yao T, Tran L, Williams G, et al. Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart. J Endocrinol. 2011;211:47-54 pubmed publisher
    ..Dietary sodium restriction has beneficial effects on the cardiac expression of factors associated with CV injury. These changes may play a role in the cardioprotective effects of dietary sodium restriction. ..
  7. Pojoga L, Romero J, Yao T, Loutraris P, Ricchiuti V, Coutinho P, et al. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology. 2010;151:1236-46 pubmed publisher
    ..WT mice, consistent with decreased MR signaling in the cav-1 KO. Thus, we conclude that the L-NAME/AngII-induced biventricular damage is mediated by a mechanism partially dependent on cav-1 and signaling via MR/ALDO. ..
  8. Parker E, Zaman M, Freedman S. GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin. Pancreas. 2000;21:219-25 pubmed
    ..This suggests that in pancreatic acini, GP2 may exist in a complex with src kinases, caveolin, and an 85-kDa phosphorylated substrate to regulate endocytosis at the APM. ..
  9. Pojoga L, Underwood P, Goodarzi M, Williams J, Adler G, Jeunemaitre X, et al. Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. J Clin Endocrinol Metab. 2011;96:E1288-92 pubmed publisher
    ..Variations in the CAV1 gene are associated with IR and hypertension. CAV1 gene polymorphisms may be a biomarker for IR and hypertension, enabling earlier detection and improved treatment strategies. ..
  10. Gonzalez E, Nagiel A, Lin A, Golan D, Michel T. Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem. 2004;279:40659-69 pubmed
  11. Souto R, Vallega G, Wharton J, Vinten J, Tranum Jensen J, Pilch P. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. J Biol Chem. 2003;278:18321-9 pubmed
    ..The results are consistent with a role for caveolae in lipid flux in and of adipocytes. ..
  12. Lu M, Schneider M, Zheng Y, Zhang X, Richie J. Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem. 2001;276:13442-51 pubmed
    ..Using a mammalian two-hybrid assay system, we determine that the NH(2) terminus region of caveolin-1 is responsible for the interaction with both the NH(2)-terminal domain and the ligand-binding domain of AR. ..
  13. Pojoga L, Yao T, Opsasnick L, Garza A, Reslan O, Adler G, et al. Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther. 2014;348:260-70 pubmed publisher
  14. Loomis S, Kang J, Weinreb R, Yaspan B, Cooke Bailey J, Gaasterland D, et al. Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. Ophthalmology. 2014;121:508-16 pubmed publisher
    ..These data support a role for caveolin 1, caveolin 2, or both in POAG and suggest that the caveolins particularly may affect POAG pathogenesis in women and in patients with early paracentral VF defects. ..