Genomes and Genes
Experts and Doctors on caenorhabditis elegans proteins in Boston, Massachusetts, United States
Locale: Boston, Massachusetts, United States
Topic: caenorhabditis elegans proteins
- Demaso C, Kovacevic I, Uzun A, Cram E. Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. PLoS ONE. 2011;6:e22428 pubmed publisher..Our results indicate that many of the key features of vertebrate filamins are preserved in C. elegans FLN-1 and FLN-2, and suggest the nematode may be a very useful model system for further study of filamin function. ..
- Fischer S, Butler M, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008;455:491-6 pubmed publisher..The ERI-6/7 protein is a superfamily I helicase that both negatively regulates the exogenous RNAi pathway and functions in an endogenous RNAi pathway. ..
- Goodwin P, Sasaki J, Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J Neurosci. 2012;32:8158-72 pubmed publisher..We propose a model in which CDK-5 regulates DCV polarity by both promoting DCV trafficking in axons and preventing dynein-dependent DCV trafficking into dendrites. ..
- Blackwell T. Germ cells: finding programs of mass repression. Curr Biol. 2004;14:R229-30 pubmed..Why are these mechanisms so diverse and complex? ..
- Li X, Matilainen O, Jin C, Glover Cutter K, Holmberg C, Blackwell T. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet. 2011;7:e1002119 pubmed publisher..The data suggest that SKN-1 may increase longevity, not only through its well-documented role in boosting stress resistance, but also through contributing to protein homeostasis. ..
- Berger M, Philippakis A, Qureshi A, He F, Estep P, Bulyk M. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat Biotechnol. 2006;24:1429-35 pubmed..The unbiased coverage of all k-mers permits high-throughput interrogation of binding site preferences, including nucleotide interdependencies, at unprecedented resolution. ..
- Phillips C, Montgomery T, Breen P, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26:1433-44 pubmed publisher..We propose that the mutator proteins and RRF-1 constitute an RNA processing compartment required for siRNA amplification and RNA silencing. ..
- Cram E, Fontanez K, Schwarzbauer J. Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase. Dev Dyn. 2008;237:837-46 pubmed publisher..Thus, the FERM domain of KIN-32, and possibly KIN-32 activity in general, appears to be dispensable for normal C. elegans physiology. ..
- Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher..Finally, REST levels during ageing are closely correlated with cognitive preservation and longevity. Thus, the activation state of REST may distinguish neuroprotection from neurodegeneration in the ageing brain. ..
- Reinhart B, Ruvkun G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157:199-209 pubmed
- Dittman J, Kaplan J. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008;28:7104-12 pubmed publisher..Thus, conserved GPCRs act in the nematode motor circuit to provide negative feedback and to regulate locomotory behaviors that underlie navigation...
- An J, Blackwell T. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 2003;17:1882-93 pubmed..This oxidative stress response thus appears to be both widely conserved and ancient, suggesting that the mesendodermal specification role of SKN-1 was predated by its function in these detoxification mechanisms. ..
- Glover Cutter K, Lin S, Blackwell T. Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 2013;9:e1003701 pubmed publisher..Regulatory integration through SKN-1/Nrf may coordinate ER and cytoplasmic homeostasis. ..
- Curran S, Wu X, Riedel C, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459:1079-84 pubmed publisher..These results indicate that the acquisition of germline characteristics by the somatic cells of C. elegans mutants with increased longevity contributes to their increased health and survival. ..
- Cahill C, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, et al. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem. 2001;276:13402-10 pubmed..Thus, our results demonstrate at least two mechanisms, one 14-3-3-dependent and the other 14-3-3-independent, whereby PI 3-kinase signaling regulates DAF-16 DNA binding and transcription function. ..
- Cheesman H, Feinbaum R, Thekkiniath J, Dowen R, Conery A, Pukkila Worley R. Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans. G3 (Bethesda). 2016;6:541-9 pubmed publisher..Together, these data suggest that the activity of the MAPKKK NSY-1 is tightly regulated as part of a physiological mechanism to control p38 MAPK-mediated innate immune hyperactivation, and ensure cellular homeostasis in C. elegans. ..
- Troemel E, Chu S, Reinke V, Lee S, Ausubel F, Kim D. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006;2:e183 pubmed..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity. ..
- Ortiz Vega S, Khokhlatchev A, Nedwidek M, Zhang X, Dammann R, Pfeifer G, et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene. 2002;21:1381-90 pubmed..The preferential ability of RASSF1A to heterodimerize with Nore and thereby associate with Ras-like GTPases may be relevant to its putative tumor suppressor function. ..
- Dahlberg C, Juo P. The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. J Biol Chem. 2014;289:3444-56 pubmed publisher..We propose that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo. ..
- Riedel C, Dowen R, Lourenco G, Kirienko N, Heimbucher T, West J, et al. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15:491-501 pubmed publisher..Thus, we give insight into the mechanisms of DAF-16/FOXO-mediated transcriptional regulation and establish a critical link between ATP-dependent chromatin remodelling and lifespan regulation. ..
- Slack F, Basson M, Liu Z, Ambros V, Horvitz H, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5:659-69 pubmed..We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29. ..
- Irazoqui J, Urbach J, Ausubel F. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat Rev Immunol. 2010;10:47-58 pubmed publisher..What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms? ..
- Salehi Ashtiani K, Lin C, Hao T, Shen Y, Szeto D, Yang X, et al. Large-scale RACE approach for proactive experimental definition of C. elegans ORFeome. Genome Res. 2009;19:2334-42 pubmed publisher..Our results show that as much as 20% of the C. elegans genome may be incorrectly annotated. Many annotation errors could be corrected proactively with our large-scale RACE platform. ..
- Madison J, Nurrish S, Kaplan J. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol. 2005;15:2236-42 pubmed..elegans and that, contrary to current models, the UNC-13/Syntaxin interaction is required for nerve-evoked vesicle fusion rather than synaptic-vesicle priming. Thus, UNC-13 may regulate multiple steps of the synaptic-vesicle cycle. ..
- Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
- Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet. 2012;8:e1002542 pubmed publisher..Regulation of small RNA pathway genes by human retinoblastoma may also underlie its role as a tumor suppressor gene. ..
- Saito T, Mohideen F, Meyer K, Harper J, COLAIACOVO M. SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline. PLoS Genet. 2012;8:e1002888 pubmed publisher..Moreover, we hypothesize that SLX-1 regulates the crossover landscape during meiosis by acting as a noncrossover-promoting factor in a subset of DSBs. ..
- O Rourke E, Ruvkun G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15:668-76 pubmed publisher..Transcriptional coupling of lysosomal lipolysis and autophagy to nutrients is also observed in mammals. Thus, MXL-3 and HLH-30 orchestrate an adaptive and conserved cellular response to nutritional status and regulate lifespan...
- Saito T, Lui D, Kim H, Meyer K, COLAIACOVO M. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. PLoS Genet. 2013;9:e1003586 pubmed publisher..elegans meiosis. ..
- Takagi T, Moore C, Diehn F, Buratowski S. An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. Cell. 1997;89:867-73 pubmed..These results broaden the superfamily of PTP-like phosphatases to include enzymes with RNA substrates. ..
- Gabel H, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15:531-3 pubmed publisher..8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference. ..
- Shim E, Walker A, Shi Y, Blackwell T. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev. 2002;16:2135-46 pubmed
- Rolls M, Hall D, Victor M, Stelzer E, Rapoport T. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell. 2002;13:1778-91 pubmed..Ribosomes were also concentrated in the cell body, suggesting they may be in part responsible for targeting RER membrane proteins...
- Paradis S, Ailion M, Toker A, Thomas J, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13:1438-52 pubmed..The activating pdk-1 mutation is located in a conserved region of the kinase domain; the equivalent amino acid substitution in human PDK1 activates its kinase activity toward mammalian Akt/PKB. ..
- Ch ng Q, Sieburth D, Kaplan J. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008;4:e1000283 pubmed publisher..Using this strategy, we identified several genes that regulate secretion of insulin-like growth factors (IGFs) and influence lifespan in a manner dependent on insulin/IGF signaling. ..
- Dreier L, Burbea M, Kaplan J. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron. 2005;46:51-64 pubmed..We hypothesize that LIN-23-mediated degradation of BAR-1 beta-catenin regulates the transcription of Wnt target genes, which in turn alter postsynaptic properties. ..
- Livesey F. Netrins and netrin receptors. Cell Mol Life Sci. 1999;56:62-8 pubmed..Netrin-DCC signaling has also been shown to regulate cell death in epithelial cells in vitro, raising the interesting possibility that netrins may also regulate cell death in the developing nervous system. ..
- Saito T, Youds J, Boulton S, COLAIACOVO M. Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates. PLoS Genet. 2009;5:e1000735 pubmed publisher..elegans BLM homolog. We propose that HIM-18 facilitates processing of HR intermediates resulting from replication fork collapse and programmed meiotic DSBs in the C. elegans germline. ..
- Berger A, Hart A, Kaplan J. G alphas-induced neurodegeneration in Caenorhabditis elegans. J Neurosci. 1998;18:2871-80 pubmed..These experiments define an intracellular signaling cascade that triggers a necrotic form of neurodegeneration. ..
- O Rourke E, Kuballa P, Xavier R, Ruvkun G. ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27:429-40 pubmed publisher..We propose that the salubrious effects of dietary supplementation with ?-3/6 PUFAs (fish oils) that have emerged from epidemiological studies in humans may be due to a similar activation of autophagic programs. ..
- Hao Y, Hu Z, Sieburth D, Kaplan J. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012;8:e1002464 pubmed publisher..These results suggest that RIC-7 promotes DCV-mediated secretion. ..
- Fischer S, Montgomery T, Zhang C, Fahlgren N, Breen P, Hwang A, et al. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7:e1002369 pubmed publisher..Thus, like several other siRNA-associated Argonautes with a conserved RNaseH motif, ERGO-1 appears to be required for siRNA maturation. ..
- Hayes G, Riedel C, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25:2079-92 pubmed publisher..Our results suggest that somi-1 coordinates a nuclear response that complements the activity of mir-84. ..
- Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2004;69:429-31 pubmed
- Matthews L, Vaglio P, Reboul J, Ge H, Davis B, Garrels J, et al. Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Genome Res. 2001;11:2120-6 pubmed..However, the generation of such maps is costly and labor intensive. Here, we investigate the extent to which a protein interaction map generated in one species can be used to predict interactions in another species. ..
- McEwen J, Madison J, Dybbs M, Kaplan J. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. Neuron. 2006;51:303-15 pubmed..Even when priming was restored, synaptic transmission remained defective in unc-13 mutants, suggesting that UNC-13 is also required for other aspects of secretion. ..
- Curran S, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3:e56 pubmed..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life. ..
- Smolikov S, Schild Prufert K, COLAIACOVO M. A yeast two-hybrid screen for SYP-3 interactors identifies SYP-4, a component required for synaptonemal complex assembly and chiasma formation in Caenorhabditis elegans meiosis. PLoS Genet. 2009;5:e1000669 pubmed publisher..Altogether our findings place SYP-4 as a central player in SC formation and broaden our understanding of the structure of the SC and its assembly. ..
- Soukas A, Kane E, Carr C, Melo J, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23:496-511 pubmed publisher..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span. ..
- Samuelson A, Carr C, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21:2976-94 pubmed..The activities of these genes may normally decline during aging. ..
- Miyata S, Begun J, Troemel E, Ausubel F. DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics. 2008;178:903-18 pubmed publisher..The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response. ..
- Dufourcq P, Victor M, Gay F, Calvo D, Hodgkin J, Shi Y. Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis. Mol Cell Biol. 2002;22:3024-34 pubmed..Our findings reveal a novel and specific function for the ubiquitously expressed HDA-1 in C. elegans gonadogenesis and place hda-1 in the Notch signaling pathway...
- Pierce S, Costa M, Wisotzkey R, Devadhar S, Homburger S, Buchman A, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15:672-86 pubmed..Of five other ins genes tested, the only other one bearing a predicted C peptide also antagonizes daf-2 signaling, whereas four ins genes without a C peptide do not, indicating functional diversity within the ins family. ..
- Serra Pages C, Medley Q, Tang M, Hart A, Streuli M. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J Biol Chem. 1998;273:15611-20 pubmed..We propose that liprins function to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. ..
- Goodwin P, Juo P. The scaffolding protein SYD-2/Liprin-? regulates the mobility and polarized distribution of dense-core vesicles in C. elegans motor neurons. PLoS ONE. 2013;8:e54763 pubmed publisher..This study shows that SYD-2 promotes bi-directional mobility of DCVs and identifies SYD-2 as a novel regulator of DCV trafficking and polarized distribution. ..
- Smolikov S, Schild Prufert K, COLAIACOVO M. CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. PLoS Genet. 2008;4:e1000088 pubmed publisher..Moreover, they reveal a scenario in which DSB formation and repair can drive the polymerization of SC components along chromosome axes in C. elegans. ..
- Pukkila Worley R, Feinbaum R, Kirienko N, Larkins Ford J, Conery A, Ausubel F. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet. 2012;8:e1002733 pubmed publisher..These data show that the immunostimulatory activity of RPW-24 is required for its efficacy and define a novel C. elegans-based strategy to identify compounds with activity against antibiotic-resistant bacterial pathogens. ..
- Walker A, Shi Y, Blackwell T. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004;279:15339-47 pubmed..Our findings imply that in metazoans TFIID may be of widespread importance for transcription and for expression of tissue-specific genes. ..
- Zhang H, Abraham N, Khan L, Hall D, Fleming J, GOBEL V. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Nat Cell Biol. 2011;13:1189-201 pubmed publisher..Our findings identify glycosphingolipids, CGT products and obligate membrane lipids, as critical determinants of in vivo polarity and indicate that they sort new components to the expanding apical membrane...
- Schild Prufert K, Saito T, Smolikov S, Gu Y, Hincapie M, Hill D, et al. Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans. Genetics. 2011;189:411-21 pubmed publisher..elegans...
- Hu P, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2:e99 pubmed..elegans Akt/PKB signaling by cell autonomous and cell nonautonomous mechanisms. Similar molecules may modulate Akt/PKB signaling in human endocrine tissues. ..
- Caffaro C, Hirschberg C, Berninsone P. Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism. J Biol Chem. 2007;282:27970-5 pubmed..2 and SRF-3. Therefore, different mechanisms for transporting multiple nucleotide sugars may have evolved parallel to transporter amino acid divergence. ..
- de Carvalho C, Zaaijer S, Smolikov S, Gu Y, Schumacher J, COLAIACOVO M. LAB-1 antagonizes the Aurora B kinase in C. elegans. Genes Dev. 2008;22:2869-85 pubmed publisher..We propose that, in C. elegans, a LAB-1-mediated mechanism evolved to offset the challenges of providing protection against separase activity throughout a larger chromosome area. ..
- Parry D, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17:2013-22 pubmed
- Caffaro C, Luhn K, Bakker H, Vestweber D, Samuelson J, Berninsone P, et al. A single Caenorhabditis elegans Golgi apparatus-type transporter of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine. Biochemistry. 2008;47:4337-44 pubmed publisher..elegans have been found to transport two or three substrates, the substrate specificity of ZK896.9 raises questions as to the evolutionary ancestry of this group of proteins in this nematode. ..
- Kang J, Wang J, Wu L, Kang Z. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004;427:504 pubmed..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs. ..
- Montgomery T, Rim Y, Zhang C, Dowen R, Phillips C, Fischer S, et al. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012;8:e1002616 pubmed publisher..Thus, PIWI-class Argonaute proteins are specifically adapted to associate with methylated small RNAs in C. elegans. ..
- Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427:645-9 pubmed..Thus, ERI-1 is a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference. ..
- Sieburth D, Madison J, Kaplan J. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007;10:49-57 pubmed..Similar neuropeptide secretion defects were found in mutants lacking unc-31 (encoding the protein CAPS) or unc-13 (encoding Munc13). These results suggest that PKC-1 selectively regulates DCV release from neurons...
- Fischer S, Pan Q, Breen P, Qi Y, Shi Z, Zhang C, et al. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27:2678-95 pubmed publisher..The conserved ARF-like small GTPase ARL-8 is required specifically for primary siRNA biogenesis or stability in the sperm-specific ALG-3/4 endogenous RNAi pathway. ..
- Yuan J, Shaham S, Ledoux S, Ellis H, Horvitz H. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 1993;75:641-52 pubmed..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals. ..