Experts and Doctors on caenorhabditis elegans in Boston, Massachusetts, United States

Summary

Locale: Boston, Massachusetts, United States
Topic: caenorhabditis elegans

Top Publications

  1. Kass J, Jacob T, Kim P, Kaplan J. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J Neurosci. 2001;21:9265-72 pubmed
    ..Taken together, these results suggest that egl-3 PC2-processed peptides normally regulate the responsiveness of C. elegans to mechanical stimuli. ..
  2. Blackwell T. Germ cells: finding programs of mass repression. Curr Biol. 2004;14:R229-30 pubmed
    ..Why are these mechanisms so diverse and complex? ..
  3. Gabel H, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15:531-3 pubmed publisher
    ..8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference. ..
  4. Perrimon N, Ni J, Perkins L. In vivo RNAi: today and tomorrow. Cold Spring Harb Perspect Biol. 2010;2:a003640 pubmed publisher
    ..Further, we discuss the applications of RNAi technologies to crop improvement, pest control and RNAi therapeutics, thus providing an appreciation of the potential for phenomenal applications of RNAi to agriculture and medicine. ..
  5. Liu T, Rechtsteiner A, Egelhofer T, Vielle A, Latorre I, Cheung M, et al. Broad chromosomal domains of histone modification patterns in C. elegans. Genome Res. 2011;21:227-36 pubmed publisher
    ..These data, which confirm and extend previous studies, allow for in-depth analysis of the organization and deployment of the C. elegans genome during development. ..
  6. Anastassopoulou C, Fuchs B, Mylonakis E. Caenorhabditis elegans-based model systems for antifungal drug discovery. Curr Pharm Des. 2011;17:1225-33 pubmed
    ..elegans-C. albicans antifungal discovery assay holds even greater promise for the identification of novel antifungal agents in the near future. ..
  7. Goodwin P, Sasaki J, Juo P. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. J Neurosci. 2012;32:8158-72 pubmed publisher
    ..We propose a model in which CDK-5 regulates DCV polarity by both promoting DCV trafficking in axons and preventing dynein-dependent DCV trafficking into dendrites. ..
  8. Fluharty B, Biasini E, Stravalaci M, Sclip A, Diomede L, Balducci C, et al. An N-terminal fragment of the prion protein binds to amyloid-? oligomers and inhibits their neurotoxicity in vivo. J Biol Chem. 2013;288:7857-66 pubmed publisher
    ..These data suggest that N1, or small peptides derived from it, could be potent inhibitors of A? oligomer toxicity and represent an entirely new class of therapeutic agents for AD. ..
  9. Riedel C, Dowen R, Lourenco G, Kirienko N, Heimbucher T, West J, et al. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15:491-501 pubmed publisher
    ..Thus, we give insight into the mechanisms of DAF-16/FOXO-mediated transcriptional regulation and establish a critical link between ATP-dependent chromatin remodelling and lifespan regulation. ..

More Information

Publications108 found, 100 shown here

  1. YOON J, Ling A, Isik M, Lee D, Steinbaugh M, Sack L, et al. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014;111:3781-6 pubmed publisher
    ..GLTSCR2 controls cellular proliferation and metabolism via the transcription factor Myc, and is induced by mitochondrial stress, suggesting it may constitute a significant component of the mitochondrial signaling pathway. ..
  2. Cheesman H, Feinbaum R, Thekkiniath J, Dowen R, Conery A, Pukkila Worley R. Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans. G3 (Bethesda). 2016;6:541-9 pubmed publisher
    ..Together, these data suggest that the activity of the MAPKKK NSY-1 is tightly regulated as part of a physiological mechanism to control p38 MAPK-mediated innate immune hyperactivation, and ensure cellular homeostasis in C. elegans. ..
  3. Dahlberg C, Juo P. The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans. J Biol Chem. 2014;289:3444-56 pubmed publisher
    ..We propose that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo. ..
  4. Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Genes Dev. 1998;12:1409-14 pubmed
    ..Significantly, SAP 155 is phosphorylated concomitant with or just after catalytic step one, making this the first example of a protein modification tightly regulated with splicing catalysis. ..
  5. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang M, et al. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS ONE. 2009;4:e8210 pubmed publisher
    ..Our results suggest that RNA editors may be an important regulator of aging in humans and that, when evaluated in C. elegans, this pathway may interact with the RNA interference machinery to regulate lifespan. ..
  6. Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet. 2012;8:e1002542 pubmed publisher
    ..Regulation of small RNA pathway genes by human retinoblastoma may also underlie its role as a tumor suppressor gene. ..
  7. Morita Y, Tilly J. Oocyte apoptosis: like sand through an hourglass. Dev Biol. 1999;213:1-17 pubmed
  8. Hitchcock A, Krebber H, Frietze S, Lin A, Latterich M, Silver P. The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell. 2001;12:3226-41 pubmed
    ..Given the recent finding that NPL4 is allelic to the ERAD gene HRD4, we further propose that this NPL4 function extends to all endoplasmic reticulum-membrane-associated targets of the proteasome. ..
  9. Bates E, Victor M, Jones A, Shi Y, Hart A. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J Neurosci. 2006;26:2830-8 pubmed
    ..Our results suggest that polyglutamine expansions perturb transcription of CREB/CBP targets and that specific targeting of HDACs will be useful in reducing associated neurodegeneration. ..
  10. Troemel E, Chu S, Reinke V, Lee S, Ausubel F, Kim D. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006;2:e183 pubmed
    ..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity. ..
  11. Ch ng Q, Sieburth D, Kaplan J. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008;4:e1000283 pubmed publisher
    ..Using this strategy, we identified several genes that regulate secretion of insulin-like growth factors (IGFs) and influence lifespan in a manner dependent on insulin/IGF signaling. ..
  12. Irazoqui J, Urbach J, Ausubel F. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat Rev Immunol. 2010;10:47-58 pubmed publisher
    ..What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms? ..
  13. Kim Y, Mylonakis E. Caenorhabditis elegans immune conditioning with the probiotic bacterium Lactobacillus acidophilus strain NCFM enhances gram-positive immune responses. Infect Immun. 2012;80:2500-8 pubmed publisher
    ..In conclusion, we describe a new system for the study of probiotic immune agents and our findings demonstrate that probiotic conditioning with L. acidophilus NCFM modulates specific C. elegans immunity traits. ..
  14. Kovacevic I, Orozco J, Cram E. Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. PLoS Genet. 2013;9:e1003510 pubmed publisher
    ..elegans spermatheca and suggests FLN-1 is needed in response to oocyte entry to trigger calcium release and coordinated contraction of the spermathecal tissue. ..
  15. Tzur Y, Friedland A, Nadarajan S, Church G, Calarco J, COLAIACOVO M. Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics. 2013;195:1181-5 pubmed publisher
    ..This system can be used to create specific insertions, deletions, and base pair changes in the germline of C. elegans. ..
  16. Spracklin G, Fields B, Wan G, Becker D, Wallig A, Shukla A, et al. The RNAi Inheritance Machinery of Caenorhabditis elegans. Genetics. 2017;206:1403-1416 pubmed publisher
  17. Galluzzi L, Baehrecke E, Ballabio A, Boya P, Bravo San Pedro J, Cecconi F, et al. Molecular definitions of autophagy and related processes. EMBO J. 2017;36:1811-1836 pubmed publisher
    ..The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research. ..
  18. Hobert O, Moerman D, Clark K, Beckerle M, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144:45-57 pubmed
    ..In addition to its localization to adherens junctions UNC-97 can also be detected in the nucleus, suggesting multiple functions for this LIM domain protein. ..
  19. Reinhart B, Ruvkun G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157:199-209 pubmed
  20. Rolls M, Hall D, Victor M, Stelzer E, Rapoport T. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell. 2002;13:1778-91 pubmed
    ..Ribosomes were also concentrated in the cell body, suggesting they may be in part responsible for targeting RER membrane proteins...
  21. Shim E, Walker A, Shi Y, Blackwell T. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev. 2002;16:2135-46 pubmed
  22. Lee S, Lee R, Fraser A, Kamath R, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet. 2003;33:40-8 pubmed
    ..These data suggest that the longer lifespan of C. elegans with compromised mitochrondria cannot simply be assigned to lower free radical production and suggest a more complex coupling of metabolism and longevity. ..
  23. Medley Q, Buchbinder E, Tachibana K, Ngo H, Serra Pagès C, Streuli M. Signaling between focal adhesion kinase and trio. J Biol Chem. 2003;278:13265-70 pubmed
    ..These results suggest Trio may be involved in the regulation of focal adhesion dynamics in addition to effecting changes in the actin cytoskeleton through the activation of Rho family GTPases. ..
  24. Pak S, Kumar V, Tsu C, Luke C, Askew Y, Askew D, et al. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. J Biol Chem. 2004;279:15448-59 pubmed
    ..These data suggest that perturbations of serpin-proteinase balance are critical for correct postembryonic development in C. elegans. ..
  25. Dupuy D, Li Q, Deplancke B, Boxem M, Hao T, Lamesch P, et al. A first version of the Caenorhabditis elegans Promoterome. Genome Res. 2004;14:2169-75 pubmed
  26. Frand A, Russel S, Ruvkun G. Functional genomic analysis of C. elegans molting. PLoS Biol. 2005;3:e312 pubmed
    ..Many molting genes are conserved in parasitic nematodes responsible for human disease, and thus represent attractive targets for pesticide and pharmaceutical development. ..
  27. Madison J, Nurrish S, Kaplan J. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol. 2005;15:2236-42 pubmed
    ..elegans and that, contrary to current models, the UNC-13/Syntaxin interaction is required for nerve-evoked vesicle fusion rather than synaptic-vesicle priming. Thus, UNC-13 may regulate multiple steps of the synaptic-vesicle cycle. ..
  28. Berger M, Philippakis A, Qureshi A, He F, Estep P, Bulyk M. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat Biotechnol. 2006;24:1429-35 pubmed
    ..The unbiased coverage of all k-mers permits high-throughput interrogation of binding site preferences, including nucleotide interdependencies, at unprecedented resolution. ..
  29. Ball A, Casadei G, Samosorn S, Bremner J, Ausubel F, Moy T, et al. Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. ACS Chem Biol. 2006;1:594-600 pubmed
    ..The hybrid molecule showed good efficacy in a Caenorhabditis elegans model of enterococcal infection, curing worms of the pathogen. ..
  30. Rual J, Klitgord N, Achaz G. Novel insights into RNAi off-target effects using C. elegans paralogs. BMC Genomics. 2007;8:106 pubmed
    ..elegans. Our predictive methods would improve the design of dsRNA and ultimately the use of RNAi as a therapeutic tool upon experimental verification. ..
  31. Dittman J, Kaplan J. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008;28:7104-12 pubmed publisher
    ..Thus, conserved GPCRs act in the nematode motor circuit to provide negative feedback and to regulate locomotory behaviors that underlie navigation...
  32. Curran S, Wu X, Riedel C, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459:1079-84 pubmed publisher
    ..These results indicate that the acquisition of germline characteristics by the somatic cells of C. elegans mutants with increased longevity contributes to their increased health and survival. ..
  33. Allard P, COLAIACOVO M. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proc Natl Acad Sci U S A. 2010;107:20405-10 pubmed publisher
    ..C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis. ..
  34. Pukkila Worley R, Ausubel F, Mylonakis E. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLoS Pathog. 2011;7:e1002074 pubmed publisher
  35. Kimura K, Riddle D, Ruvkun G. The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status. Cold Spring Harb Symp Quant Biol. 2011;76:113-20 pubmed publisher
    ..The modulation of DAF-2 protein level by nutritional status may constitute an important component in the irreversible commitment to dauer arrest. ..
  36. Phillips C, Montgomery T, Breen P, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26:1433-44 pubmed publisher
    ..We propose that the mutator proteins and RRF-1 constitute an RNA processing compartment required for siRNA amplification and RNA silencing. ..
  37. Shore D, Carr C, Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012;8:e1002792 pubmed publisher
  38. Hart A, Kass J, Shapiro J, Kaplan J. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. J Neurosci. 1999;19:1952-8 pubmed
    ..Our analysis suggests that nose touch sensitivity and osmosensation occur via distinct signaling pathways in ASH and that OSM-10 is required for osmosensory signaling. ..
  39. Li X, Matilainen O, Jin C, Glover Cutter K, Holmberg C, Blackwell T. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet. 2011;7:e1002119 pubmed publisher
    ..The data suggest that SKN-1 may increase longevity, not only through its well-documented role in boosting stress resistance, but also through contributing to protein homeostasis. ..
  40. Serra Pages C, Medley Q, Tang M, Hart A, Streuli M. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J Biol Chem. 1998;273:15611-20 pubmed
    ..We propose that liprins function to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. ..
  41. Pierce S, Costa M, Wisotzkey R, Devadhar S, Homburger S, Buchman A, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15:672-86 pubmed
    ..Of five other ins genes tested, the only other one bearing a predicted C peptide also antagonizes daf-2 signaling, whereas four ins genes without a C peptide do not, indicating functional diversity within the ins family. ..
  42. Dufourcq P, Victor M, Gay F, Calvo D, Hodgkin J, Shi Y. Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis. Mol Cell Biol. 2002;22:3024-34 pubmed
    ..Our findings reveal a novel and specific function for the ubiquitously expressed HDA-1 in C. elegans gonadogenesis and place hda-1 in the Notch signaling pathway...
  43. Walker A, Blackwell T. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. J Biol Chem. 2003;278:6181-6 pubmed
    ..Our findings suggest that TAF-5, TAF-9, and TAF-10 are part of a functional module of TFIID- and TFTC/SAGA-related complexes that can be bypassed in many metazoan-specific genes. ..
  44. Walker A, Shi Y, Blackwell T. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004;279:15339-47 pubmed
    ..Our findings imply that in metazoans TFIID may be of widespread importance for transcription and for expression of tissue-specific genes. ..
  45. Whetstine J, Ceron J, Ladd B, Dufourcq P, Reinke V, Shi Y. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Mol Cell. 2005;18:483-90 pubmed
    ..Because human HDACs are targets for cancer therapy, these findings have significant implications in cancer treatment. ..
  46. Anderson P. A Place for RNAi. Dev Cell. 2005;9:311-2 pubmed
    ..In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting protein that appears to promote the assembly of P bodies in C. elegans (Ding et al., 2005)...
  47. Caffaro C, Hirschberg C, Berninsone P. Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism. J Biol Chem. 2007;282:27970-5 pubmed
    ..2 and SRF-3. Therefore, different mechanisms for transporting multiple nucleotide sugars may have evolved parallel to transporter amino acid divergence. ..
  48. Stanvitch G, Moore L. cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis. Genetics. 2008;178:83-97 pubmed publisher
  49. Fischer S, Butler M, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008;455:491-6 pubmed publisher
    ..The ERI-6/7 protein is a superfamily I helicase that both negatively regulates the exogenous RNAi pathway and functions in an endogenous RNAi pathway. ..
  50. Yuan J, Kroemer G. Alternative cell death mechanisms in development and beyond. Genes Dev. 2010;24:2592-602 pubmed publisher
    ..The physiological relevance of alternative cell death mechanisms as primary and backup mechanisms is discussed. ..
  51. Goodwin P, Juo P. The scaffolding protein SYD-2/Liprin-? regulates the mobility and polarized distribution of dense-core vesicles in C. elegans motor neurons. PLoS ONE. 2013;8:e54763 pubmed publisher
    ..This study shows that SYD-2 promotes bi-directional mobility of DCVs and identifies SYD-2 as a novel regulator of DCV trafficking and polarized distribution. ..
  52. Xu T, Park S, Giaimo B, Hall D, Ferrante F, Ho D, et al. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J. 2017;36:3232-3249 pubmed publisher
  53. Yuan J, Shaham S, Ledoux S, Ellis H, Horvitz H. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 1993;75:641-52 pubmed
    ..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals. ..
  54. Schwartz F, Eisenman R, Knoll J, Gessler M, Bruns G. cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region. Genomics. 1995;29:526-32 pubmed
    ..The extensive conservation of the predicted protein suggests a fundamental function of the gene product and will enable evaluation of the role of the 239FB gene in neurogenesis in model organisms...
  55. Thor S, Thomas J. Motor neuron specification in worms, flies and mice: conserved and 'lost' mechanisms. Curr Opin Genet Dev. 2002;12:558-64 pubmed
    ..By comparing findings from Caenorhabditis elegans, Drosophila and vertebrate model systems, it is apparent that both evolutionarily conserved and non-conserved mechanisms are used. ..
  56. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427:645-9 pubmed
    ..Thus, ERI-1 is a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference. ..
  57. Uccelletti D, O Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg C. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. J Biol Chem. 2004;279:27390-8 pubmed
  58. Parry D, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17:2013-22 pubmed
  59. Hsu C, Chan D, Greggio E, Saha S, Guillily M, Ferree A, et al. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010;112:1593-604 pubmed publisher
    ..These results were confirmed by deletion of sek-1 in C. elegans. These data demonstrate that MKKs and LRRK2 function in similar biological pathways, and support a role for LRRK2 in modulating the cellular stress response. ..
  60. Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol. 2010;17:1169-74 pubmed publisher
    ..Bioinformatic analysis of over-represented pathways and nodes in protein-DNA interactomes formed from experimental candidate miRNA gene target lists can focus attention on biologically significant target genes. ..
  61. Montgomery T, Rim Y, Zhang C, Dowen R, Phillips C, Fischer S, et al. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012;8:e1002616 pubmed publisher
    ..Thus, PIWI-class Argonaute proteins are specifically adapted to associate with methylated small RNAs in C. elegans. ..
  62. Wood J, Rogina B, Lavu S, Howitz K, Helfand S, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430:686-9 pubmed
    ..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction. ..
  63. Tzur Y, Egydio de Carvalho C, Nadarajan S, Van Bostelen I, Gu Y, Chu D, et al. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. PLoS Biol. 2012;10:e1001378 pubmed publisher
  64. Kang J, Wang J, Wu L, Kang Z. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004;427:504 pubmed
    ..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs. ..
  65. Hu P, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2:e99 pubmed
    ..elegans Akt/PKB signaling by cell autonomous and cell nonautonomous mechanisms. Similar molecules may modulate Akt/PKB signaling in human endocrine tissues. ..
  66. Sieburth D, Madison J, Kaplan J. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007;10:49-57 pubmed
    ..Similar neuropeptide secretion defects were found in mutants lacking unc-31 (encoding the protein CAPS) or unc-13 (encoding Munc13). These results suggest that PKC-1 selectively regulates DCV release from neurons...
  67. Smolikov S, Schild Prufert K, COLAIACOVO M. CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. PLoS Genet. 2008;4:e1000088 pubmed publisher
    ..Moreover, they reveal a scenario in which DSB formation and repair can drive the polymerization of SC components along chromosome axes in C. elegans. ..
  68. Irazoqui J, Troemel E, Feinbaum R, Luhachack L, Cezairliyan B, Ausubel F. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 2010;6:e1000982 pubmed publisher
    ..aeruginosa nor the S. aureus-triggered response requires canonical TLR signaling, they imply the existence of unidentified mechanisms for pathogen detection in C. elegans, with potentially conserved roles also in mammals. ..
  69. Schild Prufert K, Saito T, Smolikov S, Gu Y, Hincapie M, Hill D, et al. Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans. Genetics. 2011;189:411-21 pubmed publisher
    ..elegans...
  70. Fischer S, Pan Q, Breen P, Qi Y, Shi Z, Zhang C, et al. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27:2678-95 pubmed publisher
    ..The conserved ARF-like small GTPase ARL-8 is required specifically for primary siRNA biogenesis or stability in the sperm-specific ALG-3/4 endogenous RNAi pathway. ..
  71. Berger A, Hart A, Kaplan J. G alphas-induced neurodegeneration in Caenorhabditis elegans. J Neurosci. 1998;18:2871-80 pubmed
    ..These experiments define an intracellular signaling cascade that triggers a necrotic form of neurodegeneration. ..
  72. Pasquinelli A, Ruvkun G. Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002;18:495-513 pubmed
    ..Instead of inventing new gene functions, even subtle changes in temporal expression of pre-existing control genes can result in speciation by altering the time at which they function. ..
  73. Ashrafi K, Chang F, Watts J, Fraser A, Kamath R, Ahringer J, et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003;421:268-72 pubmed
  74. Dreier L, Burbea M, Kaplan J. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron. 2005;46:51-64 pubmed
    ..We hypothesize that LIN-23-mediated degradation of BAR-1 beta-catenin regulates the transcription of Wnt target genes, which in turn alter postsynaptic properties. ..
  75. Curran S, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3:e56 pubmed
    ..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life. ..
  76. Samuelson A, Carr C, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21:2976-94 pubmed
    ..The activities of these genes may normally decline during aging. ..
  77. de Carvalho C, Zaaijer S, Smolikov S, Gu Y, Schumacher J, COLAIACOVO M. LAB-1 antagonizes the Aurora B kinase in C. elegans. Genes Dev. 2008;22:2869-85 pubmed publisher
    ..We propose that, in C. elegans, a LAB-1-mediated mechanism evolved to offset the challenges of providing protection against separase activity throughout a larger chromosome area. ..
  78. Saito T, Youds J, Boulton S, COLAIACOVO M. Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates. PLoS Genet. 2009;5:e1000735 pubmed publisher
    ..elegans BLM homolog. We propose that HIM-18 facilitates processing of HR intermediates resulting from replication fork collapse and programmed meiotic DSBs in the C. elegans germline. ..
  79. Hayes G, Riedel C, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25:2079-92 pubmed publisher
    ..Our results suggest that somi-1 coordinates a nuclear response that complements the activity of mir-84. ..
  80. Fischer S, Montgomery T, Zhang C, Fahlgren N, Breen P, Hwang A, et al. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7:e1002369 pubmed publisher
    ..Thus, like several other siRNA-associated Argonautes with a conserved RNaseH motif, ERGO-1 appears to be required for siRNA maturation. ..
  81. Kovacevic I, Ho R, Cram E. CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans. Mech Dev. 2012;128:548-59 pubmed publisher
  82. See R, Calvo D, Kawa H, Luke M, Yuan Z, Shi Y. Stimulation of p300-mediated transcription by the kinase MEKK1. J Biol Chem. 2001;276:16310-7 pubmed
    ..Taken together, these results identify MEKK1 as a kinase that is likely to be involved in the regulation of the transactivation potential of p300 and support a role of p300 in MEKK1-induced apoptosis. ..
  83. Caffaro C, Luhn K, Bakker H, Vestweber D, Samuelson J, Berninsone P, et al. A single Caenorhabditis elegans Golgi apparatus-type transporter of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine. Biochemistry. 2008;47:4337-44 pubmed publisher
    ..elegans have been found to transport two or three substrates, the substrate specificity of ZK896.9 raises questions as to the evolutionary ancestry of this group of proteins in this nematode. ..
  84. Coleman J, Ghosh S, Okoli I, Mylonakis E. Antifungal activity of microbial secondary metabolites. PLoS ONE. 2011;6:e25321 pubmed publisher
    ..As A. fumigatus produces gliotoxin in vivo, we propose that in addition to being a virulence factor, gliotoxin may also provide an advantage to A. fumigatus when infecting a host that harbors other opportunistic fungi. ..
  85. Pukkila Worley R, Feinbaum R, Kirienko N, Larkins Ford J, Conery A, Ausubel F. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet. 2012;8:e1002733 pubmed publisher
    ..These data show that the immunostimulatory activity of RPW-24 is required for its efficacy and define a novel C. elegans-based strategy to identify compounds with activity against antibiotic-resistant bacterial pathogens. ..
  86. Guruharsha K, Kankel M, Artavanis Tsakonas S. The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet. 2012;13:654-66 pubmed publisher
  87. Carr G, Derbyshire E, Caldera E, Currie C, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. J Nat Prod. 2012;75:1806-9 pubmed publisher
    ..Compound 5 also showed moderate cytotoxicity against HepG2 cells...
  88. Soukas A, Kane E, Carr C, Melo J, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23:496-511 pubmed publisher
    ..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span. ..
  89. Zhang H, Abraham N, Khan L, Hall D, Fleming J, GOBEL V. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Nat Cell Biol. 2011;13:1189-201 pubmed publisher
    ..Our findings identify glycosphingolipids, CGT products and obligate membrane lipids, as critical determinants of in vivo polarity and indicate that they sort new components to the expanding apical membrane...
  90. Hao Y, Hu Z, Sieburth D, Kaplan J. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012;8:e1002464 pubmed publisher
    ..These results suggest that RIC-7 promotes DCV-mediated secretion. ..
  91. Takagi T, Walker A, Sawa C, Diehn F, Takase Y, Blackwell T, et al. The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization. J Biol Chem. 2003;278:14174-84 pubmed
    ..elegans embryos shows that lack of CEL-1 causes development to arrest with a phenotype similar to that seen when RNA polymerase II elongation activity is disrupted. Therefore, capping is essential for gene expression in metazoans. ..
  92. Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2004;69:429-31 pubmed