Experts and Doctors on amino acid sequence in Cambridge, Massachusetts, United States


Locale: Cambridge, Massachusetts, United States
Topic: amino acid sequence

Top Publications

  1. Moore S, Sauer R. The tmRNA system for translational surveillance and ribosome rescue. Annu Rev Biochem. 2007;76:101-24 pubmed
    ..Additional biological roles of tmRNA include stress management and the regulation of transcriptional circuits. ..
  2. Lane W, Galat A, Harding M, Schreiber S. Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. J Protein Chem. 1991;10:151-60 pubmed
  3. Clark J, Lin L, Kriz R, Ramesha C, Sultzman L, Lin A, et al. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell. 1991;65:1043-51 pubmed
    ..We suggest that this homology delineates a Ca(2+)-dependent phospholipid-binding motif, providing a mechanism for the second messenger Ca2+ to translocate and activate cytosolic proteins. ..
  4. Sloma A, Rufo G, Theriault K, Dwyer M, Wilson S, Pero J. Cloning and characterization of the gene for an additional extracellular serine protease of Bacillus subtilis. J Bacteriol. 1991;173:6889-95 pubmed
    ..The vpr gene maps in the ctrA-sacA-epr region of the chromosome and is not required for growth or sporulation. ..
  5. Ghosh S, Gifford A, Riviere L, Tempst P, Nolan G, Baltimore D. Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell. 1990;62:1019-29 pubmed
    ..However, p65 appears homologous to c-rel, suggesting that c-rel may form heterodimers with p50 and rel may include a homodimerization motif. ..
  6. Riley M. Nucleotide sequence of the Xdh region in Drosophila pseudoobscura and an analysis of the evolution of synonymous codons. Mol Biol Evol. 1989;6:33-52 pubmed
    ..A comparison of synonymous divergence between D. melanogaster and D. pseudoobscura in five additional genes reveals variation in the level of synonymous substitution. ..
  7. Bedard P, Yannoni Y, Simmons D, Erikson R. Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src. Mol Cell Biol. 1989;9:1371-5 pubmed
    ..p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to alpha 2 mu-globulin and plasma retinol-binding protein. ..
  8. Finer M, Aho S, Gerstenfeld L, Boedtker H, Doty P. Unusual DNA sequences located within the promoter region and the first intron of the chicken pro-alpha 1(I) collagen gene. J Biol Chem. 1987;262:13323-32 pubmed
    ..Both of these tandem repeat sequences were identified at other locations in the chicken genome by Southern blot hybridization. ..
  9. Martinez Cruzado J, Swimmer C, Fenerjian M, Kafatos F. Evolution of the autosomal chorion locus in Drosophila. I. General organization of the locus and sequence comparisons of genes s15 and s19 in evolutionary distant species. Genetics. 1988;119:663-77 pubmed
    ..Highlighted by a background of extensive sequence divergence elsewhere in the extragenic region, highly conserved elements are observed in the 5' flanking DNA and might represent regulatory elements. ..

More Information

Publications230 found, 100 shown here

  1. Sloma A, Ally A, Ally D, Pero J. Gene encoding a minor extracellular protease in Bacillus subtilis. J Bacteriol. 1988;170:5557-63 pubmed
    ..The epr gene mapped near sacA and was not required for growth or sporulation. ..
  2. Bernards A, Paskind M, Baltimore D. Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing. Oncogene. 1988;2:297-304 pubmed
    ..The 5'-most c-abl promoter contains several sequence motifs that are highly conserved between mouse and man. The downstream promoter is much less conserved. ..
  3. Gu Y, Sarnecki C, Aldape R, Livingston D, Su M. Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2. J Biol Chem. 1995;270:18715-8 pubmed
    ..The abilities of ICE, TX, and Nedd-2, when expressed at high intracellular concentrations, to cleave PARP are consistent with their induction of apoptosis in transfected cells. ..
  4. Li S, Okamoto T, Chun M, Sargiacomo M, Casanova J, Hansen S, et al. Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem. 1995;270:15693-701 pubmed
    ..These data suggest that caveolin could function to negatively regulate the activation state of heterotrimeric G proteins. ..
  5. Margolis P, Driks A, Losick R. Sporulation gene spoIIB from Bacillus subtilis. J Bacteriol. 1993;175:528-40 pubmed
    ..The nature of the spoIIB spoVG mutant phenotype is discussed in terms of the events involved in the maturation of the sporulation septum and in the activation of sporulation transcription factors sigma F and sigma E. ..
  6. Li S, Couet J, Lisanti M. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 1996;271:29182-90 pubmed
    ..Fourth, it is membrane-proximal, suggesting that it may be involved in other potential protein-protein interactions. Thus, we have termed this 20-amino acid stretch of caveolin residues the caveolin scaffolding domain. ..
  7. Wang T, Guidotti G. Golgi localization and functional expression of human uridine diphosphatase. J Biol Chem. 1998;273:11392-9 pubmed
    ..9-kDa yeast protein and is less related to the previously identified yeast Golgi GDPase. ..
  8. Tsao D, McDonagh T, Telliez J, Hsu S, Malakian K, Xu G, et al. Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. Mol Cell. 2000;5:1051-7 pubmed
    ..A combination of NMR, BIAcore, and mutagenesis experiments was used to help identify the site of interaction of N-TRADD with C-TRAF2, providing a framework for future attempts to selectively inhibit the TNF signaling pathways. ..
  9. Charest A, Lane K, McMahon K, Housman D. Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. J Biol Chem. 2001;276:29456-65 pubmed
    ..Our results broaden the scope of PDZ domain-mediated functions. ..
  10. Silvian L, Jin P, Carmillo P, Boriack Sjodin P, Pelletier C, Rushe M, et al. Artemin crystal structure reveals insights into heparan sulfate binding. Biochemistry. 2006;45:6801-12 pubmed
    ..This study suggests that ART binds HSPGs and identifies residues that may be involved in HSPG binding. ..
  11. Salsas Escat R, Stultz C. Conformational selection and collagenolysis in type III collagen. Proteins. 2010;78:325-35 pubmed publisher
  12. Colgrove R, Liu X, Griffiths A, Raja P, DeLuca N, Newman R, et al. History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains. Virology. 2016;487:215-21 pubmed publisher
    ..1 phenotypic properties of increased replication at high temperature and reduced neuroinvasiveness. The study also provides sequence markers to define the provenance of specific laboratory KOS virus stocks. ..
  13. Sako D, Comess K, Barone K, Camphausen R, Cumming D, Shaw G. A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell. 1995;83:323-31 pubmed
    ..We propose that this sulfotyrosine-containing segment of PSGL-1, in conjunction with sLex presented on O-linked glycans, constitutes the high affinity P-selectin-binding site. ..
  14. Walters K, Dayie K, Reece R, Ptashne M, Wagner G. Structure and mobility of the PUT3 dimer. Nat Struct Biol. 1997;4:744-50 pubmed
    ..The dimerization domain behaves as a large protein, while the peripheral cysteine zinc clusters have dynamic properties similar to small proteins. ..
  15. Madison L, Huisman G. Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic. Microbiol Mol Biol Rev. 1999;63:21-53 pubmed
  16. Bailly V, Zhang Z, Meier W, Cate R, Sanicola M, Bonventre J. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem. 2002;277:39739-48 pubmed
  17. Rafie Kolpin M, Han A, Chen J. Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI. Biochemistry. 2003;42:6536-44 pubmed
    ..Collectively, our results demonstrate that autophosphorylation of Thr485 is essential for the hyperphosphorylation and activation of HRI and is required for the acquisition of the eIF2alpha kinase activity. ..
  18. Gunaydin H, Gu Y, Huang X. Novel binding mode of a potent and selective tankyrase inhibitor. PLoS ONE. 2012;7:e33740 pubmed publisher
    ..The TNKS1/IWR2 complex provides a molecular basis for their strong and specific interactions and suggests clues for further development of tankyrase inhibitors. ..
  19. Berlin V, Styles C, Fink G. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J Cell Biol. 1990;111:2573-86 pubmed
    ..Based on these results, we propose that BIK1 is required stoichiometrically for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation. ..
  20. Robison K, Gilbert W, Church G. Large scale bacterial gene discovery by similarity search. Nat Genet. 1994;7:205-14 pubmed publisher
    ..Seven proteins are members of families which have not been described in prokaryotic sequences. We also describe 49 re-interpretations of existing sequence data of particular biological significance...
  21. Lu M, Kleckner N. Molecular cloning and characterization of the pgm gene encoding phosphoglucomutase of Escherichia coli. J Bacteriol. 1994;176:5847-51 pubmed
    ..The predicted amino acid sequence of the pgm gene is highly conserved in E. coli, Acetobacter xylinum, Saccharomyces cerevisiae, rabbits, and humans. pgm deletion mutant strains are deficient in phosphoglucomutase activity. ..
  22. Gite S, RajBhandary U. Lysine 207 as the site of cross-linking between the 3'-end of Escherichia coli initiator tRNA and methionyl-tRNA formyltransferase. J Biol Chem. 1997;272:5305-12 pubmed
  23. Grueneberg D, Henry R, Brauer A, Novina C, Cheriyath V, Roy A, et al. A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I. Genes Dev. 1997;11:2482-93 pubmed
    ..We propose that this multifunctional protein coordinates the formation of an active promoter complex at the c-fos gene, including the linkage of specific signal responsive activator complexes to the general transcription machinery. ..
  24. Read M, Brownell J, Gladysheva T, Hottelet M, Parent L, Coggins M, et al. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol Cell Biol. 2000;20:2326-33 pubmed
    ..These observations provide a functional link between the highly related ubiquitin and Nedd8 pathways of protein modification and show how they operate together to selectively target the signal-dependent degradation of IkappaBalpha. ..
  25. Gao G, Willcox B, Wyer J, Boulter J, O Callaghan C, Maenaka K, et al. Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha. J Biol Chem. 2000;275:15232-8 pubmed
  26. Grueneberg D, Pablo L, Hu K, August P, Weng Z, Papkoff J. A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway. Mol Cell Biol. 2003;23:3936-50 pubmed
  27. Schreiter E, Sintchak M, Guo Y, Chivers P, Sauer R, Drennan C. Crystal structure of the nickel-responsive transcription factor NikR. Nat Struct Biol. 2003;10:794-9 pubmed publisher
    ..The regulatory domain of NikR contains four nickel-binding sites at the tetramer interface, each exhibiting a novel square-planar coordination by three histidines and one cysteine side chain...
  28. Coleman R, Salzberg A, Cheng A. Structure-based identification of small molecule binding sites using a free energy model. J Chem Inf Model. 2006;46:2631-7 pubmed
    ..Combining the method with a functional residue prediction method called SCA (statistical coupling analysis) results in the prediction of potentially druggable allosteric binding sites on p38alpha kinase. ..
  29. Phelps C, Huang R, Lishko P, Wang R, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 2008;47:2476-84 pubmed publisher
    ..Similar biochemical findings are also presented for the highly homologous mammalian TRPV5-ARD. The implications of the structural and biochemical data on the role of the ankyrin repeats in different TRPV channels are discussed. ..
  30. De Rienzo G, Bishop J, Mao Y, Pan L, Ma T, Moens C, et al. Disc1 regulates both ?-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. FASEB J. 2011;25:4184-97 pubmed publisher
    ..This is the first demonstration that Disc1 modulates the noncanonical Wnt pathway and suggests a previously unconsidered mechanism by which Disc1 may contribute to the etiology of neuropsychiatric disorders. ..
  31. Wanniarachchi Y, Kaczmarek P, Wan A, Nolan E. Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. Biochemistry. 2011;50:8005-17 pubmed publisher
    ..2009) J. Biol. Chem. 284, 29180-29192] and that the native disulfide array is a requirement for its activity against S. aureus. ..
  32. Tran Q, Williams S, Farid R, Erdemli G, Pearlstein R. The translocation kinetics of antibiotics through porin OmpC: insights from structure-based solvation mapping using WaterMap. Proteins. 2013;81:291-9 pubmed publisher
    ..We conclude that antibiotics figuratively "melt" their way through porin solvation at a rate determined by the cost of exchanging protein-solvent for protein-antibiotic H-bonds. ..
  33. Stevens R, Akbergenova Y, Jorquera R, Littleton J. Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants. J Neurosci. 2012;32:18054-67, 18067a pubmed publisher
    ..These results suggest that synaptogyrin modulates the synaptic vesicle exo-endocytic cycle and is required for the proper biogenesis of synaptic vesicles at nerve terminals. ..
  34. Nolan G, Ghosh S, Liou H, Tempst P, Baltimore D. DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell. 1991;64:961-9 pubmed
  35. Brink R, Lodish H. Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation. J Biol Chem. 1998;273:4129-34 pubmed
    ..TRAF2A thus represents a novel signal transduction protein, the expression of which can act to inhibit TRAF2-dependent NF-kappaB activation. ..
  36. Frederick A, Rolfe M, Chiu M. The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines. Oncogene. 1998;16:153-65 pubmed
    ..These findings directly contradict and offer alternative interpretations to a number of previously published observations on Unp. ..
  37. Borowsky M, Hynes R. Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J Cell Biol. 1998;143:429-42 pubmed
    ..We have identified a short region within talin's amino-terminal 435 amino acids capable of binding to layilin in vitro. This region overlaps a binding site for focal adhesion kinase...
  38. Joshi S, Hersch G, Baker T, Sauer R. Communication between ClpX and ClpP during substrate processing and degradation. Nat Struct Mol Biol. 2004;11:404-11 pubmed
    ..A simple model explains the observed relationships between ATP binding, ATP hydrolysis and functional interactions between ClpX, protein substrates and ClpP. ..
  39. Gray S, Iglesias A, Lizcano F, Villanueva R, Camelo S, Jingu H, et al. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem. 2005;280:28507-18 pubmed
    ..The ability of JMJD2A to associate with pRb and HDACs and potentiate pRb-mediated repression of E2F-regulated promoters implies an important role for this protein in cell proliferation and oncogenesis. ..
  40. Marmorstein R, Carey M, Ptashne M, Harrison S. DNA recognition by GAL4: structure of a protein-DNA complex. Nature. 1992;356:408-14 pubmed
    ..The relatively open structure of the complex would allow another protein to bind coordinately with GAL4. ..
  41. Kunkel B, Kroos L, Poth H, Youngman P, Losick R. Temporal and spatial control of the mother-cell regulatory gene spoIIID of Bacillus subtilis. Genes Dev. 1989;3:1735-44 pubmed
  42. McNabb D, Xing Y, Guarente L. Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev. 1995;9:47-58 pubmed
    ..These data suggest that the HAP2/3/5 heterotrimer represents a unique DNA-binding factor in which all three subunits of the complex are absolutely required for DNA-binding activity. ..
  43. Aldovini A, Husson R, Young R. The uraA locus and homologous recombination in Mycobacterium bovis BCG. J Bacteriol. 1993;175:7282-9 pubmed
    ..These results have implications for understanding the role of mycobacterial genes in disease pathogenesis and for the genetic engineering of improved mycobacterial vaccines. ..
  44. Lavallie E, Rehemtulla A, Racie L, DiBlasio E, Ferenz C, Grant K, et al. Cloning and functional expression of a cDNA encoding the catalytic subunit of bovine enterokinase. J Biol Chem. 1993;268:23311-7 pubmed
  45. Tang J, Kriz R, Wolfman N, Shaffer M, Seehra J, Jones S. A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs. J Biol Chem. 1997;272:8567-75 pubmed
    ..Finally the enzyme is able to hydrolyze the acetyl moiety at the sn-2 position of platelet-activating factor. ..
  46. Tong J, Hassig C, Schnitzler G, Kingston R, Schreiber S. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature. 1998;395:917-21 pubmed
    ..Our results establish a physical and functional link between the distinct chromatin-modifying activities of histone deacetylases and nucleosome remodelling proteins. ..
  47. Ferrer M, Harrison S. Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries. J Virol. 1999;73:5795-802 pubmed
    ..The functional properties of 12p1 suggest that it might be a useful lead for the development of inhibitors of HIV entry. ..
  48. Miao N, Fung B, Sanchez R, Lydon J, Barker D, Pang K. Isolation and expression of PASK, a serine/threonine kinase, during rat embryonic development, with special emphasis on the pancreas. J Histochem Cytochem. 2000;48:1391-400 pubmed
    ..In addition, a search of the EST database revealed a related human kinase not previously described. ..
  49. Pandey A, Ibarrola N, Kratchmarova I, Fernandez M, Constantinescu S, Ohara O, et al. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. J Biol Chem. 2002;277:19131-8 pubmed
    ..This report therefore implicates SLAP and SLAP-2 as a family of adapter proteins that negatively regulate T cell receptor signaling. ..
  50. Chen Y, Irie Y, Keung W, Maret W. S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation. Biochemistry. 2002;41:8360-7 pubmed
    ..This could bear importantly on the physiological action of MT-III, whose biological activity as a neuronal growth inhibitory factor is unique, and for brain diseases that have been related to oxidative or nitrosative stress. ..
  51. Hwang H, Olson S, Esko J, Horvitz H. Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature. 2003;423:439-43 pubmed
    ..Our findings show that chondroitin is crucial for both cytokinesis and morphogenesis during C. elegans development. ..
  52. Schebesta M, Serluca F. olig1 Expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling. Dev Dyn. 2009;238:887-98 pubmed publisher
    ..Lastly, knockdown of Olig1 in an Olig2-sensitized background did result in defects in CNS myelination, indicating a functional overlap between Olig1 and Olig2 proteins. ..
  53. Marcotte D, Liu Y, Arduini R, Hession C, Miatkowski K, Wildes C, et al. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci. 2010;19:429-39 pubmed publisher
    ..Analysis of the structural differences between the TEC and Src families of kinases near the Trp-Glu-Ile motif in the N-terminal region of the kinase domain suggests a mechanism of regulation of the TEC family members. ..
  54. Zhang F, Cong L, Lodato S, Kosuri S, Church G, Arlotta P. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol. 2011;29:149-53 pubmed publisher
    ..We synthesized 17 TALEs that are customized to recognize specific DNA-binding sites, and demonstrate that they can specifically modulate transcription of endogenous genes (SOX2 and KLF4) in human cells. ..
  55. Liu M, Kang S, Ray S, Jackson J, Zaitsev A, Gerber S, et al. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry. 2011;50:9399-408 pubmed publisher
    ..Finally, the GTPase activity of the t-G2019S mutant was characterized, and the mutation modestly decreases GTPase activity without significantly affecting GTP binding affinity. ..
  56. Blainey P, Graziano V, Pérez Berná A, McGrath W, FLINT S, San Martín C, et al. Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates. J Biol Chem. 2013;288:2092-102 pubmed publisher
    ..Sliding of AVP-pVIc complexes along DNA illustrates a new biochemical mechanism by which a proteinase can locate its substrates, represents a new paradigm for virion maturation, and reveals a new way of exploiting the surface of DNA. ..
  57. de Cuevas M, Tao T, Goldstein L. Evidence that the stalk of Drosophila kinesin heavy chain is an alpha-helical coiled coil. J Cell Biol. 1992;116:957-65 pubmed
    ..We suggest that this difference in stability may play a role in the force-generating mechanism or regulation of kinesin. ..
  58. Ephrussi A, Dickinson L, Lehmann R. Oskar organizes the germ plasm and directs localization of the posterior determinant nanos. Cell. 1991;66:37-50 pubmed
    ..We propose that the pole plasm is assembled stepwise and that continued interaction among its components is required for germ cell determination. ..
  59. Hunt T, Fields T, Casey P, Peralta E. RGS10 is a selective activator of G alpha i GTPase activity. Nature. 1996;383:175-7 pubmed
    ..These results demonstrate that RGS proteins can attenuate signalling pathways involving heterotrimeric G proteins by serving as GTPase-activating proteins for specific types of G alpha subunits. ..
  60. Bickel P, Scherer P, Schnitzer J, Oh P, Lisanti M, Lodish H. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997;272:13793-802 pubmed
    ..Significantly, flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected. ..
  61. Sims R, van der Lee S, Naj A, Bellenguez C, Badarinarayan N, Jakobsdottir J, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017;49:1373-1384 pubmed publisher
    ..These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. ..
  62. Sekelsky J, Newfeld S, Raftery L, Chartoff E, Gelbart W. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics. 1995;139:1347-58 pubmed
    ..Hence, MAD is a member of a novel, highly conserved protein family. ..
  63. Burkly L, Hession C, Ogata L, Reilly C, Marconi L, Olson D, et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 1995;373:531-6 pubmed
  64. Tang Z, Scherer P, Okamoto T, Song K, Chu C, Kohtz D, et al. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem. 1996;271:2255-61 pubmed
    ..Our results also suggest that other as yet unknown caveolin family members are likely to exist and may be expressed in a regulated or tissue-specific fashion. ..
  65. Schievella A, Chen J, Graham J, Lin L. MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. J Biol Chem. 1997;272:12069-75 pubmed
    ..These data indicate that MADD links TNFR1 with MAP kinase activation and arachidonic acid release and provide further insight into the mechanisms by which TNF exerts its pleiotropic effects. ..
  66. Underwood K, Song C, Kriz R, Chang X, Knopf J, Lin L. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. J Biol Chem. 1998;273:21926-32 pubmed
    ..Identification of cPLA2-gamma reveals a newly defined family of phospholipases A2 with homology to cPLA2-alpha. ..
  67. Nurminsky D, Nurminskaya M, De Aguiar D, Hartl D. Selective sweep of a newly evolved sperm-specific gene in Drosophila. Nature. 1998;396:572-5 pubmed
    ..The discovery of this gene supports other results that point to the rapid molecular evolution of male reproductive functions. ..
  68. Grinblat Y, Sive H. zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula. Dev Dyn. 2001;222:688-93 pubmed
    ..These data show an early subdivision of the A/P axis in the presumptive neurectoderm. ..
  69. Maston G, Ruvolo M. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. Mol Biol Evol. 2002;19:320-35 pubmed
    ..In addition, newly generated DNA sequences from the promoter of the CG alpha subunit gene indicate that platyrrhine monkeys use a different mechanism of alpha gene expression control than that found in catarrhines. ..
  70. Pandey A, Blagoev B, Kratchmarova I, Fernandez M, Nielsen M, Kristiansen T, et al. Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene. 2002;21:8029-36 pubmed
    ..Taken together, our results indicate that Odin may play a negative role in growth factor receptor signaling pathways. ..
  71. Perlstein D, Ge J, Ortigosa A, Robblee J, Zhang Z, Huang M, et al. The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry. 2005;44:15366-77 pubmed
    ..These studies together demonstrate that beta' plays a crucial role in cluster assembly in vitro and in vivo and that the active form of the yeast R2 is betabeta'. ..
  72. Kosmrlj A, Chakraborty A, Kardar M, Shakhnovich E. Thymic selection of T-cell receptors as an extreme value problem. Phys Rev Lett. 2009;103:068103 pubmed
    ..We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions). ..
  73. Bai A, Meetze K, Vo N, Kollipara S, Mazsa E, Winston W, et al. GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling. Cancer Res. 2010;70:7630-9 pubmed publisher
    ..Cancer patients with aberrantly activated/amplified FGFR2 signaling could potentially benefit from therapeutic intervention with FGFR2-targeting antibodies. ..
  74. Dobbin M, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, et al. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci. 2013;16:1008-15 pubmed publisher
    ..We propose that SIRT1 is an apical transducer of the DSB response and that SIRT1 activation offers an important therapeutic avenue in neurodegeneration. ..
  75. Sloma A, Rufo G, Rudolph C, Sullivan B, Theriault K, Pero J. Bacillopeptidase F of Bacillus subtilis: purification of the protein and cloning of the gene. J Bacteriol. 1990;172:5520-1 pubmed
  76. Levin P, Losick R. Characterization of a cell division gene from Bacillus subtilis that is required for vegetative and sporulation septum formation. J Bacteriol. 1994;176:1451-9 pubmed
  77. McCormick J, Losick R. Cell division gene ftsQ is required for efficient sporulation but not growth and viability in Streptomyces coelicolor A3(2). J Bacteriol. 1996;178:5295-301 pubmed
    ..This makes S. coelicolor an advantageous system for the study of cell division genes...
  78. Bertin J, Nir W, Fischer C, Tayber O, Errada P, Grant J, et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. J Biol Chem. 1999;274:12955-8 pubmed
    ..In addition, coexpression of CARD4 augmented caspase-9-induced apoptosis. Thus, CARD4 coordinates downstream NF-kappaB and apoptotic signaling pathways and may be a component of the host innate immune response. ..
  79. Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer Romero P, et al. SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4. Oncogene. 2000;19:3529-36 pubmed
    ..Our results also suggest that ubiquitin is transferred directly from the Ubc to phospho-I kappa B alpha in a SCF beta-TRCP dependent reaction. Oncogene (2000) 19, 3529 - 3536 ..
  80. Arroyo J, Guirakhoo F, Fenner S, Zhang Z, Monath T, Chambers T. Molecular basis for attenuation of neurovirulence of a yellow fever Virus/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE). J Virol. 2001;75:934-42 pubmed
  81. Nasrin N, Kaushik V, Fortier E, Wall D, Pearson K, De Cabo R, et al. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE. 2009;4:e8414 pubmed publisher
    ..These findings identify a mechanism for regulation of SIRT1 enzymatic activity in response to oxidative stress and shed new light on its role in the stress protection pathway. ..
  82. Dubreuil R, Byers T, Stewart C, Kiehart D. A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin. J Cell Biol. 1990;111:1849-58 pubmed
    ..By size and sequence similarity, dystrophin is more similar to this newly described beta-spectrin isoform (beta H) than to other members of the spectrin gene family such as alpha-spectrin and alpha-actinin. ..
  83. Paul S, Merberg D, Finnerty H, Morris G, Morris J, Jones S, et al. Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met. Int J Cell Cloning. 1992;10:309-14 pubmed
    ..Also, the nyk-r gene is expressed in a wide range of tissues and cell lines. ..
  84. Osborn L, Vassallo C, Browning B, Tizard R, Haskard D, Benjamin C, et al. Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1). J Cell Biol. 1994;124:601-8 pubmed
    ..The VCAM-1 sequence G65NEH also appears to be involved in binding VLA-4. ..
  85. Scherer P, Tang Z, Chun M, Sargiacomo M, Lodish H, Lisanti M. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe. J Biol Chem. 1995;270:16395-401 pubmed
    ..We discuss the possible implications of these differences between alpha- and beta-caveolin. ..
  86. Peterson R, Schreiber S. Kinase phosphorylation: Keeping it all in the family. Curr Biol. 1999;9:R521-4 pubmed
    ..Recent findings suggest that the elusive PDK2 may actually be a familiar kinase with an atypical associate. ..
  87. Luciano B, Hsu S, Channavajhala P, Lin L, Cuozzo J. Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity. J Biol Chem. 2004;279:52117-23 pubmed
    ..Together these results showed that phosphorylation of Cot at Thr-290 is necessary but not sufficient for full kinase activity in the MEK/ERK pathway. ..
  88. Wang X, Lin H, Ng Eaton E, Downward J, Lodish H, Weinberg R. Expression cloning and characterization of the TGF-beta type III receptor. Cell. 1991;67:797-805 pubmed
    ..This indicates that the type III receptor may regulate the ligand-binding ability or surface expression of the type II receptor. ..
  89. Lavallie E, Stahl M. Cloning of the flagellin gene from Bacillus subtilis and complementation studies of an in vitro-derived deletion mutation. J Bacteriol. 1989;171:3085-94 pubmed
    ..Transport analysis of various flagellin gene mutations expressed in the hag deletion strain suggest that the extreme C-terminal portion of flagellin is functionally involved in export of the protein. ..
  90. Echelard Y, Epstein D, St Jacques B, Shen L, Mohler J, McMahon J, et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993;75:1417-30 pubmed
    ..Ectopic expression of Shh in the mouse CNS leads to the activation of floor plate-expressed genes. These results suggest that Shh may play a role in the normal inductive interactions that pattern the ventral CNS. ..
  91. Nalefski E, Sultzman L, Martin D, Kriz R, Towler P, Knopf J, et al. Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain. J Biol Chem. 1994;269:18239-49 pubmed
    ..These results delineate two functionally distinct domains of cPLA2, the Ca(2+)-independent catalytic domain, and the regulatory CaLB domain that presents the catalytic domain to the membrane in response to elevated Ca2+. ..
  92. Chao D, Gadbois E, Murray P, Anderson S, Sonu M, Parvin J, et al. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. Nature. 1996;380:82-5 pubmed
    ..This holoenzyme is more responsive to transcriptional activators than core RNA polymerase II when assayed in the presence of coactivators. ..