Experts and Doctors on amino acid oxidoreductases in Boston, Massachusetts, United States


Locale: Boston, Massachusetts, United States
Topic: amino acid oxidoreductases

Top Publications

  1. Fan B, Pasquale L, Rhee D, Li T, Haines J, Wiggs J. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. Invest Ophthalmol Vis Sci. 2011;52:2372-8 pubmed publisher
    ..The purpose of this study was to investigate the disease association of LOXL1 variants spanning the gene region, including the 5' and 3' regulatory regions, in a U.S. Caucasian case-control sample...
  2. Robinson L, Weremowicz S, Morton C, Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics. 1994;19:350-7 pubmed
    ..abstract truncated at 250 words) ..
  3. Mannick J, Asano K, Izumi K, Kieff E, Stamler J. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell. 1994;79:1137-46 pubmed
    ..These results suggest that NO plays a physiological role in human B cell biology by inhibiting programmed cell death and maintaining viral latency. ..
  4. Kagan H, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003;88:660-72 pubmed
    ..Recent studies have demonstrated that LO appears to function within the cell in a manner, which strongly modifies cellular activity. Newly discovered LO-like proteins also likely play unique roles in biology. ..
  5. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer J, et al. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004;36:178-82 pubmed
    ..Thus elastin polymer deposition is a crucial aspect of elastic fiber maintenance and is dependent on LOXL1, which serves both as a cross-linking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin...
  6. Fan B, Pasquale L, Grosskreutz C, Rhee D, Chen T, DeAngelis M, et al. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity. BMC Med Genet. 2008;9:5 pubmed publisher
  7. Yu H, Liu X, Kiss S, Connolly E, Gragoudas E, Michaud N, et al. Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1. Invest Ophthalmol Vis Sci. 2008;49:2599-605 pubmed publisher
    ..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV...
  8. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..Also, decorin and biglycan were doubled in Aspn-/- skin. Overall, asporin deficiency changes skin glycosaminoglycan composition, and decorin and biglycan content, which may explain the changes in skin mechanical properties. ..
  9. Lyons C, Orloff G, Cunningham J. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992;267:6370-4 pubmed

More Information


  1. Busconi L, Michel T. Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem. 1993;268:8410-3 pubmed
    ..N-terminal myristoylation of the endothelial NO synthase may provide a potential point of regulation of the biological functions of endothelium-derived NO in situ. ..
  2. Iftikhar M, Hurtado P, Bais M, Wigner N, Stephens D, Gerstenfeld L, et al. Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation. J Biol Chem. 2011;286:909-18 pubmed publisher
    ..LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. ..
  3. Wiggs J, Pawlyk B, Connolly E, Adamian M, Miller J, Pasquale L, et al. Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1). Invest Ophthalmol Vis Sci. 2014;55:856-64 pubmed publisher
    ..These results show that mice lacking LOXL1 have some ES features but that complete disease manifestation requires other factors that could be genetic and/or environmental. ..
  4. Aung T, Ozaki M, Lee M, Schlötzer Schrehardt U, Thorleifsson G, Mizoguchi T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49:993-1004 pubmed publisher
    ..3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology. ..