Experts and Doctors on abelson murine leukemia virus in Boston, Massachusetts, United States


Locale: Boston, Massachusetts, United States
Topic: abelson murine leukemia virus

Top Publications

  1. Yi C, Rosenberg N. Gag influences transformation by Abelson murine leukemia virus and suppresses nuclear localization of the v-Abl protein. J Virol. 2007;81:9461-8 pubmed
    ..These data indicate that Gag sequences are important for normal v-Abl signaling and that they suppress nuclear localization of the molecule. ..
  2. Chen Y, Wang L, Huang M, Rosenberg N. An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 1994;8:688-97 pubmed
  3. Mainville C, Parmar K, Unnikrishnan I, Gong L, Raffel G, Rosenberg N. Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain. J Virol. 2001;75:1816-23 pubmed
    ..These data suggest that alteration of the FLVRES pocket affects the ability of v-Abl to interact with at least some of its substrates in a temperature-dependent fashion and identify a novel type of temperature-sensitive Abelson virus. ..
  4. Parmar K, Rosenberg N. Ras complements the carboxyl terminus of v-Abl protein in lymphoid transformation. J Virol. 1996;70:1009-15 pubmed
    ..Signals transmitted via this connection may enhance those mediated via other regions of the v-Abl protein and facilitate transformation of primary, nonimmortalized cells such as pre-B lymphocytes...
  5. Bailey S, Rosenberg N. Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement. Mol Cell Biol. 1997;17:887-94 pubmed
    ..Considering the large numbers of lymphocytes generated throughout life, aberrant rearrangements generated by the V(D)J recombinase may be relatively common...
  6. Mostecki J, Halgren A, Radfar A, Sachs Z, Ravitz J, Thome K, et al. Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells. J Virol. 2000;74:9479-87 pubmed
    ..These data demonstrate that a single copy of the Ink4a/Arf locus is not sufficient to fully mediate the effects of these genes on transformation...
  7. Fessler S, Rosenberg N, Baughn L. SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus. J Virol. 2011;85:9239-42 pubmed publisher
    ..Forced expression of full-length SHIP significantly reduces Ab-MLV pre-B-cell transformation. Therefore, reduction of SHIP protein by v-Abl is a critical component in Ab-MLV transformation. ..
  8. Rosenberg N, Witte O. The viral and cellular forms of the Abelson (abl) oncogene. Adv Virus Res. 1988;35:39-81 pubmed
    ..Future progress will certainly depend on the intensive efforts by many workers in the broader field of cellular growth control mechanisms...
  9. Jenab Wolcott J, Rodriguez Correa D, Reitmair A, Mak T, Rosenberg N. The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. Mol Cell Biol. 2000;20:8373-81 pubmed
    ..Therefore, the absence of mismatch repair alters the molecular mechanisms involved in transformation by affecting a gene that controls apoptosis and cell cycle progression, rather than by affecting these processes directly. ..

More Information


  1. Saez E, Oppenheim H, Smoluk J, Andersen J, Van Etten R, Spiegelman B. c-fos is not essential for v-abl-induced lymphomagenesis. Cancer Res. 1995;55:6196-9 pubmed
    ..Moreover, the transformed cell that brings about the malignancy in mutant mice is the same pre-B-cell lymphoblast that is seen in control animals. These results demonstrate that c-fos is not required for in vivo transformation by v-abl...
  2. Nussenzweig M, Schmidt E, Shaw A, Sinn E, Campos Torres J, Mathey Prevot B, et al. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature. 1988;336:446-50 pubmed
    ..This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene...
  3. Warren D, Heilpern A, Berg K, Rosenberg N. The carboxyl terminus of v-Abl protein can augment SH2 domain function. J Virol. 2000;74:4495-504 pubmed
  4. Unnikrishnan I, Rosenberg N. Absence of p53 complements defects in Abelson murine leukemia virus signaling. J Virol. 2003;77:6208-15 pubmed
    ..These results indicate that one important transforming function of v-Abl proteins is overcoming the effects of a functional p53 pathway...
  5. Gong L, Unnikrishnan I, Raghavan A, Parmar K, Rosenberg N. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. J Virol. 2004;78:1636-44 pubmed
    ..These data indicate that an intact Src homology 2 (SH2) domain is not critical for apoptosis suppression and suggest that signals transmitted through Akt and p53 play an important role in the response. ..
  6. Ramakrishnan L, Rosenberg N. Novel B-cell precursors blocked at the stage of DJH recombination. Mol Cell Biol. 1988;8:5216-23 pubmed
  7. Yi C, Rosenberg N. Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV. J Virol. 2008;82:5307-15 pubmed publisher
    ..These results indicate that MA sequences within the Gag moiety of the v-Abl protein contribute to proper localization by playing a dominant role in trafficking of the v-Abl molecule. ..
  8. Zimmerman R, Rosenberg N. Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus. J Virol. 2008;82:8383-91 pubmed publisher