Experts and Doctors on xenopus laevis in Bethesda, Maryland, United States


Locale: Bethesda, Maryland, United States
Topic: xenopus laevis

Top Publications

  1. Osteen J, Mindell J. Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition. Biophys J. 2008;95:4668-75 pubmed publisher
  2. Je H, Yang F, Zhou J, Lu B. Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms. J Cell Biol. 2006;175:1029-42 pubmed
    ..These findings may have implications in the general mechanisms of long-term synaptic modulation by neurotrophins. ..
  3. Fu L, Ishizuya Oka A, Buchholz D, Amano T, Matsuda H, Shi Y. A causative role of stromelysin-3 in extracellular matrix remodeling and epithelial apoptosis during intestinal metamorphosis in Xenopus laevis. J Biol Chem. 2005;280:27856-65 pubmed
    ..These results thus suggest that ST3 regulates cell fate and tissue morphogenesis through direct or indirect ECM remodeling. ..
  4. Mathew S, Fu L, Hasebe T, Ishizuya Oka A, Shi Y. Tissue-dependent induction of apoptosis by matrix metalloproteinase stromelysin-3 during amphibian metamorphosis. Birth Defects Res C Embryo Today. 2010;90:55-66 pubmed publisher
    ..Our investigations demonstrate that stromelysin-3 controls apoptosis in different tissues via at least two distinct mechanisms. ..
  5. Sun H, Hu X, Moradel E, Weight F, Zhang L. Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C. J Biol Chem. 2003;278:34150-7 pubmed
    ..The observations suggest that PKC can modulate 5-HT3A receptor function and trafficking through an F-actin-dependent mechanism. ..
  6. Fu L, Tomita A, Wang H, Buchholz D, Shi Y. Transcriptional regulation of the Xenopus laevis Stromelysin-3 gene by thyroid hormone is mediated by a DNA element in the first intron. J Biol Chem. 2006;281:16870-8 pubmed
    ..These results suggest that the intronic TRE mediates the inductive effect of T3 and that promoter context plays an important role in gene repression by unliganded TR. ..
  7. Bulavin D, Demidenko Z, Phillips C, Moody S, Fornace A. Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in pre-midblastula embryos. Cell Cycle. 2003;2:263-6 pubmed
    ..We propose that phosphorylation of XeCdc25C Ser285 may account for the lack of a DNA replication checkpoint in cleaving Xenopus embryos prior to the MBT. ..
  8. Good P, Richter K, Dawid I. The sequence of a nervous system-specific, class II beta-tubulin gene from Xenopus laevis. Nucleic Acids Res. 1989;17:8000 pubmed
  9. Rosa F, Sargent T, Rebbert M, Michaels G, Jamrich M, Grunz H, et al. Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis. Dev Biol. 1988;129:114-23 pubmed
    ..The last remnants of DG42 protein are seen in ventral regions of the gut at the tailbud stage. ..

More Information


  1. Patterton D, Hayes W, Shi Y. Transcriptional activation of the matrix metalloproteinase gene stromelysin-3 coincides with thyroid hormone-induced cell death during frog metamorphosis. Dev Biol. 1995;167:252-62 pubmed
  2. Taira M, Otani H, Jamrich M, Dawid I. Expression of the LIM class homeobox gene Xlim-1 in pronephros and CNS cell lineages of Xenopus embryos is affected by retinoic acid and exogastrulation. Development. 1994;120:1525-36 pubmed
    ..RA treatment of exogastrulae did not revert this reduction. ..
  3. Pastori R, Moskaitis J, Smith L, Schoenberg D. Estrogen regulation of Xenopus laevis gamma-fibrinogen gene expression. Biochemistry. 1990;29:2599-605 pubmed
  4. Moskaitis J, Pastori R, Schoenberg D. Sequence of Xenopus laevis ferritin mRNA. Nucleic Acids Res. 1990;18:2184 pubmed
  5. Shuldiner A, Bennett C, Robinson E, Roth J. Isolation and characterization of two different insulins from an amphibian, Xenopus laevis. Endocrinology. 1989;125:469-77 pubmed
    ..5-fold more potent than pork insulin in stimulating glucose oxidation in rat adipocytes. We were unable to purify Xenopus insulin II sufficiently for immunological and biological characterization. ..
  6. Panchenko V, Glasser C, Mayer M. Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis. J Gen Physiol. 2001;117:345-60 pubmed
  7. Winning R, Shea L, Marcus S, Sargent T. Developmental regulation of transcription factor AP-2 during Xenopus laevis embryogenesis. Nucleic Acids Res. 1991;19:3709-14 pubmed
    ..Our results suggest that XAP-2 may play a distinctive role during Xenopus embryogenesis. ..
  8. Shi Y, Hayes W. Thyroid hormone-dependent regulation of the intestinal fatty acid-binding protein gene during amphibian metamorphosis. Dev Biol. 1994;161:48-58 pubmed
    ..Thus, the down-regulation of IFABP mRNA is one of the early molecular events preceding epithelial cell death during intestinal remodeling. ..
  9. Su Y, Shi Y, Stolow M, Shi Y. Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix. J Cell Biol. 1997;139:1533-43 pubmed
    ..Thus, our data provide an important molecular and cellular basis for the differential responses of different cell types to the endogenous T3 during metamorphosis and support a role of ECM during frog metamorphosis. ..
  10. Shaytan A, Armeev G, Goncearenco A, Zhurkin V, Landsman D, Panchenko A. Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomistic Insights into Nucleosome Functions. J Mol Biol. 2016;428:221-237 pubmed publisher
    ..We discuss the implications of the observed results on the nucleosome function and compare our results to different experimental studies. ..
  11. Shuldiner A, Nirula A, Scott L. Determination of the genomic structures of two nonallelic preproinsulin genes in Xenopus laevis using the polymerase chain reaction. Gen Comp Endocrinol. 1995;97:220-30 pubmed
    ..e., pancreatic expression) or important for differential expression (i.e., prepancreatic expression). ..
  12. Rebbert M, Bhatia Dey N, Dawid I. The sequence of TGF-beta 2 from Xenopus laevis. Nucleic Acids Res. 1990;18:2185 pubmed
  13. Moskaitis J, Pastori R, Schoenberg D. The nucleotide sequence of Xenopus laevis transferrin mRNA. Nucleic Acids Res. 1990;18:6135 pubmed
  14. Sukhareva M, Hackos D, Swartz K. Constitutive activation of the Shaker Kv channel. J Gen Physiol. 2003;122:541-56 pubmed
    ..This mechanism is discussed in the context of allosteric models for activation of Kv channels and what is known about the structure of this critical region in K+ channels. ..
  15. Corpe C, Lee J, Kwon O, Eck P, Narayanan J, Kirk K, et al. 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways. J Biol Chem. 2005;280:5211-20 pubmed
  16. Shuldiner A, Nirula A, Scott L, Roth J. Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes. Biochem Biophys Res Commun. 1990;166:223-30 pubmed
    ..Furthermore, both IGF-I mRNAs are expressed in similar quantities in adult liver. ..
  17. Wade P, Jones P, Vermaak D, Wolffe A. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase. Curr Biol. 1998;8:843-6 pubmed
    ..This association of a histone deacetylase with a Snf2 superfamily ATPase suggests a functional link between these two disparate classes of chromatin regulators. ..
  18. Smith N, Acharya M, Desai N, Figg W, Sparreboom A. Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther. 2005;4:815-8 pubmed
    ..These data suggest that OATP1B3 is a key regulator of hepatic uptake, and may therefore play a role in the variable response to treatment with taxanes. ..
  19. Hwang Y, Luo T, Xu Y, Sargent T. Myosin-X is required for cranial neural crest cell migration in Xenopus laevis. Dev Dyn. 2009;238:2522-9 pubmed publisher
    ..These data support the conclusion that MyoX has an essential function in CNC migration in the vertebrate embryo. ..
  20. Je H, Ji Y, Wang Y, Yang F, Wu W, Lu B. Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation. Mol Brain. 2011;4:1 pubmed publisher
    ..The GyrB-PKR system may be useful tool to study protein synthesis in a cell-specific manner. ..
  21. Shi Y, Liang V. Cloning and characterization of the ribosomal protein L8 gene from Xenopus laevis. Biochim Biophys Acta. 1994;1217:227-8 pubmed
    ..The Xenopus gene is ubiquitously expressed at fairly constant levels during development, consistent with its role as a house-keeping gene. ..
  22. Sandberg K, Ji H, Millan M, Catt K. Amphibian myocardial angiotensin II receptors are distinct from mammalian AT1 and AT2 receptor subtypes. FEBS Lett. 1991;284:281-4 pubmed
    ..These results indicate that amphibian AII receptors are pharmacologically distinct from both the AT1 and AT2 receptors characterized in mammalian tissues. ..
  23. Buchholz D, Singamsetty S, Karadge U, Williamson S, Langer C, Elinson R. Nutritional endoderm in a direct developing frog: a potential parallel to the evolution of the amniote egg. Dev Dyn. 2007;236:1259-72 pubmed
    ..The presence of cellularized nutritional endoderm in E. coqui may parallel changes that occurred in the evolution of the amniote egg 360 million years ago. ..
  24. Heimeier R, Hsia V, Shi Y. Participation of Brahma-related gene 1 (BRG1)-associated factor 57 and BRG1-containing chromatin remodeling complexes in thyroid hormone-dependent gene activation during vertebrate development. Mol Endocrinol. 2008;22:1065-77 pubmed publisher
    ..Together, these findings suggest a role of BRG1/BAF57-containing chromatin remodeling complexes in TR-regulated gene expression during postembryonic development. ..
  25. Pu R, Dasso M. The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport. Mol Biol Cell. 1997;8:1955-70 pubmed
    ..The results further suggest that the balance of GTP- and GDP-Ran is critical for proper nuclear assembly and function in vitro. ..
  26. Shi Y. Unliganded thyroid hormone receptor regulates metamorphic timing via the recruitment of histone deacetylase complexes. Curr Top Dev Biol. 2013;105:275-97 pubmed publisher
    ..Similar mechanisms likely mediate TR function in mammals as the maturation of many organs during postembryonic development is dependent upon TH and resembles organ metamorphosis in amphibians. ..
  27. Richter K, Grunz H, Dawid I. Gene expression in the embryonic nervous system of Xenopus laevis. Proc Natl Acad Sci U S A. 1988;85:8086-90 pubmed
    ..Expression of all six genes is suppressed in axis-deficient embryos that lack dorsal structures including the brain. ..
  28. Shuldiner A, Phillips S, Roberts C, LeRoith D, Roth J. Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective. J Biol Chem. 1989;264:9428-32 pubmed
    ..R., Bennett, C., Robinson, E.A., and Roth, J. (1989) Endocrinology, in press). These cDNAs represent the first amphibian preproinsulin sequences to be elucidated. ..
  29. Wolf Y, Koonin E. Origin of an animal mitochondrial DNA polymerase subunit via lineage-specific acquisition of a glycyl-tRNA synthetase from bacteria of the Thermus-Deinococcus group. Trends Genet. 2001;17:431-3 pubmed
  30. Winning R, Sargent T. Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos. Mech Dev. 1994;46:219-29 pubmed
    ..Based on this localized expression, we propose that Pag may play a role in the differentiation of cranial neural crest and other tissues. ..
  31. Matsuda H, Shi Y. An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development. Stem Cells. 2010;28:2073-83 pubmed publisher
    ..These findings are not only important for the understanding of organ-specific adult stem cell development but also have important implications in regenerative medicine of the digestive tract. ..
  32. Sato Y, Ding A, Heimeier R, Yousef A, Mymryk J, Walfish P, et al. The adenoviral E1A protein displaces corepressors and relieves gene repression by unliganded thyroid hormone receptors in vivo. Cell Res. 2009;19:783-92 pubmed publisher
    ..Taken together, our results thus indicate that E1A affects TR function through distinct mechanisms that are dependent upon the presence or absence of T3. ..
  33. Shi Y, Liang V, Parkison C, Cheng S. Tissue-dependent developmental expression of a cytosolic thyroid hormone protein gene in Xenopus: its role in the regulation of amphibian metamorphosis. FEBS Lett. 1994;355:61-4 pubmed
    ..These results suggest that CTHBP could function to modulate the metamorphic process by regulating the level of intracellular thyroid hormones. ..
  34. Tanegashima K, Zhao H, Dawid I. WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. EMBO J. 2008;27:606-17 pubmed publisher
    ..These results indicate that WGEF is a component of the Wnt-PCP pathway that connects Dishevelled to Rho activation. ..
  35. Zhang Y, Luo T, Sargent T. Expression of TFAP2beta and TFAP2gamma genes in Xenopus laevis. Gene Expr Patterns. 2006;6:589-95 pubmed
    ..All three are induced by Wnt/beta-catenin -- BMP signals and all bind to a consensus TFAP2 recognition site from an epidermal keratin gene. ..
  36. Yun C, Wang Y, Mukhopadhyay D, Backlund P, Kolli N, Yergey A, et al. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. J Cell Biol. 2008;183:589-95 pubmed publisher
    ..Together, these results suggest that regulation of SUMO deconjugation may be a major facet of B23/nucleophosmin function in vivo. ..
  37. Drew P, Nagle J, Canning R, Ozato K, Biddison W, Becker K. Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA. Gene. 1995;159:215-8 pubmed
    ..laevis (57%) and Rana pipiens (59%). This human clone contains nine C2H2-type zinc fingers like frog TFIIIA. Northern blot analysis indicates that the C2H2-34.10 RNA is expressed in human ovary, as well as human neuronal cell lines. ..
  38. Chen H, Brown J, Morell J, Huang C. Synthetic magainin analogues with improved antimicrobial activity. FEBS Lett. 1988;236:462-6 pubmed
  39. Daopin S, Piez K, Ogawa Y, Davies D. Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. Science. 1992;257:369-73 pubmed
    ..Sequence profile analysis of other members of the TGF-beta superfamily, including the activins, inhibins, and several developmental factors, imply that they also adopt the TGF-beta fold. ..
  40. Matsuo Takasaki M, Lim J, Beanan M, Sato S, Sargent T. Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000;93:201-4 pubmed
    ..The mouse homologue of Fez is similarly expressed in the mouse forebrain by embryonic day 11. ..
  41. Corpe C, Bovelander F, Munoz C, Hoekstra J, Simpson I, Kwon O, et al. Cloning and functional characterization of the mouse fructose transporter, GLUT5. Biochim Biophys Acta. 2002;1576:191-7 pubmed
  42. Milescu M, Vobecky J, Roh S, Kim S, Jung H, Kim J, et al. Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol. 2007;130:497-511 pubmed
  43. Good P, Richter K, Dawid I. A nervous system-specific isotype of the beta subunit of Na+,K(+)-ATPase expressed during early development of Xenopus laevis. Proc Natl Acad Sci U S A. 1990;87:9088-92 pubmed
    ..We suggest that beta 3 is a major Na+,K(+)-ATPase beta subunit present during early nervous system development in the frog. ..
  44. Ji H, Sandberg K, Zhang Y, Catt K. Molecular cloning, sequencing and functional expression of an amphibian angiotensin II receptor. Biochem Biophys Res Commun. 1993;194:756-62 pubmed
    ..Comparative analysis of xAT and AT1 receptors should facilitate elucidation of the structural basis of their binding and activation properties. ..
  45. Paul B, Shi Y. Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis. Cell Res. 2003;13:459-64 pubmed
    ..These results support the view that these coactivators participate in gene regulation by TR during metamorphosis. ..
  46. Yusufzai T, Wolffe A. Functional consequences of Rett syndrome mutations on human MeCP2. Nucleic Acids Res. 2000;28:4172-9 pubmed
    ..Together, these results provide evidence of how Rett syndrome mutations can affect distinct functions of MeCP2 and give insight into these mutations that may contribute to the disease. ..
  47. Stolow M, Shi Y. Xenopus sonic hedgehog as a potential morphogen during embryogenesis and thyroid hormone-dependent metamorphosis. Nucleic Acids Res. 1995;23:2555-62 pubmed
    ..Together, these data suggest a putative role for Xhh in organ development during both amphibian embryogenesis and metamorphosis. ..
  48. Bhatia Dey N, Adelstein R, Dawid I. Cloning of the cDNA encoding a myosin heavy chain B isoform of Xenopus nonmuscle myosin with an insert in the head region. Proc Natl Acad Sci U S A. 1993;90:2856-9 pubmed
    ..In contrast to chicken, all frog tissues and embryonic stages tested contained the insert-bearing form, and no evidence for a non-insert-bearing MHC-B isoform was found in Xenopus. ..
  49. Wank S, Harkins R, Jensen R, Shapira H, De Weerth A, Slattery T. Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc Natl Acad Sci U S A. 1992;89:3125-9 pubmed
    ..In vitro transcripts of the cDNA clone were functionally expressed in Xenopus oocytes and displayed the expected agonist and antagonist specificity. ..
  50. Bhatia Dey N, Taira M, Conti M, Nooruddin H, Adelstein R. Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis. Mech Dev. 1998;78:33-6 pubmed
  51. Je H, Yang F, Ji Y, Nagappan G, Hempstead B, Lu B. Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc Natl Acad Sci U S A. 2012;109:15924-9 pubmed publisher
    ..Thus, proBDNF and mBDNF may serve as potential "punishment" and "reward" signals for inactive and active terminals, respectively, and activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination...
  52. Kong D, Coleman T, DePamphilis M. Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC. EMBO J. 2003;22:3441-50 pubmed
    ..These results reveal that XlORC initiates DNA replication preferentially at the same or similar sites to those targeted in S.pombe. ..
  53. Fiorentino M, Fu L, Shi Y. Mutational analysis of the cleavage of the cancer-associated laminin receptor by stromelysin-3 reveals the contribution of flanking sequences to site recognition and cleavage efficiency. Int J Mol Med. 2009;23:389-97 pubmed
    ..Furthermore, the LR cleavage mutants generated here will also be valuable tools for future studies on the role of LR cleavage by ST3 in vertebrate development and cancer progression. ..
  54. Rollag M. Pertussis toxin sensitive photoaggregation of pigment in isolated Xenopus tail-fin melanophores. Photochem Photobiol. 1993;57:862-6 pubmed
  55. Dasso M, Seki T, Azuma Y, Ohba T, Nishimoto T. A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation. EMBO J. 1994;13:5732-44 pubmed
  56. Hasebe T, Hartman R, Matsuda H, Shi Y. Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis. Cell Tissue Res. 2006;324:105-16 pubmed
  57. Kim R, Wang D, Tsang M, Martin J, Huff C, de Caestecker M, et al. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Genes Dev. 2000;14:1605-16 pubmed
    ..Thus, SNIP1 is a nuclear inhibitor of CBP/p300 and its level of expression in specific cell types has important physiological consequences by setting a threshold for TGF-beta-induced transcriptional activation involving CBP/p300. ..
  58. Heimeier R, Das B, Buchholz D, Fiorentino M, Shi Y. Studies on Xenopus laevis intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adult. Genome Biol. 2010;11:R55 pubmed publisher
    ..This study significantly contributes towards our understanding of the dynamics of molecular regulation during development and tissue renewal, which is important for future basic and clinical research and for medicinal applications. ..
  59. Amano T, Fu L, Marshak A, Kwak O, Shi Y. Spatio-temporal regulation and cleavage by matrix metalloproteinase stromelysin-3 implicate a role for laminin receptor in intestinal remodeling during Xenopus laevis metamorphosis. Dev Dyn. 2005;234:190-200 pubmed
    ..Interestingly, high levels of LR are known to be expressed in tumor cells, which are often surrounded by fibroblasts expressing ST3, suggesting that LR cleavage by ST3 plays a role in both physiological and pathological processes. ..
  60. Murphy K, Cutter A, Fang H, Postnikov Y, Bustin M, Hayes J. HMGN1 and 2 remodel core and linker histone tail domains within chromatin. Nucleic Acids Res. 2017;45:9917-9930 pubmed publisher
    ..Our studies provide new insights into the molecular mechanisms whereby HMGNs affect chromatin structure...
  61. Amano T, Kwak O, Fu L, Marshak A, Shi Y. The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domain. Cell Res. 2005;15:150-9 pubmed
  62. Kitaguchi T, Sukhareva M, Swartz K. Stabilizing the closed S6 gate in the Shaker Kv channel through modification of a hydrophobic seal. J Gen Physiol. 2004;124:319-32 pubmed
    ..This mechanism is discussed in the context of the structure of this critical region in K+ channels. ..
  63. Whiteley M, Noguchi P, Sensabaugh S, Odenwald W, Kassis J. The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes. Mech Dev. 1992;36:117-27 pubmed
    ..Later in development, escargot is expressed in cells that will form the larval imaginal tissues, escargot is allelic with l(2)35Ce, an essential gene located near snail in the genome. ..
  64. Marion D, Zasloff M, Bax A. A two-dimensional NMR study of the antimicrobial peptide magainin 2. FEBS Lett. 1988;227:21-6 pubmed
    ..The transition to the alpha-helical conformation occurs at very low concentrations of TFE. ..
  65. Hackos D, Chang T, Swartz K. Scanning the intracellular S6 activation gate in the shaker K+ channel. J Gen Physiol. 2002;119:521-32 pubmed
    ..Collective examination of the three types of substitutions support the notion that the intracellular portion of S6 forms an activation gate and identifies V478 and F481 as candidates for occlusion of the pore in the closed state. ..
  66. Witta S, Agarwal V, Sato S. XIPOU 2, a noggin-inducible gene, has direct neuralizing activity. Development. 1995;121:721-30 pubmed
    ..In the absence of mesoderm induction, XIPOU 2 has the ability to induce a neuronal phenotype in uncommitted ectoderm. These data demonstrate the potential of XIPOU 2 to act as a master regulator of neurogenesis. ..
  67. Natale D, Li C, Sun W, DePamphilis M. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. EMBO J. 2000;19:2728-38 pubmed publisher
  68. Stump D, Landsberger N, Wolffe A. The cDNA encoding Xenopus laevis heat-shock factor 1 (XHSF1): nucleotide and deduced amino-acid sequences, and properties of the encoded protein. Gene. 1995;160:207-11 pubmed
    ..Microinjection of XHSF1 mRNA into Xl oocytes leads to synthesis of XHSF1 which accumulates in the nucleus and selectively activates Xl phsp70p activity at 18 degrees C. ..
  69. Urrutia R, Cruciani R, Barker J, Kachar B. Spontaneous polymerization of the antibiotic peptide magainin 2. FEBS Lett. 1989;247:17-21 pubmed
    ..Polymerization of the magainin 2 peptide may be involved in its recently described in vitro membrane-disrupting and antibiotic activities. ..
  70. Buchholz D, Ishizuya Oka A, Shi Y. Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis. Gene Expr Patterns. 2004;4:321-8 pubmed
  71. Daruwala R, Song J, Koh W, Rumsey S, Levine M. Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. FEBS Lett. 1999;460:480-4 pubmed
    ..Availability of the human transporter clones may facilitate new strategies for determining vitamin C intake. ..
  72. Silberberg S, Chang T, Swartz K. Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels. J Gen Physiol. 2005;125:347-59 pubmed
    ..The observation that the majority of nonconducting mutations are clustered toward the inner end of TM2 suggests a critical functional role for this region. ..
  73. Provencio I, Jiang G, de Grip W, Hayes W, Rollag M. Melanopsin: An opsin in melanophores, brain, and eye. Proc Natl Acad Sci U S A. 1998;95:340-5 pubmed
    ..Its expression in retinal and nonretinal tissues suggests a role in vision and nonvisual photoreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and photoperiodic physiology...
  74. Hong S, Tanegashima K, Dawid I. XIer2 is required for convergent extension movements during Xenopus development. Int J Dev Biol. 2011;55:917-21 pubmed publisher
    ..These results indicate that Xenopus Ier2 is essential for the execution of convergent extension movements during early Xenopus development. ..
  75. Yamashita S, Wada K, Horikoshi M, Gong D, Kokubo T, Hisatake K, et al. Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB. Proc Natl Acad Sci U S A. 1992;89:2839-43 pubmed
    ..This suggests that TFIIB has a more rigid structure, consistent with its function as a "bridging" protein between TFIID and RNA polymerase II. Further implications of the TFIIB structure are discussed. ..
  76. Good P. A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A. 1995;92:4557-61 pubmed
    ..Surprisingly, elrA is expressed in all adult tissues tested and at all times during development. Thus, the widely expressed elrA is expected to have a related function in all cells. ..
  77. Greene J, Otani H, Good P, Dawid I. A novel family of retrotransposon-like elements in Xenopus laevis with a transcript inducible by two growth factors. Nucleic Acids Res. 1993;21:2375-81 pubmed
    ..e., sequences internal to the repeats in the cDNA). Inverted repeats of 5 bp and apparent target site duplications of 5 bp surround the sequenced solo LTR. Thus, 1A11 is a new retrotransposon-like element in Xenopus laevis. ..
  78. Gong D, Horikoshi M, Nakatani Y. Analysis of cDNA encoding Drosophila transcription initiation factor TFIIF alpha (RAP74). Nucleic Acids Res. 1993;21:1492 pubmed
  79. He X, Saint Jeannet J, Wang Y, Nathans J, Dawid I, Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. 1997;275:1652-4 pubmed
    ..Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A. ..
  80. Rothenburg S, Deigendesch N, Dey M, Dever T, Tazi L. Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications. BMC Biol. 2008;6:12 pubmed
    ..Further implications of our findings for the evolution of the PKR family and for studying PKR/PKZ interactions with viral gene products and their roles in viral infections are discussed...
  81. Tsang M, Friesel R, Kudoh T, Dawid I. Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol. 2002;4:165-9 pubmed
    ..Injection of antisense sef morpholino oligos mimicked the phenotypes observed by ectopic fgf8 expression, suggesting that Sef is required to limit FGF signalling during development. ..
  82. Hasebe T, Hartman R, Fu L, Amano T, Shi Y. Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development. Mech Dev. 2007;124:11-22 pubmed
    ..Thus, our studies support a cooperative role of these MMPs in embryonic development, likely through the activation of pro-GelA by MT1-MMP. ..
  83. Cho H, Wolffe A. Xenopus laevis B4, an intron-containing oocyte-specific linker histone-encoding gene. Gene. 1994;143:233-8 pubmed
    ..Tissue-specific expression, a low copy number and presence of introns are all unusual features for vertebrate genes encoding linker histones. ..
  84. Dutta S, Dawid I. Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output. Development. 2010;137:3013-8 pubmed publisher
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range. ..
  85. Zhang Y, Chang C, Gehling D, Hemmati Brivanlou A, Derynck R. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2001;98:974-9 pubmed
  86. Kwon O, Eck P, Chen S, Corpe C, Lee J, Kruhlak M, et al. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J. 2007;21:366-77 pubmed
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