Experts and Doctors on transfer rna in Bethesda, Maryland, United States


Locale: Bethesda, Maryland, United States
Topic: transfer rna

Top Publications

  1. Shin B, Maag D, Roll Mecak A, Arefin M, Burley S, Lorsch J, et al. Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Cell. 2002;111:1015-25 pubmed
    ..The translational defect suggests eIF5B stabilizes Met-tRNA(i)(Met) binding and that GTP hydrolysis by eIF5B is a checkpoint monitoring 80S ribosome assembly in the final step of translation initiation. ..
  2. Stadtman T, Davis J, Zehelein E, Bock A. Biochemical and genetic analysis of Salmonella typhimurium and Escherichia coli mutants defective in specific incorporation of selenium into formate dehydrogenase and tRNAs. Biofactors. 1989;2:35-44 pubmed
    ..coli formate dehydrogenase selenopolypeptide-lacZ gene fusion showed that the selD gene allowed readthrough of the UGA codon and synthesis of beta-galactosidase in the Salmonella mutant. ..
  3. Veres Z, Stadtman T. A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium. Proc Natl Acad Sci U S A. 1994;91:8092-6 pubmed
    ..A labeled compound in the nucleoside mixture was coeluted with authentic 5-methylaminomethyl-2-selenouridine...
  4. Sattlegger E, Hinnebusch A. Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells. EMBO J. 2000;19:6622-33 pubmed
    ..GCN1 expression conferred sensitivity to paromomycin in a manner dependent on its ribosome binding domain, supporting the idea that GCN1 binds near the ribosomal acceptor site to promote GCN2 activation by uncharged tRNA. ..
  5. Intine R, Tenenbaum S, Sakulich A, Keene J, Maraia R. Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. Mol Cell. 2003;12:1301-7 pubmed
  6. Kawano M, Reynolds A, Miranda Rios J, Storz G. Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli. Nucleic Acids Res. 2005;33:1040-50 pubmed
    ..In addition, we identified a few small RNAs that are expressed opposite protein-coding genes and could base pair with 5' or 3' ends of the mRNAs with perfect complementarity. ..
  7. Noma K, Cam H, Maraia R, Grewal S. A role for TFIIIC transcription factor complex in genome organization. Cell. 2006;125:859-72 pubmed
    ..Our analyses uncover a general genome organization mechanism involving conserved TFIIIC complex. ..
  8. Bayfield M, Kaiser T, Intine R, Maraia R. Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation. Mol Cell Biol. 2007;27:3303-12 pubmed
  9. Carlson B, Yoo M, Sano Y, Sengupta A, Kim J, Irons R, et al. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol. 2009;10:57 pubmed publisher
    ..Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages. ..

More Information


  1. Wolfe M. Mechanistic insights revealed through characterization of a novel chromophore in selenophosphate synthetase from Escherichia coli. IUBMB Life. 2003;55:689-93 pubmed
  2. Huang Y, Intine R, Mozlin A, Hasson S, Maraia R. Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing. Mol Cell Biol. 2005;25:621-36 pubmed
    ..The data indicate that Rpc11p limits RNA 3'-U length and that this significantly restricts pre-tRNAs to a La-independent pathway of maturation in fission yeast. ..