Experts and Doctors on surface plasmon resonance in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Topic: surface plasmon resonance
Kontrogianni Konstantopoulos A, Jones E, van Rossum D, Bloch R. Obscurin is a ligand for small ankyrin 1 in skeletal muscle. Mol Biol Cell. 2003;14:1138-48 pubmed
..Our findings suggest that obscurin binds sAnk1, and are the first to document a specific and direct interaction between proteins of the sarcomere and the SR. ..
Willis C, Oashi T, Busby B, MacKerell A, Bloch R. Hydrophobic residues in small ankyrin 1 participate in binding to obscurin. Mol Membr Biol. 2012;29:36-51 pubmed publisher
..Our results suggest that hydrophobic interactions contribute to the higher affinity of Obsc????????? for sAnk1 and to the dominant role exhibited by this sequence in binding. ..
Antolik C, Catino D, Resneck W, Bloch R. The tetratricopeptide repeat domains of rapsyn bind directly to cytoplasmic sequences of the muscle-specific kinase. Neuroscience. 2006;141:87-100 pubmed
..Our results support a model in which the tetratricopeptide repeat domains of rapsyn bind directly to the cytoplasmic portion of MuSK, which could thereby serve as an initial scaffold for the clustering of acetylcholine receptors. ..
Bowman A, Catino D, Strong J, Randall W, Kontrogianni Konstantopoulos A, Bloch R. The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. Mol Biol Cell. 2008;19:3782-92 pubmed publisher
..Our results suggest that the Rho-GEF domain interacts with RanBP9 and that both can interact with the N-terminal region of titin to influence the formation of the Z-disk and A/I junction. ..
Zhang Y, Resneck W, Lee P, Randall W, Bloch R, Ursitti J. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat. J Mol Cell Cardiol. 2010;48:1050-9 pubmed publisher
..Our results suggest that the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth. ..
Boucher L, Bosch J. Development of a multifunctional tool for drug screening against plasmodial protein-protein interactions via surface plasmon resonance. J Mol Recognit. 2013;26:496-500 pubmed publisher
..Adaptation of this tool will allow researchers to pursue their own studies of protein-protein interactions. ..
Raasi S, Orlov I, Fleming K, Pickart C. Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. J Mol Biol. 2004;341:1367-79 pubmed
..Our findings provide new insights into polyubiquitin chain recognition and set the stage for future structural investigations of UBA/polyubiquitin complexes. ..
Yao N, Johnson A, Bowman G, Kuriyan J, O Donnell M. Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C. J Biol Chem. 2006;281:17528-39 pubmed
..Interestingly, the Rad.RFC DNA damage checkpoint clamp loader unloads PCNA clamps from DNA. We propose that Rad.RFC may clear PCNA from DNA to facilitate shutdown of replication in the face of DNA damage. ..
Antolik C, Catino D, O Neill A, Resneck W, Ursitti J, Bloch R. The actin binding domain of ACF7 binds directly to the tetratricopeptide repeat domains of rapsyn. Neuroscience. 2007;145:56-65 pubmed
..These results suggest that, in mammalian skeletal muscle, AChRs are immobilized in the membrane through rapsyn-mediated anchoring to an ACF7-containing network that in turn is linked to the actin cytoskeleton. ..