Experts and Doctors on signal transduction in Baltimore, Maryland, United States


Locale: Baltimore, Maryland, United States
Topic: signal transduction

Top Publications

  1. Whitford K, Marillat V, Stein E, Goodman C, Tessier Lavigne M, Chedotal A, et al. Regulation of cortical dendrite development by Slit-Robo interactions. Neuron. 2002;33:47-61 pubmed
    ..These experiments indicate that Slit-Robo interactions may exert a significant influence over the specification of cortical neuron morphology by regulating both axon guidance and dendritic patterning. ..
  2. Galm O, Yoshikawa H, Esteller M, Osieka R, Herman J. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood. 2003;101:2784-8 pubmed
    ..Silencing of the SOCS-1 gene may impair negative regulation of the Jak/STAT pathway and therefore result in greater responsiveness to cytokines, thus supporting survival and expansion of MM cells. ..
  3. Silver D, Montell D. A new trick for Cyclin-Cdk: activation of STAT. Dev Cell. 2003;4:148-9 pubmed
    ..Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation. ..
  4. Dumler J. The biological basis of severe outcomes in Anaplasma phagocytophilum infection. FEMS Immunol Med Microbiol. 2012;64:13-20 pubmed publisher
    ..Whether severity relates to microbial factors or genetically determined diversity in human immune and inflammatory response needs more investigation. ..
  5. Kolla V, Weihua X, Kalvakolanu D. Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. J Biol Chem. 1997;272:9742-8 pubmed
    ..In vivo, RA receptor beta and retinoid X receptor alpha preferentially interacted with this element. Thus, these data define a molecular basis for the synergy between IFNs and retinoids in tumor growth inhibition. ..
  6. Rubinstein A, Lee D, Luo R, Henion P, Halpern M. Genes dependent on zebrafish cyclops function identified by AFLP differential gene expression screen. Genesis. 2000;26:86-97 pubmed
    ..The identification of calreticulin suggests that a differential screen between wild-type and mutant cDNA is a useful approach to reveal regulation of unexpected gene expression in response to cellular signals. genesis 26:86-97, 2000. ..
  7. Afanasyeva M, Wang Y, Kaya Z, Stafford E, Dohmen K, Sadighi Akha A, et al. Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. Circulation. 2001;104:3145-51 pubmed
    ..In contrast, IFN-gamma plays a protective role. The disease-limiting effects of IFN-gamma might be explained by its ability to control the expansion of activated T lymphocytes. ..
  8. Guo Z, Iyun T, Fu W, Zhang P, Mattson M. Bone marrow transplantation reveals roles for brain macrophage/microglia TNF signaling and nitric oxide production in excitotoxic neuronal death. Neuromolecular Med. 2004;5:219-34 pubmed
  9. Frisancho Kiss S, Nyland J, Davis S, Barrett M, Gatewood S, Njoku D, et al. Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunol. 2006;176:6411-5 pubmed
    ..These results indicate that regulation of inflammation in the heart begins during innate immunity and that Tim-3 signaling on cells of the innate immune system critically influences regulation of the adaptive immune response. ..

More Information

Publications645 found, 100 shown here

  1. Kang S, Chae Y, Woo J, Kim M, Park J, Lee J, et al. Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol. 2008;173:518-25 pubmed publisher
  2. Gerdes J, Davis E, Katsanis N. The vertebrate primary cilium in development, homeostasis, and disease. Cell. 2009;137:32-45 pubmed publisher
    ..Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction. ..
  3. Alberi L, Liu S, Wang Y, Badie R, Smith Hicks C, Wu J, et al. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron. 2011;69:437-44 pubmed publisher
    ..Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation. ..
  4. Rothman S, Mattson M. Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience. 2013;239:228-40 pubmed publisher
    ..Collectively, the findings described in this article suggest the possibility of developing prescriptions for optimal brain health based on activity-dependent BDNF signaling. ..
  5. Tripathi P, Wang Y, Coussens M, Manda K, Casey A, Lin C, et al. Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. Oncogene. 2014;33:1840-9 pubmed publisher
    ..This study provides direct evidence for the ability of NFATc1 in inducing primary tumor formation in vivo and supports targeting NFAT signaling in anti-tumor therapy. ..
  6. Dawson T, Arriza J, Jaworsky D, Borisy F, Attramadal H, Lefkowitz R, et al. Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Science. 1993;259:825-9 pubmed
    ..These results suggest that beta ARK-2 and beta-arrestin-2 mediate agonist-dependent desensitization in olfaction. ..
  7. Kim J, Feldman R. Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1. Mol Cell Biol. 2002;22:1903-18 pubmed
    ..Our results strongly implicate Fes as a key regulator of terminal macrophage differentiation and identify PU.1 as a transcription factor that may mediate some of its biological activities in myeloid cells. ..
  8. Cooper M, Wassif C, Krakowiak P, Taipale J, Gong R, Kelley R, et al. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet. 2003;33:508-13 pubmed
    ..We further find that sterol depletion affects the activity of Smoothened (Smo), an essential component of the Hh signal transduction apparatus. ..
  9. Zou T, Liu L, Rao J, Marasa B, Chen J, Xiao L, et al. Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. Biochem J. 2008;409:389-98 pubmed
  10. Raufman J, Samimi R, Shah N, Khurana S, Shant J, Drachenberg C, et al. Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res. 2008;68:3573-8 pubmed publisher
    ..001). Compared with WT, azoxymethane-treated M(3)R-deficient mice have attenuated epithelial cell proliferation, tumor number, and size. M(3)R and post-M(3)R signaling are novel therapeutic targets for colon cancer. ..
  11. Leary R, Lin J, Cummins J, Boca S, Wood L, Parsons D, et al. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A. 2008;105:16224-9 pubmed publisher
    ..These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy. ..
  12. Yadav A, Fitzgerald P, Sajadi M, Gilliam B, Lafferty M, Redfield R, et al. Increased expression of suppressor of cytokine signaling-1 (SOCS-1): A mechanism for dysregulated T helper-1 responses in HIV-1 disease. Virology. 2009;385:126-33 pubmed publisher
    ..These results suggest a link between high levels of SOCS-1, defects in innate immunity and adaptive Th1 responses that may be reflected in the loss of Th1 immune competence observed with AIDS patients. ..
  13. Wilson K, Berk J. The nuclear envelope at a glance. J Cell Sci. 2010;123:1973-8 pubmed publisher
  14. Chakraborty A, Werner J, Koldobskiy M, Mustafa A, Juluri K, Pietropaoli J, et al. Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A. 2011;108:2205-9 pubmed publisher
    ..CK2 phosphorylation at the degradation motif of IP6K2 enhances its ubiquitination and subsequent degradation. IP6K2 mutants at the CK2 sites that are resistant to CK2 phosphorylation are metabolically stable. ..
  15. Wang M, Spinetti G, Monticone R, Zhang J, Wu J, Jiang L, et al. A local proinflammatory signalling loop facilitates adverse age-associated arterial remodeling. PLoS ONE. 2011;6:e16653 pubmed publisher
    ..Intervention that suppressed this signaling loop may potentially retard age-associated adverse arterial remodeling. ..
  16. Zhang B, Saijilafu -, Liu C, Wang R, Zhu Q, Jiao Z, et al. Akt-independent GSK3 inactivation downstream of PI3K signaling regulates mammalian axon regeneration. Biochem Biophys Res Commun. 2014;443:743-8 pubmed publisher
    ..Together, these results indicate that in response to peripheral nerve injury GSK3 inactivation, regulated by an alternative mechanism independent of Akt-mediated phosphorylation, controls sensory axon regeneration. ..
  17. Yokota N, Burne Taney M, Racusen L, Rabb H. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2003;285:F319-25 pubmed
    ..IL-4 deficiency is a likely mechanism underlying the STAT6 effect. A "yin-yang" role for inflammation is emerging in renal IRI, similar to recent observations in atherosclerosis. ..
  18. Hara M, Agrawal N, Kim S, Cascio M, Fujimuro M, Ozeki Y, et al. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol. 2005;7:665-74 pubmed
    ..The NO-S-nitrosylation-GAPDH-Siah1 cascade may represent an important molecular mechanism of cytotoxicity. ..
  19. Ferlito M, Irani K, Faraday N, Lowenstein C. Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells. Proc Natl Acad Sci U S A. 2006;103:11689-94 pubmed
    ..Our data suggest that Ras mediates NO inhibition of lymphocyte cytotoxicity and emphasize that alterations in the cellular redox state may regulate the exocytic signaling pathway...
  20. Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A. 2007;104:16158-63 pubmed
    ..This study suggests the existence of prosurvival signaling pathways critical for cancer stem-like cell maintenance, which could be selectively targeted for inhibiting cancer stem-like cells for improved treatment. ..
  21. Wang Y, Dawson V, Dawson T. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol. 2009;218:193-202 pubmed publisher
    ..Targeting PAR-mediated AIF release could be a potential approach for the therapy of neurologic disorders. ..
  22. O Connell M, Fiori J, Xu M, Carter A, Frank B, Camilli T, et al. The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene. 2010;29:34-44 pubmed publisher
    ..Using in vitro and in vivo metastasis assays, we show that ROR2 is necessary for the Wnt5A-mediated metastasis of melanoma cells. These data imply that ROR2 may represent a novel target for melanoma therapy. ..
  23. Yao Y, Brodie A, Davidson N, Kensler T, Zhou Q. Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer. Breast Cancer Res Treat. 2010;124:585-91 pubmed publisher
    ..Moreover, shikonin reverses the inhibitory effects of estrogen on this pathway and may contribute to breast cancer prevention. ..
  24. Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, et al. c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A. 2011;108:9951-6 pubmed publisher
    ..These findings show that c-Met enhances the population of glioblastoma stem cells (GBM SCs) via a mechanism requiring Nanog and potentially other c-Met-responsive reprogramming transcription factors. ..
  25. Futrega K, Yu J, Jones J, KANE M, Lott W, Atkinson K, et al. Polydimethylsiloxane (PDMS) modulates CD38 expression, absorbs retinoic acid and may perturb retinoid signalling. Lab Chip. 2016;16:1473-83 pubmed publisher
    ..We demonstrate here that ATRA is absorbed by PDMS in a time-dependent manner and results in the concomitant reduced expression of CD38 on the cell surface of CB-derived CD34(+) cells. ..
  26. Janiak A, Zemskov E, Belkin A. Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway. Mol Biol Cell. 2006;17:1606-19 pubmed
    ..Together, these findings show that surface tTG amplifies integrin-mediated signaling to RhoA/ROCK via integrin clustering and down-regulation of the Src-p190RhoGAP regulatory pathway. ..
  27. Cui C, Hashimoto T, Grivennikov S, Piao Y, Nedospasov S, Schlessinger D. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A. 2006;103:9142-7 pubmed
    ..Thus, as an EDA target, LTbeta regulates the form of hair in developing hair follicles; and when EDA is defective, failure of LTbeta activation can account for part of the Ta phenotype. ..
  28. Choi Y, Nicholas J. Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines. J Virol. 2008;82:6501-13 pubmed publisher
  29. Pardoll D. Metastasis-promoting immunity: when T cells turn to the dark side. Cancer Cell. 2009;16:81-2 pubmed publisher
    ..In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion. ..
  30. Liu X, Li C, Gebremedhin D, Hwang S, Hammock B, Falck J, et al. Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. Am J Physiol Heart Circ Physiol. 2011;301:H373-81 pubmed publisher
    ..Epoxide hydrolase activity and 20-HETE synthesis limit the duration of the response to prolonged mGluR activation. ..
  31. Chakir K, DEPRY C, Dimaano V, Zhu W, Vanderheyden M, Bartunek J, et al. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011;3:100ra88 pubmed publisher
    ..These results identify a key pathway that is triggered by restoring contractile synchrony and that may represent a new therapeutic approach for a broad population of HF patients. ..
  32. Hart G. Nutrient regulation of immunity: O-GlcNAcylation regulates stimulus-specific NF-?B-dependent transcription. Sci Signal. 2013;6:pe26 pubmed publisher
    ..This study not only illustrates how specific stimuli that act on the same transcription factor can elicit the expression of particular sets of genes, it also suggests a possible mechanism for autoimmunity in diabetes. ..
  33. Hobbs R, Smith S, Getsios S. Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes. J Invest Dermatol. 2017;137:1410-1412 pubmed publisher
  34. Ostrand Rosenberg S, Sinha P, Clements V, Dissanayake S, Miller S, Davis C, et al. Signal transducer and activator of transcription 6 (Stat6) and CD1: inhibitors of immunosurveillance against primary tumors and metastatic disease. Cancer Immunol Immunother. 2004;53:86-91 pubmed
  35. Healy Z, Lee N, Gao X, Goldring M, Talalay P, Kensler T, et al. Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci U S A. 2005;102:14010-5 pubmed
  36. Harris T, Grosso J, Yen H, Xin H, Kortylewski M, Albesiano E, et al. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179:4313-7 pubmed
    ..Thus, STAT3 is a candidate target for T(H)17-dependent autoimmune disease immunotherapy that could selectively inhibit pathogenic immune pathways. ..
  37. Kaneda A, Wang C, Cheong R, Timp W, Onyango P, Wen B, et al. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A. 2007;104:20926-31 pubmed
  38. Gao X, Zhang J. Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell. 2008;19:4366-73 pubmed publisher
  39. Semba R, Ferrucci L, Fink J, Sun K, Beck J, Dalal M, et al. Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women. Am J Kidney Dis. 2009;53:51-8 pubmed publisher
    ..AGEs are amenable to interventions because serum AGE levels can be decreased by change in dietary pattern and pharmacological treatment. ..
  40. Nagai N, Klimava A, Lee W, Izumi Nagai K, Handa J. CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways. Invest Ophthalmol Vis Sci. 2009;50:1903-10 pubmed publisher
    ..CTGF is increased in basal deposits and drusen of AMD specimens, and it induces matrix protein production in ARPE-19 cells through the ERK (p42/p44(mapk)) and p38(mapk) signaling pathways. ..
  41. Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, et al. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009;139:610-22 pubmed publisher
    ..One such uDBP, ERK2, acts as a transcriptional repressor for interferon gamma-induced genes, suggesting important biological roles for such proteins. ..
  42. Lee Y, Brandal S, Noel P, Wentzel E, Mendell J, McDevitt M, et al. KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation. Blood. 2011;117:3629-40 pubmed publisher
    ..This work demonstrates a novel regulatory pathway between 2 critical mast cell factors, KIT and MITF, mediated by miRNAs; dysregulation of this pathway may contribute to abnormal mast cell proliferation and malignant mast cell diseases. ..
  43. Ma B, Sen T, Asnaghi L, Valapala M, Yang F, Hose S, et al. ?A3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis. Cell Death Dis. 2011;2:e217 pubmed publisher
    ..We propose that ?A3/A1-crystallin is a novel regulator of both life and death decisions in ocular astrocytes. ..
  44. Beazley K, Banyard D, Lima F, Deasey S, Nurminsky D, Konoplyannikov M, et al. Transglutaminase inhibitors attenuate vascular calcification in a preclinical model. Arterioscler Thromb Vasc Biol. 2013;33:43-51 pubmed publisher
    ..Inhibition of the TG2/?-catenin signaling axis seems to prevent warfarin-induced elastocalcinosis and to control isolated systolic hypertension. ..
  45. Kuo M, Kim D, Jandu S, Bergman Y, Tan S, Wang H, et al. MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol. 2016;310:H71-9 pubmed publisher
    ..This has important implications for H2S-based therapy in healthy and diseased coronary arteries. ..
  46. Cha S, Rodgers J, Puigserver P, Chohnan S, Lane M. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A. 2006;103:15410-5 pubmed
    ..PGC-1alpha also increased the expression of ERRalpha, PPARalpha, and enzymes that support mitochondrial fatty acid oxidation, ATP synthesis, and thermogenesis, apparently mediated by an increased expression of UCP3. ..
  47. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways. ..
  48. Riccomagno M, Sun L, Brady C, Alexandropoulos K, Seo S, Kurokawa M, et al. Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014;81:779-86 pubmed publisher
    ..These data reveal an essential role for Cas adaptor proteins in ?1-Integrin-mediated signaling events critical for the formation of the single-cell GCL in the mammalian retina. ..
  49. Krop I, Shaffer A, Fearon D, Schlissel M. The signaling activity of murine CD19 is regulated during cell development. J Immunol. 1996;157:48-56 pubmed
    ..These biochemical properties of CD19 will be important for understanding its function in B cell development and the humoral immune response. ..
  50. Wolkow C. Life span: getting the signal from the nervous system. Trends Neurosci. 2002;25:212-6 pubmed
    ..This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging. ..
  51. Schaphorst K, Chiang E, Jacobs K, Zaiman A, Natarajan V, Wigley F, et al. Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. Am J Physiol Lung Cell Mol Physiol. 2003;285:L258-67 pubmed
    ..These results indicate that a major physiologically relevant vascular barrier-protective mediator produced by human platelets is S1P. ..
  52. Nowak S, Corces V. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. 2004;20:214-20 pubmed
    ..3 variant, which has a conserved N-terminal tail, can replace histone H3 at sites of active transcription, adds a new layer of complexity and possibilities to the regulation of transcription through changes in chromatin structure. ..
  53. Zeng X, Miura T, Luo Y, Bhattacharya B, Condie B, Chen J, et al. Properties of pluripotent human embryonic stem cells BG01 and BG02. Stem Cells. 2004;22:292-312 pubmed
    ..These data provide a detailed characterization and an initial gene expression profile for the BG01 and BG02 human ES cell lines. ..
  54. Roper R, Baxter L, Saran N, Klinedinst D, Beachy P, Reeves R. Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A. 2006;103:1452-6 pubmed
    ..These results demonstrate a basis for and a potential therapeutic approach to a fundamental aspect of CNS pathology in DS. ..
  55. Gami M, Wolkow C. Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Aging Cell. 2006;5:31-7 pubmed
    ..These insights into pathways affecting invertebrate lifespan may provide a basis for developing strategies for pharmacological manipulation of human lifespan. ..
  56. Vonakis B, Vasagar K, Gibbons S, Gober L, Sterba P, Chang H, et al. Basophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria. J Allergy Clin Immunol. 2007;119:441-8 pubmed
    ..In CIU basophils, the observed changes in FcepsilonRI signaling pathway molecule expression may underlie changes in releasability. Patients with CIU can be segregated on the basis of basophil functional phenotype. ..
  57. Giri B, Dixit V, Ghosh M, Collins G, Khan I, Madara K, et al. CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. Eur J Immunol. 2007;37:2104-16 pubmed
  58. Rudin C, Hann C, Laterra J, Yauch R, Callahan C, Fu L, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med. 2009;361:1173-8 pubmed publisher
  59. Dang C. PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect. Sci Signal. 2009;2:pe75 pubmed publisher
    ..This effect, which describes the propensity for cancer cells to convert glucose to lactate at a high rate, must now accommodate links among glycolysis, the tricarboxylic acid cycle, and glutamine metabolism in cancer cells. ..
  60. Woods A. The dopamine D(4) receptor, the ultimate disordered protein. J Recept Signal Transduct Res. 2010;30:331-6 pubmed publisher
    ..Among GPCRs in general, the unusually proline-rich IL3 is unique to the D4 receptor (D4R). We believe that, as in the D2R, this region of the receptor plays a role in it's interaction with other receptors. ..
  61. Rao A, Zhang Y, Muend S, Rao R. Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway. Antimicrob Agents Chemother. 2010;54:5062-9 pubmed publisher
    ..The results point to the activation of specific signaling pathways downstream of cellular interaction with carvacrol rather than a nonspecific lesion of membranes, as has been previously proposed. ..
  62. Munk R, Ghosh P, Ghosh M, Saito T, Xu M, Carter A, et al. Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS ONE. 2011;6:e24667 pubmed publisher
    ..Our data demonstrate a new role for mTOR in CXCL12-induced T cell migration, and enrich the current knowledge regarding the clinical use of rapamycin. ..
  63. Chu S, Heiser D, Li L, Kaplan I, Collector M, Huso D, et al. FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm. Cell Stem Cell. 2012;11:346-58 pubmed publisher
    ..This indicates an important link between stem cell quiescence/homeostasis and myeloproliferative disease while also giving novel insight into the emergence of FLT3-ITD mutations in the evolution of leukemic transformation. ..
  64. Yang Z, Sun R, Grinchuk V, Fernández Blanco J, Blanco J, Notari L, et al. IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent. Am J Physiol Gastrointest Liver Physiol. 2013;304:G381-9 pubmed publisher
    ..Thus manipulating IL-33 or related signaling pathways represents a potential therapeutic strategy for treating inflammatory diseases associated with dysregulated intestinal function. ..
  65. Reddi A, Culotta V. SOD1 integrates signals from oxygen and glucose to repress respiration. Cell. 2013;152:224-35 pubmed publisher
    ..Our data therefore may provide mechanistic insight into how rapidly proliferating cells and many cancers accomplish glucose-mediated repression of respiration in favor of aerobic glycolysis. ..
  66. Strickland D, Au D, Cunfer P, Muratoglu S. Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity. Arterioscler Thromb Vasc Biol. 2014;34:487-98 pubmed publisher
    ..Defining pathways modulated by LRP1 that lead to aneurysm formation and defining its role in thrombosis may allow for more effective intervention in patients. ..
  67. Wang Y, Lee Kwon W, Martindale J, Adams L, Heller P, Egan J, et al. Modulation of CCAAT/enhancer-binding protein-alpha gene expression by metabolic signals in rodent adipocytes. Endocrinology. 1999;140:2938-47 pubmed
    ..Taken together, these results suggest that metabolic signals serve to down-regulate C/EBPalpha expression both in vitro and in vivo. ..
  68. Lee C, Buttitta L, Fan C. Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A. 2001;98:11347-52 pubmed
    ..Taken together, these data suggest that GAS1 functions to reduce the availability of active SHH within the dorsal somite. ..
  69. Ghosh P, Buchholz M, Yano S, Taub D, Longo D. Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway. Blood. 2002;99:4517-24 pubmed
    ..The inhibitory effect of rapamycin was on messenger RNA stability and translation, rather than on IL-2 transcription or protein turnover. ..
  70. Mann R, Beachy P. Novel lipid modifications of secreted protein signals. Annu Rev Biochem. 2004;73:891-923 pubmed
  71. Minhas K, Khan S, Raju S, Phan A, Gonzalez D, Skaf M, et al. Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. J Physiol. 2005;565:463-74 pubmed
    ..Taken together, these data reveal a novel link between the leptin signalling pathway and normal cardiac function and suggest a mechanism by which leptin deficiency or resistance may lead to cardiac depression. ..
  72. Yang R, Wheeler C, Chen X, Uematsu S, Takeda K, Akira S, et al. Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer. J Virol. 2005;79:6741-50 pubmed publisher
    ..Tumor progression is associated with genetic instability and L1 mutants. Selection for assembly-deficient L1 mutations suggests the evasion of MyD88-dependent immune control during cervical carcinogenesis...
  73. Rao M, Sockanathan S. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science. 2005;309:2212-5 pubmed
    ..A single amino acid mutation in the extracellular catalytic domain abolishes protein function. This reveals a critical role for glycerophosphodiester metabolism in motor neuron differentiation. ..
  74. Wagmaister J, Gleason J, Eisenmann D. Transcriptional upregulation of the C. elegans Hox gene lin-39 during vulval cell fate specification. Mech Dev. 2006;123:135-50 pubmed
    ..Finally, we found that when the Wnt pathway is over activated, expression from the transcriptional lin-39::GFP increases, suggesting that the Wnt pathway also regulates lin-39 at the transcriptional level. ..
  75. Shaikh S, Edidin M. Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation. Am J Clin Nutr. 2006;84:1277-89 pubmed
    ..Our data-based models show that membrane modification of both effectors and targets is an important, often overlooked, mechanism of immunomodulation by PUFAs. ..
  76. Köttgen M. TRPP2 and autosomal dominant polycystic kidney disease. Biochim Biophys Acta. 2007;1772:836-50 pubmed
    ..This review summarizes the known and emerging functions of TRPP2, focusing on the question of how channel function translates into complex morphogenetic programs regulating tubular structure. ..
  77. Vij N, Amoako M, Mazur S, Zeitlin P. CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol. 2008;38:176-84 pubmed
    ..We confirmed the regulation of IL-8 promoter by CHOP in CF cells using the IL-8 reporter assay. We conclude that PGE-2 stimulates IL-8 production through the CHOP transcription factor in CF cells. ..
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