Experts and Doctors on s100 proteins in Bethesda, Maryland, United States


Locale: Bethesda, Maryland, United States
Topic: s100 proteins

Top Publications

  1. Burbelo P, Lebovitz E, Bren K, Bayat A, Paviol S, Wenzlau J, et al. Extrapancreatic autoantibody profiles in type I diabetes. PLoS ONE. 2012;7:e45216 pubmed publisher
    ..Taken together, these results suggest that autoantibody portraits derived from islet and organ-specific targets will likely be useful for enhancing the clinical management of T1D. ..
  2. Torres Cabala C, Panizo Santos A, Krutzsch H, Barazi H, Namba M, Sakaguchi M, et al. Differential expression of S100C in thyroid lesions. Int J Surg Pathol. 2004;12:107-15 pubmed
  3. Wolf R, Voscopoulos C, FitzGerald P, Goldsmith P, Cataisson C, Gunsior M, et al. The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. J Invest Dermatol. 2006;126:1600-8 pubmed
    ..The regulation, expression pattern and crosslinking of mS100A15 are consistent with the characteristics of the human orthologs, providing a valid surrogate model to study changes in these proteins associated with cutaneous pathologies. ..
  4. Torres Cabala C, Bibbo M, Panizo Santos A, Barazi H, Krutzsch H, Roberts D, et al. Proteomic identification of new biomarkers and application in thyroid cytology. Acta Cytol. 2006;50:518-28 pubmed
    ..Immunohistochemical validation of potential markers is a crucial step before clinical application in diagnosis. Galectin-3, galectin-1 and S100C can be used to help in discriminating benign and malignant thyroid lesions. ..
  5. Yang X, Popescu N, Zimonjic D. DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism. Cancer Res. 2011;71:2916-25 pubmed publisher
    ..These results suggest that a novel GAP-independent mechanism contributes to the tumor suppressive activity of DLC1, and highlight the importance and complexity of protein-protein interactions involving DLC1 in certain cancers. ..
  6. Jegalian A, Buxbaum N, Facchetti F, Raffeld M, Pittaluga S, Wayne A, et al. Blastic plasmacytoid dendritic cell neoplasm in children: diagnostic features and clinical implications. Haematologica. 2010;95:1873-9 pubmed publisher
    ..Focal expression of S-100 may be seen in concert with other markers of plasmacytoid dendritic cells. ..
  7. Smith K, Skelton H, Heimer W, Baxter D, Angritt P, Frisman D, et al. Melanocytic activation in HIV-1 disease: HMB-45 staining in common acquired nevi. Military Medical Consortium for the Advancement of Retroviral Research. J Am Acad Dermatol. 1993;29:539-44 pubmed
    ..In some HIV-1-infected patients there is stimulation of melanosome production without significant melanocyte proliferation. ..
  8. Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, et al. Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. Cancer Lett. 2009;277:101-7 pubmed publisher
    ..The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers. ..
  9. Wei B, Hoover S, Ross M, Zhou W, Meani F, Edwards J, et al. Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients. PLoS ONE. 2009;4:e7670 pubmed publisher
    ..The data signify that S100A6 may prove useful in detecting and/or monitoring ovarian cancer, when used in concert with other biomarkers. ..

More Information


  1. Saha A, Kim S, Zhang Z, Lee Y, Sarkar C, Tsai P, et al. RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis. FEBS Lett. 2008;582:3823-31 pubmed publisher
    ..We propose that RAGE signaling contributes to neuroinflammation in INCL. ..
  2. Zhao F, Hoechst B, Duffy A, Gamrekelashvili J, Fioravanti S, Manns M, et al. S100A9 a new marker for monocytic human myeloid-derived suppressor cells. Immunology. 2012;136:176-83 pubmed publisher
    ..We propose S100 proteins as useful markers for the analysis and further characterization of human MDSC. ..
  3. Zhang L, Li C, Su T, Hu X, Lanius R, Webster M, et al. P11 expression and PET in bipolar disorders. J Psychiatr Res. 2011;45:1426-31 pubmed publisher
    ..This study demonstrates that PBMC p11 mRNA expression is associated with neural activation in the brain of BD patients and warrants a larger translational study to determine its clinical utility. ..
  4. Wolf R, Mascia F, Dharamsi A, Howard O, Cataisson C, Bliskovski V, et al. Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med. 2010;2:61ra90 pubmed publisher
    ..This study provides a pathogenetic psoriasis model using a psoriasis candidate gene to link the epidermis and innate immune system in inflammation priming, highlighting the S100A7A15-RAGE axis as a potential therapeutic target. ..
  5. Wolf R, Howard O, Dong H, Voscopoulos C, Boeshans K, Winston J, et al. Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol. 2008;181:1499-506 pubmed
    ..The identified S100A7 interaction with RAGE may provide a novel therapeutic target for inflammation. ..
  6. Zhang L, Li H, Su T, Barker J, Maric D, Fullerton C, et al. p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter. Neuroscience. 2008;153:1126-34 pubmed publisher
  7. Zhang Y, Zhou Z, Bugge T, Wahl L. Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin. J Immunol. 2007;179:3297-304 pubmed
    ..Furthermore, binding of inactive plasmin to annexin A2 inhibited plasmin induction of MMP-1, suggesting that inactive plasmin may be useful in suppressing inflammation. ..
  8. List K, Szabo R, Wertz P, Segre J, Haudenschild C, Kim S, et al. Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol. 2003;163:901-10 pubmed
    ..The data identify keratinocyte Matriptase/MT-SP1 as an essential component of the profilaggrin-processing pathway and a key regulator of terminal epidermal differentiation. ..
  9. Zhang L, Su T, Choi K, Maree W, Li C, Chung M, et al. P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J Psychiatr Res. 2011;45:435-41 pubmed publisher
    ..These results suggest that PBMC p11 mRNA levels may be a potential adjunctive biomarker for the assessment of suicide risk in mental disorders and warrants a larger translational study to determine its clinical utility. ..
  10. Zhang L, Li H, Hu X, Li X, Smerin S, Ursano R. Glucocorticoid-induced p11 over-expression and chromatin remodeling: a novel molecular mechanism of traumatic stress?. Med Hypotheses. 2011;76:774-7 pubmed publisher
    ..e., chromatin remodeling. ..
  11. Hahn Y, Jeong S, Lee B. Inactivation of MOXD2 and S100A15A by exon deletion during human evolution. Mol Biol Evol. 2007;24:2203-12 pubmed publisher
    ..We propose that modification or inactivation of MOXD2 and S100A15A genes have contributed to the loss of certain smell sense in humans and to the development of human skin...
  12. Boeshans K, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser T, et al. Purification, crystallization and preliminary X-ray diffraction of human S100A15. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:467-70 pubmed
    ..0 angstroms resolution. This structural analysis of the human S100A15 will further aid in the phylogenic comparison between the other members of the S100 protein family, especially the highly homologous paralog S100A7. ..