Experts and Doctors on replication origin in Baltimore, Maryland, United States


Locale: Baltimore, Maryland, United States
Topic: replication origin

Top Publications

  1. Spradling A. ORC binding, gene amplification, and the nature of metazoan replication origins. Genes Dev. 1999;13:2619-23 pubmed
  2. Datta S, Larkin C, Schildbach J. Structural insights into single-stranded DNA binding and cleavage by F factor TraI. Structure. 2003;11:1369-79 pubmed
    ..The full positive charge on the Mg(2+) and the architecture of the active site suggest multiple roles for Mg(2+) in DNA cleavage...
  3. Spradling A, Bellen H, Hoskins R. Drosophila P elements preferentially transpose to replication origins. Proc Natl Acad Sci U S A. 2011;108:15948-53 pubmed publisher
    ..The advantage transposons gain by moving from replicated to unreplicated genomic regions may contribute to the association of heterochromatin with late-replicating genomic regions. ..
  4. Chuang R, Kelly T. The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. Proc Natl Acad Sci U S A. 1999;96:2656-61 pubmed
    ..pombe replication origin, ars1. The DNA binding properties of Orp4p provide a plausible explanation for the characteristic features of Sc. pombe origins of replication, which differ significantly from those of Sa. cerevisiae. ..
  5. Drew M, Englund P. Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates. J Cell Biol. 2001;153:735-44 pubmed
    ..The final replication events, including primer removal, repair of many of the gaps, and reattachment of the progeny minicircles to the network periphery, are thought to take place within the antipodal sites...
  6. Calvi B, Spradling A. The nuclear location and chromatin organization of active chorion amplification origins. Chromosoma. 2001;110:159-72 pubmed
    ..We discuss the implications of these results for understanding the role of higher order structure in amplification and chromosome duplication. ..
  7. Maeder D, Anderson I, Brettin T, Bruce D, Gilna P, Han C, et al. The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes. J Bacteriol. 2006;188:7922-31 pubmed
    ..barkeri genome is characterized by localized inversions associated with the loss of gene content. In contrast, the short M. mazei genome most closely approximates the putative ancestral organizational state of these species...
  8. Coker J, DasSarma P, Capes M, Wallace T, McGarrity K, Gessler R, et al. Multiple replication origins of Halobacterium sp. strain NRC-1: properties of the conserved orc7-dependent oriC1. J Bacteriol. 2009;191:5253-61 pubmed publisher
    ..Our results suggest that replication in this model system is intriguing and more complex than previously thought. We discuss these results from the perspective of the replication strategy and evolution of haloarchaeal genomes...
  9. Capes M, Coker J, Gessler R, Grinblat Huse V, Dassarma S, Jacob C, et al. The information transfer system of halophilic archaea. Plasmid. 2011;65:77-101 pubmed publisher