Experts and Doctors on pregnancy proteins in Bethesda, Maryland, United States


Locale: Bethesda, Maryland, United States
Topic: pregnancy proteins

Top Publications

  1. Snyder S, Wessner D, Wessells J, Waterhouse R, Wahl L, Zimmermann W, et al. Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes. Am J Reprod Immunol. 2001;45:205-16 pubmed
    ..Human and murine PSGs exhibit cross-species activity. Our results are consistent with a role for PSGs in modulation of the innate immune system. ..
  2. Waterhouse R, Ha C, Dveksler G. Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. J Exp Med. 2002;195:277-82 pubmed
    ..We have identified the first receptor for a murine PSG as well as the first natural ligand for a member of the tetraspanin superfamily. ..
  3. Zhang J, Dyer K, Rosenberg H. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. Nucleic Acids Res. 2002;30:1169-75 pubmed
    ..The rapid evolution, species-limited deactivation and tissue-specific expression of RNase 8 suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily...
  4. Soni K, Mardones G, Sougrat R, Smirnova E, Jackson C, Bonifacino J. Coatomer-dependent protein delivery to lipid droplets. J Cell Sci. 2009;122:1834-41 pubmed publisher
    ..Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators. ..
  5. Wessells J, Wessner D, Parsells R, White K, Finkenzeller D, Zimmermann W, et al. Pregnancy specific glycoprotein 18 induces IL-10 expression in murine macrophages. Eur J Immunol. 2000;30:1830-40 pubmed
    ..Taken together, these results suggest that PSG18 selectively up-regulates IL-10 production by macrophages, providing a possible mechanism by which this protein helps promote successful pregnancy. ..
  6. Chaiworapongsa T, Romero R, Korzeniewski S, Kusanovic J, Soto E, Lam J, et al. Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia. Am J Obstet Gynecol. 2013;208:287.e1-287.e15 pubmed publisher
    ..Risk assessment for stillbirth and severe late preeclampsia in the third trimester is possible with the determination of maternal plasma concentrations of angiogenic and antiangiogenic factors at 30-34 weeks of gestation. ..
  7. Vaisbuch E, Whitty J, Hassan S, Romero R, Kusanovic J, Cotton D, et al. Circulating angiogenic and antiangiogenic factors in women with eclampsia. Am J Obstet Gynecol. 2011;204:152.e1-9 pubmed publisher
    ..These findings suggest that eclampsia shares a common pathogenic pathway as severe preeclampsia. ..
  8. Ha C, Wu J, Irmak S, Lisboa F, Dizon A, Warren J, et al. Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol Reprod. 2010;83:27-35 pubmed publisher
  9. Muranski P, Boni A, Antony P, Cassard L, Irvine K, Kaiser A, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112:362-73 pubmed publisher
    ..This principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies. ..

More Information


  1. Romero R, Nien J, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a smal. J Matern Fetal Neonatal Med. 2008;21:9-23 pubmed publisher
  2. Levine R, Lam C, Qian C, Yu K, Maynard S, Sachs B, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992-1005 pubmed
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  3. Hickenbottom S, Kimmel A, Londos C, Hurley J. Structure of a lipid droplet protein; the PAT family member TIP47. Structure. 2004;12:1199-207 pubmed
    ..The structure suggests an analogy between PAT proteins and apolipoproteins in which helical repeats interact with lipid while the ordered C-terminal region is involved in protein:protein interactions. ..
  4. Bera T, Hahn Y, Lee B, Pastan I. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003;312:1209-15 pubmed
    ..Selective expression of TEPP in testis, prostate, and in placenta and its high conservation among different species indicate that TEPP might have a role in reproductive biology. ..
  5. Ogge G, Romero R, Lee D, Gotsch F, Than N, Lee J, et al. Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome. J Pathol. 2011;223:553-65 pubmed publisher
  6. Sulkowski G, Warren J, Ha C, Dveksler G. Characterization of receptors for murine pregnancy specific glycoproteins 17 and 23. Placenta. 2011;32:603-10 pubmed publisher
  7. Leslie K, Watanabe S, Lei K, Chou D, Plouzek C, Deng H, et al. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. Proc Natl Acad Sci U S A. 1990;87:5822-6 pubmed
    ..The coding region of PSG95 is identical to the previously reported cDNA clones PSG1d and FL-NCA, but PSG95 contains an additional 518 and 523 base pairs in the 3' end as compared with PSG1d and FL-NCA, respectively. ..
  8. Ha C, Waterhouse R, Wessells J, Wu J, Dveksler G. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1. J Leukoc Biol. 2005;77:948-57 pubmed
    ..The induction of anti-inflammatory cytokines by various PSGs supports the hypothesis that these glycoproteins have an essential role in the regulation of the maternal immune response in species with hemochorial placentation. ..