Experts and Doctors on ppar gamma in Bethesda, Maryland, United States


Locale: Bethesda, Maryland, United States
Topic: ppar gamma

Top Publications

  1. Zappalà G, Rechler M. IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription. Biochem Biophys Res Commun. 2009;382:785-9 pubmed publisher
    ..These results suggest that IGFBP-3 may mediate the inhibition of adiponectin transcription by hypoxia and TNF-alpha, and that IGFBP-3 binding to RXR-alpha may be required for the observed inhibition. ..
  2. Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, et al. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program. Nat Cell Biol. 2017;19:1081-1092 pubmed publisher
    ..These results indicate that NFIA activates the cell-type-specific enhancers and facilitates the binding of PPARγ to control the brown fat gene program. ..
  3. St Louis D, Romero R, Plazyo O, Arenas Hernandez M, Panaitescu B, Xu Y, et al. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. J Immunol. 2016;196:1044-59 pubmed publisher
  4. Matsusue K, Aibara D, Hayafuchi R, Matsuo K, Takiguchi S, Gonzalez F, et al. Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice. FEBS Lett. 2014;588:2277-81 pubmed publisher
    ..These results suggest that hepatic PPARγ and LXRα signals independently contribute to the development of fatty liver. ..
  5. Mueller E. Understanding the variegation of fat: novel regulators of adipocyte differentiation and fat tissue biology. Biochim Biophys Acta. 2014;1842:352-7 pubmed publisher
    ..This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. ..
  6. Gold P, Licinio J, Pavlatou M. Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-? systems. Mol Psychiatry. 2013;18:154-65 pubmed publisher
  7. Kapetanovic I, Lyubimov A, Kabirova E, Kabirov K, Rasay L, Swezey R, et al. Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact. 2012;197:16-22 pubmed publisher
    ..However, the results shown here suggest that additional animal toxicological and bioavailability studies are required to establish a role of GW9662 as a chemopreventive agent. ..
  8. Pang T, Benicky J, Wang J, Orecna M, Sanchez Lemus E, Saavedra J. Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes. J Hypertens. 2012;30:87-96 pubmed publisher
  9. Huang R, Xia M, Cho M, Sakamuru S, Shinn P, Houck K, et al. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect. 2011;119:1142-8 pubmed publisher
    ..The results demonstrate the feasibility of qHTS to identify the potential for environmentally relevant chemicals to interact with key toxicity pathways related to human disease induction. ..

More Information


  1. Li W, Tuli R, Huang X, Laquerriere P, Tuan R. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials. 2005;26:5158-66 pubmed
    ..These results suggest that the PCL-based nanofibrous scaffold is a promising candidate scaffold for cell-based, multiphasic tissue engineering. ..
  2. Lan M, Yuan P, Chen G, Manji H. Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate. J Mol Neurosci. 2008;35:225-34 pubmed publisher
    ..These biochemical changes may have functional consequences for either valproate's therapeutic mechanism or for its neurological side effects and merit further investigation. ..
  3. Guettier J, Park J, Cochran E, Poitou C, Basdevant A, Meier M, et al. Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation. Clin Endocrinol (Oxf). 2008;68:547-554 pubmed publisher
    ..In the context of previously published work, our findings suggest that the response to r-MetHuLeptin is independent of the aetiology in lipodystrophy. ..
  4. Ge K, Cho Y, Guo H, Hong T, Guermah M, Ito M, et al. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol. 2008;28:1081-91 pubmed
  5. Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab. 2008;7:302-11 pubmed publisher
    ..Taken together, these results indicate that FSP27 is a direct mediator of PPARgamma-dependent hepatic steatosis. ..
  6. Sato K, Feng X, Chen J, Li J, Muranski P, Desierto M, et al. PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function. Haematologica. 2016;101:57-67 pubmed publisher
  7. Fernandez Boyanapalli R, Falcone E, Zerbe C, Marciano B, Frasch S, Henson P, et al. Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment. J Allergy Clin Immunol. 2015;136:1399-1401.e3 pubmed publisher
  8. Ying H, Araki O, Furuya F, Kato Y, Cheng S. Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor. Mol Cell Biol. 2007;27:2359-71 pubmed
    ..The present study suggests that defects in adipogenesis could contribute to the phenotypic manifestation of reduced body weight in TRalpha1(PV/+) mice. ..
  9. Barlic J, Murphy P. An oxidized lipid-peroxisome proliferator-activated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion. Trends Cardiovasc Med. 2007;17:269-74 pubmed
    ..Switching CX3CR1 on and CCR2 off in vivo may result in cessation of CCR2-dependent migration and activation of CX3CR1-dependent retention that together may promote foam cell accumulation in the vessel wall. ..
  10. Zhu X, Kim D, Goodson M, Privalsky M, Cheng S. NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. J Mol Endocrinol. 2011;46:233-44 pubmed publisher
  11. Olivo Marston S, Zhu Y, Lee R, Cabanes A, Khan G, Zwart A, et al. Gene signaling pathways mediating the opposite effects of prepubertal low-fat and high-fat n-3 polyunsaturated fatty acid diets on mammary cancer risk. Cancer Prev Res (Phila). 2008;1:532-45 pubmed publisher
  12. Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, et al. Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. Biochem Biophys Res Commun. 2009;378:433-8 pubmed publisher
    ..Given the important role of exosomes as intercellular messengers, the discovery of PPARgamma as a component of human plasma exosomes identifies a potential new pathway for the paracrine transfer of nuclear receptors. ..
  13. Lubet R, Fischer S, Steele V, Juliana M, Desmond R, Grubbs C. Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. Int J Cancer. 2008;123:2254-9 pubmed publisher
    ..In summary, rosiglitazone over a wide dose range enhanced urinary bladder carcinogenesis in the OH-BBN model in rats. ..
  14. Chang S, Rashid A, Gao Y, Andreotti G, Shen M, Wang B, et al. Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. Carcinogenesis. 2008;29:944-8 pubmed publisher
    ..Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones...
  15. Cho Y, Hong S, Jin Q, Wang L, Lee J, Gavrilova O, et al. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab. 2009;10:27-39 pubmed publisher
    ..Finally, deletion of PTIP in brown adipose tissue significantly reduces tissue weight. Thus, by regulating PPARgamma and C/EBPalpha expression, PTIP plays a critical role in adipogenesis. ..
  16. Qu A, Shah Y, Manna S, Gonzalez F. Disruption of endothelial peroxisome proliferator-activated receptor ? accelerates diet-induced atherogenesis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol. 2012;32:65-73 pubmed publisher
    ..Endothelial PPAR? plays an important protective role in atherogenesis. ..
  17. Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, et al. Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy. Mol Endocrinol. 2008;22:234-47 pubmed
    ..Vpr may alter sensitivity to insulin and thereby contribute to the development of lipodystrophy and insulin resistance observed in HIV-1-infected patients. ..
  18. Villapol S, Yaszemski A, Logan T, Sanchez Lemus E, Saavedra J, Symes A. Candesartan, an angiotensin II AT?-receptor blocker and PPAR-? agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 2012;37:2817-29 pubmed publisher
    ..Overall, our data suggest that ARBs with dual AT?R-blocking and PPAR? activation properties may have therapeutic value in treating TBI. ..
  19. Wang L, Xu S, Lee J, Baldridge A, Grullon S, Peng W, et al. Histone H3K9 methyltransferase G9a represses PPAR? expression and adipogenesis. EMBO J. 2013;32:45-59 pubmed publisher
    ..Finally, deletion of G9a in mouse adipose tissues increases adipogenic gene expression and tissue weight. Thus, by inhibiting PPAR? expression and facilitating Wnt10a expression, G9a represses adipogenesis. ..
  20. Ptasinska A, Wang S, Zhang J, Wesley R, Danner R. Nitric oxide activation of peroxisome proliferator-activated receptor gamma through a p38 MAPK signaling pathway. FASEB J. 2007;21:950-61 pubmed
    ..PPARgamma activation by p38 MAPK may contribute to the anti-inflammatory and cytoprotective effects of NO* in the vasculature. This crosstalk mechanism suggests new strategies for preventing and treating vascular dysfunction. ..
  21. Shah Y, Morimura K, Gonzalez F. Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. Am J Physiol Gastrointest Liver Physiol. 2007;292:G657-66 pubmed
    ..The present study has identified a novel protective role for macrophage PPAR-gamma in the DSS-induced IBD model. The data suggest that PPAR-gamma regulates recruitment of macrophages to inflammatory foci in the colon. ..
  22. Jun H, Weinstein D, Lee Y, Mansfield B, Chou J. Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib. Blood. 2014;123:2843-53 pubmed publisher
    ..We further show that the mechanism of neutrophil dysfunction in GSD-Ib arises from activation of the hypoxia-inducible factor-1?/peroxisome-proliferators-activated receptor-? pathway. ..
  23. Barlic J, Zhang Y, Foley J, Murphy P. Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway. Circulation. 2006;114:807-19 pubmed
    ..Moreover, they identify macrophage binding to coronary artery smooth muscle cells as the first primary cell setting in which CX3CR1 functions as the major adhesion system. ..
  24. Kato Y, Ying H, Zhao L, Furuya F, Araki O, Willingham M, et al. PPARgamma insufficiency promotes follicular thyroid carcinogenesis via activation of the nuclear factor-kappaB signaling pathway. Oncogene. 2006;25:2736-47 pubmed
    ..These results suggest that PPARgamma is a critical modifier in thyroid carcinogenesis and could be tested as a therapeutic target in thyroid follicular carcinoma. ..
  25. Kim J, Yamaori S, Tanabe T, Takagi M, Matsubara T, Okamoto M, et al. Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung. Biochem Biophys Res Commun. 2017;491:271-276 pubmed publisher
    ..Taken together, PPARγ may play an important role in fetal lung development via alveolar cell-to-cell adhesion system. ..
  26. Araki O, Ying H, Furuya F, Zhu X, Cheng S. Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action. Proc Natl Acad Sci U S A. 2005;102:16251-6 pubmed