Experts and Doctors on neurogranin in Bethesda, Maryland, United States
Locale: Bethesda, Maryland, United States
Szabo S, Machado Vieira R, Yuan P, Wang Y, Wei Y, Falke C, et al
. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology. 2009;56:47-55 pubmed publisher
..These results suggest that PKC modulators or their intracellular targets may ultimately represent novel avenues for the development of new therapeutics for mood disorders. ..
Huang F, Huang K. Methylphenidate improves the behavioral and cognitive deficits of neurogranin knockout mice. Genes Brain Behav. 2012;11:794-805 pubmed publisher
..Taken together these NgKO mice may be useful for the development of better drug treatment to improve cognitive and behavioral impairments. ..
Huang K, Huang F, Li J, Schuck P, McPhie P. Calcium-sensitive interaction between calmodulin and modified forms of rat brain neurogranin/RC3. Biochemistry. 2000;39:7291-9 pubmed
..These results indicate that modification of NG to form intramolecular disulfides outside the IQ domain provides an alternative mechanism for regulation of its binding affinity to CaM. ..
Pak J, Huang F, Li J, Balschun D, Reymann K, Chiang C, et al
. Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. Proc Natl Acad Sci U S A. 2000;97:11232-7 pubmed
..These results indicate a central role of Ng in the regulation of CaMKII activity with decisive influences on synaptic plasticity and spatial learning. ..
Huang K, Huang F, Shetty P. Stimulation-mediated translocation of calmodulin and neurogranin from soma to dendrites of mouse hippocampal CA1 pyramidal neurons. Neuroscience. 2011;178:1-12 pubmed publisher
..These findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes. ..