Experts and Doctors on myosin heavy chains in Baltimore, Maryland, United States


Locale: Baltimore, Maryland, United States
Topic: myosin heavy chains

Top Publications

  1. Yang Y, Wang W, Cleaves R, Zahurak M, Cheng L, Civin C, et al. Acceleration of G(1) cooperates with core binding factor beta-smooth muscle myosin heavy chain to induce acute leukemia in mice. Cancer Res. 2002;62:2232-5 pubmed
    ..The INV/p16p19 and INV/E7 leukemias were lymphoid and were clonal and retransplantable. Overall, these findings indicate that CBF mutations cooperate with genetic alterations that accelerate G(1) to induce acute leukemia. ..
  2. Gehlbach P, Demetriades A, Yamamoto S, Deering T, Xiao W, Duh E, et al. Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier. Hum Gene Ther. 2003;14:129-41 pubmed
    ..These data suggest that periocular gene transfer of sFlt-1 should be considered for treatment of choroidal neovascularization and diabetic macular edema. ..
  3. Zu L, Bedja D, Fox Talbot K, Gabrielson K, Van Kaer L, Becker L, et al. Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. J Mol Cell Cardiol. 2010;49:5-15 pubmed publisher
  4. Shah K, Duda M, O Shea K, Sparagna G, Chess D, Khairallah R, et al. The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling. Hypertension. 2009;54:605-11 pubmed publisher
    ..In conclusion, whereas treatment with EPA+DHA prevented tetralinoloyl cardiolipin depletion, LV hypertrophy, and abnormal genes expression with pressure overload, these effects were absent with a high-fat diet. ..
  5. Cihakova D, Sharma R, Fairweather D, Afanasyeva M, Rose N. Animal models for autoimmune myocarditis and autoimmune thyroiditis. Methods Mol Med. 2004;102:175-93 pubmed
    ..H2h4 mice. These mice express the H-2A(k) allele on an NOD genetic background and develop spontaneous thyroiditis, which is exacerbated with dietary iodine. ..
  6. Duda M, O Shea K, Tintinu A, Xu W, Khairallah R, Barrows B, et al. Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. Cardiovasc Res. 2009;81:319-27 pubmed publisher
    ..Dietary supplementation with omega-3 PUFA derived from fish, but not from vegetable sources, increased plasma adiponectin, suppressed inflammation, and prevented cardiac remodelling and dysfunction under pressure overload conditions. ..
  7. Chen L, Zhang J, Gan T, Chen Izu Y, Hasday J, Karmazyn M, et al. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J Appl Physiol (1985). 2008;104:218-23 pubmed
    ..In conclusion, CIH-mediated LV global dysfunction is associated with myocyte hypertrophy and apoptosis at the cellular level. ..
  8. Shiotani A, Nakagawa H, Flint P. Modulation of myosin heavy chains in rat laryngeal muscle. Laryngoscope. 2001;111:472-7 pubmed
    ..The expression of normal MHC composition is dependent on the condition of appropriate neural contact and functional reinnervation. ..
  9. Flint P, Nakagawa H, Shiotani A, Coleman M, O Malley B. Effects of insulin-like growth factor-1 gene transfer on myosin heavy chains in denervated rat laryngeal muscle. Laryngoscope. 2004;114:368-71 pubmed
    ..These findings suggest that the myotrophic effect of hIGF-1 gene transfer results in normalization of MHC composition in denervated muscle, with suppression of type IIA/X MHC and promotion of type IIL expression. ..

More Information


  1. Li Y, Zhu G, Paolocci N, Zhang P, Takahashi C, Okumus N, et al. Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo. Circ Heart Fail. 2017;10: pubmed publisher
    ..However, paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI. ..
  2. Porter J, Hicks J, Williams D, Montell C. Differential localizations of and requirements for the two Drosophila ninaC kinase/myosins in photoreceptor cells. J Cell Biol. 1992;116:683-93 pubmed
    ..This suggests that the p174 myosin-I type tail is the domain responsible for association with the rhabdomeres and that the substrate for the p174 putative kinase may be a rhabdomeric protein important in photo-transduction. ..
  3. Iizuka Y, Mooneyham A, Sieben A, Chen K, Maile M, Hellweg R, et al. UNC-45A is required for neurite extension via controlling NMII activation. Mol Biol Cell. 2017;28:1337-1346 pubmed publisher
    ..Collectively our results provide novel insights into the molecular mechanisms of neurite growth and define UNC-45A as a novel and master regulator of NMII-mediated cellular processes in neurons. ..
  4. Gupta A, Schell M, Bhattacharjee A, Lutsenko S, Hubbard A. Myosin Vb mediates Cu+ export in polarized hepatocytes. J Cell Sci. 2016;129:1179-89 pubmed publisher
    ..Our data suggest that reduced hepatic Cu(+) clearance in idiopathic non-Wilsonian types of disease might be associated with the loss of function of myosin Vb. ..
  5. Xu J, Gao J, Li J, Xue L, Clark K, Ekker S, et al. Functional analysis of slow myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles. J Genet Genomics. 2012;39:69-80 pubmed publisher
    ..Together, these studies indicate that myosin thick filaments are required for M-line organization and M-line localization of myomesin-3. In contrast, myomesin-3 is dispensable for sarcomere organization in slow muscles...
  6. Dunn T, Chen S, Faith D, Hicks J, Platz E, Chen Y, et al. A novel role of myosin VI in human prostate cancer. Am J Pathol. 2006;169:1843-54 pubmed
    ..These results support that myosin VI is critical in maintaining the malignant properties of the majority of human prostate cancers diagnosed today. ..
  7. Pinheiro E, Montell D. Requirement for Par-6 and Bazooka in Drosophila border cell migration. Development. 2004;131:5243-51 pubmed
    ..Taken together, these results indicate that cells need not lose apical/basal polarity in order to invade neighboring tissues and in some cases even require such polarity for proper motility. ..
  8. Lee S, Montell C. Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron. 2004;43:95-103 pubmed
    ..These data demonstrate that the light-dependent translocation of Arr2 into the rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III. ..
  9. Li Z, Lehar M, Nakagawa H, Hoh J, Flint P. Differential expression of myosin heavy chain isoforms between abductor and adductor muscles in the human larynx. Otolaryngol Head Neck Surg. 2004;130:217-22 pubmed
    ..This study examines the differential expression of myosin heavy chain (MyHC) components in human laryngeal muscle groups...
  10. Bernardin F, Yang Y, Civin C, Friedman A. c-Myc overcomes cell cycle inhibition by CBFbeta-SMMHC, a myeloid leukemia oncoprotein. Cancer Biol Ther. 2002;1:492-6 pubmed
    ..In a subset of CBF leukemias, elevated expression of c-Myc is expected to facilitate the proliferation of the leukemic blasts and thereby potentiate the ability of CBF oncoproteins to block differentiation. ..
  11. Geisbrecht E, Montell D. Myosin VI is required for E-cadherin-mediated border cell migration. Nat Cell Biol. 2002;4:616-20 pubmed
    ..Multiple biochemical mechanisms may exist, therefore, for cadherins to associate with diverse unconventional myosins that are required for normal stereocilium formation or maintenance. ..
  12. Porter J, Yu M, Doberstein S, Pollard T, Montell C. Dependence of calmodulin localization in the retina on the NINAC unconventional myosin. Science. 1993;262:1038-42 pubmed
    ..A general function of unconventional myosins may be to control the subcellular distribution of calmodulin. ..
  13. Porter J, Minke B, Montell C. Calmodulin binding to Drosophila NinaC required for termination of phototransduction. EMBO J. 1995;14:4450-9 pubmed
    ..These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction. ..