Genomes and Genes
Experts and Doctors on molecular sequence data in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Topic: molecular sequence data
Publications455 found, 100 shown here
- Shirahata M, Hirasawa S, Okumura M, Mendoza J, Okumura A, Balbir A, et al. Identification of M1 and M2 muscarinic acetylcholine receptors in the cat carotid body chemosensory system. Neuroscience. 2004;128:635-44 pubmed..Thus, activation of M1 mAChRs on afferent nerve endings may be linked to the increase in neural output during hypoxia. Further, M1 and M2 mAChRs on glomus cells modulate the release of neurotransmitters. ..
- Lal A, Kawai T, Yang X, Mazan Mamczarz K, Gorospe M. Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J. 2005;24:1852-62 pubmed..Together, our data support a regulatory scheme whereby HuR binds the ProTalpha mRNA, elevates its cytoplasmic abundance and translation, and thereby elicits an antiapoptotic program. ..
- Bouyain S, Longo P, Li S, Ferguson K, Leahy D. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proc Natl Acad Sci U S A. 2005;102:15024-9 pubmed..These results indicate an important role for ligand in determining pH-dependent binding and may explain different responses observed when the same ErbB receptor is stimulated by different ligands. ..
- Delisle A, Barcak G, Guo M. Isolation and expression of the lysis genes of Actinomyces naeslundii phage Av-1. Appl Environ Microbiol. 2006;72:1110-7 pubmed publisher..We were able to subclone and express these genes and determine some of the functional properties of their gene products...
- Tomiya N, Narang S, Park J, Abdul Rahman B, Choi O, Singh S, et al. Purification, characterization, and cloning of a Spodoptera frugiperda Sf9 beta-N-acetylhexosaminidase that hydrolyzes terminal N-acetylglucosamine on the N-glycan core. J Biol Chem. 2006;281:19545-60 pubmed
- Xu X, Dong C, Vogel B. Hemicentins assemble on diverse epithelia in the mouse. J Histochem Cytochem. 2007;55:119-26 pubmed
- Guo Y, Singleton P, Rowshan A, Gucek M, Cole R, Graham D, et al. Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. Mol Cell Proteomics. 2007;6:689-96 pubmed
- Yu X, Lin J, Zack D, Qian J. Identification of tissue-specific cis-regulatory modules based on interactions between transcription factors. BMC Bioinformatics. 2007;8:437 pubmed..These results demonstrate that identifying relevant sets of binding motifs can help in the mapping of DNA regulatory regions, and suggest that non-conserved CRMs play an important role in gene regulation. ..
- Scott A, Ghedin E. The genome of Brugia malayi - all worms are not created equal. Parasitol Int. 2009;58:6-11 pubmed publisher..The goal of this review is to provide an overview of the results of genomic analysis and how these observations provide new insights into the biology of filarial species...
- Sakabe K, Wang Z, Hart G. Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A. 2010;107:19915-20 pubmed publisher..Finally, we show that histone O-GlcNAcylation changes during mitosis and with heat shock. Taken together, these data show that O-GlcNAc cycles dynamically on histones and can be considered part of the histone code. ..
- O Hagan H, Wang W, Sen S, DeStefano Shields C, Lee S, Zhang Y, et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell. 2011;20:606-19 pubmed publisher..Thus, oxidative damage induces formation and relocalization of a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing. ..
- Hermankova M, Ray S, Ruff C, Powell Davis M, Ingersoll R, D Aquila R, et al. HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy. JAMA. 2001;286:196-207 pubmed..Low-level viremia below 50 copies/mL may represent less of a concern regarding impending drug failure of current HAART regimens. However, the archival drug-resistant virus may be relevant regarding future treatment strategies. ..
- Farber J. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci U S A. 1990;87:5238-42 pubmed..It is proposed that the gene encoding this protein be called mig, for monokine induced by gamma interferon. ..
- Yaoita Y, Shi Y, Brown D. Xenopus laevis alpha and beta thyroid hormone receptors. Proc Natl Acad Sci U S A. 1990;87:7090-4 pubmed..The 5' UTR of transcripts from both TR alpha and TR beta genes contain multiple AUG sequences with short open reading frames suggesting translational control mechanisms might play a role in expression of TR genes. ..
- Dietz H, Kendzior R. Maintenance of an open reading frame as an additional level of scrutiny during splice site selection. Nat Genet. 1994;8:183-8 pubmed..We propose that maintenance of an open reading frame can serve as an additional level of scrutiny during exon definition. This process may have pathogenic and evolutionary significance. ..
- Bellus G, Hefferon T, Ortiz de Luna R, Hecht J, Horton W, Machado M, et al. Achondroplasia is defined by recurrent G380R mutations of FGFR3. Am J Hum Genet. 1995;56:368-73 pubmed..The homogeneity of mutations in achondroplasia is unprecedented for an autosomal dominant disorder and may explain the relative lack of heterogeneity in the achondroplasia phenotype. ..
- Okkema P, Fire A. The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development. 1994;120:2175-86 pubmed..Expression continues throughout embryonic and larval development. This expression pattern suggests CEH-22 plays a key role in pharyngeal muscle-specific activity of the myo-2 enhancer. ..
- Su L, Vogelstein B, Kinzler K. Association of the APC tumor suppressor protein with catenins. Science. 1993;262:1734-7 pubmed..A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion. ..
- Wang W, Chevray P, Nathans D. Mammalian Sug1 and c-Fos in the nuclear 26S proteasome. Proc Natl Acad Sci U S A. 1996;93:8236-40 pubmed..We conclude that FZA-B is the mammalian homolog of SUG1 (mSug1) and that it is present in the nuclear 26S proteasome of cells. Our results suggest that mSug1 may be involved in the degradation of c-Fos and other transcription factors. ..
- Hendricks J, Mobley H. Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity. J Bacteriol. 1997;179:5892-902 pubmed..0001]). Synthesis of urease apoenzyme, however, was unaffected by mutations in any of the abc genes. We conclude that the abc gene cluster, in addition to nixA, is involved in production of a catalytically active urease...
- Dianov G, Thybo T, Dianova I, Lipinski L, Bohr V. Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts. J Biol Chem. 2000;275:11809-13 pubmed..Cell extracts deficient in XPG protein had an average 25% reduction in TG incision. These data show that BER is the primary pathway for repair of TG in DNA and that XPG protein may be involved in repair of TG as an accessory factor. ..
- Blank T, Zhong H, Bell A, Whittam T, Donnenberg M. Molecular variation among type IV pilin (bfpA) genes from diverse enteropathogenic Escherichia coli strains. Infect Immun. 2000;68:7028-38 pubmed..These results have important implications for our understanding of bundlin structure, transmission of the bfp gene cluster among EPEC strains, and the role of bundlin variation in the evasion of host immune system responses. ..
- Caspersen K, Park J, Patil S, Dumler J. Genetic variability and stability of Anaplasma phagocytophila msp2 (p44). Infect Immun. 2002;70:1230-4 pubmed..The predominant Msp2 pattern in vitro is determined by transcription from a single gene. ..
- Sperandio V, Torres A, Kaper J. Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli. Mol Microbiol. 2002;43:809-21 pubmed
- Wang S, Betz A, Reed R. Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection. Mol Cell Neurosci. 2002;20:404-14 pubmed..In summary, we have identified O/E-4 utilizing a novel homology screening method. Our results suggest that O/E-4 may interact with other O/E family members to regulate gene expression in the olfactory sensory neurons. ..
- Du S, Gao J, Anyangwe V. Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter. Comp Biochem Physiol B Biochem Mol Biol. 2003;134:123-34 pubmed..In addition, because these regulatory elements control myogenin expression in mouse and human embryos, these data suggest that the regulatory mechanism controlling myogenin expression might be conserved during evolution. ..
- Tengs T, Bowers H, Glasgow H, Burkholder J, Oldach D. Identical ribosomal DNA sequence data from Pfiesteria piscicida (Dinophyceae) isolates with different toxicity phenotypes. Environ Res. 2003;93:88-91 pubmed..piscicida are linked to factors other than genetic strain variation detectable by ribosomal gene sequence analyses...
- Perry T, Greig N. The glucagon-like peptides: a double-edged therapeutic sword?. Trends Pharmacol Sci. 2003;24:377-83 pubmed
- Ruley K, Ansede J, Pritchett C, Talaat A, Reimschuessel R, Trucksis M. Identification of Mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis. FEMS Microbiol Lett. 2004;232:75-81 pubmed..DNA sequence analysis of these 40 mutants identified transposon insertions in 35 unique loci. Twenty-eight out of 33 (85%) loci encoding putative virulence genes have homologous genes in M. tuberculosis. ..
- Rahman M, Simser J, Macaluso K, Azad A. Functional analysis of secA homologues from rickettsiae. Microbiology. 2005;151:589-96 pubmed..coli strain MM52 secA51(ts) at the non-permissive temperature (42 degrees C). These results suggest that the N-terminal ATPase domain is highly conserved, whereas the C-terminal domain appears to be species specific...
- Huang G, Zeng W, Kim J, Yuan J, Han L, Muallem S, et al. STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol. 2006;8:1003-10 pubmed..These observations implicate STIM1 as a key regulator of activity rather than a channel component, and reveal similar regulation of SOC, I(crac) and TRPC channel activation by STIM1. ..
- Stastna M, Chimenti I, Marban E, Van Eyk J. Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics. 2010;10:245-53 pubmed publisher..These findings suggest that relative concentration of each protein may be crucial for cellular intertalk and for the final outcome of cardiac cell therapy. ..
- Zou J, Mali P, Huang X, Dowey S, Cheng L. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood. 2011;118:4599-608 pubmed publisher..This study also provides a new strategy for gene therapy of monogenic diseases using patient-specific iPSCs, even if the underlying disease-causing mutation is not expressed in iPSCs. ..
- Willis C, Oashi T, Busby B, MacKerell A, Bloch R. Hydrophobic residues in small ankyrin 1 participate in binding to obscurin. Mol Membr Biol. 2012;29:36-51 pubmed publisher..Our results suggest that hydrophobic interactions contribute to the higher affinity of Obsc????????? for sAnk1 and to the dominant role exhibited by this sequence in binding. ..
- Kinzler K, Nilbert M, Su L, Vogelstein B, Bryan T, Levy D, et al. Identification of FAP locus genes from chromosome 5q21. Science. 1991;253:661-5 pubmed..Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia. ..
- Bantia S, Mane S, Bell W, Dang C. Fibrinogen Baltimore I: polymerization defect associated with a gamma 292Gly----Val (GGC----GTC) mutation. Blood. 1990;76:2279-83 pubmed..The molecular defect of Fibrinogen Baltimore I lies in a region of the gamma-chain required for fibrin polymerization, suggesting that the integrity of gamma Gly292 is critical for fibrin assembly. ..
- Klein J, Horn T, Forman J, Silver R, Teirstein A, Moller D. Selection of oligoclonal V beta-specific T cells in the intradermal response to Kveim-Siltzbach reagent in individuals with sarcoidosis. J Immunol. 1995;154:1450-60 pubmed..These results suggest that the Kveim-Siltzbach reaction is characterized by a limited TCR beta-chain repertoire consistent with an Ag-driven T cell immune response. ..
- Wang J, Johnson P, Persico A, Hawkins A, Griffin C, Uhl G. Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett. 1994;338:217-22 pubmed..An MspI polymorphism, producing a 3.7 kb band, may prove useful in assessing this gene's involvement in neuropsychiatric disorders involving opiatergic systems. ..
- Nicholas J, Ruvolo V, Zong J, Ciufo D, Guo H, Reitz M, et al. A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. J Virol. 1997;71:1963-74 pubmed..We conclude that the DL-B locus of gammaherpesviruses displays considerably more variability that previously appreciated and that expression of many of these genes is likely to have important implications for HHV-8 biology and therapy. ..
- Hotta K, Gustafson T, Yoshioka S, Ortmeyer H, Bodkin N, Hansen B. Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys. Int J Obes Relat Metab Disord. 1998;22:1000-10 pubmed..The ratio of PPARgamma2 mRNA to total PPARgamma mRNA is related to obesity in the rhesus monkey and mRNA expression of PPARgamma1, PPARgamma2, C/EBPalpha, LPL and GLUT4 appear to be coordinated in vivo...
- Borgnia M, Kozono D, Calamita G, Maloney P, Agre P. Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J Mol Biol. 1999;291:1169-79 pubmed..Expression of native and modified AqpZ in milligram quantities has permitted biophysical characterization of this remarkably stable aquaporin tetramer, which is being utilized for high-resolution structural studies. ..
- Orr N, Galen J, Levine M. Novel use of anaerobically induced promoter, dmsA, for controlled expression of fragment C of tetanus toxin in live attenuated Salmonella enterica serovar Typhi strain CVD 908-htrA. Vaccine. 2001;19:1694-700 pubmed..007). Mice immunized with CVD 908-htrA carrying pTETdmsA3 and pTETnir15 survived tetanus toxin challenge. P(dmsA) derivatives are attractive promoters for in vivo expression of foreign genes in attenuated live vector vaccines. ..
- Lawrence S, Huddleston K, Tomiya N, Nguyen N, Lee Y, Vann W, et al. Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. Glycoconj J. 2001;18:205-13 pubmed..Engineering the CMP-SA metabolic pathway may be beneficial in various cell lines in which CMP-Neu5Ac production limits sialylation of glycoproteins or other glycans. ..
- Strichman Almashanu L, Lee R, Onyango P, Perlman E, Flam F, Frieman M, et al. A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res. 2002;12:543-54 pubmed..These sequences will provide a valuable resource in the search for novel imprinted genes, for defining the molecular substrates of the normal methylome, and for identifying novel targets for mammalian chromatin formation. ..
- Hong S, Li H, Becker K, Dawson V, Dawson T. Identification and analysis of plasticity-induced late-response genes. Proc Natl Acad Sci U S A. 2004;101:2145-50 pubmed..Our results provide a molecular dissection of the activity-dependent long-lasting neuronal responses induced by NMDA receptor activation. ..
- Xu W, Dunn C, Jones C, D Souza G, Bessman M. The 26 Nudix hydrolases of Bacillus cereus, a close relative of Bacillus anthracis. J Biol Chem. 2004;279:24861-5 pubmed..Furthermore, as a result of this and previous work we have identified a new sub-family of the Nudix hydrolase superfamily recognizable by a specific amino acid motif outside of the Nudix box. ..
- Kelm K, Huyer G, Huang J, Michaelis S. The internalization of yeast Ste6p follows an ordered series of events involving phosphorylation, ubiquitination, recognition and endocytosis. Traffic. 2004;5:165-80 pubmed..Our results demonstrate that Ste6p follows the PURE pathway and that GFP-tagged Ste6p provides a powerful model protein for studies of endocytosis and post-endocytic events in yeast...
- Castano I, Pan S, Zupancic M, Hennequin C, Dujon B, Cormack B. Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata. Mol Microbiol. 2005;55:1246-58 pubmed..The analysis here is the first evidence that multiple EPA genes encode adhesins and demonstrates that transcription of at least two of these adhesins is regulated by subtelomeric silencing. ..
- Cheng Q, Hallmann A, Edwards L, Miller S. Characterization of a heat-shock-inducible hsp70 gene of the green alga Volvox carteri. Gene. 2006;371:112-20 pubmed..hsp70A appears to be the only gene in the genome that encodes a cytoplasmic Hsp70, so we conclude that Hsp70A is clearly the best candidate to be the chaperone that participates with GlsA in asymmetric cell division...
- Octtaviani E, Effler J, Robinson D. Enlazin, a natural fusion of two classes of canonical cytoskeletal proteins, contributes to cytokinesis dynamics. Mol Biol Cell. 2006;17:5275-86 pubmed publisher..Thus, enlazin has roles in cell mechanics and adhesion, and these roles seem to be differentially significant for cytokinesis, depending on the genetic background...
- McMiller T, Sims D, Lee T, Williams T, Johnson C. Molecular characterization of the Caenorhabditis elegans REF-1 family member, hlh-29/hlh-28. Biochim Biophys Acta. 2007;1769:5-19 pubmed..Loss of hlh-29/hlh-28 function via RNA interference (RNAi) results in multiple phenotypes including late embryonic lethality, yolk protein accumulation, everted vulva, bordering behavior, and alter chemosensory responses. ..
- Park C, Lee H, Lee H, Park C, Choi O. Cloning and characterization of rat sphingosine kinase 1 with an N-terminal extension. Biochem Biophys Res Commun. 2007;364:702-7 pubmed..Taken together, the fact that long-rSK1 with similar enzymatic characteristics to rSK1 displays differential tissue distribution may suggest an additional role of long-rSK1. ..
- Chakraborty A, Koldobskiy M, Sixt K, Juluri K, Mustafa A, Snowman A, et al. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A. 2008;105:1134-9 pubmed publisher..Thus, the prosurvival actions of HSP90 reflect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effective and safer modes of chemotherapy. ..
- Chen X, Xie S, Bhat S, Kumar N, Shapiro T, Liu J. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol. 2009;16:193-202 pubmed publisher..These findings suggest that PfMetAP2 is a viable target, and fumarranol is a promising lead compound for the development of novel antimalarial agents. ..
- Xiao J, Buka S, Cannon T, Suzuki Y, Viscidi R, Torrey E, et al. Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring. Microbes Infect. 2009;11:1011-8 pubmed publisher..These findings suggest an influence of the parasite genotype on increased risk of psychosis and provide further support for a substantive role of Toxoplasma in the etiology of psychosis. ..
- Wechsler D, Dang C. Opposite orientations of DNA bending by c-Myc and Max. Proc Natl Acad Sci U S A. 1992;89:7635-9 pubmed
- Takeuchi M, Kobata A. Structures and functional roles of the sugar chains of human erythropoietins. Glycobiology. 1991;1:337-46 pubmed
- Tsai Wu J, Radicella J, Lu A. Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of micA and mutY. J Bacteriol. 1991;173:1902-10 pubmed..Furthermore, our results suggest that micA is the same gene as the closely mapped mutY, which encodes the A/G mismatch-specific glycosylase. ..
- Kaestner K, Christy R, McLenithan J, Braiterman L, Cornelius P, Pekala P, et al. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 1989;86:3150-4 pubmed..This increase in mRNA content correlates closely with the acquisition of insulin-stimulated glucose uptake. We propose that GT2 is an insulin-regulated glucose transporter. ..
- Gough N, Hatem C, Fambrough D. The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c. DNA Cell Biol. 1995;14:863-7 pubmed..Thus, the family of LAMP-2 proteins is conserved from bird to mammals and the diversity is generated by alternative splicing of a single LAMP-2 gene. ..
- Wes P, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C. TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci U S A. 1995;92:9652-6 pubmed..TRPC1 was expressed at the highest levels in the fetal brain and in the adult heart, brain, testis, and ovaries. Evidence is also presented that TRPC1 represents the archetype of a family of related human proteins. ..
- Fu C, Maier R. Organization of the hydrogenase gene cluster from Bradyrhizobium japonicum: sequences and analysis of five more hydrogenase-related genes. Gene. 1994;145:91-6 pubmed..The latter proteins contain two 'C-X-X-C' motifs, which may serve as iron ligands for non-heme iron proteins involved as intermediate electron carriers or in the assembly process for Fe-S (or NiFe-S) clusters...
- Takahashi N, Uhl G. Murine vesicular monoamine transporter 2: molecular cloning and genomic structure. Brain Res Mol Brain Res. 1997;49:7-14 pubmed
- Seabold R, Schleif R. Apo-AraC actively seeks to loop. J Mol Biol. 1998;278:529-38 pubmed..These affinities allowed accurate calculation of basal level and induced levels of expression from pBAD under a wide variety of natural and mutant conditions. The calculations independently predicted the looping preference of apo-AraC. ..
- Cabin D, McKee Johnson J, Matesic L, Wiltshire T, Rue E, Mjaatvedt A, et al. Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res. 1998;8:940-50 pubmed..Comparison of this physical map with that of the corresponding region on Chr. 21 shows conservation not only of gene order but of size in the 3 Mb from Cbr1 to Ets2; distal to Ets2, the human map is expanded. ..
- Sabatini D, Barrow R, Blackshaw S, Burnett P, Lai M, Field M, et al. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science. 1999;284:1161-4 pubmed..The interaction with gephyrin ascribes a function to the large amino-terminal region of an ATM-related protein and reveals a role in signal transduction for the clustering protein gephyrin. ..
- Conn G, Draper D, Lattman E, Gittis A. Crystal structure of a conserved ribosomal protein-RNA complex. Science. 1999;284:1171-4 pubmed..This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome. ..
- Behrens M, Venkatraman G, Gronostajski R, Reed R, Margolis F. NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression. Eur J Neurosci. 2000;12:1372-84 pubmed..These data on NFI activity, and on transcription factor expression, provide a basis to understand the role of NFI in regulating gene expression in olfactory receptor neurons. ..
- Harmer T, Wu M, Schleif R. The role of rigidity in DNA looping-unlooping by AraC. Proc Natl Acad Sci U S A. 2001;98:427-31 pubmed..These results are consistent with the light switch mechanism for the action of AraC, refine the model, and extend the range of experimental tests to which it has been subjected. ..
- Joshi B, Robalino J, Schott E, Jagus R. Yeast "knockout-and-rescue" system for identification of eIF4E-family members possessing eIF4E-activity. Biotechniques. 2002;33:392-3, 395-6, 398 passim pubmed
- Xu W, Shen J, Dunn C, Bessman M. A new subfamily of the Nudix hydrolase superfamily active on 5-methyl-UTP (ribo-TTP) and UTP. J Biol Chem. 2003;278:37492-6 pubmed..We propose the acronym and mnemonic, utp, for the gene designating this unique UTPase. ..
- Karban A, Okazaki T, Panhuysen C, Gallegos T, Potter J, Bailey Wilson J, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet. 2004;13:35-45 pubmed..Therefore, we have identified the first potentially functional polymorphism of NFKB1 and demonstrated its genetic association with a common human disease, ulcerative colitis. ..
- Ibarrola N, Kratchmarova I, Nakajima D, Schiemann W, Moustakas A, Pandey A, et al. Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling. BMC Cell Biol. 2004;5:2 pubmed..Our results suggest that this effect could be partially explained by AMSH-2 mediated decrease of the action of Smad7 on TGF-beta signaling pathway. ..
- Yang M, Jensen L, Gardner A, Culotta V. Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family. Biochem J. 2005;386:479-87 pubmed..This is the first report of a eukaryotic ACDP family protein involved in metal homoeostasis. ..
- Hitchman T, Schmidt E, Trail F, Rarick M, Linz J, Townsend C. Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis. Bioorg Chem. 2001;29:293-307 pubmed..Phylogenetic predictions and an analysis of GC-bias in AF and ST pathway genes compared with primary metabolic Aspergillus genes were used as a basis to propose a route for the evolution of the AF and ST clusters. ..
- Leung L, Hyland J, Young A, Goldberg M, Handa J. A novel mutation in intron 11 of the COL2A1 gene in a patient with type 1 Stickler syndrome. Retina. 2006;26:106-9 pubmed
- Zhang L, Jie C, Obie C, Abidi F, Schwartz C, Stevenson R, et al. X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation. Genome Res. 2007;17:641-8 pubmed..We conclude that our XCA screening is an efficient strategy to identify genes that show significant changes in transcript abundance as candidate genes for XLMR. ..
- Foster D, Rucker J, Marban E. Is Kir6.1 a subunit of mitoK(ATP)?. Biochem Biophys Res Commun. 2008;366:649-56 pubmed..1D-, 2D-, and native gel analyses were consistent with these assignments. The data suggest it is premature to assign Kir6.1 a role in mitoK(ATP) on the basis of immunoreactivity alone. ..
- Geng H, Belas R. TdaA regulates Tropodithietic acid synthesis by binding to the tdaC promoter region. J Bacteriol. 2011;193:4002-5 pubmed publisher..Here, we showed that an LysR-type transcriptional regulator, TdaA, is a positive regulator of tdaCDE gene expression and binds to the tdaC promoter region. ..
- Davidsen J, Townsend C. In vivo characterization of nonribosomal peptide synthetases NocA and NocB in the biosynthesis of nocardicin A. Chem Biol. 2012;19:297-306 pubmed publisher..Conversely, production of nocardicin A was not affected by mutation of the NocB histidine motif or the R828G mutation in NocA...
- Padmanabhan A, Li X, Bieberich C. Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner. J Biol Chem. 2013;288:14158-69 pubmed publisher..These results establish PKA as a regulator of MYC and highlight the distinct biological roles of the different PKA catalytic subunits. ..
- Yu J, Kaper J. Cloning and characterization of the eae gene of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol. 1992;6:411-7 pubmed..pseudotuberculosis and Y. enterocolitica invasins shows striking regions of identity with the greatest divergence at the C-terminal end, the putative receptor-binding portion of invasin. ..
- Luke M, Coffey D. Human androgen receptor binding to the androgen response element of prostate specific antigen. J Androl. 1994;15:41-51 pubmed..Androgen receptors purified by ion-exchange chromatography were unable to bind to ARE, suggesting the presence of other factors required for DNA binding. ..
- Walker N, Gastel J, Costa L, Clark G, Lucier G, Sutter T. Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. Carcinogenesis. 1995;16:1319-27 pubmed..In Sprague-Dawley rats, TCDD is a more potent hepatocarcinogen in females than in males. The induction of CYP1B1 in TCDD rat liver may be a contributing factor to the carcinogenic action of this persistent environmental pollutant. ..
- Pietenpol J, Papadopoulos N, Markowitz S, Willson J, Kinzler K, Vogelstein B. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res. 1994;54:3714-7 pubmed..In contrast, a COOH-terminal deletion mutant of bcl2 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types. ..
- Borchelt D, Lee M, Slunt H, Guarnieri M, Xu Z, Wong P, et al. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A. 1994;91:8292-6 pubmed