Genomes and Genes
Experts and Doctors on membrane potentials in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Topic: membrane potentials
- Hoffman A, Lupica C. Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids. J Neurophysiol. 2001;85:72-83 pubmed
- Vazin T, Chen J, Spivak C, Amable R, Gabitzsch E, Lee C, et al. Dopaminergic neurons derived from BG01V2, a variant of human embryonic stem cell line BG01. Restor Neurol Neurosci. 2008;26:447-58 pubmed..TH+ cells derived from the BG01V2 hESC line using SDIA are postmitotic and have functional characteristics of normal dopaminergic neurons. ..
- Zhang L, Yu J, Park B, Kinzler K, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science. 2000;290:989-92 pubmed..These results establish an unambiguous role for BAX in apoptotic processes in human epithelial cancers and may have implications for cancer chemoprevention strategies. ..
- Kushnareva Y, Polster B, Sokolove P, Kinnally K, Fiskum G. Mitochondrial precursor signal peptide induces a unique permeability transition and release of cytochrome c from liver and brain mitochondria. Arch Biochem Biophys. 2001;386:251-60 pubmed
- Lucas P, Ukhanov K, Leinders Zufall T, Zufall F. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003;40:551-61 pubmed..Thus, a previously unanticipated mechanism involving direct channel opening by DAG underlies the transduction of sensory cues in the accessory olfactory system...
- Nutku E, Hudson S, Bochner B. Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun. 2005;336:918-24 pubmed..These experiments show that Siglec-8-induced apoptosis occurs through the sequential production of ROS, followed by induction of mitochondrial injury and caspase cleavage. ..
- MacDonald K, McKenzie K, Henderson M, Hawkins C, Vij N, Zeitlin P. Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol Lung Cell Mol Physiol. 2008;295:L933-40 pubmed publisher..RT-PCR confirmed expression of ClC-2 mRNA in murine lung homogenate. The direct application of lubiprostone in the CF murine nasal airway restores nearly normal levels of chloride secretion in nasal epithelia. ..
- Ecker J, Dumitrescu O, Wong K, Alam N, Chen S, LeGates T, et al. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron. 2010;67:49-60 pubmed publisher..Thus, nonclassical retinal photoreception occurs within diverse cell types and influences circuits and functions encompassing luminance as well as spatial information. ..
- Teshima Y, Akao M, Baumgartner W, Marban E. Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels. Brain Res. 2003;990:45-50 pubmed..These effects were abolished by 5-hydroxydecanoate (5HD; 500 micromol/l), a mitoKATP channel blocker. The present results showed that nicorandil has anti-apoptotic effects in neurons, at least in part, by preserving DeltaPsim. ..
- Gustina A, Trudeau M. hERG potassium channel gating is mediated by N- and C-terminal region interactions. J Gen Physiol. 2011;137:315-25 pubmed publisher..Together, these data suggest that the mechanism for regulation of slow deactivation in hERG channels is an interaction between the N-terminal PAS domain and the C-terminal CNBD. ..
- Sekar R, Kizana E, Smith R, Barth A, Zhang Y, Marban E, et al. Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. Am J Physiol Heart Circ Physiol. 2007;293:H2757-70 pubmed..In addition, LV-mediated overexpression of Kir2.1 opens up the prospect of studying the functional role of inward rectifier K(+) current in cardiac arrhythmias. ..
- Liu D, Pitta M, Lee J, Ray B, Lahiri D, Furukawa K, et al. The KATP channel activator diazoxide ameliorates amyloid-Î² and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;22:443-57 pubmed publisher..Our findings show that diazoxide can ameliorate molecular, cytopathological, and behavioral alterations in a mouse model of AD suggesting a therapeutic potential for drugs that activate KATP channels in the treatment of AD. ..
- Ma D, Nakata T, Zhang G, Hoshi T, Li M, Shikano S. Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels. FEBS Lett. 2007;581:1000-8 pubmed..The results together support the notion that Slo1_DEC nucleates isoform-specific protein complexes and possesses a cis element(s) for regulating trafficking of the Slo1 channels. ..
- Yellen G, Jurman M, Abramson T, MacKinnon R. Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science. 1991;251:939-42 pubmed..Further, a stretch of only eight amino acid residues must traverse 80 percent of the transmembrane electric potential difference. ..
- Liu D, Chan S, de Souza Pinto N, Slevin J, Wersto R, Zhan M, et al. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8:389-414 pubmed..By shifting energy metabolism to reduce ROS production and cellular reliance on mitochondrial respiration, UCP4 can protect neurons against oxidative stress and calcium overload. ..
- Rivers D, Crawley T, Bauser H. Localization of intracellular calcium release in cells injured by venom from the ectoparasitoid Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae) and dependence of calcium mobilization on G-protein activation. J Insect Physiol. 2005;51:149-60 pubmed..Mobilization of calcium in this fashion could stimulate cAMP formation, and subsequently promote calcium release from NAADP-sensitive stores. ..
- Mustafa A, Sikka G, Gazi S, Steppan J, Jung S, Bhunia A, et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res. 2011;109:1259-68 pubmed publisher..Because EDHF activity is a principal determinant of vasorelaxation in numerous vascular beds, drugs influencing H(2)S biosynthesis offer therapeutic potential. ..
- Lloyd T, Machamer J, O Hara K, Kim J, Collins S, Wong M, et al. The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. Neuron. 2012;74:344-60 pubmed publisher..Therefore, the p150(Glued) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron disease. ..
- Schiffhauer E, Vij N, Kovbasnjuk O, Kang P, Walker D, Lee S, et al. Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol. 2013;304:L324-31 pubmed publisher..The utilization of CLCN2 as an alternative chloride efflux channel could provide clinical benefit to patients with CF, especially if the pharmacological activator is administered as an aerosol. ..
- O Leary M, Krueger B. Batrachotoxin and alpha-scorpion toxin stabilize the open state of single voltage-gated sodium channels. Mol Pharmacol. 1989;36:789-95 pubmed..This effect on activation gating is not predicted from the individual effects of the toxins. ..
- Cutting G, Lu L, O Hara B, Kasch L, Montrose Rafizadeh C, Donovan D, et al. Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A. 1991;88:2673-7 pubmed..These features are consistent with our identification of a GABA subunit, GABA rho 1, with prominent retinal expression that increases the diversity and tissue specificity of this ligand-gated ion-channel receptor family. ..
- Ivanov A, Gerzanich V, Ivanova S, Denhaese R, Tsymbalyuk O, Simard J. Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. J Physiol. 2006;570:73-84 pubmed
- Fandy T, Shankar S, Ross D, Sausville E, Srivastava R. Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. Neoplasia. 2005;7:646-57 pubmed..Our study demonstrated the enhancing effects of HDAC inhibitors on apoptosis when combined with TRAIL and, for the first time, emphasized the role of AIF in mediating the cytotoxic effects of HDAC inhibitors. ..
- Oz M, Yang K, Shippenberg T, Renaud L, O Donovan M. Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons. J Neurophysiol. 2007;98:1108-14 pubmed..These observations imply functional postsynaptic G-protein-coupled CCK B receptors are prevalent in neonatal rodent spinal cord. ..
- Prosser B, Hernández Ochoa E, Zimmer D, Schneider M. Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres. J Physiol. 2009;587:4543-59 pubmed publisher..The decreased Ca(2+) release at each voltage is insufficient to activate Q(gamma) in fibres lacking S100A1. ..
- Britt J, Benaliouad F, McDevitt R, Stuber G, Wise R, Bonci A. Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron. 2012;76:790-803 pubmed publisher..Finally, direct optical activation of medium spiny neurons proved to be capable of supporting self-stimulation, demonstrating that behavioral reinforcement is an explicit consequence of strong excitatory drive to the NAc. ..
- Nassenstein C, Taylor Clark T, Myers A, Ru F, Nandigama R, Bettner W, et al. Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. J Physiol. 2010;588:4769-83 pubmed publisher..Due to distinctions in their gene expression profile, each type will respond to noxious or inflammatory conditions in their own unique manner. ..
- Prosser B, Hernández Ochoa E, Zimmer D, Schneider M. The Qgamma component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1. J Physiol. 2009;587:4523-41 pubmed publisher..These results shed light on voltage sensor activation in mammalian muscle, and support S100A1 as a positive regulator of the voltage sensor and Ca(2+) release channel in skeletal muscle EC coupling. ..
- Grant L, Fuchs P. Calcium- and calmodulin-dependent inactivation of calcium channels in inner hair cells of the rat cochlea. J Neurophysiol. 2008;99:2183-93 pubmed publisher..CDI provides a means for the rate of spontaneous transmitter release to be adjusted to variations in hair cell resting potential and steady state calcium influx. ..
- Colecraft H, Alseikhan B, Takahashi S, Chaudhuri D, Mittman S, Yegnasubramanian V, et al. Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J Physiol. 2002;541:435-52 pubmed..Overall, the work establishes a powerful experimental paradigm to explore novel functions of ion channel subunits in their native environments. ..
- Sun S, Farrell B, Chana M, Oster G, Brownell W, Spector A. Voltage and frequency dependence of prestin-associated charge transfer. J Theor Biol. 2009;260:137-44 pubmed publisher..The revealed nature of the transferred charge can help reconcile the high-frequency electrical and mechanical observations associated with prestin, and it is important for further analysis of the structure and function of this protein. ..
- Tadross M, Ben Johny M, Yue D. Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. J Gen Physiol. 2010;135:197-215 pubmed publisher..3 channels that is specialized to repel lid closure. These findings reveal long-sought downstream mechanisms of inactivation and may furnish a framework for the understanding of Ca(2+) channelopathies involving S6 mutations. ..
- Calhoon G, O DONNELL P. Closing the gate in the limbic striatum: prefrontal suppression of hippocampal and thalamic inputs. Neuron. 2013;78:181-90 pubmed publisher..This interaction may enable the PFC to exert influence on basal ganglia loops during decision-making instances with minimal disturbance from ongoing contextual inputs. ..
- Cao C, Lee Kwon W, Payne K, EDWARDS A, Pallone T. Descending vasa recta endothelia express inward rectifier potassium channels. Am J Physiol Renal Physiol. 2007;293:F1248-55 pubmed..1, K(IR)2.2, and K(IR)2.3 subunits. We conclude that strong, inwardly rectifying K(IR)2.x isoforms are expressed in DVR and mediate K(+)-induced hyperpolarization of the endothelium. ..
- Yuan J, Kiselyov K, Shin D, Chen J, Shcheynikov N, Kang S, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-89 pubmed..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function. ..
- Sekar R, Kizana E, Cho H, Molitoris J, Hesketh G, Eaton B, et al. IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers. Circ Res. 2009;104:355-64 pubmed publisher..Our study provides direct evidence for the contribution of I(K1) heterogeneity and level to the genesis and stability of spiral waves and highlights the potential importance of I(K1) as an antiarrhythmia target. ..
- Xiong Q, Gao Z, Wang W, Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci. 2008;29:99-107 pubmed publisher..Recent advances in defining the activator-binding sites and in understanding their mechanism of action have begun to provide insight into the activation of voltage-gated channels by synthetic compounds. ..
- Starkov A, Fiskum G. Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J Neurochem. 2003;86:1101-7 pubmed
- Wildman S, Hooper K, Turner C, Sham J, Lakatta E, King B, et al. The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry. Am J Physiol Renal Physiol. 2003;285:F1168-78 pubmed..Our findings are concordant with increasing evidence for a role of polycystin-1 in cell Ca2+ homeostasis and indicate that dysregulated Ca2+ entry might promote Cl- secretion and cyst expansion in ADPKD. ..
- Yu S, Wang H, Poitras M, Coombs C, Bowers W, Federoff H, et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002;297:259-63 pubmed..These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death. ..
- Oaklander A, Belzberg A. Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia. Brain Res Mol Brain Res. 1997;52:162-5 pubmed
- Ravindran A, Kobrinsky E, Lao Q, Soldatov N. Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits. Channels (Austin). 2009;3:25-31 pubmed..2 channel. The data suggest a previously unknown action of CaM that in the presence of CaVbeta; translates into activation of the alpha2delta-deficient calcium channel and alteration of its properties. ..
- Morrell C, Sun H, Ikeda M, Beique J, Swaim A, Mason E, et al. Glutamate mediates platelet activation through the AMPA receptor. J Exp Med. 2008;205:575-84 pubmed publisher..Importantly, mice lacking GluR1 have a prolonged time to thrombosis in vivo. Our data identify glutamate as a regulator of platelet activation, and suggest that the AMPA receptor is a novel antithrombotic target. ..
- Wang T, Wang X, Xie Q, Montell C. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 2008;57:56-68 pubmed publisher..Moreover, this work demonstrates that a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling in vivo. ..
- Zhang P, Furukawa K, Opresko P, Xu X, Bohr V, Mattson M. TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. J Neurochem. 2006;97:567-81 pubmed
- Teshima Y, Akao M, Jones S, Marban E. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res. 2003;93:192-200 pubmed..Thus, overexpression of UCP2 attenuates ROS generation and prevents mitochondrial Ca2+ overload, revealing a novel mechanism of cardioprotection. ..
- Bredt D, Wang T, Cohen N, Guggino W, Snyder S. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Proc Natl Acad Sci U S A. 1995;92:6753-7 pubmed..BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation. ..
- Chaudhuri D, Issa J, Yue D. Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels. J Gen Physiol. 2007;129:385-401 pubmed..This enhanced-opening mechanism suggests that the CDF evoked during action-potential trains would produce not only larger, but longer-lasting Ca(2+) responses, an outcome with potential ramifications for short-term synaptic plasticity. ..
- Porter J, Minke B, Montell C. Calmodulin binding to Drosophila NinaC required for termination of phototransduction. EMBO J. 1995;14:4450-9 pubmed..These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction. ..