Experts and Doctors on inbred c57bl mice in College Park, Maryland, United States
Locale: College Park, Maryland, United States
Topic: inbred c57bl mice
Yuan S, Roney C, Wierwille J, Chen C, Xu B, Griffiths G, et al
. Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging. Phys Med Biol. 2010;55:191-206 pubmed publisher
..This relationship could help in correcting reconstructed dye concentration. Imaging of colon polyps of the APC(min) mouse model is presented as an example of biological applications of this co-registered OCT/FMI system. ..
Carr E, Kelman A, Wu G, Gopaul R, Senkevitch E, Aghvanyan A, et al
. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J Immunol. 2010;185:1037-44 pubmed publisher
..Together, these data indicate that regulation of glutamine use is an important component of T cell activation. Thus, a better understanding of glutamine sensing and use in T cells may reveal novel targets for immunomodulation. ..
Lee H, Takamiya K, He K, Song L, Huganir R. Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. J Neurophysiol. 2010;103:479-89 pubmed publisher
..Taken together with our previous results from the "double phosphomutants," our data suggest that either S831 or S845 alone may support LTP, whereas the S845 site is critical for LTD expression. ..
Srinivasan M, Frauwirth K. Reciprocal NFAT1 and NFAT2 nuclear localization in CD8+ anergic T cells is regulated by suboptimal calcium signaling. J Immunol. 2007;179:3734-41 pubmed
..Thus, our work provides new insight into how T cell stimulation conditions might dictate specific NFAT isoform activation and implicates NFAT2 involvement in the expression of anergy-related genes. ..
Conrad S, Strauss Ayali D, Field A, Mack M, Mosser D. Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages. Infect Immun. 2007;75:653-65 pubmed
..This work suggests that the parasite-derived MCP-1 can recruit a restrictive population of CCR2-positive macrophages into lesions that can be optimally stimulated by MCP-1 and IFN-gamma to efficiently kill Leishmania parasites. ..
Richard K, Pierce S, Song W. The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo. J Immunol. 2008;181:1746-52 pubmed
..Thus, although memory B cells are sensitive to TLR agonists in vitro, TLR agonists alone appear to have little affect on B cell memory in vivo. ..
Bohsali A, Abdalla H, Velmurugan K, Briken V. The non-pathogenic mycobacteria M. smegmatis and M. fortuitum induce rapid host cell apoptosis via a caspase-3 and TNF dependent pathway. BMC Microbiol. 2010;10:237 pubmed publisher
..These observations lend support to the hypothesis that the strong induction of the innate immune response is a major reason for the lack of pathogenicity in fast-growing mycobacteria. ..
Yang Z, Zhang X, Darrah P, Mosser D. The regulation of Th1 responses by the p38 MAPK. J Immunol. 2010;185:6205-13 pubmed publisher
..major plus CpG without SB203580. Thus, this work suggests that MAPK/p38 inhibitors may be applied as adjuvants to bias immune responses and improve vaccinations against intracellular pathogens. ..
Darrah P, Monaco M, Jain S, Hondalus M, Golenbock D, Mosser D. Innate immune responses to Rhodococcus equi. J Immunol. 2004;173:1914-24 pubmed
..equi. We conclude that the efficient activation of innate immunity by R. equi may account for the relative lack of virulence of this organism in immunocompetent adults. ..