Experts and Doctors on hyperglycemia in Baltimore, Maryland, United States


Locale: Baltimore, Maryland, United States
Topic: hyperglycemia

Top Publications

  1. Rubin J, Nambi V, Chambless L, Steffes M, Juraschek S, Coresh J, et al. Hyperglycemia and arterial stiffness: the Atherosclerosis Risk in the Communities study. Atherosclerosis. 2012;225:246-51 pubmed publisher
    ..This is consistent with the hypothesis that hyperglycemia contributes to arterial stiffness beyond its effects on atherosis and suggests that hyperglycemia is associated with altered material within the arterial wall. ..
  2. Juraschek S, Steffes M, Selvin E. Associations of alternative markers of glycemia with hemoglobin A(1c) and fasting glucose. Clin Chem. 2012;58:1648-55 pubmed publisher
    ..Fructosamine and glycated albumin may be useful adjuncts to Hb A(1c) and fasting glucose. Future studies should examine these markers in situations in which fasting glucose or Hb A(1c) measurements are invalid or not available. ..
  3. McGirt M, Woodworth G, Ali M, Than K, Tamargo R, Clatterbuck R. Persistent perioperative hyperglycemia as an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2007;107:1080-5 pubmed
    ..Isolated hyperglycemic events were not predictive of poor outcome. Serum glucose levels in the acute setting of aneurysmal SAH may help predict outcomes months after surgery. ..
  4. Bochicchio G, Joshi M, Bochicchio K, Pyle A, Johnson S, Meyer W, et al. Early hyperglycemic control is important in critically injured trauma patients. J Trauma. 2007;63:1353-8; discussion 1358-9 pubmed publisher
    ..05). Early euglycemia is associated with improved outcome and appears to be protective regardless of glucose levels in subsequent weeks. Further studies are warranted to determine the etiology of this protective effect. ..
  5. Reece E. Obesity, diabetes, and links to congenital defects: a review of the evidence and recommendations for intervention. J Matern Fetal Neonatal Med. 2008;21:173-80 pubmed publisher
    ..This strategy needs to encompass a spectrum of tax breaks, economic incentives, legislation, and educational approaches in order to be effective. ..
  6. Zhiyong Zhao -, Wu Y, Reece E. Demonstration of the essential role of protein kinase C isoforms in hyperglycemia-induced embryonic malformations. Reprod Sci. 2008;15:349-56 pubmed publisher
    ..Activation of cPLA(2) was also decreased, suggesting that PKCs mediate the hyperglycemic effects through the cPLA(2)-phospholipid peroxidation pathway. ..
  7. Zachara N. The roles of O-linked ?-N-acetylglucosamine in cardiovascular physiology and disease. Am J Physiol Heart Circ Physiol. 2012;302:H1905-18 pubmed publisher
    ..Here we summarize the current understanding of the roles of O-GlcNAc in the heart and vasculature. ..
  8. Zhao Z. Endoplasmic reticulum stress in maternal diabetes-induced cardiac malformations during critical cardiogenesis period. Birth Defects Res B Dev Reprod Toxicol. 2012;95:1-6 pubmed publisher
    ..Maternal diabetes increases ER stress in the developing heart. ER stress plays an essential role in mediating the effect of hyperglycemia on endocardial cell migration. ..
  9. Golden S. Emerging therapeutic approaches for the management of diabetes mellitus and macrovascular complications. Am J Cardiol. 2011;108:59B-67B pubmed publisher
    ..This article reviews established and emerging therapeutic approaches for managing DM and prevention of macrovascular complications. ..

More Information


  1. Reece E. The fetal and maternal consequences of gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2010;23:199-203 pubmed publisher
    ..There remains, however, a great deal of controversy over when to begin screening for hyperglycemia in pregnancy and at what level of hyperglycemia should aggressive intervention be initiated. ..
  2. Zu L, Bedja D, Fox Talbot K, Gabrielson K, Van Kaer L, Becker L, et al. Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. J Mol Cell Cardiol. 2010;49:5-15 pubmed publisher
  3. Davis S, Wei W, Garg S. Clinical impact of initiating insulin glargine therapy with disposable pen versus vial in patients with type 2 diabetes mellitus in a managed care setting. Endocr Pract. 2011;17:845-52 pubmed publisher
  4. Li X, Weng H, Reece E, Yang P. SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy. Am J Obstet Gynecol. 2011;205:84.e1-6 pubmed publisher
    ..RACK1 levels did not differ among the 3 groups. Mitigating oxidative stress by SOD1 overexpression blocks maternal hyperglycemia-induced activation of specific PKC isoforms and downstream cascades. ..
  5. Yang P, Li X, Xu C, Eckert R, Reece E, Zielke H, et al. Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal. 2013;6:ra74 pubmed publisher
    ..Thus, activation of an ASK1-FoxO3a-TRADD-caspase 8 pathway participates in the development of neural tube defects, which could be prevented by inhibiting intermediates in this cascade. ..
  6. Hernández Ochoa E, Robison P, Contreras M, Shen T, Zhao Z, Schneider M. Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood). 2012;237:1068-83 pubmed
    ..Our results suggest the hypothesis that these changes in skeletal muscle could play a role in the pathophysiology of acute and severe hyperglycemic episodes commonly observed in uncontrolled diabetes. ..
  7. Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song W, Sereda S, et al. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011;22:2235-45 pubmed publisher
    ..Consequently, mice lacking Opa1 in beta cells develop hyperglycemia. The data suggest that the function of Opa1 in the maintenance of the electron transport chain is physiologically relevant in beta cells...
  8. Rao Kondapally Seshasai S, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364:829-841 pubmed publisher
    ..Funded by the British Heart Foundation and others.). ..
  9. Lodh S, Hostelley T, Leitch C, O Hare E, Zaghloul N. Differential effects on β-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes. Hum Mol Genet. 2016;25:57-68 pubmed publisher
    ..Taken together, these findings implicate discrepant production and maintenance of β-cells in the differential susceptibility to diabetes found between these two genetic syndromes. ..
  10. Derr R, Ye X, Islas M, Desideri S, Saudek C, Grossman S. Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma. J Clin Oncol. 2009;27:1082-6 pubmed publisher
    ..The effect of intensive management of glucocorticoid-related hyperglycemia on survival deserves additional study in patients with GBM. ..
  11. Simard J, Yurovsky V, Tsymbalyuk N, Melnichenko L, Ivanova S, Gerzanich V. Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke. Stroke. 2009;40:604-9 pubmed publisher
    ..However, the therapeutic window for treatment with glibenclamide has not been studied...
  12. Andrade A, Hendrix C, Parsons T, Caballero B, Yuan C, Flexner C, et al. Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir. BMC Complement Altern Med. 2008;8:50 pubmed publisher
    ..03, n = 11), M/I remained unchanged after co-administration of IDV and AG. IDV decreases insulin sensitivity, which is unaltered by AG co-administration. AG does not significantly affect IDV pharmacokinetics. ..
  13. Yang P, Zhao Z, Reece E. Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro. Am J Obstet Gynecol. 2008;198:321.e1-7 pubmed publisher
    ..In addition, during embryopathy, teratogen such as hyperglycemia is associated with concomitant injury to the yolk sac and embryo...
  14. Steinle N, Kazlauskaite R, Imumorin I, Hsueh W, Pollin T, O Connell J, et al. Variation in the lamin A/C gene: associations with metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:1708-13 pubmed
    ..The H566H polymorphism was associated with metabolic syndrome and also higher mean fasting triglyceride and lower mean HDL-cholesterol concentrations in the Old Order Amish. ..
  15. Hegde K, Varma S. Combination of glycemic and oxidative stress in lens: implications in augmentation of cataract formation in diabetes. Free Radic Res. 2005;39:513-7 pubmed
    ..Similarly, the galactosemic lenses were also more susceptible to menadione dependent decrease in ATP and GSH. ..
  16. Hsu S, Kass D. Can Nitrite AMPk Up Sirt-ainty to Treat Heart Failure With Preserved Ejection Fraction?. Circulation. 2016;133:692-4 pubmed publisher
  17. Yang P, Cao Y, Li H. Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation. Am J Obstet Gynecol. 2010;203:185.e5-11 pubmed publisher
    ..The jnk2 gene deletion blocked diabetes-induced protein nitrosylation. JNK1/2 activation mediates hyperglycemia-induced iNOS gene expression and consequent nitrosative stress in diabetic embryopathy. ..
  18. Yang P, Zhao Z, Reece E. Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. Biochem Biophys Res Commun. 2007;357:749-54 pubmed
    ..JNK activation itself is sufficient to induce embryonic anomalies, and thus mimics the teratogenic effect of hyperglycemia. ..