Experts and Doctors on guinea pigs in Bethesda, Maryland, United States

Summary

Locale: Bethesda, Maryland, United States
Topic: guinea pigs

Top Publications

  1. Kuznetsov S, Mankani M, Gronthos S, Satomura K, Bianco P, Robey P. Circulating skeletal stem cells. J Cell Biol. 2001;153:1133-40 pubmed
    ..This is the first definitive proof of the existence of circulating skeletal stem cells in mammals. ..
  2. Frolenkov G, Mammano F, Kachar B. Regulation of outer hair cell cytoskeletal stiffness by intracellular Ca2+: underlying mechanism and implications for cochlear mechanics. Cell Calcium. 2003;33:185-95 pubmed
    ..This may be the key phenomenon for controlling gain and operating point of the cochlear amplifier. ..
  3. Steele K, Crise B, Kuehne A, Kell W. Ebola virus glycoprotein demonstrates differential cellular localization in infected cell types of nonhuman primates and guinea pigs. Arch Pathol Lab Med. 2001;125:625-30 pubmed
    ..Differential cellular localization of GP could be relevant to the pathogenesis of Ebola hemorrhagic fever. ..
  4. Rothman R, France C, Bykov V, de Costa B, Jacobson A, Woods J, et al. Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes. Eur J Pharmacol. 1989;167:345-53 pubmed
    ..The order of potency was (-)-(1S,2S)-U50,488 greater than (+/-)-U50,488 greater than (+/-)-cis diastereomer of U50,488 greater than (+)-(1R,2R)-U50,488.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  5. Laszlo G, Hathcock K, Dickler H, Hodes R. Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells. J Immunol. 1993;150:5252-62 pubmed
    ..GL7 thus appears to identify a previously uncharacterized cell-surface molecule expressed selectively on subpopulations of activated B and T cells as well as on discrete subpopulations of T and B lineage cells in vivo. ..
  6. Struble E, Ma L, Zhong L, Lesher A, BEREN J, Zhang P. Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy. Clin Dev Immunol. 2012;2012:538701 pubmed
    ..These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates. ..
  7. He X, Raymon L, Mattson M, Eldefrawi M, de Costa B. Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites. J Med Chem. 1993;36:1188-93 pubmed
    ..These compounds will allow further study of the structure and function of the "cocaine" receptor as well as the development of potential cocaine antagonists. ..
  8. Wang K, Hoshino Y, Dowdell K, Bosch Marce M, Myers T, Sarmiento M, et al. Glutamine supplementation suppresses herpes simplex virus reactivation. J Clin Invest. 2017;127:2626-2630 pubmed publisher
    ..Thus, glutamine may enhance the IFN-?-associated immune response and reduce the rate of reactivation of latent virus infection. ..
  9. Juweid M, Neumann R, Paik C, Perez Bacete M, Sato J, van Osdol W, et al. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res. 1992;52:5144-53 pubmed
    ..The same general principles of micropharmacology may apply to biological ligands other than antibodies, including those secreted by genetically modified cells. ..

More Information

Publications45

  1. Davies C, Tingley D, Kachar B, Wenthold R, Petralia R. Distribution of members of the PSD-95 family of MAGUK proteins at the synaptic region of inner and outer hair cells of the guinea pig cochlea. Synapse. 2001;40:258-68 pubmed
    ..In addition, PSD-93 and PSD-95 are found in postsynaptic afferent terminals on inner hair cells, while postsynaptic afferent terminals on outer hair cells have PSD-93. ..
  2. de Costa B, Bowen W, Hellewell S, George C, Rothman R, Reid A, et al. Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands. J Med Chem. 1989;32:1996-2002 pubmed
    ..Compound (-)-1 exhibited a Ki of 81 +/- 13 nM at sigma receptors [[3H]-(+)-3-PPP] and 250 +/- 8 nM ([3H]DTG).(ABSTRACT TRUNCATED AT 400 WORDS) ..
  3. Tang S, Bertke A, Patel A, Wang K, Cohen J, Krause P. An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor. Proc Natl Acad Sci U S A. 2008;105:10931-6 pubmed publisher
    ..5, a key viral neurovirulence factor. We hypothesize that miR-I may modulate the outcome of viral infection in the peripheral nervous system by functioning as a molecular switch for ICP34.5 expression. ..
  4. Odegard J, Flynn P, Campbell D, Robbins S, Dong L, Wang K, et al. A novel HSV-2 subunit vaccine induces GLA-dependent CD4 and CD8 T cell responses and protective immunity in mice and guinea pigs. Vaccine. 2016;34:101-9 pubmed publisher
    ..Taken together, the data show that G103 is a viable candidate for development of a novel prophylactic and therapeutic HSV-2 vaccine. ..
  5. Arnold M, Brownback C, Taraporewala Z, Patton J. Rotavirus variant replicates efficiently although encoding an aberrant NSP3 that fails to induce nuclear localization of poly(A)-binding protein. J Gen Virol. 2012;93:1483-94 pubmed publisher
  6. McLamore S, Ullrich T, Rothman R, Xu H, Dersch C, Coop A, et al. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. J Med Chem. 2001;44:1471-4 pubmed
    ..It also had high affinity for the delta-opioid receptor (K(i) = 4.7 nM in the binding assay) and high antagonist potency (1.2 nM in the GTPgammaS assay; 8.9 nM in the MVD assay). ..
  7. Porcalla A, Rodriguez W. Soft tissue and cartilage infection by Salmonella oranienburg in a healthy girl. South Med J. 2001;94:435-7 pubmed
    ..She subsequently had an isolated soft tissue infection with cartilaginous involvement of the anterior chest wall due to Salmonella enterica serogroup C1 (bioserotype oranienburg). ..
  8. Klinman D, Xie H, Ivins B. CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine. Ann N Y Acad Sci. 2006;1082:137-50 pubmed
    ..IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection. ..
  9. Brennan M, Morris S, Sizemore C. Tuberculosis vaccine development: research, regulatory and clinical strategies. Expert Opin Biol Ther. 2004;4:1493-504 pubmed
  10. Bertke A, Patel A, Imai Y, Apakupakul K, Margolis T, Krause P. Latency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LAT. J Virol. 2009;83:10007-15 pubmed publisher
  11. Colton J, Gilman S, Chang P, Colton C. Effect of helium and heliox on glutamate decarboxylase activity. Undersea Biomed Res. 1990;17:297-303 pubmed
    ..h-1.mg-1 protein, respectively). These data indicate that pressures up to 6.8 MPa do not affect the GAD-catalyzed synthesis of gamma-aminobutyric acid, but that the enzyme, as previously reported, is sensitive to low levels of oxygen. ..
  12. Andrade L, Salles F, Grati M, Manor U, Kachar B. Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. J Struct Biol. 2016;194:139-46 pubmed publisher
  13. Crisler C, Rapp H, Weintraub R, Borsos T. Forssman antigen content of guinea pig hepatomas induced by diethylnitrosamine: a quantitative approach to the search for tumor-specific antibodies. J Natl Cancer Inst. 1966;36:529-38 pubmed
    ..The results of these experiments indicate that, in the absence of strict quantitation, quantitative differences may be mistaken for qualitative differences...
  14. Ambagala A, Bosma T, Ali M, Poustovoitov M, Chen J, Gershon M, et al. Varicella-zoster virus immediate-early 63 protein interacts with human antisilencing function 1 protein and alters its ability to bind histones h3.1 and h3.3. J Virol. 2009;83:200-9 pubmed publisher
    ..Since ASF1 mediates eviction and deposition of histones during transcription, the interaction of VZV IE63 with ASF1 may help to regulate transcription of viral or cellular genes during lytic and/or latent infection...
  15. Grati M, Kachar B. Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction. Proc Natl Acad Sci U S A. 2011;108:11476-81 pubmed publisher
    ..We propose that MYO7A, sans, and harmonin-b form the core components of the UTLD molecular complex. In this complex, MYO7A is likely the motor element that pulls on CDH23 to exert tension on the tip-link. ..
  16. Frolenkov G, Belyantseva I, Kurc M, Mastroianni M, Kachar B. Cochlear outer hair cell electromotility can provide force for both low and high intensity distortion product otoacoustic emissions. Hear Res. 1998;126:67-74 pubmed
    ..Our results suggest that the OHC electromotility might provide the force for DPOAE generation not only at low, but also at high stimulus intensities. ..
  17. Basile A, Decosta B, Paul I. Multiple [3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding. Eur J Pharmacol. 1994;252:139-46 pubmed
    ..Thus, a substantial component of 1,3-di(2-[5-3H]tolyl)guanidine binding in the guinea pig cerebellum is to non-specific, proteinaceous binding sites with some of the pharmacological characteristics of the sigma 2 binding site. ..
  18. Nunes F, Lopez L, Lin H, Davies C, Azevedo R, Gow A, et al. Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J Cell Sci. 2006;119:4819-27 pubmed
  19. Andrade L, Lins U, Farina M, Kachar B, Thalmann R. Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of otoconia, and pathogenesis of benign positional vertigo. Hear Res. 2012;292:14-25 pubmed publisher
    ..The combinations of these observations in humans, together with the presented animal experiments, provide a tentative pathogenetic basis of the early stage of BPV. ..
  20. Creveling C, Bell M, Burke T, Chang E, Lewandowski Lovenberg G, Kim C, et al. Procaine isothiocyanate: an irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels. Neurochem Res. 1990;15:441-8 pubmed
    ..Protection studies with procaine and other local anesthetics suggest that only the 68 kDa species was related to local anesthetic binding. ..
  21. Bukreyev A, Yang L, Zaki S, Shieh W, Rollin P, Murphy B, et al. A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge. J Virol. 2006;80:2267-79 pubmed publisher
  22. Wu X, Sambor A, Nason M, Yang Z, Wu L, Zolla Pazner S, et al. Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses. Virology. 2008;380:285-95 pubmed publisher
    ..These findings confirm that V3 antibodies recognize most primary viral strains, but that the epitope often has limited accessibility in the context of native envelope spike. ..
  23. Hoshino Y, Pesnicak L, Dowdell K, Lacayo J, Dudek T, Knipe D, et al. Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs. Vaccine. 2008;26:4034-40 pubmed publisher
    ..Both dl5-29-41L and dl5-29 are equally effective and immunogenic in guinea pigs, and dl5-29 is very safe in immunocompromised animals...
  24. Zurawski D, Mitsuhata C, Mumy K, McCormick B, Maurelli A. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infect Immun. 2006;74:5964-76 pubmed
    ..Ultimately, OspF and OspC1 are essential for PMN transepithelial migration, a phenotype associated with increased inflammation and bacterial access to the submucosa, which are fundamental aspects of S. flexneri pathogenesis...
  25. Rodokanaki A, Holmes R, Borras T. Zeta-crystallin, a novel protein from the guinea pig lens is related to alcohol dehydrogenases. Gene. 1989;78:215-24 pubmed
    ..Comparison of the amino acid sequence with the National Biomedical Research Foundation protein data base reveals a significant similarity of zeta-crystallin with the enzyme of the alcohol dehydrogenase family. ..
  26. Bukreyev A, Marzi A, Feldmann F, Zhang L, Yang L, Ward J, et al. Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge. Virology. 2009;383:348-61 pubmed publisher
    ..Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV. ..
  27. Ambagala A, Krogmann T, Qin J, Pesnicak L, Cohen J. A varicella-zoster virus mutant impaired for latency in rodents, but not impaired for replication in cell culture. Virology. 2010;399:194-200 pubmed publisher
    ..A VZV Oka mutant, replicating to similar titers and inducing a comparable immune response as parental virus, but impaired for latency, might serve as a safer vaccine and be less likely to reactivate to cause zoster. ..
  28. Yan Y, Liu Q, Wollenberg K, Martin C, Buckler White A, Kozak C. Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV. J Virol. 2010;84:11970-80 pubmed publisher
  29. Ohashi M, Bertke A, Patel A, Krause P. Spread of herpes simplex virus to the spinal cord is independent of spread to dorsal root ganglia. J Virol. 2011;85:3030-2 pubmed publisher
  30. Roberts A, Wood J, Subbarao K, Ferguson M, Wood D, Cherian T. Animal models and antibody assays for evaluating candidate SARS vaccines: summary of a technical meeting 25-26 August 2005, London, UK. Vaccine. 2006;24:7056-65 pubmed
  31. Layer R, Skolnick P, Bertha C, Bandarage U, Kuehne M, Popik P. Structurally modified ibogaine analogs exhibit differing affinities for NMDA receptors. Eur J Pharmacol. 1996;309:159-65 pubmed
    ..These findings are consistent with the hypothesis that inhibition of the expression of morphine dependence by ibogaine is related to its NMDA receptor antagonist properties. ..
  32. Komatsu K, Driscoll W, Koh Y, Strott C. A P-loop related motif (GxxGxxK) highly conserved in sulfotransferases is required for binding the activated sulfate donor. Biochem Biophys Res Commun. 1994;204:1178-85 pubmed
    ..These data strongly support the notion that the P-loop motif found in all cloned sulfotransferases constitutes, at least in part, the PAPS binding site for these enzymes. ..
  33. de La Rosa A, Williams R, Steeg P. Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions. Bioessays. 1995;17:53-62 pubmed
    ..We review recent cellular, genetic, biochemical and X-ray crystallographic data to formulate and evaluate hypotheses concerning the molecular mechanism of nm23 action. ..
  34. Wank S, Pisegna J, De Weerth A. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Proc Natl Acad Sci U S A. 1992;89:8691-5 pubmed
    ..We conclude that this cDNA isolated from rat brain and AR42-J cells is a receptor of the CCKB subtype and that the respective cDNAs for both CCKA and CCKB are identical in the brain and gastrointestinal system. ..
  35. Zhao X, Howell K, He S, Brannan J, Wec A, Davidson E, et al. Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability. Cell. 2017;169:891-904.e15 pubmed publisher
    ..These findings have important implications for developing pan-ebolavirus vaccine and immunotherapeutic cocktails. ..
  36. Rao P, Zigler J. Purification and characterization of zeta-crystallin/quinone reductase from guinea pig liver. Biochim Biophys Acta. 1992;1117:315-20 pubmed
    ..Western blot analysis using antibodies raised against zeta-crystallin peptides demonstrated the presence of substantial amounts of this protein in human liver homogenates...