Genomes and Genes
Experts and Doctors on glucose in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
- Bhargava S, Wenger K, Marten M. Pulsed addition of limiting-carbon during Aspergillus oryzae fermentation leads to improved productivity of a recombinant enzyme. Biotechnol Bioeng. 2003;82:111-7 pubmed
- He L, Cao J, Meng S, Ma A, Radovick S, Wondisford F. Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage. Mol Endocrinol. 2013;27:1322-32 pubmed publisher..Our study demonstrates the important and unique role of p300 in glycogen synthesis through maintaining basal gluconeogenesis. ..
- Chung J, Webster S. Binding sites of crustacean hyperglycemic hormone and its second messengers on gills and hindgut of the green shore crab, Carcinus maenas: a possible osmoregulatory role. Gen Comp Endocrinol. 2006;147:206-13 pubmed..Thus, it seems likely that CHH is a pertinent neurohormone involved in osmoregulation, thus expanding its many functions as a pleiotropic hormone in crustaceans. ..
- Marano C, Workman C, Kramer E, Hermann C, Ma Y, Dhawan V, et al. Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. Int J Geriatr Psychiatry. 2013;28:417-23 pubmed publisher..Longer duration follow-up studies and the integration of other molecular imaging methods will have implications for understanding the clinical and neurobiological significance of these metabolic changes. ..
- Barnett B, Hwang Y, Taylor M, Kirchner H, Pfluger P, Bernard V, et al. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science. 2010;330:1689-92 pubmed publisher..In addition to serving as a research tool for mapping ghrelin actions, GO-CoA-Tat may help pave the way for clinical targeting of GOAT in metabolic diseases. ..
- Stewart Z, Cameron A, Singer A, Montgomery R, Segev D. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death. Am J Transplant. 2009;9:286-93 pubmed publisher..31, p = 0.007), DCD allografts (OR 1.63, p = 0.09) and donors over 70 years (OR 1.67, p = 0.081). These results suggest that the increasing use of HTK for abdominal organ preservation should be reexamined. ..
- Lu L, Seidel C, Iwase T, Stevens R, Gong Y, Wang X, et al. Suppression of GLUT1; a new strategy to prevent diabetic complications. J Cell Physiol. 2013;228:251-7 pubmed publisher..These data identify GLUT1 as a promising therapeutic target for prevention of diabetic retinopathy. ..
- Morris J, Wang Z, Drew M, Englund P. Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library. EMBO J. 2002;21:4429-38 pubmed..These data suggest that T.brucei 'senses' changes in glucose level and modulates procyclin expression accordingly. ..
- Yang P, Shen W, Reece E, Chen X, Yang P. High glucose suppresses embryonic stem cell differentiation into neural lineage cells. Biochem Biophys Res Commun. 2016;472:306-12 pubmed publisher..The low glucose adapted and high glucose responsive GR-E14Â cell line is a useful inÂ vitro model for assessing the adverse effect of high glucose on the development of the central nervous system. ..
- Xu J, Fan J, Wang X, Eacker S, Kam T, Chen L, et al. Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med. 2016;8:333ra48 pubmed publisher..This culture system provides a new platform for the study of human cortical neurotoxicity and suggests that PARP inhibitors may be useful for ameliorating excitotoxic and ischemic cell death in human neurons. ..
- Napora J, Short R, Muller D, Carlson O, Odetunde J, Xu X, et al. High-dose isoflavones do not improve metabolic and inflammatory parameters in androgen-deprived men with prostate cancer. J Androl. 2011;32:40-8 pubmed publisher..We found that high-dose isoflavones over a course of 12 weeks do not improve metabolic or inflammatory parameters in androgen-deprived men. ..
- Cascella N, Tarazi F, Shirakawa O, Tamminga C. Savoxepine fails to selectively influence glucose metabolism in the rat limbic system. Psychopharmacology (Berl). 1994;114:275-80 pubmed..Our findings demonstrate the difficulty of designing a neuroleptic with a preferential blockade of limbic DA receptors and point to the need for functional assessment of regional receptor binding differences. ..
- Ahmad A, Yun Y, Ahmad M, Maruyama T, DORE S. Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation. Neurotox Res. 2008;14:343-51 pubmed..These findings support the notion that the EP1receptor propagates neurotoxicity and that selective blockade could be considered as a potential preventive and/or therapeutic tool against ischemic/hypoxic neurological conditions. ..
- Stewart Z, Lonze B, Warren D, Dagher N, Singer A, Montgomery R, et al. Histidine-tryptophan-ketoglutarate (HTK) is associated with reduced graft survival of deceased donor kidney transplants. Am J Transplant. 2009;9:1048-54 pubmed publisher..18, p = 0.5). Given recent studies that also demonstrate that HTK preservation reduces liver and pancreas allograft survival, we suggest that the use of HTK for abdominal organ recovery should be reconsidered. ..
- Tang S, Arumugam T, Cutler R, Jo D, Magnus T, Chan S, et al. Neuroprotective actions of a histidine analogue in models of ischemic stroke. J Neurochem. 2007;101:729-36 pubmed..These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions. ..
- Kim J, Dang C. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 2006;66:8927-30 pubmed..Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy. ..
- Housley M, Rodgers J, Udeshi N, Kelly T, Shabanowitz J, Hunt D, et al. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008;283:16283-92 pubmed publisher..GlcNAcylation of FoxO provides a new mechanism for direct nutrient control of transcription to regulate metabolism and stress response through control of FoxO1 activity. ..
- El Sayed M, Brown S, Mupparapu K, Tolosa L. The effect of pH on the glucose response of the glucose-galactose binding protein L255C labeled with Acrylodan. Int J Biol Macromol. 2016;86:282-7 pubmed publisher..Frequency domain lifetime measurements and quenching with KI suggest that at highly acidic conditions both the glucose-free and the glucose-bound protein are in a conformation distinct from those observed at higher pH values. ..
- Le A, Lane A, Hamaker M, Bose S, Gouw A, Barbi J, et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012;15:110-21 pubmed publisher..The essential role of glutamine metabolism in cell survival and proliferation under hypoxia and glucose deficiency makes them susceptible to the glutaminase inhibitor BPTES and hence could be targeted for cancer therapy...
- Zhen G, Kim Y, Li R, Yocum J, Kapoor N, Langer J, et al. PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease. Neurobiol Aging. 2012;33:2215-9 pubmed publisher..Exploring potential therapeutic agent targeting EP1 receptor could potentially benefit treatments for stroke and AD patients. ..
- Dotson C, Zhang L, Xu H, Shin Y, Vigues S, Ott S, et al. Bitter taste receptors influence glucose homeostasis. PLoS ONE. 2008;3:e3974 pubmed publisher..Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease. ..
- Smith G, Workman C, Kramer E, Hermann C, Ginsberg R, Ma Y, et al. The relationship between the acute cerebral metabolic response to citalopram and chronic citalopram treatment outcome. Am J Geriatr Psychiatry. 2011;19:53-63 pubmed
- Smith G, KAHN A, Sacher J, Rusjan P, van Eimeren T, Flint A, et al. Serotonin transporter occupancy and the functional neuroanatomic effects of citalopram in geriatric depression. Am J Geriatr Psychiatry. 2011;19:1016-25 pubmed publisher..The functional neuroanatomic changes associated with selective serotonin reuptake inhibitor (SSRI) treatment have been the focus of positron emission tomography (PET) studies of cerebral glucose metabolism in geriatric depression...
- Lodh S, Hostelley T, Leitch C, O Hare E, Zaghloul N. Differential effects on Î²-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes. Hum Mol Genet. 2016;25:57-68 pubmed publisher..Taken together, these findings implicate discrepant production and maintenance of Î²-cells in the differential susceptibility to diabetes found between these two genetic syndromes. ..
- Yang P, Li X, Xu C, Eckert R, Reece E, Zielke H, et al. Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal. 2013;6:ra74 pubmed publisher..Thus, activation of an ASK1-FoxO3a-TRADD-caspase 8 pathway participates in the development of neural tube defects, which could be prevented by inhibiting intermediates in this cascade. ..
- Borden P, Houtz J, Leach S, Kuruvilla R. Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Rep. 2013;4:287-301 pubmed publisher..This study reveals that islet architecture requires extrinsic inductive cues from neighboring tissues such as sympathetic nerves and suggests that early perturbations in sympathetic innervation might underlie metabolic disorders. ..
- Dailey M, Kim S. Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun. 2012;421:1-3 pubmed publisher..Here we review and discuss a novel role for the hypothalamic IPMK signaling in the control of AMPK and central energy homeostasis...
- Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song W, Sereda S, et al. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011;22:2235-45 pubmed publisher..Consequently, mice lacking Opa1 in beta cells develop hyperglycemia. The data suggest that the function of Opa1 in the maintenance of the electron transport chain is physiologically relevant in beta cells...
- Kim E, Kleman A, Ronnett G. Fatty acid synthase gene regulation in primary hypothalamic neurons. Neurosci Lett. 2007;423:200-4 pubmed..Insulin, glucose and AICAR (an activator of AMP-activated protein kinase) affected changes in hypothalamic FAS mRNA, which may be regulated via the SREBP1c dependent or independent pathway. ..
- Jiao Y, Moon S, Wang X, Ren Q, Montell C. Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 2008;18:1797-801 pubmed publisher..These data suggest that Drosophila sugar receptors function as multimers and that Gr64f is required broadly as a coreceptor for the detection of sugars. ..
- Cha S, Wolfgang M, Tokutake Y, Chohnan S, Lane M. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A. 2008;105:16871-5 pubmed publisher..These findings explain the paradoxical fructose effect on food intake and lend credence to the malonyl-CoA hypothesis. ..
- Kim W, Egan J. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60:470-512 pubmed publisher..The elevated levels of GLP-1 are thought to be the mechanism underlying their blood glucose-lowering effects. ..
- Zhao Z, Yang P, Eckert R, Reece E. Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol. 2009;86:72-7 pubmed publisher..These data suggest that caspase-8 may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway. ..
- McConville P, Lakatta E, Spencer R. Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart. Am J Physiol Endocrinol Metab. 2007;293:E1828-35 pubmed..These findings are consistent with beta(1)-AR-specific PKA-dependent glycogen phosphorylase kinase signaling. ..
- Cai H, Cong W, Ji S, Rothman S, Maudsley S, Martin B. Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. Curr Alzheimer Res. 2012;9:5-17 pubmed..It is likely that in the near future, therapeutics with combinatorial neuroprotective and 'eumetabolic' activities may possess superior efficacies compared to less pluripotent remedies. ..
- Liu D, Chan S, de Souza Pinto N, Slevin J, Wersto R, Zhan M, et al. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med. 2006;8:389-414 pubmed..By shifting energy metabolism to reduce ROS production and cellular reliance on mitochondrial respiration, UCP4 can protect neurons against oxidative stress and calcium overload. ..
- Lee E, Kim W, Tominaga K, Martindale J, Yang X, Subaran S, et al. RNA-binding protein HuD controls insulin translation. Mol Cell. 2012;45:826-35 pubmed publisher..In sum, our results identify HuD as a pivotal regulator of insulin translation in pancreatic Î² cells. ..
- Jang H, Kokrashvili Z, Theodorakis M, Carlson O, Kim B, Zhou J, et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A. 2007;104:15069-74 pubmed..Modulating GLP-1 secretion in gut "taste cells" may provide an important treatment for obesity, diabetes and abnormal gut motility. ..
- Saleem S, Kim Y, Maruyama T, Narumiya S, DORE S. Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia. J Neuroimmunol. 2009;208:87-93 pubmed publisher..The results further support a role for EP3 receptors in contributing to acute ischemic stroke, but EP3 is not likely the sole contributor to the long-term detrimental consequences of PGE(2). ..
- Shim H, Chun Y, Lewis B, Dang C. A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci U S A. 1998;95:1511-6 pubmed..These studies provide insights on the coupling of glucose metabolism and the cell cycle in c-Myc-transformed cells and may in the future be exploited for cancer therapeutics. ..
- Chung J, Zmora N. Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus - the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress. FEBS J. 2008;275:693-704 pubmed publisher..In contrast, the mRNA transcripts encoding two CHHs were differentially regulated: PO-CHH increased, whereas ES-CHH decreased. This result suggests a possible differential regulation of transcription of these CHHs...
- Souza Menezes J, Morales M, Tukaye D, Guggino S, Guggino W. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cell Physiol Biochem. 2007;20:455-64 pubmed..05). Our results suggest that low plasma insulin concentration together with renal function changes observed in KO mice significantly contribute towards the glucose intolerance and documented glycosuria observed in this animal. ..
- Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science. 2009;325:1555-9 pubmed publisher..Together, these data suggest that glucose deprivation can drive the acquisition of KRAS pathway mutations in human tumors. ..
- Keller K, Tan I, Lee Y. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science. 2012;338:1069-72 pubmed publisher..This allosteric regulation may explain how cancer cells coordinate different metabolic pathways to optimize their growth in the nutrient-limited conditions commonly observed in the tumor microenvironment. ..
- ..On balance, the case for fructose being less satiating than glucose or HFCS being less satiating than sucrose is not compelling. ..
- Semenza G. Hypoxia-inducible factor 1 and cancer pathogenesis. IUBMB Life. 2008;60:591-7 pubmed publisher..Proof of principle studies in mouse models suggests that inhibition of HIF-1 activity may have therapeutic effects, especially in combination with other anticancer drugs. ..
- Ryan A, Muller D, Elahi D. Sequential hyperglycemic-euglycemic clamp to assess beta-cell and peripheral tissue: studies in female athletes. J Appl Physiol (1985). 2001;91:872-81 pubmed..We have shown that physical activity improves beta-cell efficiency across the age span in women and ameliorates the effect of age on the decline of peripheral tissue sensitivity to insulin...
- Buscaglia J, Faris J. Unsteady, unfocused, and unable to hear. Am J Med. 2005;118:1215-7 pubmed
- Kaestner K, Christy R, McLenithan J, Braiterman L, Cornelius P, Pekala P, et al. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 1989;86:3150-4 pubmed..This increase in mRNA content correlates closely with the acquisition of insulin-stimulated glucose uptake. We propose that GT2 is an insulin-regulated glucose transporter. ..
- Bi S, Kim Y, Zheng F. Dorsomedial hypothalamic NPY and energy balance control. Neuropeptides. 2012;46:309-14 pubmed publisher..Overall, the recent findings provide clear evidence demonstrating critical roles for DMH NPY in energy balance control, and also imply a potential role for DMH NPY in maintaining glucose homeostasis. ..
- Hernández Ochoa E, Robison P, Contreras M, Shen T, Zhao Z, Schneider M. Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood). 2012;237:1068-83 pubmed..Our results suggest the hypothesis that these changes in skeletal muscle could play a role in the pathophysiology of acute and severe hyperglycemic episodes commonly observed in uncontrolled diabetes. ..
- Vigues S, Dotson C, Munger S. The receptor basis of sweet taste in mammals. Results Probl Cell Differ. 2009;47:187-202 pubmed publisher..In this chapter, we discuss some of the mechanisms underlying the detection of sweeteners by mammals, with a particular focus on the function and role of the T1R2:T1R3 receptor in these processes. ..
- Song W, Seshadri M, Ashraf U, Mdluli T, Mondal P, Keil M, et al. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab. 2011;13:308-19 pubmed publisher..Thus, snapin is a critical node in GSIS regulation and provides a potential therapeutic target to improve β cell function in T2DM. ..
- Semenza G. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev. 2010;20:51-6 pubmed publisher..Many metabolic abnormalities in cancer cells increase HIF-1 activity. As a result, a feed-forward mechanism can be activated that drives HIF-1 activation and may promote tumor progression. ..
- Reddi A, Culotta V. SOD1 integrates signals from oxygen and glucose to repress respiration. Cell. 2013;152:224-35 pubmed publisher..Our data therefore may provide mechanistic insight into how rapidly proliferating cells and many cancers accomplish glucose-mediated repression of respiration in favor of aerobic glycolysis. ..
- DiGirolamo D, Clemens T, Kousteni S. The skeleton as an endocrine organ. Nat Rev Rheumatol. 2012;8:674-83 pubmed publisher..The recognition of bone as a true endocrine organ represents a fertile area for further research and should improve the diagnosis and treatment of metabolic diseases such as osteoporosis and diabetes mellitus...
- Luo W, Semenza G. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab. 2012;23:560-6 pubmed publisher..Given its pleiotropic effects on cancer biology, PKM2 represents an attractive target for cancer therapy. ..
- Hussain M, Porras D, Rowe M, West J, Song W, Schreiber W, et al. Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol. 2006;26:7747-59 pubmed..In these beta cells, however, glucose-stimulated insulin secretion was diminished, resulting from concomitant CREB-CBP-mediated pgc1a gene activation. ..