Experts and Doctors on gibbon ape leukemia virus in Bethesda, Maryland, United States
Locale: Bethesda, Maryland, United States
Topic: gibbon ape leukemia virus
Eglitis M, Schneiderman R, Rice P, Eiden M. Evaluation of retroviral vectors based on the gibbon ape leukemia virus. Gene Ther. 1995;2:486-92 pubmed
..These results suggest that judicious combinations of retroviral genomes and structural components can significantly improve gene transfer into human cells...
Lam J, Reeves M, Cowherd R, Rosenberg S, Hwu P. Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope. Hum Gene Ther. 1996;7:1415-22 pubmed
Jensen T, Sullivan D, Morgan R, Taichman L, Nussenblatt R, Blaese R, et al
. Retrovirus-mediated gene transfer of ornithine-delta-aminotransferase into keratinocytes from gyrate atrophy patients. Hum Gene Ther. 1997;8:2125-32 pubmed
..Ornithine catabolism was maintained at high levels when the transduced patient keratinocytes were differentiated in vitro as a multilayered cutaneous organoid...
Sabatino D, Do B, Pyle L, Seidel N, Girard L, Spratt S, et al
. Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines. Blood Cells Mol Dis. 1997;23:422-33 pubmed
..We conclude that the improved transduction was a direct effect of the increased levels of receptor mRNA and unrelated to changes in the cell cycle status...
Bunnell B, Kluge K, Lee Lin S, Byrne E, Orlic D, Metzger M, et al
. Transplantation of transduced nonhuman primate CD34+ cells using a gibbon ape leukemia virus vector: restricted expression of the gibbon ape leukemia virus receptor to a subset of CD34+ cells. Gene Ther. 1999;6:48-56 pubmed
..Our findings suggest that, in rhesus macaques, PG13-derived retroviral vectors may only be able to transduce a subset of CD34+ cells as only CD34+ Thy-1+ cells express the GaLV receptor...