Experts and Doctors on g protein coupled receptors in Baltimore, Maryland, United States


Locale: Baltimore, Maryland, United States
Topic: g protein coupled receptors

Top Publications

  1. Xu Q, Wang Y, Dabdoub A, Smallwood P, Williams J, Woods C, et al. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell. 2004;116:883-95 pubmed
    ..These data define a Norrin-Fz4 signaling system that plays a central role in vascular development in the eye and ear, and they indicate that ligands unrelated to Wnts can act through Fz receptors. ..
  2. Guan Y, Liu Q, Tang Z, Raja S, Anderson D, Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Proc Natl Acad Sci U S A. 2010;107:15933-8 pubmed publisher
    ..Agonists for these receptors may, therefore, represent a class of antihyperalgesics for treating persistent pain with minimal side effects because of the highly specific expression of their targets. ..
  3. Miller C, Murakami P, Ruczinski I, Ross R, Sinkus M, Sullivan B, et al. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. Schizophr Res. 2009;113:259-67 pubmed publisher
  4. Nelson T, Munger S, Boughter J. Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses. 2003;28:695-704 pubmed
    ..Most strikingly, these results demonstrate that in mice, unlike in humans, PTC and PROP taste sensitivities vary independently, thereby suggesting a subtle functional diversity of bitter-taste mechanisms across mammalian species. ..
  5. Zohar Y, Muñoz Cueto J, Elizur A, Kah O. Neuroendocrinology of reproduction in teleost fish. Gen Comp Endocrinol. 2010;165:438-55 pubmed publisher
  6. Miliaras N, Park J, Wendland B. The function of the endocytic scaffold protein Pan1p depends on multiple domains. Traffic. 2004;5:963-78 pubmed
    ..Collectively, our data support a view of Pan1p as a dimeric/oligomeric scaffold whose functions require both the amino- and carboxy-termini, linked by the central region. ..
  7. Zhang C, Williams E, Guo Y, Lum L, Beachy P. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A. 2004;101:17900-7 pubmed
    ..Our studies confirm and extend previous studies showing a positive effect for cAMP-dependent protein kinase and uncover a positive role for casein kinase 1alpha in Hh pathway activation. ..
  8. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways. ..
  9. Lentschat A, Karahashi H, Michelsen K, Thomas L, Zhang W, Vogel S, et al. Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages. J Immunol. 2005;174:4252-61 pubmed

More Information


  1. Wachira S, Guruswamy B, Uradu L, Hughes Darden C, Denaro F. Activation and endocytic internalization of melanocortin 3 receptor in neuronal cells. Ann N Y Acad Sci. 2007;1096:271-86 pubmed
  2. Jang H, Kokrashvili Z, Theodorakis M, Carlson O, Kim B, Zhou J, et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A. 2007;104:15069-74 pubmed
    ..Modulating GLP-1 secretion in gut "taste cells" may provide an important treatment for obesity, diabetes and abnormal gut motility. ..
  3. Wang Y, Chang H, Nathans J. When whorls collide: the development of hair patterns in frizzled 6 mutant mice. Development. 2010;137:4091-9 pubmed publisher
    ..Physical systems that undergo an analogous ordering of vector components suggest potential mechanisms that might apply to the patterning of hair follicles and related biological structures...
  4. Dotson C, Zhang L, Xu H, Shin Y, Vigues S, Ott S, et al. Bitter taste receptors influence glucose homeostasis. PLoS ONE. 2008;3:e3974 pubmed publisher
    ..Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease. ..
  5. Dann C, Hsieh J, Rattner A, Sharma D, Nathans J, Leahy D. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature. 2001;412:86-90 pubmed
    ..This work provides a framework for studies of homologous CRDs in proteins including muscle-specific kinase and Smoothened, a component of the Hedgehog signalling pathway. ..
  6. Sicklick J, Li Y, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, et al. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis. 2006;27:748-57 pubmed
  7. Chen J, Taipale J, Young K, Maiti T, Beachy P. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002;99:14071-6 pubmed
    ..The mechanistic differences between the Smo antagonists may be useful in the therapeutic manipulation of Hh signaling...
  8. Brett C, Tukaye D, Mukherjee S, Rao R. The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking. Mol Biol Cell. 2005;16:1396-405 pubmed
    ..This presents the newly defined family of eukaryotic endosomal NHE as novel targets for pharmacological inhibition to alleviate pathological states associated with organellar alkalinization. ..
  9. Dixit V, Weeraratna A, Yang H, Bertak D, Cooper Jenkins A, Riggins G, et al. Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. J Biol Chem. 2006;281:16681-90 pubmed
    ..Together, these findings suggest a novel role for the ghrelin/GHS-R axis in astrocytoma cell migration and invasiveness of cancers of central nervous system origin. ..
  10. Calabresi P, Yun S, Allie R, Whartenby K. Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells. J Neuroimmunol. 2002;127:96-105 pubmed
    ..CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS). ..
  11. Yu H, Smallwood P, Wang Y, Vidaltamayo R, Reed R, Nathans J. Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development. 2010;137:3707-17 pubmed publisher
    ..These observations indicate that frizzled signaling is involved in diverse tissue closure processes, defects in which account for some of the most common congenital anomalies in humans...
  12. Liu Q, Tang Z, Surdenikova L, Kim S, Patel K, Kim A, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009;139:1353-65 pubmed publisher
    ..Therefore, Mrgprs may provide molecular access to itch-selective neurons and constitute novel targets for itch therapeutics. ..
  13. Ye X, Wang Y, Cahill H, Yu M, Badea T, Smallwood P, et al. Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009;139:285-98 pubmed publisher
  14. Alcendor D, Zong J, Dolan A, Gatherer D, Davison A, Hayward G. Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes. Virology. 2009;395:21-32 pubmed publisher
    ..Both clusters appear to have evolved via complex duplication and deletion events. ..
  15. Lum L, Zhang C, Oh S, Mann R, von Kessler D, Taipale J, et al. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell. 2003;12:1261-74 pubmed
    ..Positive response of Cos2 to Hh stimulation requires a portion of the Smo cytoplasmic tail and the Cos2 cargo domain, which interacts directly with Smo. ..
  16. Vigues S, Dotson C, Munger S. The receptor basis of sweet taste in mammals. Results Probl Cell Differ. 2009;47:187-202 pubmed publisher
    ..In this chapter, we discuss some of the mechanisms underlying the detection of sweeteners by mammals, with a particular focus on the function and role of the T1R2:T1R3 receptor in these processes. ..
  17. Miller C, Dulay J. The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia. Brain Res Bull. 2008;77:33-41 pubmed publisher
    ..These results are consistent with the blunted niacin flush response reported for individuals with schizophrenia and may be relevant to different rates of comorbid disease. ..
  18. Nyan D, Anbazhagan R, Hughes Darden C, Wachira S. Endosomal colocalization of melanocortin-3 receptor and beta-arrestins in CAD cells with altered modification of AKT/PKB. Neuropeptides. 2008;42:355-66 pubmed publisher
    ..These studies suggest that the AKT/PKB pathway plays an important role in the proliferation of CAD cells and suggest a link between MC3R and cell growth pathways that may involve the alteration of AKT/PKB signaling pathway. ..
  19. Morrell C, Sun H, Ikeda M, Beique J, Swaim A, Mason E, et al. Glutamate mediates platelet activation through the AMPA receptor. J Exp Med. 2008;205:575-84 pubmed publisher
    ..Importantly, mice lacking GluR1 have a prolonged time to thrombosis in vivo. Our data identify glutamate as a regulator of platelet activation, and suggest that the AMPA receptor is a novel antithrombotic target. ..
  20. Nair S, Golden S, Shaham Y. Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats. Br J Pharmacol. 2008;154:406-16 pubmed publisher
  21. Yu S, Hackmann K, Gao J, Gao J, He X, Piontek K, et al. Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007;104:18688-93 pubmed
    ..Our study establishes a critical but restricted role of cleavage for PC1 function and suggests a differential function of the two types of PC1 molecules in vivo. ..
  22. Guo N, Hawkins C, Nathans J. Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A. 2004;101:9277-81 pubmed
    ..These data imply that hair patterning in mammals uses a Fz-dependent tissue polarity system similar to the one that patterns the Drosophila cuticle. ..
  23. Duggal P, An P, Beaty T, Strathdee S, Farzadegan H, Markham R, et al. Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. Genes Immun. 2003;4:245-50 pubmed
    ..We suggest that CXCR6 may play a role in late-stage HIV-1 infection and may alter the progression to death after initial infection with PCP. ..
  24. Dotson C, Shaw H, Mitchell B, Munger S, Steinle N. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. Appetite. 2010;54:93-9 pubmed publisher
    ..Therefore, our results indicate that a polymorphism in TAS2R38 is associated with differences in ingestive behavior. ..
  25. Mulligan T, Blaser H, Raz E, Farber S. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Cell Signal. 2010;22:221-33 pubmed publisher
  26. Lum L, Beachy P. The Hedgehog response network: sensors, switches, and routers. Science. 2004;304:1755-9 pubmed
  27. Zhu W, Chakir K, Zhang S, Yang D, Lavoie C, Bouvier M, et al. Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility. Circ Res. 2005;97:244-51 pubmed
  28. Nie Y, Hobbs J, Vigues S, Olson W, Conn G, Munger S. Expression and purification of functional ligand-binding domains of T1R3 taste receptors. Chem Senses. 2006;31:505-13 pubmed
    ..This methodology should not only facilitate the characterization of T1R ligand interactions but may also be useful for dissecting the function of other class C GPCRs such as the large family of orphan V2R vomeronasal receptors. ..
  29. Liu C, Nathans J. An essential role for frizzled 5 in mammalian ocular development. Development. 2008;135:3567-76 pubmed publisher
    ..These results demonstrate a central role for frizzled signaling in mammalian eye development and are likely to be relevant to the etiology of congenital human ocular anomalies. ..
  30. Lee M, Dong X, Liu Q, Patel K, Choi O, Vonakis B, et al. Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. J Immunol. 2008;180:2251-5 pubmed
    ..These data support the hypothesis that agonists of certain sensory nerve specific receptors or mas related genes may participate in mast cell sensory nerve interactions. ..
  31. Wang Y, Badea T, Nathans J. Order from disorder: Self-organization in mammalian hair patterning. Proc Natl Acad Sci U S A. 2006;103:19800-5 pubmed
    ..These experiments define two systems for hair orientation: a global orienting system that acts early in development and is Fz6-dependent, and a local self-organizing system that acts later and is Fz6 independent. ..