Genomes and Genes
Experts and Doctors on dna in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Publications262 found, 100 shown here
- Chernak J. Structural features of the 5' upstream regulatory region of the gene encoding rat amyloid precursor protein. Gene. 1993;133:255-60 pubmed..On the other hand, the rat sequence is missing four potential SP1 sites, four potential AP2 sites, and nine potential GC boxes which are found in the human sequence.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Zhang N, Chen H, Koch V, Schmitz H, Liao C, Bretner M, et al. Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus. J Med Chem. 2003;46:4149-64 pubmed
- Fan J, Matsumoto Y, Wilson D. Nucleotide sequence and DNA secondary structure, as well as replication protein A, modulate the single-stranded abasic endonuclease activity of APE1. J Biol Chem. 2006;281:3889-98 pubmed..The data herein suggested a model whereby RPA selectively suppresses the nontemplated ss cleavage activity of Ape1 in vivo, particularly at sites of ongoing replication/recombination, by coating the ssDNA. ..
- Park J, Cai J, McIntosh I, Jabs E, Fallin M, Ingersoll R, et al. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. J Med Genet. 2006;43:598-608 pubmed..Many of the genes reported here have not been previously studied as candidates for oral clefts and warrant further investigation. ..
- Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell. 2008;14:388-98 pubmed publisher..Our results uncover a heretofore missing link in the Hpo signaling pathway and provide a glimpse of the molecular events on a Hpo-responsive enhancer element. ..
- Maiti A, Morgan M, Pozharski E, Drohat A. Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition. Proc Natl Acad Sci U S A. 2008;105:8890-5 pubmed publisher..We find striking differences between hTDG and its prokaryotic ortholog (MUG), despite the relatively high (32%) sequence identity. ..
- Xu D, Muniandy P, Leo E, Yin J, Thangavel S, Shen X, et al. Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J. 2010;29:3140-55 pubmed publisher..Our data suggest that Rif1 provides a new DNA-binding interface for the BLM complex to restart stalled replication forks. ..
- Tse C, Ma A, Yang V, Watson A, Levine S, Montrose M, et al. Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. EMBO J. 1991;10:1957-67 pubmed..The near identity of the basolateral Na+/H+ exchanger and the human Na+/H+ exchanger plus the ubiquitous expression of this message suggests that the ileal basolateral Na+/H+ exchanger is the 'housekeeping' Na+/H+ exchanger. ..
- Nijbroek G, Sood S, McIntosh I, Francomano C, Bull E, Pereira L, et al. Fifteen novel FBN1 mutations causing Marfan syndrome detected by heteroduplex analysis of genomic amplicons. Am J Hum Genet. 1995;57:8-21 pubmed
- Takenaka M, Bagnasco S, Preston A, Uchida S, Yamauchi A, Kwon H, et al. The canine betaine gamma-amino-n-butyric acid transporter gene: diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner. Proc Natl Acad Sci U S A. 1995;92:1072-6 pubmed..Diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner. ..
- Surratt C, Persico A, Yang X, Edgar S, Bird G, Hawkins A, et al. A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs. FEBS Lett. 1993;318:325-30 pubmed..The cDNA, and a subclone, recognize TaqI polymorphisms that may prove useful to assess this gene's involvement in neuropsychiatric disorders involving monoaminergic brain systems. ..
- Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown J, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998;282:1497-501 pubmed..Thus, p53 and p21 appear to be essential for maintaining the G2 checkpoint in human cells. ..
- Mu W, Burt D. The mouse GABA(A) receptor alpha3 subunit gene and promoter. Brain Res Mol Brain Res. 1999;73:172-80 pubmed..Upstream GA repeats enhanced activity of the SV40 promoter, and the GA repeat sequence bound nuclear proteins from several tissues. ..
- Harmer T, Wu M, Schleif R. The role of rigidity in DNA looping-unlooping by AraC. Proc Natl Acad Sci U S A. 2001;98:427-31 pubmed..These results are consistent with the light switch mechanism for the action of AraC, refine the model, and extend the range of experimental tests to which it has been subjected. ..
- Gonzalgo M, Pavlovich C, Lee S, Nelson W. Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens. Clin Cancer Res. 2003;9:2673-7 pubmed..This molecular assay has potential application for stratification of patients into low- and high-risk groups for surveillance versus repeat biopsy. ..
- Wilson D. Properties of and substrate determinants for the exonuclease activity of human apurinic endonuclease Ape1. J Mol Biol. 2003;330:1027-37 pubmed..However, Ape1 was able to excise double nucleotide mispairs, apparently through a novel 3'-flap-type endonuclease activity, again activating these substrates for polymerase beta extension. ..
- Downey A, Graczyk T, Sullivan D. In vitro activity of pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis using radiolabelled thymidine incorporation and an SYBR Green I-based fluorescence assay. J Antimicrob Chemother. 2009;64:751-4 pubmed publisher..Pyrvinium is a potential gut lumen agent for treatment of intestinal amoebiasis, but possibly not for giardiasis. SYBR Green I is an alternative screening method for E. histolytica, but not G. intestinalis. ..
- Newman C, Resendiz M, Sczepanski J, Greenberg M. Photochemical generation and reactivity of the 5,6-dihydrouridin-6-yl radical. J Org Chem. 2009;74:7007-12 pubmed publisher..Overall, tert-butyl ketone 2b is a clean source of 5'-benzoyl-5,6-dihydrouridin-6-yl (1b) and should prove useful for studying the reactivity of the respective radical in RNA. ..
- Qiu Y, Levendosky R, Chakravarthy S, Patel A, Bowman G, Myong S. The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer. Mol Cell. 2017;68:76-88.e6 pubmed publisher..We propose that active interplay of the ATPase motor with the regulatory domains may promote dynamic nucleosome structures uniquely suited for histone exchange and chromatin reorganization during transcription. ..
- Kitayama S, Shimada S, Xu H, Markham L, Donovan D, Uhl G. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc Natl Acad Sci U S A. 1992;89:7782-5 pubmed
- Danoff S, Ferris C, Donath C, Fischer G, Munemitsu S, Ullrich A, et al. Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation. Proc Natl Acad Sci U S A. 1991;88:2951-5 pubmed..The phosphorylation kinetics by cAMP-dependent protein kinase and the phosphopeptide maps differ for inositol 1,4,5-trisphosphate receptors purified from tissues predominantly expressing different forms of the transcript. ..
- Higuchi M, Kazazian H, Kasch L, Warren T, McGinniss M, Phillips J, et al. Molecular characterization of severe hemophilia A suggests that about half the mutations are not within the coding regions and splice junctions of the factor VIII gene. Proc Natl Acad Sci U S A. 1991;88:7405-9 pubmed
- Kinzler K, Ruppert J, Bigner S, Vogelstein B. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature. 1988;332:371-4 pubmed..The link between the developmentally important Kruppel family of genes and GLI is interesting considering the similarities between developing embryonic and neoplastic tissue. ..
- Murphy D, Wallis K, Machlin P, Ratrie H, Cleveland D. The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. J Biol Chem. 1987;262:14305-12 pubmed..Interestingly, c beta 6-tubulin exhibits 18% amino acid sequence divergence relative to MB1, the analogous hematopoietic beta-tubulin contained in mouse. ..
- Spradling A. ORC binding, gene amplification, and the nature of metazoan replication origins. Genes Dev. 1999;13:2619-23 pubmed
- Tang Q, Zhang J, Daniel Lane M. Sequential gene promoter interactions of C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis. Biochem Biophys Res Commun. 2004;319:235-9 pubmed..g., 422/aP2) in the terminally differentiated state. Together these findings provide compelling evidence that C/EBPbeta, C/EBPalpha, and PPARgamma participate in a cascade during adipogenesis. ..
- Roy S, Hu J, Meng Q, Hu J, Reddy S, Kalvakolanu D. Development of monoclonal antibodies against GBF1 and their use in studying its functions. J Interferon Cytokine Res. 2005;25:666-73 pubmed..Furthermore, other cytokines, such as interleukin-1 (IL-1) and IL-6, induced the expression of GBF1. These antibodies may be useful tools for investigating the role of GBF1 in cytokine-induced responses. ..
- Yegnasubramanian S, Lin X, Haffner M, DeMarzo A, Nelson W. Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation. Nucleic Acids Res. 2006;34:e19 pubmed..This novel technology could significantly improve our ability to detect CGI hypermethylation. ..
- Gupta R, Sharma S, Doherty K, Sommers J, Cantor S, Brosh R. Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res. 2006;34:6673-83 pubmed..Alternatively, increasing the length of the 5' tail of the DNA substrate allowed BACH1 to overcome the backbone discontinuity, suggesting that BACH1 loading mechanism is critical for its ability to unwind damaged DNA molecules. ..
- Harrigan J, Fan J, Momand J, Perrino F, Bohr V, Wilson D. WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. Mech Ageing Dev. 2007;128:259-66 pubmed
- Okulate M, Kalume D, Reddy R, Kristiansen T, Bhattacharyya M, Chaerkady R, et al. Identification and molecular characterization of a novel protein Saglin as a target of monoclonal antibodies affecting salivary gland infectivity of Plasmodium sporozoites. Insect Mol Biol. 2007;16:711-22 pubmed..If Saglin is indeed involved in the process of invasion of A. gambiae salivary glands by sporozoites of Plasmodium, it could provide a novel target for future investigations aimed at interruption of malaria transmission...
- San Pedro J, Beerman T, Greenberg M. DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases. Bioorg Med Chem. 2012;20:4744-50 pubmed publisher..In addition, analysis of the chemical stability of ICLs suggests that they result from reaction with the deoxyribose ring on one strand but direct addition to a nucleobase on the opposite strand. ..
- Ekker S, von Kessler D, Beachy P. Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J. 1992;11:4059-72 pubmed..Such differences in DNA sequence recognition and target activation provide a biochemical basis for at least part of the biological specificity of homeotic gene action. ..
- Shen R, Zhang L, Baek S, Tai H, Lee K. The porcine thromboxane synthase-encoding cDNA: sequence, mRNA expression and enzyme production in Sf9 insect cells. Gene. 1994;140:261-5 pubmed..TS activity was detectable in the microsomes of Sf9 cells 12-h post-infection and reached maximum by 48 h. The produced TS resembles purified pTS in catalysis, as well as inhibition by a substrate analog inhibitor. ..
- Dianov G, Bischoff C, Sunesen M, Bohr V. Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res. 1999;27:1365-8 pubmed..We suggest that the CSB mutation leads to deficient transcription of the hOGG1 gene and thus to deficient repair of 8-oxoguanine in DNA...
- Tang Q, Lane M. Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis. Proc Natl Acad Sci U S A. 2000;97:12446-50 pubmed..In support of these findings, up-regulation of CHOP-10 with the protease inhibitor N-acetyl-Leu-Leu-norleucinal prevents activation of C/EBPbeta, expression of C/EBPalpha, and adipogenesis. ..
- Zeng X, Negrete G, Kasmer C, Yang W, Gearhart P. Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med. 2004;199:917-24 pubmed..This data shows for the first time that C is preferentially mutated in vivo and pol eta generates hypermutation in the mu and gamma switch regions. ..
- Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J Biol Chem. 2006;281:7118-28 pubmed
- Cai D, Wang D, Keefer J, Yeamans C, Hensley K, Friedman A. C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1. Oncogene. 2008;27:2772-9 pubmed..C/EBPalpha:cJun binds and activates the endogenous PU.1 promoter, providing one mechanism for induction of monopoiesis by this complex. ..
- Friedman J, Majumdar A, Stivers J. Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage. Nucleic Acids Res. 2009;37:3493-500 pubmed publisher..These results suggest that DNA structure and the spontaneous dynamics of base pairs may drive the evolution of a protein sequence that is tuned to respond to this dynamic regime. ..
- Kusumoto Matsuo R, Opresko P, Ramsden D, Tahara H, Bohr V. Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops. Aging (Albany NY). 2010;2:274-84 pubmed..These results suggest that WRN and DNA-PKcs may cooperatively prevent G-tail shortening in vivo. ..
- Tzeng S, Yang P, Grayson W, Green J. Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells. Int J Nanomedicine. 2011;6:3309-22 pubmed publisher..PEAs and PAAs can be separated into groups that form polymeric nanoparticles effective for siRNA delivery, for DNA delivery, or for both. ..
- Tsao W, Jeong Y, Lin S, Ling J, Price D, Chiang P, et al. Rodent models of TDP-43: recent advances. Brain Res. 2012;1462:26-39 pubmed publisher..This article is part of a Special Issue entitled RNA-Binding Proteins. ..
- Mulepati S, Orr A, Bailey S. Crystal structure of the largest subunit of a bacterial RNA-guided immune complex and its role in DNA target binding. J Biol Chem. 2012;287:22445-9 pubmed publisher..Finally, DNA binding experiments show that CasA is essential for binding of Cascade to DNA target. ..
- Berquist B, Canugovi C, Sykora P, Wilson D, Bohr V. Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation. Nucleic Acids Res. 2012;40:8392-405 pubmed..These observations provide strong evidence for the importance of CSB in maintaining mitochondrial function and argue that the pathologies associated with CS are in part, a direct result of the roles that CSB plays in mitochondria. ..
- Ye Y, Stahley M, Xu J, Friedman J, Sun Y, McKnight J, et al. Enzymatic excision of uracil residues in nucleosomes depends on the local DNA structure and dynamics. Biochemistry. 2012;51:6028-38 pubmed..We present structural models and plausible reaction mechanisms for the reaction of UNG at three distinct uracil sites in the NCP. ..
- Ferrarelli L, Popuri V, Ghosh A, Tadokoro T, Canugovi C, Hsu J, et al. The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. DNA Repair (Amst). 2013;12:518-28 pubmed publisher..RECQL4's function at the telomere is not yet understood, and our findings suggest a novel role for RECQL4 in the repair of thymine glycol lesions to promote efficient telomeric maintenance. ..
- Weitz C, Miyake Y, Shinzato K, Montag E, Zrenner E, Went L, et al. Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin. Am J Hum Genet. 1992;50:498-507 pubmed..These results complete the genetic evidence for the trichromatic theory of human color vision. ..
- Christy B, Sanders L, Lau L, Copeland N, Jenkins N, Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991;88:1815-9 pubmed..On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development. ..
- Kaestner K, Christy R, McLenithan J, Braiterman L, Cornelius P, Pekala P, et al. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 1989;86:3150-4 pubmed..This increase in mRNA content correlates closely with the acquisition of insulin-stimulated glucose uptake. We propose that GT2 is an insulin-regulated glucose transporter. ..
- Paschen W, Hedreen J, Ross C. RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. J Neurochem. 1994;63:1596-602 pubmed..abstract truncated at 250 words) ..
- Soisson S, MacDougall Shackleton B, Schleif R, Wolberger C. Structural basis for ligand-regulated oligomerization of AraC. Science. 1997;276:421-5 pubmed..The ligand-gated oligomerization as seen in AraC provides the basis of a plausible mechanism for modulating the protein's DNA-looping properties. ..
- Aurelian L, Smith C, Winchurch R, Kulka M, Gyotoku T, Zaccaro L, et al. A novel gene expressed in human keratinocytes with long-term in vitro growth potential is required for cell growth. J Invest Dermatol. 2001;116:286-95 pubmed..Antisense oligonucleotides that inhibit H11 expression inhibit DNA synthesis and keratinocyte proliferation, suggesting that H11 expression is required for cell growth. ..
- Choudhary S, Sommers J, Brosh R. Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein. J Biol Chem. 2004;279:34603-13 pubmed..These are the first reported kinetic parameters of a human RecQ unwinding reaction based on real time measurements, and they provide mechanistic insights into WRN-catalyzed DNA unwinding. ..
- Chong R, Oswald L, Yang X, Uhart M, Lin P, Wand G. The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress. Neuropsychopharmacology. 2006;31:204-11 pubmed..We speculate that increased opioid avidity of the minor allele receptor contributes to the differential response to naloxone vs stress. ..
- Bowman K, Sarkar R, Raut S, Leong K. Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles. J Control Release. 2008;132:252-9 pubmed publisher..While further optimization would be required to render this type of delivery system practical for hemophilia A gene therapy, the findings suggest the feasibility of oral, non-viral delivery for gene medicine applications. ..
- Suyama T, Shiraishi T, Zeng Y, Yu W, Parekh N, Vessella R, et al. Expression of cancer/testis antigens in prostate cancer is associated with disease progression. Prostate. 2010;70:1778-87 pubmed publisher..The data also suggest that the CT-X antigens may be novel therapeutic targets for CRPC for which there are currently no effective therapeutics. ..
- Aryee M, Wu Z, Ladd Acosta C, Herb B, Feinberg A, Yegnasubramanian S, et al. Accurate genome-scale percentage DNA methylation estimates from microarray data. Biostatistics. 2011;12:197-210 pubmed publisher..We illustrate the method on data generated to detect methylation differences between tissues and between normal and tumor colon samples. ..
- Sczepanski J, Wong R, McKnight J, Bowman G, Greenberg M. Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle. Proc Natl Acad Sci U S A. 2010;107:22475-80 pubmed publisher..These results show that AP sites within the nucleosome produce significant amounts of DNA-protein cross-links and generate double strand breaks, the most deleterious form of DNA damage. ..
- Uhl G, Kitayama S, Gregor P, Nanthakumar E, Persico A, Shimada S. Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations. Brain Res Mol Brain Res. 1992;16:353-9 pubmed
- Ross C, Danoff S, Schell M, Snyder S, Ullrich A. Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues. Proc Natl Acad Sci U S A. 1992;89:4265-9 pubmed..Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting heterogeneity of IP3 action within a single cell. ..
- Moshier J, Deutch A, Huang R. Structure and in vitro transcription of a mouse B1 cluster containing a unique B1 dimer. Gene. 1987;58:19-27 pubmed..We conclude that this B1 dimer is unlikely to give rise to a new dimeric retroposon family in the mouse genome. ..
- Dietz H, Valle D, Francomano C, Kendzior R, Pyeritz R, Cutting G. The skipping of constitutive exons in vivo induced by nonsense mutations. Science. 1993;259:680-3 pubmed..All genomic DNA sequences flanking these exons that are known to influence RNA splicing were unaltered, which suggests that nonsense mutations can alter splice site selection in vivo. ..
- Farber J. HuMig: a new human member of the chemokine family of cytokines. Biochem Biophys Res Commun. 1993;192:223-30 pubmed..Analysis of mouse and human genomic DNAs suggested that the Mumig and Humig genes are true mouse-human homologues. The Humig mRNA encodes a predicted secreted HuMig protein of 103 residues, M(r) 11,725. ..
- Draganescu A, Tullius T. The DNA binding specificity of engrailed homeodomain. J Mol Biol. 1998;276:529-36 pubmed..Our results underscore the utility of chemical probe experiments for defining the variety of modes of interaction of proteins with DNA that can occur in solution, but that might not be apparent in a crystal structure. ..
- Karmakar P, Snowden C, Ramsden D, Bohr V. Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res. 2002;30:3583-91 pubmed..The strong interaction between Ku and WRN suggests that these two proteins function together in one or more pathways of DNA metabolism. ..
- Cleaves R, Wang Q, Friedman A. C/EBPalphap30, a myeloid leukemia oncoprotein, limits G-CSF receptor expression but not terminal granulopoiesis via site-selective inhibition of C/EBP DNA binding. Oncogene. 2004;23:716-25 pubmed..Variation in affinity for selected cis elements among isoforms may affect the biology of basic region-leucine zipper (bZIP) proteins. ..
- Dohm J, Hsu M, Hwu J, Huang R, Moudrianakis E, Lattman E, et al. Influence of ions, hydration, and the transcriptional inhibitor P4N on the conformations of the Sp1 binding site. J Mol Biol. 2005;349:731-44 pubmed..Although P4N was not visualized unambiguously in the electron density maps, the effect of the drug is evident from significant differences in the lattice constants, crystal packing, and overall conformation of the structure. ..
- To C, Petri M. Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus?. Arthritis Rheum. 2005;52:4003-10 pubmed..9%) was also more common in cluster 3 than in cluster 2. Autoantibody clustering is a valuable tool to differentiate between various subsets of SLE, allowing prediction of subsequent clinical course and organ damage. ..
- Hill J, Evans M. Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucleic Acids Res. 2006;34:1620-32 pubmed..The altered substrate specificity, lack of stimulation by AP-endonuclease 1 (APE1) and anomalous DNA binding conformation of S326C OGG1 may contribute to its linkage to cancer incidence. ..
- Vijayakumar S, Chapados B, Schmidt K, Kolodner R, Tainer J, Tomkinson A. The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res. 2007;35:1624-37 pubmed
- Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson G, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008;68:3169-77 pubmed publisher..Thus, these novel human DNA ligase inhibitors will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents. ..
- Omwancha J, Anway M, Brown T. Differential age-associated regulation of clusterin expression in prostate lobes of brown Norway rats. Prostate. 2009;69:115-25 pubmed publisher..Regulation of clusterin expression in the prostate lobes of aging rats appears complex and is neither directly repressed by androgen nor dependent on apoptotic-induced stress. ..
- Tulapurkar M, Asiegbu B, Singh I, Hasday J. Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells. Cell Stress Chaperones. 2009;14:499-508 pubmed publisher..Instead, HSF-1-mediated HSP expression following hyperthermia and heat shock appears to be mediated, in addition to HSF-1 activation, by posttranslational modifications of HSF-1 protein. ..
- Garcia Garcia J, Rennoll Bankert K, Pelly S, Milstone A, Dumler J. Silencing of host cell CYBB gene expression by the nuclear effector AnkA of the intracellular pathogen Anaplasma phagocytophilum. Infect Immun. 2009;77:2385-91 pubmed publisher..These data suggest a mechanism by which intracellular pathogens directly regulate host cell gene expression mediated by nuclear effectors and changes in host chromatin structure. ..
- Liu K, Brock M, Shih I, Wang T. Decoding circulating nucleic acids in human serum using microfluidic single molecule spectroscopy. J Am Chem Soc. 2010;132:5793-8 pubmed publisher..This demonstrates that microfluidic single molecule spectroscopy can be a rapid, facile, and inexpensive alternative to the established PCR-based methods that have been used near exclusively for CNA analysis. ..
- Zink C, Soissons N, Fishbein J. Products of the direct reaction of the diazonium ion of a metabolite of the carcinogen N-nitrosomorpholine with purines of nucleosides and DNA. Chem Res Toxicol. 2010;23:1223-33 pubmed publisher..In part or whole, this may be due to methodological differences in the conduct of the present and previous reports...
- West A, Evans S, Gonzalez J, Carter L, Tsuruta H, Pozharski E, et al. Ni(II) coordination to mixed sites modulates DNA binding of HpNikR via a long-range effect. Proc Natl Acad Sci U S A. 2012;109:5633-8 pubmed publisher..A model of DNA recognition by HpNikR is proposed in which Ni(II) coordination to specific sites in the MBD have a long-range effect on the flexibility of the DNA-binding domains and, consequently, the DNA recognition properties. ..
- Massanyi E, Gearhart J, KOLP L, Migeon C. Novel mutation among two sisters with 17? hydroxysteroid dehydrogenase type 3 deficiency. Urology. 2013;81:1069-71 pubmed publisher..Confirmatory diagnosis through gene sequencing identified a heterozygous mutation for both a known splicing mutation and a previously unreported amplification mutation of the HSD17B3 gene. ..
- Buckbinder L, Brown D. Expression of the Xenopus laevis prolactin and thyrotropin genes during metamorphosis. Proc Natl Acad Sci U S A. 1993;90:3820-4 pubmed..This increase in TH in turn depends upon the lack of a traditional thyroid-pituitary negative-feedback loop throughout prometamorphosis. ..
- Corin S, Juhasz O, Zhu L, Conley P, Kedes L, Wade R. Structure and expression of the human slow twitch skeletal muscle troponin I gene. J Biol Chem. 1994;269:10651-9 pubmed..A muscle-specific enhancer regulated slow troponin I promoter activity. ..
- Ball D, Azzoli C, Baylin S, Chi D, Dou S, Donis Keller H, et al. Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proc Natl Acad Sci U S A. 1993;90:5648-52 pubmed..Expression of hASH1 may provide a useful marker for cancers with neuroendocrine features and may contribute to the differentiation and growth regulation of these cells. ..
- Lijam N, Sussman D. Organization and promoter analysis of the mouse dishevelled-1 gene. Genome Res. 1995;5:116-24 pubmed..Multiple transcription initiation sites were mapped by primer extension analysis and confirmed by reporter gene assay. ..
- Zhang J, Yang J, Roy S, Tininini S, Hu J, Bromberg J, et al. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A. 2003;100:9342-7 pubmed..Because constitutively active STAT3 up-regulates antiapoptotic genes to promote tumor survival, its inhibition by GRIM-19 also demonstrates an antioncogenic effect exerted by biological therapeutics. ..
- Cheng W, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, et al. WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Mol Biol Cell. 2008;19:3923-33 pubmed publisher..These results suggest that WRN and ATM participate in a replication checkpoint response, in which WRN facilitates ATM activation in cells with psoralen DNA cross-link-induced collapsed replication forks. ..
- Rossi M, Ghosh A, Kulikowicz T, Croteau D, Bohr V. Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst). 2010;9:796-804 pubmed publisher..Together, these data indicate that specific biochemical activities and protein partners of RecQ4 are conserved with those of the other RecQ helicases. ..
- Harduin Lepers A, Shaper N, Mahoney J, Shaper J. Murine beta 1,4-galactosyltransferase: round spermatid transcripts are characterized by an extended 5'-untranslated region. Glycobiology. 1992;2:361-8 pubmed..1 kb round spermatid beta 1,4-GT transcripts are distinguished by the presence of an additional 5'-untranslated sequence of approximately 560 bp that is absent in premeiotic germ cells and somatic cells.(ABSTRACT TRUNCATED AT 250 WORDS) ..