Experts and Doctors on dna binding proteins in College Park, Maryland, United States


Locale: College Park, Maryland, United States
Topic: dna binding proteins

Top Publications

  1. Xiao Y, Heu S, Yi J, Lu Y, Hutcheson S. Identification of a putative alternate sigma factor and characterization of a multicomponent regulatory cascade controlling the expression of Pseudomonas syringae pv. syringae Pss61 hrp and hrmA genes. J Bacteriol. 1994;176:1025-36 pubmed
    ..The results indicate that hrpRS and hrpL are part of a regulatory cascade in which HrpR and HrpS activate expression of hrpL and HrpL, a putative sigma factor, induces expression of HrpL-responsive genes...
  2. Zhang X, Julin D. Isolation and characterization of the C-terminal nuclease domain from the RecB protein of Escherichia coli. Nucleic Acids Res. 1999;27:4200-7 pubmed
    ..The results show that the Asp-->Ala mutation has not caused a significant structural change in the isolated domain and they support the conclusion that the C-terminal domain of RecB has the sole nuclease active site of RecBCD. ..
  3. Lilja A, Jenssen J, Kahn J. Geometric and dynamic requirements for DNA looping, wrapping and unwrapping in the activation of E.coli glnAp2 transcription by NtrC. J Mol Biol. 2004;342:467-78 pubmed
    ..This dynamic DNA wrapping around the NtrC octamer is proposed to be necessary for efficient activation, and the wrapping may also reduce adventitious activation of other promoters. ..
  4. Muldoon Jacobs K, Dinman J. Specific effects of ribosome-tethered molecular chaperones on programmed -1 ribosomal frameshifting. Eukaryot Cell. 2006;5:762-70 pubmed
    ..Thus, the findings presented here suggest that these trans-acting factors could be used by cells to posttranscriptionally regulate gene expression through -1 PRF. ..
  5. Hardin S, Wolniak S. Molecular cloning and characterization of maize ZmMEK1, a protein kinase with a catalytic domain homologous to mitogen- and stress-activated protein kinase kinases. Planta. 1998;206:577-84 pubmed
    ..ZmMEK1 encodes an enzyme that is structurally and functionally similar to other M/SAPKK proteins. ..
  6. Streaker E, Beckett D. Ligand-linked structural changes in the Escherichia coli biotin repressor: the significance of surface loops for binding and allostery. J Mol Biol. 1999;292:619-32 pubmed
  7. Conner J, Liu Z. LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development. Proc Natl Acad Sci U S A. 2000;97:12902-7 pubmed
    ..Our finding suggests that both animals and plants use similar repressor proteins to regulate critical developmental processes. ..
  8. Bretz J, Losada L, Lisboa K, Hutcheson S. Lon protease functions as a negative regulator of type III protein secretion in Pseudomonas syringae. Mol Microbiol. 2002;45:397-409 pubmed
    ..These results indicate that expression of the hrp regulon and type III secretion are negatively regulated by Lon-mediated degradation of HrpR...
  9. Bretz J, Mock N, Charity J, Zeyad S, Baker C, Hutcheson S. A translocated protein tyrosine phosphatase of Pseudomonas syringae pv. tomato DC3000 modulates plant defence response to infection. Mol Microbiol. 2003;49:389-400 pubmed
    ..The results indicate that HopPtoD2 is a translocated effector with protein tyrosine phosphatase activity that modulates plant defence responses. ..

More Information


  1. Losada L, Hutcheson S. Type III secretion chaperones of Pseudomonas syringae protect effectors from Lon-associated degradation. Mol Microbiol. 2005;55:941-53 pubmed publisher
    ..The results imply that Lon is involved at two distinct levels in the regulation of the P. syringae TTSS: regulation of assembly of the secreton and modulation of effector secretion...
  2. Lucas M, Zhang X, Prasanna V, Mosser D. ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus. J Immunol. 2005;175:469-77 pubmed
    ..The rapid and transient regulation of transcription factor accessibility to the IL-10 promoter by MAPK activation represents a novel way that the production of this cytokine is regulated. ..
  3. Morgan M, Okamoto K, Kahn J, English D. Single-molecule spectroscopic determination of lac repressor-DNA loop conformation. Biophys J. 2005;89:2588-96 pubmed
    ..By using multiple excitation wavelengths and by carefully examining the behavior of the zero-ET peak during titration with LacI, we show that the LacI-9C14 loop exists exclusively in a single closed form exhibiting essentially 100% ET. ..
  4. Williams E, Lowe T, Savas J, DiRuggiero J. Microarray analysis of the hyperthermophilic archaeon Pyrococcus furiosus exposed to gamma irradiation. Extremophiles. 2007;11:19-29 pubmed
    ..Finally, we identified several transcriptional regulators and protein kinases highly regulated in response to gamma irradiation. ..
  5. Pal S, Wu J, Wu L. Microarray analyses reveal distinct roles for Rel proteins in the Drosophila immune response. Dev Comp Immunol. 2008;32:50-60 pubmed
    ..This expression was sufficient to drive expression of some immune genes, suggesting redundancy in the regulation of these genes. Combining this data, we also identified novel genes that may be specific targets of Dif. ..
  6. Haririnia A, Verma R, Purohit N, Twarog M, Deshaies R, Bolon D, et al. Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins. J Mol Biol. 2008;375:979-96 pubmed
    ..These studies emphasize an unexpected role for Ub's core in molecular recognition and suggest that the diversity of protein-protein interactions in which Ub engages placed enormous constraints on its evolvability. ..
  7. Hill R, Haag E. A sensitized genetic background reveals evolution near the terminus of the Caenorhabditis germline sex determination pathway. Evol Dev. 2009;11:333-42 pubmed publisher
    ..These results represent another way in which C. briggsae germline sex determination is incongruent with that of the outwardly similar C. elegans. ..