Experts and Doctors on cytoplasm in Bethesda, Maryland, United States

Summary

Locale: Bethesda, Maryland, United States
Topic: cytoplasm

Top Publications

  1. Satheshkumar P, Moss B. Characterization of a newly identified 35-amino-acid component of the vaccinia virus entry/fusion complex conserved in all chordopoxviruses. J Virol. 2009;83:12822-32 pubmed publisher
    ..In addition, the assembly or stability of the EFC was impaired when expression of O3 was repressed. Thus, O3 is the newest recognized component of the EFC and the smallest VACV protein shown to have a function...
  2. Petrie R, Koo H, Yamada K. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science. 2014;345:1062-5 pubmed publisher
    ..Thus, the nucleus can act as a piston that physically compartmentalizes the cytoplasm and increases the hydrostatic pressure between the nucleus and the leading edge of the cell to drive lamellipodia-independent 3D cell migration. ..
  3. Miyoshi K, Shillingford J, Le Provost F, Gounari F, Bronson R, von Boehmer H, et al. Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A. 2002;99:219-24 pubmed
    ..These data demonstrate that the activation of beta-catenin signaling induces a program that results in loss of mammary epithelial cell differentiation and induction of epidermal structures. ..
  4. Giniger E. Notch signaling and neural connectivity. Curr Opin Genet Dev. 2012;22:339-46 pubmed publisher
    ..Coordinating the many functions of Notch to produce neural structure is thus a pivotal aspect of building and maintaining the nervous system. ..
  5. Kim H, Cheon Y, Modi H, Rapoport S, Rao J. Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. Psychopharmacology (Berl). 2012;222:663-74 pubmed publisher
    ..The increased iPLAâ‚‚ expression following clozapine suggests increased production of anti-inflammatory DHA metabolites, and, with increased BDNF and drebrin, clear neuroprotective action. ..
  6. Ainsworth W, Hughes B, Au W, Sakelaris S, Kerscher O, Benton M, et al. Cytoplasmic localization of Hug1p, a negative regulator of the MEC1 pathway, coincides with the compartmentalization of Rnr2p-Rnr4p. Biochem Biophys Res Commun. 2013;439:443-8 pubmed publisher
    ..Taken together, the genetic interactions, gene expression, and localization studies support a novel role for Hug1p as a negative regulator of the MEC1 checkpoint response through its compartmentalization with Rnr2p-Rnr4p. ..
  7. Kleiner D. The pathology of drug-induced liver injury. Semin Liver Dis. 2009;29:364-72 pubmed publisher
  8. Kino T, Kozasa T, Chrousos G. Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity. Eur J Clin Invest. 2005;35:508-13 pubmed
  9. Forgues M, Marrogi A, Spillare E, Wu C, Yang Q, Yoshida M, et al. Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway. J Biol Chem. 2001;276:22797-803 pubmed
    ..We suggest that Crm1 may play a role in HBx-mediated liver carcinogenesis. ..

More Information

Publications75

  1. Dmitrieva N, Burg M. Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl. Am J Physiol Renal Physiol. 2008;295:F1678-88 pubmed publisher
    ..We conclude that gammaH2AX induction and MRN activation in response to high NaCl are associated with apoptosis, not DNA repair. ..
  2. Jones E, Sun D, Kobierski L, Symes A. NFAT4 is expressed in primary astrocytes and activated by glutamate. J Neurosci Res. 2003;72:191-7 pubmed
    ..These data suggest that NFAT4 functions as a calcium-responsive transcription factor in astrocytes. ..
  3. May Simera H, Kelley M. Planar cell polarity in the inner ear. Curr Top Dev Biol. 2012;101:111-40 pubmed publisher
    ..Finally, the presence of shortened cochleae in many PCP mouse mutants has revealed an additional role for the PCP pathway in the development of the auditory system. ..
  4. Zeng X, Bhasin S, Wu X, Lee J, Maffi S, Nichols C, et al. Hsp70 dynamics in vivo: effect of heat shock and protein aggregation. J Cell Sci. 2004;117:4991-5000 pubmed
    ..This provides strong evidence that Hsp70 interacts not only with organelles but also with diffusive proteins in the nucleoplasm and cytoplasm during heat shock as well as with diffusive huntingtin fragments. ..
  5. Tao Cheng J, Zhou F. Differential polarization of serotonin transporters in axons versus soma-dendrites: an immunogold electron microscopy study. Neuroscience. 1999;94:821-30 pubmed
    ..The highly polarized distribution also indicates that the major serotonin uptake sites are on axons and not on soma-dendrites. ..
  6. Oh H, Yu C, Dambuza I, MARRERO B, Egwuagu C. STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells. J Biol Chem. 2012;287:30436-43 pubmed publisher
  7. Wu Z, Xue H, Bernard J, Zeng R, Issakov D, Bollenbacher Reilley J, et al. The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. Blood. 2008;112:4411-9 pubmed publisher
    ..These experiments collectively indicate that IL-15Ralpha can act in cis in addition to acting in trans to present IL-15 to responding cells. ..
  8. Gannavaram S, Debrabant A. Involvement of TatD nuclease during programmed cell death in the protozoan parasite Trypanosoma brucei. Mol Microbiol. 2012;83:926-35 pubmed publisher
    ..Further, in conjunction with endonucleaseG, TatD may represent a critical nuclease in a caspase-independent PCD pathway in trypanosomatid parasites since caspases have not been identified in these organisms...
  9. Sato H, Tsai Morris C, Dufau M. Relevance of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) in the structural integrity of the chromatoid body during spermatogenesis. Biochim Biophys Acta. 2010;1803:534-43 pubmed publisher
  10. Rohan P, Davis P, Moskaluk C, Kearns M, Krutzsch H, Siebenlist U, et al. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993;259:1763-6 pubmed
    ..PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells. ..
  11. Furuya T, Mu J, Hayton K, Liu A, Duan J, Nkrumah L, et al. Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis. Proc Natl Acad Sci U S A. 2005;102:16813-8 pubmed
    ..Mosquito infectivity of the knockout parasites was also greatly reduced but not completely lost. The results suggest that pfmdv-1 plays a key role in gametocyte membrane formation and integrity. ..
  12. Good P, Rebbert M, Dawid I. Three new members of the RNP protein family in Xenopus. Nucleic Acids Res. 1993;21:999-1006 pubmed
    ..The xrp1 gene may have a function in all cells that is similar to that executed by nrp1 specifically within the nervous system. ..
  13. Satheshkumar P, Weisberg A, Moss B. Vaccinia virus H7 protein contributes to the formation of crescent membrane precursors of immature virions. J Virol. 2009;83:8439-50 pubmed publisher
    ..These features are most similar to those previously seen when expression of A11, another conserved nonvirion protein, is repressed...
  14. Yutin N, Koonin E. Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity. Biol Direct. 2009;4:51 pubmed publisher
    ..However, the details of the evolution of these genes that bear on the complexity of the putative ancestral NCLDV and on the evolutionary relationships between viruses and their hosts are not well understood...
  15. Arun P, Moffett J, Namboodiri A. Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells. Neurochem Int. 2009;55:219-25 pubmed publisher
    ..We conclude that NAA biosynthesis occurs in both the cytoplasm and mitochondria of SH-SY5Y cells, and that the contribution from the mitochondrial compartment is quantitatively larger than that in the extramitochondrial compartment...
  16. Yang Z, Bruno D, Martens C, Porcella S, Moss B. Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing. Proc Natl Acad Sci U S A. 2010;107:11513-8 pubmed publisher
    ..The overrepresented functional categories of the up-regulated RNAs were NF-kappaB cascade, apoptosis, signal transduction, and ligand-mediated signaling, which likely represent the host response to invasion...
  17. Daniels B, Rikhy R, Renz M, Dobrowsky T, Lippincott Schwartz J. Multiscale diffusion in the mitotic Drosophila melanogaster syncytial blastoderm. Proc Natl Acad Sci U S A. 2012;109:8588-93 pubmed publisher
  18. Annunziata C, Kleinberg L, Davidson B, Berner A, Gius D, Tchabo N, et al. BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer. Clin Cancer Res. 2007;13:6585-92 pubmed
    ..The findings presented here support involvement of these proteins in the propagation of ovarian cancer and provide a basis for the development of molecular therapeutics modulating these survival pathways. ..
  19. Peruzzi B, Athauda G, Bottaro D. The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells. Proc Natl Acad Sci U S A. 2006;103:14531-6 pubmed
    ..These findings identify beta-catenin as a potential target in biomarker and drug development for RCC. ..
  20. Kutty R, Chen S, Samuel W, Vijayasarathy C, Duncan T, Tsai J, et al. Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. Biochem Biophys Res Commun. 2006;345:1333-41 pubmed
    ..Deletion and mutation analysis indicated that the identified nuclear localization sequence is indispensable for nuclear targeting. ..
  21. Lu X, Gibbs J, Hickman H, David A, Dolan B, Jin Y, et al. Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters. Proc Natl Acad Sci U S A. 2012;109:15407-12 pubmed
    ..We propose that endogenous processing generates peptide-specific clusters of class I molecules to maximize the sensitivity and speed of T-cell immunosurveillance. ..
  22. Arbore G, Kemper C, Kolev M. Intracellular complement - the complosome - in immune cell regulation. Mol Immunol. 2017;89:2-9 pubmed publisher
    ..We also discuss what the existence of the complosome potentially means for how the host handles intracellular pathogens such as viruses. ..
  23. Xu L, Yang L, Moitra P, Hashimoto K, Rallabhandi P, Kaul S, et al. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Exp Cell Res. 2003;288:84-93 pubmed
    ..Thus, four protein modules found on each of these putative ubiquitin ligases, a RING, a B-box and two PHR repeats, are present on BTBD1/2 and TRIM5delta that are colocalized to cytoplasmic bodies. ..
  24. Zhou X, Gallazzini M, Burg M, Ferraris J. Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A. 2010;107:7072-7 pubmed publisher
    ..Thus, TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP. ..
  25. Blackstone C, Roberts R, Seeburg D, Sheng M. Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1. Biochem Biophys Res Commun. 2003;305:345-52 pubmed
    ..Thus, DDP binding may alter the interactions of STAM1 with several cytoplasmic proteins involved in cell signaling and endosomal trafficking. ..
  26. Love D, Kochan J, Cathey R, Shin S, Hanover J, Kochran J. Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase. J Cell Sci. 2003;116:647-54 pubmed
    ..The differential localization of mitochondrial and nucleocytoplasmic isoforms of OGT suggests that they perform unique intracellular functions. ..
  27. Kryndushkin D, Wickner R, Shewmaker F. FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis. Protein Cell. 2011;2:223-36 pubmed publisher
    ..Moreover, the biophysical properties of FUS aggregates in yeast are distinctly different from many amyloidogenic proteins, suggesting they are not composed of amyloid. ..
  28. Beverly L, Lockwood W, Shah P, Erdjument Bromage H, Varmus H. Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proc Natl Acad Sci U S A. 2012;109:E119-26 pubmed publisher
  29. Raval A, Weissman J, Howcroft T, Singer D. The GTP-binding domain of class II transactivator regulates its nuclear export. J Immunol. 2003;170:922-30 pubmed
    ..Thus, fine-tuning of the nucleocytoplasmic distribution of coactivator proteins involved in transcription is an active and dynamic process that defines a novel mechanism for controlling gene regulation. ..
  30. Caplan S, Naslavsky N, Hartnell L, Lodge R, Polishchuk R, Donaldson J, et al. A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J. 2002;21:2557-67 pubmed
    ..These observations suggest an additional function of EHD1 as a tubule-inducing factor in the Arf6 pathway for recycling of plasma membrane proteins internalized by clathrin-independent endocytosis. ..
  31. Ross K, COHEN FIX O. A role for the FEAR pathway in nuclear positioning during anaphase. Dev Cell. 2004;6:729-35 pubmed
    ..We propose that at anaphase onset, the FEAR pathway activates cytoplasmic microtubule-associated forces that facilitate chromosome segregation to the mother cell. ..
  32. Juang Y, Solomou E, Rellahan B, Tsokos G. Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain. J Immunol. 2002;168:2865-71 pubmed
    ..In conclusion, different forms of Elf-1 are the products of posttranslational modifications that determine its subcellular localization, activity, and metabolic degradation. ..
  33. Nishikomori R, Usui T, Wu C, Morinobu A, O Shea J, Strober W. Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol. 2002;169:4388-98 pubmed
    ..This implies that STAT4 is an essential element in the early events of Th1 differentiation. ..
  34. Suh J, Tang C, Cai M, Clore G. Visualization of the phosphorylated active site loop of the cytoplasmic B domain of the mannitol transporter II(Mannitol) of the Escherichia coli phosphotransferase system by NMR spectroscopy and residual dipolar couplings. J Mol Biol. 2005;353:1129-36 pubmed
  35. Woodard G, Lin L, Zhang J, Agarwal S, Marx S, Simonds W. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene. 2005;24:1272-6 pubmed
    ..These results demonstrate that human parafibromin is a nucleocytoplasmic protein with functions consistent with its postulated role as a tumor suppressor protein. ..
  36. Hanover J, Yu S, Lubas W, Shin S, Ragano Caracciola M, Kochran J, et al. Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene. Arch Biochem Biophys. 2003;409:287-97 pubmed
    ..These results provide the basis for a more detailed analysis of the significance and regulation of the nucleocytoplasmic and mitochondrial isoforms of OGT in mammals. ..
  37. Jin D, Wang H, Zhou Y, Chun A, Kibler K, Hou Y, et al. Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. EMBO J. 2000;19:729-40 pubmed
    ..Our findings suggest that LZIP might serve a novel cellular tumor suppressor function that is targeted by the HCV core. ..
  38. Lee M, Craigie R. A previously unidentified host protein protects retroviral DNA from autointegration. Proc Natl Acad Sci U S A. 1998;95:1528-33 pubmed
    ..The identity of the protein was confirmed by expressing it in Escherichia coli and demonstrating the activity of the heterologously expressed protein in the reconstitution assay. ..
  39. Horii Y, Beeler J, Sakaguchi K, Tachibana M, Miki T. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J. 1994;13:4776-86 pubmed
    ..Of the tissues examined, expression of ost was the highest in brain and could be localized to neurons and alpha-tanycytes, suggesting that Ost may participate in axonal transport in these specialized cells. ..
  40. Boehm M, Yoshimoto T, Crook M, Nallamshetty S, True A, Nabel G, et al. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 2002;21:3390-401 pubmed
    ..Through phosphorylation of p27(Kip1) on S10, hKIS regulates cell cycle progression in response to mitogens. ..
  41. Yutin N, Wolf Y, Raoult D, Koonin E. Eukaryotic large nucleo-cytoplasmic DNA viruses: clusters of orthologous genes and reconstruction of viral genome evolution. Virol J. 2009;6:223 pubmed publisher
  42. Salerno M, Palmieri D, Bouadis A, Halverson D, Steeg P. Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol Cell Biol. 2005;25:1379-88 pubmed
    ..Metastasis suppressor expression levels can impact traditional signaling pathways, such as the Erk pathway, resulting in altered tumor cell sensitivity to cancer therapeutics. ..
  43. Shahjee H, Bhattacharyya N, Zappala G, Wiench M, Prakash S, Rechler M. An N-terminal fragment of insulin-like growth factor binding protein-3 (IGFBP-3) induces apoptosis in human prostate cancer cells in an IGF-independent manner. Growth Horm IGF Res. 2008;18:188-97 pubmed
    ..The N-terminal 1-97-IGFBP-3 fragment induces apoptosis in human prostate cancer cells in an IGF-independent manner. Generation of the fragment might contribute to the proapoptotic activity of IGFBP-3 in vivo. ..
  44. Lee S, Park J, Kaevel J, Sramkova M, Weigert R, Park M. The effect of hypusine modification on the intracellular localization of eIF5A. Biochem Biophys Res Commun. 2009;383:497-502 pubmed publisher
    ..These findings provide strong evidence that the hypusine modification of eIF5A dictates its localization in the cytoplasmic compartment where it is required for protein synthesis. ..
  45. Lynn E, McLeod C, Gordon J, Bao J, Sack M. SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells. FEBS Lett. 2008;582:2857-62 pubmed publisher
    ..SIRT2 functions to moderate cellular stress-tolerance, in part, by modulating the levels of 14-3-3 zeta with the concordant control of BAD subcellular localization. ..
  46. Hershfield J, Madhavarao C, Moffett J, Benjamins J, Garbern J, Namboodiri A. Aspartoacylase is a regulated nuclear-cytoplasmic enzyme. FASEB J. 2006;20:2139-41 pubmed
    ..GFP-hASPA was enzymatically active and showed mixed nuclear-cytoplasmic distribution. We conclude that ASPA is a regulated nuclear-cytoplasmic protein that may have distinct functional roles in the two cellular compartments. ..
  47. Takikawa S, Engle R, Emerson S, Purcell R, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006;103:3345-50 pubmed
  48. Azzam H, DeJarnette J, Huang K, Emmons R, Park C, Sommers C, et al. Fine tuning of TCR signaling by CD5. J Immunol. 2001;166:5464-72 pubmed
    ..Together, these results indicate that inducible regulation of CD5 surface expression during thymocyte selection functions to fine tune the TCR signaling response. ..
  49. Mosinger B, Tillmann U, Westphal H, Tremblay M. Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1992;89:499-503 pubmed
    ..An additional 1.3-kilobase message was found to be expressed specifically in testes. Finally, we report the isolation of a human T-cell PTP cDNA containing a 3' end sequence homologous to the mouse PTP. ..
  50. Toyofuku K, Valencia J, Kushimoto T, Costin G, Virador V, Vieira W, et al. The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase. Pigment Cell Res. 2002;15:217-24 pubmed
    ..This study provides a basis to understand the relationship of the p protein with tyrosinase function and melanin synthesis, and also provides a rational approach to unveil the consequences of P gene mutations in the pathogenesis of OCA2...
  51. Sambuughin N, Swietnicki W, Techtmann S, Matrosova V, Wallace T, Goldfarb L, et al. KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase. Biochem Biophys Res Commun. 2012;421:743-9 pubmed publisher
  52. Katz B, Miyamoto S, Teramoto H, Zohar M, Krylov D, Vinson C, et al. Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim Biophys Acta. 2002;1592:141-52 pubmed
    ..This study identifies a proximity mechanism for regulating the initiation of FAK-mediated biochemical signaling. ..
  53. Zhou X, Thorgeirsson S, Popescu N. Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene. 2004;23:1308-13 pubmed
    ..These observations thus support the notion that Dlc-1 protein is involved in hepatocarcinogenesis and has oncosuppressive activity in HCC. ..
  54. Brooks B, Buchanan S. Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors. Biochim Biophys Acta. 2008;1778:1930-45 pubmed
    ..coli. Homologues from other Gram-negative bacteria suggest that these two signaling mechanisms and variations on these mechanisms may be the general schemes by which ECF sigma factors are regulated in Gram-negative bacteria. ..
  55. Choi S, Lee J, Zoll W, Merrick W, Dever T. Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science. 1998;280:1757-60 pubmed
    ..Thus, the mechanism of protein synthesis in eukaryotes and prokaryotes is more similar than was previously realized...
  56. Jeong S, Gaume B, Lee Y, Hsu Y, Ryu S, Yoon S, et al. Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J. 2004;23:2146-55 pubmed
    ..The C-terminal tail of Bcl-x(L) is also required to mediate Bcl-x(L)/Bax heterodimer formation. Both mitochondrial import and antiapoptotic activity of different Bcl-x(L) mutants correlate with their ability to form homodimers. ..
  57. Marchler G, Wu C. Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1. EMBO J. 2001;20:499-509 pubmed
    ..Our findings support a model in which synergistic interactions between DROJ1 and the HSP70/HSC70 and HSP90 chaperones modulate HSF activity by feedback repression. ..
  58. Chung J, Kitano H, Takikita M, Cho H, Noh K, Kim T, et al. Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer. Hum Pathol. 2013;44:472-9 pubmed publisher
  59. Komlodi Pasztor E, Trostel S, Sackett D, Poruchynsky M, Fojo T. Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells. Oncogene. 2009;28:3111-20 pubmed publisher
    ..We also identified impaired association with importin as a novel mechanism of p53 cytoplasmic sequestration that impairs nuclear transport rendering cells functionally deficient in p53. ..
  60. Forgues M, Difilippantonio M, Linke S, Ried T, Nagashima K, Feden J, et al. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol. 2003;23:5282-92 pubmed
    ..Based on this evidence, we suggest that Crm1 is actively involved in maintaining centrosome integrity and that HBx disrupts this process by inactivating Crm1 and thus contributes to HBV-mediated carcinogenesis. ..
  61. Smith A, Ganesh L, Leung K, Jongstra Bilen J, Jongstra J, Nabel G. Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells. J Exp Med. 2007;204:421-30 pubmed
    ..Collectively, these data suggest that LSP1 protein facilitates virus transport into the proteasome after its interaction with DC-SIGN through its interaction with cytoskeletal proteins. ..
  62. Tong W, Rouault T. Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis. Biometals. 2007;20:549-64 pubmed
    ..This review discusses the central role of aconitases in intermediary metabolism and explores how iron homeostasis and Fe-S cluster biogenesis regulate the Fe-S cluster switch and modulate intracellular citrate flux. ..
  63. Zurawski D, Mitsuhata C, Mumy K, McCormick B, Maurelli A. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infect Immun. 2006;74:5964-76 pubmed
    ..Ultimately, OspF and OspC1 are essential for PMN transepithelial migration, a phenotype associated with increased inflammation and bacterial access to the submucosa, which are fundamental aspects of S. flexneri pathogenesis...
  64. Cassiani Ingoni R, Coksaygan T, Xue H, Reichert Scrivner S, Wiendl H, Rao M, et al. Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation. Exp Neurol. 2006;201:349-58 pubmed
    ..Together, these data ascribe a pivotal role to Olig2+ glial precursor cells in the adult CNS, linking autoimmune inflammation and glial scar formation. ..
  65. Yedavalli V, Neuveut C, Chi Y, Kleiman L, Jeang K. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Cell. 2004;119:381-92 pubmed
    ..Plausibly, DDX3 is the human RNA helicase which functions in the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export. ..
  66. Basile J, Afkhami T, Gutkind J. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol. 2005;25:6889-98 pubmed
    ..These findings suggest that Plexin-B1 may achieve its numerous physiological functions through the direct activation of intracellular tyrosine kinase cascades. ..