Experts and Doctors on centrioles in Bethesda, Maryland, United States


Locale: Bethesda, Maryland, United States
Topic: centrioles

Top Publications

  1. Forgues M, Difilippantonio M, Linke S, Ried T, Nagashima K, Feden J, et al. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol. 2003;23:5282-92 pubmed
    ..Based on this evidence, we suggest that Crm1 is actively involved in maintaining centrosome integrity and that HBx disrupts this process by inactivating Crm1 and thus contributes to HBV-mediated carcinogenesis. ..
  2. Soung N, Kang Y, Kim K, Kamijo K, Yoon H, Seong Y, et al. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol Cell Biol. 2006;26:8316-35 pubmed
    ..Our results further suggest that the anti-Odf2 immunoreactive centrosomal antigen previously detected in non-germ line cells is likely hCenexin1. ..
  3. Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
    ..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
  4. Chang J, Seo S, Lee K, Nagashima K, Bang J, Kim B, et al. Essential role of Cenexin1, but not Odf2, in ciliogenesis. Cell Cycle. 2013;12:655-62 pubmed publisher
    ..The presence of multiple splicing variants hints that the function of Odf2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes. ..
  5. Kemp C, Kopish K, Zipperlen P, Ahringer J, O Connell K. Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell. 2004;6:511-23 pubmed
    ..Thus, we have identified SPD-2 as a factor critical for the two basic functions of the centrosome-microtubule organization and duplication. ..
  6. Song M, Aravind L, MULLER REICHERT T, O Connell K. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell. 2008;15:901-12 pubmed publisher
    ..Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process. ..
  7. Peters N, Perez D, Song M, Liu Y, MULLER REICHERT T, Caron C, et al. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. J Cell Sci. 2010;123:795-805 pubmed publisher
    ..Our data reveal differences in the regulation of mitotic and meiotic centrosome duplication, particularly with regard to ZYG-1 activity, and reveal an important role for centrosomes in spermatid formation...
  8. Kim T, Park J, Shukla A, Choi S, Murugan R, Lee J, et al. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A. 2013;110:E4849-57 pubmed publisher
    ..Thus, the spatiotemporal regulation of Plk4 localization by two hierarchical scaffolds, Cep192 and Cep152, is critical for centriole biogenesis. ..