Experts and Doctors on centrioles in Bethesda, Maryland, United States
Locale: Bethesda, Maryland, United States
Forgues M, Difilippantonio M, Linke S, Ried T, Nagashima K, Feden J, et al
. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol. 2003;23:5282-92 pubmed
..Based on this evidence, we suggest that Crm1 is actively involved in maintaining centrosome integrity and that HBx disrupts this process by inactivating Crm1 and thus contributes to HBV-mediated carcinogenesis. ..
Soung N, Kang Y, Kim K, Kamijo K, Yoon H, Seong Y, et al
. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol Cell Biol. 2006;26:8316-35 pubmed
..Our results further suggest that the anti-Odf2 immunoreactive centrosomal antigen previously detected in non-germ line cells is likely hCenexin1. ..
Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
Chang J, Seo S, Lee K, Nagashima K, Bang J, Kim B, et al
. Essential role of Cenexin1, but not Odf2, in ciliogenesis. Cell Cycle. 2013;12:655-62 pubmed publisher
..The presence of multiple splicing variants hints that the function of Odf2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes. ..
Kemp C, Kopish K, Zipperlen P, Ahringer J, O Connell K. Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell. 2004;6:511-23 pubmed
..Thus, we have identified SPD-2 as a factor critical for the two basic functions of the centrosome-microtubule organization and duplication. ..
Song M, Aravind L, MULLER REICHERT T, O Connell K. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell. 2008;15:901-12 pubmed publisher
..Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process. ..
Peters N, Perez D, Song M, Liu Y, MULLER REICHERT T, Caron C, et al
. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. J Cell Sci. 2010;123:795-805 pubmed publisher
..Our data reveal differences in the regulation of mitotic and meiotic centrosome duplication, particularly with regard to ZYG-1 activity, and reveal an important role for centrosomes in spermatid formation...
Kim T, Park J, Shukla A, Choi S, Murugan R, Lee J, et al
. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A. 2013;110:E4849-57 pubmed publisher
..Thus, the spatiotemporal regulation of Plk4 localization by two hierarchical scaffolds, Cep192 and Cep152, is critical for centriole biogenesis. ..