Experts and Doctors on cell death in Baltimore, Maryland, United States

Summary

Locale: Baltimore, Maryland, United States
Topic: cell death

Top Publications

  1. Cutler R, Kelly J, Storie K, Pedersen W, Tammara A, Hatanpaa K, et al. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A. 2004;101:2070-5 pubmed
  2. Chu L, Vijay C, Annex B, Bader J, Popel A. PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease. Physiol Genomics. 2015;47:331-43 pubmed publisher
  3. Milhavet O, Gary D, Mattson M. RNA interference in biology and medicine. Pharmacol Rev. 2003;55:629-48 pubmed
    ..Pharmacologists have long dreamed of the ability to selectively antagonize or eliminate the function of individual proteins--RNAi technology may eventually make that dream a reality. ..
  4. Darman J, Backovic S, Dike S, Maragakis N, Krishnan C, Rothstein J, et al. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. J Neurosci. 2004;24:7566-75 pubmed
    ..Similar changes may occur in other motor neuron disorders such as amyotrophic lateral sclerosis or West Nile Virus-induced poliomyelitis, suggesting a common tissue injury pathway. ..
  5. Shahani N, Sawa A. Protein S-nitrosylation: role for nitric oxide signaling in neuronal death. Biochim Biophys Acta. 2012;1820:736-42 pubmed publisher
    ..Elucidating specific targets of S-nitrosylation as well as their regulatory mechanisms may aid in the development of therapeutic intervention in a wide range of brain diseases. ..
  6. Liu C, Zhang Y, Liu M, Zhou H, Chowdhury W, Lupold S, et al. Evaluation of continuous low dose rate versus acute single high dose rate radiation combined with oncolytic viral therapy for prostate cancer. Int J Radiat Biol. 2010;86:220-9 pubmed publisher
    ..Our data demonstrate substantial differences in CRAd efficacy based on the mode of radiation delivery. ..
  7. Ivanovska I, Hardwick J. Viruses activate a genetically conserved cell death pathway in a unicellular organism. J Cell Biol. 2005;170:391-9 pubmed
    ..This virus-host relationship in yeast resembles that of pathogenic human viruses that persist in their infected host cells but trigger programmed death of uninfected cells. ..
  8. Li H, Pauza C. Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells. Retrovirology. 2013;10:60 pubmed publisher
  9. Koliatsos V, Kecojevic A, Troncoso J, Gastard M, Bennett D, Schneider J. Early involvement of small inhibitory cortical interneurons in Alzheimer's disease. Acta Neuropathol. 2006;112:147-62 pubmed

More Information

Publications143 found, 100 shown here

  1. Xu J, Fan J, Wang X, Eacker S, Kam T, Chen L, et al. Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med. 2016;8:333ra48 pubmed publisher
    ..This culture system provides a new platform for the study of human cortical neurotoxicity and suggests that PARP inhibitors may be useful for ameliorating excitotoxic and ischemic cell death in human neurons. ..
  2. Pepling M, Spradling A. Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles. Dev Biol. 2001;234:339-51 pubmed
    ..Cysts may ensure that oocytes destined to form primordial follicles acquire populations of functional mitochondria, through an active process that has been evolutionarily conserved. ..
  3. Nargi Aizenman J, Griffin D. Sindbis virus-induced neuronal death is both necrotic and apoptotic and is ameliorated by N-methyl-D-aspartate receptor antagonists. J Virol. 2001;75:7114-21 pubmed
    ..These results provide evidence that SV infection activates neurotoxic pathways that result in aberrant NMDA receptor stimulation and damage to infected and uninfected neurons. ..
  4. Tirumalai R, Rajesh Kumar T, Mai K, Biswal S. Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol Lett. 2002;132:27-36 pubmed
    ..The ability of acrolein to transcriptionaly activate genes responsible for phase II enzymes may form the basis of resistance against cell death and can have implications in cigarette smoke related lung carcinogenesis. ..
  5. Clerc P, Carey G, Mehrabian Z, Wei M, Hwang H, Girnun G, et al. Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry. PLoS ONE. 2012;7:e42487 pubmed publisher
  6. Visser J, Smith D, Moy S, Breese G, Friedmann T, Rothstein J, et al. Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. Brain Res Dev Brain Res. 2002;133:127-39 pubmed
  7. Chan S, Pedersen W, Zhu H, Mattson M. Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease. Neuromolecular Med. 2002;1:55-67 pubmed
    ..Our findings also suggest that the effects of Numb on cell fate decisions, both during development of the nervous system and in neurodegenertive disorders, are mediated by changes in cellular calcium homeostasis. ..
  8. Lodh S, Hostelley T, Leitch C, O Hare E, Zaghloul N. Differential effects on β-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes. Hum Mol Genet. 2016;25:57-68 pubmed publisher
    ..Taken together, these findings implicate discrepant production and maintenance of β-cells in the differential susceptibility to diabetes found between these two genetic syndromes. ..
  9. Mattson M, Fu W, Zhang P. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech Ageing Dev. 2001;122:659-71 pubmed
  10. Boehning D, van Rossum D, Patterson R, Snyder S. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A. 2005;102:1466-71 pubmed
    ..Small-molecule inhibitors of cytochrome c/IP3R interactions may prove useful in treating disorders associated with inappropriate intrinsic and extrinsic apoptotic signaling. ..
  11. Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A. CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors. J Immunol. 2007;179:1996-2004 pubmed
    ..Taken together, this work represents a novel concept that may allow control of growth and dissemination of tumors that use chemokine receptors to metastasize and circumvent immunosurveillance. ..
  12. Damico R, Chesley A, Johnston L, Bind E, Amaro E, Nijmeh J, et al. Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis. Am J Respir Cell Mol Biol. 2008;39:77-85 pubmed publisher
    ..These results show that MIF can protect vascular endothelial cells from inflammation-associated cell damage. ..
  13. Perry T, Haughey N, Mattson M, Egan J, Greig N. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther. 2002;302:881-8 pubmed
  14. Furukawa K, Matsuzaki Kobayashi M, Hasegawa T, Kikuchi A, Sugeno N, Itoyama Y, et al. Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells. J Neurochem. 2006;97:1071-7 pubmed
    ..These findings suggest that the high membrane ion permeability caused by mutant alpha-synuclein may contribute to the degeneration of neurons in PD. ..
  15. Tian J, Kim S, Hester L, Snyder S. S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity. Proc Natl Acad Sci U S A. 2008;105:10537-40 pubmed publisher
    ..nNOS, via its PDZ domain, binds COX-2 with the generated NO S-nitrosylating and activating the enzyme. Selective disruption of nNOS-COX-2 binding prevents NMDA neurotoxicity. ..
  16. Sen T, Sen N, Huang Y, Sinha D, Luo Z, Ratovitski E, et al. Tumor protein p63/nuclear factor ?B feedback loop in regulation of cell death. J Biol Chem. 2011;286:43204-13 pubmed publisher
    ..Overall, our data defined the regulatory feedback loop between TAp63? and NF-?B involved in the activation of cell death process of cancer cells. ..
  17. Tang S, Arumugam T, Cutler R, Jo D, Magnus T, Chan S, et al. Neuroprotective actions of a histidine analogue in models of ischemic stroke. J Neurochem. 2007;101:729-36 pubmed
    ..These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions. ..
  18. Pirooznia S, Dawson V, Dawson T. Motor neuron death in ALS: programmed by astrocytes?. Neuron. 2014;81:961-963 pubmed publisher
    ..2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue. ..
  19. Danilov C, Chandrasekaran K, Racz J, Soane L, Zielke C, Fiskum G. Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. Glia. 2009;57:645-56 pubmed publisher
    ..We conclude that sulforaphane stimulates the NRF2 pathway of antioxidant gene expression in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion. ..
  20. Jiang M, Porat Shliom Y, Pei Z, Cheng Y, Xiang L, Sommers K, et al. Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism. J Neurochem. 2010;114:419-29 pubmed publisher
    ..Baicalein has potential as a tool to understand the relation between different aggregation species and toxicity, and might be a candidate compound for further validation by using in vivo alpha-syn genetic PD models. ..
  21. Loftus T, Kuhajda F, Lane M. Insulin depletion leads to adipose-specific cell death in obese but not lean mice. Proc Natl Acad Sci U S A. 1998;95:14168-72 pubmed
    ..Thus insulin may promote the survival side of the physiological balance between adipocyte survival and death. ..
  22. Chandrasekaran K, Mehrabian Z, Spinnewyn B, Chinopoulos C, Drieu K, Fiskum G. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry. 2003;36 Suppl 1:S89-94 pubmed
  23. Pedersen P. The cancer cell's "power plants" as promising therapeutic targets: an overview. J Bioenerg Biomembr. 2007;39:1-12 pubmed
    ..Regardless how death is inflicted, every cancer cell must die, be it fast or slow. ..
  24. Pisharath H. Validation of nitroreductase, a prodrug-activating enzyme, mediated cell death in embryonic zebrafish (Danio rerio). Comp Med. 2007;57:241-6 pubmed
    ..Neither the prodrugs themselves nor the NTR-EGFP fusion protein were toxic to the developing zebrafish embryos. Thus the NTR-CB 1954 and NTR-Met systems can be used to ablate a wide variety of cells and tissues in zebrafish embryos. ..
  25. Li R, Saleem S, Zhen G, Cao W, Zhuang H, Lee J, et al. Heme-hemopexin complex attenuates neuronal cell death and stroke damage. J Cereb Blood Flow Metab. 2009;29:953-64 pubmed publisher
    ..We propose that the heme-HPX system protects against stroke-related damage by maintaining a tight balance between free and bound heme. Thus, regulating extracellular free heme levels, such as with HPX, could be neuroprotective. ..
  26. Krasnova I, Cadet J. Methamphetamine toxicity and messengers of death. Brain Res Rev. 2009;60:379-407 pubmed publisher
  27. Kalakonda S, Nallar S, Lindner D, Hu J, Reddy S, Kalvakolanu D. Tumor-suppressive activity of the cell death activator GRIM-19 on a constitutively active signal transducer and activator of transcription 3. Cancer Res. 2007;67:6212-20 pubmed
    ..In this study, we show that GRIM-19 suppresses constitutive STAT3-induced cellular transformation in vitro and in vivo by down-regulating the expression of a number of cellular genes involved in cell proliferation and apoptosis. ..
  28. Poeggeler B, Rassoulpour A, Wu H, Guidetti P, Roberts R, Schwarcz R. Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity. Neuroscience. 2007;148:188-97 pubmed
    ..Thus, the present study identifies a previously unappreciated role of KYNA as a functional link between dopamine receptor stimulation and NMDA neurotoxicity in the striatum. ..
  29. Le A, Cooper C, Gouw A, Dinavahi R, Maitra A, Deck L, et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010;107:2037-42 pubmed publisher
  30. Dawson T, Ko H, Dawson V. Genetic animal models of Parkinson's disease. Neuron. 2010;66:646-61 pubmed publisher
    ..In this review, we discuss the animal models for these genetic causes of PD, their limitations, and value. Moreover, we discuss future directions and potential strategies for optimization of the genetic models. ..
  31. Liu Z, Yu Y, Li X, Ross C, Smith W. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacol Res. 2011;63:439-44 pubmed publisher
  32. Wu H, Wu T, Li M, Wang J. Efficacy of the lipid-soluble iron chelator 2,2'-dipyridyl against hemorrhagic brain injury. Neurobiol Dis. 2012;45:388-94 pubmed publisher
    ..Post-treatment reduced brain lesion volume and edema and improved neurologic function. These results indicate that the lipid-soluble ferrous iron chelator 2,2'-dipyridyl can reduce brain injury and improve functional outcome after ICH. ..
  33. Itoh K, Nakamura K, Iijima M, Sesaki H. Mitochondrial dynamics in neurodegeneration. Trends Cell Biol. 2013;23:64-71 pubmed publisher
    ..Here, we review the recent findings on mitochondrial dynamics in neurodegeneration. ..
  34. Bhatia P, Bernier M, Sanghvi M, Moaddel R, Schwarting R, Ramamoorthy A, et al. Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells. Xenobiotica. 2012;42:748-55 pubmed publisher
    ..In conclusion, BCRP is expressed in the nuclear extracts of select GBM and astrocytoma cell lines and in a human GBM tumour biopsy. Its presence in the nucleus of cancer cells suggests new role for BCRP in MDR. ..
  35. Kohr M, Evangelista A, Ferlito M, Steenbergen C, Murphy E. S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death. J Mol Cell Cardiol. 2014;69:67-74 pubmed publisher
  36. Sauerwald T, Figueroa B, Hardwick J, Oyler G, Betenbaugh M. Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures. Biotechnol Bioeng. 2006;94:362-72 pubmed
    ..Thus, the concurrent expression of multiple apoptosis inhibitors may be the most effective strategy to increase survival of mammalian cells in culture. ..
  37. Isaacs J, D Antonio J, Chen S, Antony L, Dalrymple S, Ndikuyeze G, et al. Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer. Prostate. 2012;72:1491-505 pubmed publisher
    ..BAT therapy is effective in xenografts and based upon positive results has entered clinical testing. ..
  38. Vlaicu S, Tegla C, Cudrici C, Danoff J, Madani H, Sugarman A, et al. Role of C5b-9 complement complex and response gene to complement-32 (RGC-32) in cancer. Immunol Res. 2013;56:109-21 pubmed publisher
    ..Thus, through the activation of tumor cells, the C5b-9-mediated induction of the cell cycle plays an important role in tumor proliferation and oncogenesis. ..
  39. Chatterjee S. Sphingolipids in atherosclerosis and vascular biology. Arterioscler Thromb Vasc Biol. 1998;18:1523-33 pubmed
    ..The findings described here indicate an important role for sphingolipids in vascular biology and provide an exciting opportunity for further research in vascular disease and atherosclerosis. ..
  40. Wu H, Wu T, Xu X, Wang J, Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow Metab. 2011;31:1243-50 pubmed publisher
    ..Results of our study indicate that iron toxicity contributes to collagenase-induced hemorrhagic brain injury and that reducing iron accumulation can reduce neuronal death and modestly improve functional outcome after ICH in mice. ..
  41. Ugolino J, Fang S, Kubisch C, Monteiro M. Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death. Hum Mol Genet. 2011;20:3565-77 pubmed publisher
    ..Lastly, we show Atp13a2 mutants have increased cytotoxicity and predispose cells to ER-stress-induced cell death. These results provide new insight into the properties of wild-type and mutant Atp13a2 proteins involved in KRS. ..
  42. McCranor B, Bozym R, Vitolo M, Fierke C, Bambrick L, Polster B, et al. Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion. J Bioenerg Biomembr. 2012;44:253-63 pubmed publisher
    ..The increase in intramitochondrial zinc observed during reoxygenation after OGD may contribute to bioenergetic dysfunction and cell death that occurs with both in vitro and in vivo models of reperfusion. ..
  43. Hossain M, Russell J, Gomez R, Laterra J, Gomes R. Neuroprotection by scatter factor/hepatocyte growth factor and FGF-1 in cerebellar granule neurons is phosphatidylinositol 3-kinase/akt-dependent and MAPK/CREB-independent. J Neurochem. 2002;81:365-78 pubmed
    ..These data show that both SF/HGF and FGF-1 protect cerebellar granule neurons against excitotoxicity with similar potency in a P13-K/Akt-dependent and MAP-kinase/CREB-independent manner. ..
  44. Yu S, Andrabi S, Wang H, Kim N, Poirier G, Dawson T, et al. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A. 2006;103:18314-9 pubmed
    ..Cells with reduced levels of AIF are resistant to PARP-1-dependent cell death and PAR polymer cytotoxicity. These results reveal PAR polymer as an AIF-releasing factor that plays important roles in PARP-1-dependent cell death. ..
  45. Goetz W, Morgan M, Baulch J. The effect of radiation quality on genomic DNA methylation profiles in irradiated human cell lines. Radiat Res. 2011;175:575-87 pubmed publisher
  46. Yoon J, Lee J, Tweedie D, Mughal M, Chigurupati S, Greig N, et al. 3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation. J Neurosci Res. 2013;91:671-80 pubmed publisher
    ..These findings suggest that anti-inflammatory mechanisms underlie the therapeutic actions of 3,6-DT in an animal model of stroke. ..
  47. Teshima Y, Akao M, Jones S, Marban E. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res. 2003;93:192-200 pubmed
    ..Thus, overexpression of UCP2 attenuates ROS generation and prevents mitochondrial Ca2+ overload, revealing a novel mechanism of cardioprotection. ..
  48. Mao C, Hung C, Kang T, He L, Tsai Y, Wu C, et al. Combined administration with DNA encoding vesicular stomatitis virus G protein enhances DNA vaccine potency. J Virol. 2010;84:2331-9 pubmed publisher
    ..Thus, the incorporation of FMGs into DNA vaccines holds promise for the successful control of viral infections and cancers in the clinic. ..
  49. Zhang Z, Kageyama Y, Sesaki H. Mitochondrial division prevents neurodegeneration. Autophagy. 2012;8:1531-3 pubmed publisher
    ..These findings suggest that mitochondrial division functions as an important quality control mechanism that suppresses oxidative damage and neurodegeneration in vivo. ..
  50. Clatterbuck R, Price D, Koliatsos V. Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc Natl Acad Sci U S A. 1993;90:2222-6 pubmed
    ..The present findings establish that CNTF has significant effects on neurons of the central nervous system in vivo and demonstrate that neurocytokines can prevent cell death in the adult central nervous system. ..
  51. Kerrigan Baumrind L, Quigley H, Pease M, Kerrigan D, Mitchell R. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci. 2000;41:741-8 pubmed
    ..001). At least 25% to 35% RGC loss is associated with statistical abnormalities in automated visual field testing. In addition, these data corroborate previous findings that RGCs with larger diameter axons preferentially die in glaucoma. ..
  52. Zhang Y, Feng H. Pathogenic effects of glucosyltransferase from Clostridium difficile toxins. Pathog Dis. 2016;74:ftw024 pubmed publisher
    ..In this review, we summarize the pathogenic effects of glucosyltransferase domain of the toxins in the past years. ..
  53. Majors B, Betenbaugh M, Chiang G. Links between metabolism and apoptosis in mammalian cells: applications for anti-apoptosis engineering. Metab Eng. 2007;9:317-26 pubmed
    ..Second, the review turns to look at potentially new cell engineering strategies that are linked to metabolism for improving cell culture viability and protein production. ..
  54. Chuang C, Monie A, Wu A, Mao C, Hung C. Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer. Hum Gene Ther. 2009;20:303-13 pubmed publisher
    ..Thus, our data suggest that the combination of CpG-ODN with LL-37 peptide may lead to the control of ovarian tumors through the activation of innate immunity. ..
  55. Brubaker S, Gauthier A, Mills E, Ingolia N, Kagan J. A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity. Cell. 2014;156:800-11 pubmed publisher
    ..This study therefore reveals the existence of a functionally important bicistronic antiviral mRNA and suggests a widespread role for polycistronic mRNAs in the innate immune system. ..
  56. Guo Z, Lee J, Lane M, Mattson M. Iodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat-shock proteins and Bcl-2. J Neurochem. 2001;79:361-70 pubmed
    ..Our data demonstrate that IAA can stimulate cytoprotective mechanisms within neurons, and suggest the possible use of IAA and related compounds in the prevention and/or treatment of neurodegenerative conditions. ..
  57. Kaspar J, Jaiswal A. Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression. FASEB J. 2011;25:1076-87 pubmed publisher
    ..The preinduction regulation of Nrf2 is controlled by the nuclear export of Fyn, allowing for activation of defensive gene expression. ..
  58. Kim W, Lao Q, Shin Y, Carlson O, Lee E, Gorospe M, et al. Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation. Sci Signal. 2012;5:ra23 pubmed publisher
  59. Zhang Q, Tsoi H, Peng S, Li P, Lau K, Rudnicki D, et al. Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila. Dis Model Mech. 2016;9:321-34 pubmed publisher
    ..Our findings indicate that targeting toxic RNAs and/or simultaneous targeting of toxic RNAs and their corresponding proteins could open up a new therapeutic strategy for treating polyQ degeneration. ..
  60. Liu D, Slevin J, Lu C, Chan S, Hansson M, Elmér E, et al. Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death. J Neurochem. 2003;86:966-79 pubmed
  61. Collis S, Schwaninger J, Ntambi A, Keller T, Nelson W, Dillehay L, et al. Evasion of early cellular response mechanisms following low level radiation-induced DNA damage. J Biol Chem. 2004;279:49624-32 pubmed
  62. Moreira E, Adler R. Effects of follistatin overexpression on cell differentiation in the chick embryo retina. Dev Biol. 2006;298:272-84 pubmed
    ..Increases in cell death were also observed in FS-treated retinas. Taken together with previous in vitro studies, our results suggest that activin is a powerful regulator of neuronal differentiation in the central nervous system. ..
  63. Ota S, Geschwind J, Buijs M, Wijlemans J, Kwak B, Ganapathy Kanniappan S. Ultrasound-guided direct delivery of 3-bromopyruvate blocks tumor progression in an orthotopic mouse model of human pancreatic cancer. Target Oncol. 2013;8:145-51 pubmed publisher
    ..Our data suggest that this new therapeutic approach consisting of a direct intratumoral injection of antiglycolytic agents may represent an exciting opportunity to treat patients with pancreas cancer. ..
  64. Nunez J, Alt J, McCarthy M. A new model for prenatal brain damage. I. GABAA receptor activation induces cell death in developing rat hippocampus. Exp Neurol. 2003;181:258-69 pubmed
    ..Ischemia in newborn rats induces GABA release and we propose that treatment with muscimol mimics the cell death cascade induced by hypoxia-ischemia in premature human infants. ..
  65. Xu Y, Zhang B, Hua Z, Johns R, Bredt D, Tao Y. Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. Exp Neurol. 2004;189:16-24 pubmed
  66. Coulombe P, Wong P. Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds. Nat Cell Biol. 2004;6:699-706 pubmed
  67. Iida K, Li Y, McGrath B, Frank A, Cavener D. PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol. 2007;8:38 pubmed
    ..To determine if the exocrine pancreatic atrophy is due to a cell-autonomous defect, the Perk gene was specifically ablated in acinar cells of the exocrine pancreas in mice...
  68. McGrath Morrow S, Rangasamy T, Cho C, Sussan T, Neptune E, Wise R, et al. Impaired lung homeostasis in neonatal mice exposed to cigarette smoke. Am J Respir Cell Mol Biol. 2008;38:393-400 pubmed
    ..These findings may in part explain the increased incidence of respiratory symptoms in infants and children exposed to CS. ..
  69. Lu C, Mattson M. Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons. Exp Neurol. 2001;170:180-5 pubmed
    ..Our data also identify a mechanism that might explain clinical effects of DMSO on both peripheral and CNS neurons and suggest a potential use for DMSO in the treatment of excitotoxic neurodegenerative conditions. ..
  70. Gabrielson K, Mok G, Nimmagadda S, Bedja D, Pin S, Tsao A, et al. Detection of dose response in chronic doxorubicin-mediated cell death with cardiac technetium 99m annexin V single-photon emission computed tomography. Mol Imaging. 2008;7:132-8 pubmed
    ..99mTc-HYNIC-annexin V SPECT-based molecular imaging may provide an attractive new technique for assessing early changes in myocardial function in patients undergoing DOX therapy. ..
  71. Karuppagounder S, Alim I, Khim S, Bourassa M, Sleiman S, John R, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016;8:328ra29 pubmed publisher
    ..Together, these findings demonstrate that brain-specific inactivation of the HIF-PHD metalloenzymes with the blood-brain barrier-permeable inhibitor adaptaquin can improve functional outcomes after ICH in several rodent models. ..
  72. Tomac A, Agulnick A, Haughey N, Chang C, Zhang Y, Backman C, et al. Effects of cerebral ischemia in mice deficient in Persephin. Proc Natl Acad Sci U S A. 2002;99:9521-6 pubmed
  73. Adamson D, Wildemann B, Sasaki M, Glass J, McArthur J, Christov V, et al. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science. 1996;274:1917-21 pubmed
    ..Thus, gp41-induced NO formation may contribute to the severe cognitive dysfunction associated with HIV-1 infection. ..
  74. Guo Z, Iyun T, Fu W, Zhang P, Mattson M. Bone marrow transplantation reveals roles for brain macrophage/microglia TNF signaling and nitric oxide production in excitotoxic neuronal death. Neuromolecular Med. 2004;5:219-34 pubmed
  75. Arumugam T, Tang S, Lathia J, Cheng A, Mughal M, Chigurupati S, et al. Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A. 2007;104:14104-9 pubmed
    ..Our data suggest a major role for complement-mediated cell death in ischemic brain injury and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke. ..
  76. Rothstein J. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol. 2009;65 Suppl 1:S3-9 pubmed publisher
    ..Convergence of these pathways is likely to mediate disease onset and progression. ..
  77. Wang Y, Dawson V, Dawson T. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol. 2009;218:193-202 pubmed publisher
    ..Targeting PAR-mediated AIF release could be a potential approach for the therapy of neurologic disorders. ..
  78. Ko H, Lee Y, Shin J, Karuppagounder S, Gadad B, Koleske A, et al. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci U S A. 2010;107:16691-6 pubmed publisher
    ..Moreover, inhibition of c-Abl may be a neuroprotective approach in the treatment of PD. ..
  79. Bumpus N. Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011;257:227-34 pubmed publisher
    ..Further, activation of the JNK signaling pathway and BimEL mRNA expression appear to be required for EFV- and 8-OHEFV-mediated hepatocyte death. ..
  80. Piao C, Loane D, Stoica B, Li S, Hanscom M, Cabatbat R, et al. Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis. 2012;46:745-58 pubmed publisher
  81. Simard J, Woo S, Gerzanich V. Transient receptor potential melastatin 4 and cell death. Pflugers Arch. 2012;464:573-82 pubmed publisher
    ..Future studies will be needed to determine whether TRPM4 also plays a role in regulated necrosis and apoptosis. ..
  82. Chung K, Thomas B, Li X, Pletnikova O, Troncoso J, Marsh L, et al. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science. 2004;304:1328-31 pubmed
    ..The inhibition of parkin's ubiquitin E3 ligase activity by S-nitrosylation could contribute to the degenerative process in these disorders by impairing the ubiquitination of parkin substrates. ..
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