Experts and Doctors on cdc2 protein kinase in Baltimore, Maryland, United States


Locale: Baltimore, Maryland, United States
Topic: cdc2 protein kinase

Top Publications

  1. Chin L, Murray S, Doherty P, Singh S. K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c. Cancer Invest. 1999;17:391-5 pubmed
    ..Finally, cell cycle arrest in T98G cells resulted in apoptosis as determined by cell morphology and DNA laddering. K252a is a useful tool for studying the effects of CDK inhibition and cell cycle blockade in tumor cells. ..
  2. Brown G, Jallepalli P, Huneycutt B, Kelly T. Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast. Proc Natl Acad Sci U S A. 1997;94:6142-7 pubmed
    ..These interactions between Cdc18 and cyclin-dependent kinases suggest mechanisms by which cyclin-dependent kinases could activate the initiation of DNA replication and could prevent rereplication. ..
  3. Hansel D, Dhara S, Huang R, Ashfaq R, Deasel M, Shimada Y, et al. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol. 2005;29:390-9 pubmed
    ..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target. ..
  4. Zhao R, Elder R. Viral infections and cell cycle G2/M regulation. Cell Res. 2005;15:143-9 pubmed
  5. Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J Biol Chem. 2006;281:7118-28 pubmed
  6. Spinette S, Mahoney J, Rosen A. The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death. Biochem Biophys Res Commun. 2006;347:1103-12 pubmed
  7. Zhang L, Fried F, Guo H, Friedman A. Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood. 2008;111:1193-200 pubmed
    ..Together these findings indicate that cdk phosphorylation of RUNX1 potentially couples stem/progenitor proliferation and lineage progression. ..
  8. Kim Y, Buchholz M, Chrest F, Nordin A. Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes. J Immunol. 1994;152:4328-35 pubmed
    ..Together these studies demonstrate that c-myc regulates the expression of these cdk and suggest a role for c-myc in the G1/S transition. ..
  9. Jallepalli P, Brown G, Muzi Falconi M, Tien D, Kelly T. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev. 1997;11:2767-79 pubmed
    ..Regulation of p65cdc18 by CDK phosphorylation is likely to contribute to the CDK-driven "replication switch" that restricts initiation at eukaryotic origins to once per cell cycle. ..

More Information


  1. Fosbrink M, Cudrici C, Tegla C, Soloviova K, Ito T, Vlaicu S, et al. Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. Exp Mol Pathol. 2009;86:87-94 pubmed publisher
    ..All these data together suggest that cell cycle induction by C5b-9 in AEC is RGC-32 dependent and this is in part through regulation of Akt and growth factor release. ..
  2. Cheng K, Klancer R, Singson A, Seydoux G. Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell. 2009;139:560-72 pubmed publisher
    ..Our findings link cell-cycle progression to MBK-2/DYRK activation and the oocyte-to-embryo transition. ..
  3. Wang Z, Udeshi N, Slawson C, Compton P, Sakabe K, Cheung W, et al. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal. 2010;3:ra2 pubmed publisher