Experts and Doctors on cdc2 protein kinase in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Topic: cdc2 protein kinase
Chin L, Murray S, Doherty P, Singh S. K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c. Cancer Invest. 1999;17:391-5 pubmed
..Finally, cell cycle arrest in T98G cells resulted in apoptosis as determined by cell morphology and DNA laddering. K252a is a useful tool for studying the effects of CDK inhibition and cell cycle blockade in tumor cells. ..
Brown G, Jallepalli P, Huneycutt B, Kelly T. Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast. Proc Natl Acad Sci U S A. 1997;94:6142-7 pubmed
..These interactions between Cdc18 and cyclin-dependent kinases suggest mechanisms by which cyclin-dependent kinases could activate the initiation of DNA replication and could prevent rereplication. ..
Hansel D, Dhara S, Huang R, Ashfaq R, Deasel M, Shimada Y, et al
. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol. 2005;29:390-9 pubmed
..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target. ..
Zhao R, Elder R. Viral infections and cell cycle G2/M regulation. Cell Res. 2005;15:143-9 pubmed
Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J Biol Chem. 2006;281:7118-28 pubmed
Spinette S, Mahoney J, Rosen A. The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death. Biochem Biophys Res Commun. 2006;347:1103-12 pubmed
Zhang L, Fried F, Guo H, Friedman A. Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood. 2008;111:1193-200 pubmed
..Together these findings indicate that cdk phosphorylation of RUNX1 potentially couples stem/progenitor proliferation and lineage progression. ..
Kim Y, Buchholz M, Chrest F, Nordin A. Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes. J Immunol. 1994;152:4328-35 pubmed
..Together these studies demonstrate that c-myc regulates the expression of these cdk and suggest a role for c-myc in the G1/S transition. ..
Jallepalli P, Brown G, Muzi Falconi M, Tien D, Kelly T. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev. 1997;11:2767-79 pubmed
..Regulation of p65cdc18 by CDK phosphorylation is likely to contribute to the CDK-driven "replication switch" that restricts initiation at eukaryotic origins to once per cell cycle. ..