Genomes and Genes
Experts and Doctors on calcium in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Publications278 found, 100 shown here
- Gover T, Abrams T. Insights into a molecular switch that gates sensory neuron synapses during habituation in Aplysia. Neurobiol Learn Mem. 2009;92:155-65 pubmed publisher..5. This molecular switch may explain the sensory gating that allows animals to discriminate which stimuli are innocuous and appropriate to ignore and which stimuli are more important and should continue to elicit responses. ..
- Hayashi T, Fujimoto M. Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. Mol Pharmacol. 2010;77:517-28 pubmed publisher..These findings suggest that the MAM, bearing cholesterol and ceramide-enriched microdomains at the ER, may use the microdomains to anchor Sig-1Rs to the location; thus, it serves to stage Sig-1R at ER-mitochondria junctions. ..
- Yaniv Y, Maltsev V, Escobar A, Spurgeon H, Ziman B, Stern M, et al. Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm. J Mol Cell Cardiol. 2011;51:902-5 pubmed publisher..Our results directly support the hypothesis that intracellular Ca(2+) regulates normal SANC automaticity on a beat-to-beat basis. ..
- Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer K, et al. Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol. 2012;303:L343-53 pubmed publisher..Silencing AQP1 via siRNA also prevented hypoxia-induced migration of PASMCs. Our results suggest that hypoxia induces a PASMC-specific increase in [Ca(2+)](i) that results in increased AQP1 protein levels and cell migration. ..
- De Leon M, Wang Y, Jones L, Perez Reyes E, Wei X, Soong T, et al. Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels. Science. 1995;270:1502-6 pubmed..Donation of the alpha 1C EF-hand region to the alpha 1E channel conferred the Ca(2+)-inactivating phenotype. These results strongly suggest that Ca2+ binding to the alpha 1C subunit initiates Ca2+ inactivation. ..
- Xu K, Huso D, Dawson T, Bredt D, Becker L. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci U S A. 1999;96:657-62 pubmed..These results suggest that a cardiac muscle nNOS isoform is located on SR of cardiac myocytes, where it may respond to intracellular Ca2+ concentration and modulate SR Ca2+ ion active transport in the heart. ..
- Hoesch R, Yienger K, Weinreich D, Kao J. Coexistence of functional IP(3) and ryanodine receptors in vagal sensory neurons and their activation by ATP. J Neurophysiol. 2002;88:1212-9 pubmed..These results indicate that functional IP(3)Rs and RyRs coexist in nodose neurons and that both IP(3)-induced Ca(2+) release and CICR can be activated by ATP. ..
- Markowitz J, Chen I, Gitti R, Baldisseri D, Pan Y, Udan R, et al. Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction. J Med Chem. 2004;47:5085-93 pubmed
- Golovina V. Visualization of localized store-operated calcium entry in mouse astrocytes. Close proximity to the endoplasmic reticulum. J Physiol. 2005;564:737-49 pubmed..Thus, Ca(2+) entry through TRPC-encoded SOCs is closely linked, not only functionally, but also structurally, to the ER Ca(2+) stores. ..
- Kolosova I, Mirzapoiazova T, Adyshev D, Usatyuk P, Romer L, Jacobson J, et al. Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement. Circ Res. 2005;97:115-24 pubmed..We conclude that the mechanisms of ATP-induced barrier enhancement are independent of intracellular Ca2+, but involve activation of myosin phosphatase via a novel G-protein-coupled mechanism and PKA. ..
- Liu Y, Hubbi M, Pan F, McDonald K, Mansharamani M, Cole R, et al. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem. 2007;282:37064-73 pubmed..These results indicate that intracellular calcium levels can regulate HIF-1alpha expression by modulating calcineurin activity and RACK1 dimerization. ..
- Jung I, Lee H, Lee H, Choi O. FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. Cell Signal. 2009;21:1698-705 pubmed publisher..Cell migration mediated by either Fc epsilon RI or S1P receptors involves activation of both PI3K and MAPK. ..
- Liu D, Pitta M, Lee J, Ray B, Lahiri D, Furukawa K, et al. The KATP channel activator diazoxide ameliorates amyloid-Î² and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;22:443-57 pubmed publisher..Our findings show that diazoxide can ameliorate molecular, cytopathological, and behavioral alterations in a mouse model of AD suggesting a therapeutic potential for drugs that activate KATP channels in the treatment of AD. ..
- Brochet D, Yang D, Cheng H, Lederer W. Elementary calcium release events from the sarcoplasmic reticulum in the heart. Adv Exp Med Biol. 2012;740:499-509 pubmed publisher..The Ca(2+) spark termination mechanism and the number of RyR2 channels activated during a Ca(2+) spark will be discussed with respect to both Ca(2+) sparks and QCR events. ..
- Bazzazi H, Popel A. Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells. PLoS Comput Biol. 2017;13:e1005332 pubmed publisher..The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing. ..
- Dang D, Prasad H, Rao R. Secretory pathway Ca2+ -ATPases promote in vitro microcalcifications in breast cancer cells. Mol Carcinog. 2017;56:2474-2485 pubmed publisher..Our new findings offer mechanistic insight and functional implications on a widely observed, yet poorly understood radiographic signature of breast cancer. ..
- Ward C, Reiken S, Marks A, Marty I, Vassort G, Lacampagne A. Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats. FASEB J. 2003;17:1517-9 pubmed..The observed changes in Ca2+ signaling may contribute to defective excitation-contraction coupling in muscle that can contribute to the reduced exercise capacity in PMI, out of proportion to the degree of cardiac dysfunction. ..
- Stanley A, Chuawong P, Hendrickson T, Fleming K. Energetics of outer membrane phospholipase A (OMPLA) dimerization. J Mol Biol. 2006;358:120-31 pubmed
- Gopalakrishnan S, Tripathi A, Tamiz A, Alkan S, Pandey N. Larazotide acetate promotes tight junction assembly in epithelial cells. Peptides. 2012;35:95-101 pubmed publisher..Taken together, our data indicate that larazotide acetate enhances TJ assembly and barrier function by promoting actin rearrangement and redistribution of TJ and AJ proteins. ..
- Gao W, Murray C, Tian Y, Zhong X, DuMond J, Shen X, et al. Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res. 2012;111:1002-11 pubmed..These findings indicate a novel, redox-based modulation of the contractile apparatus, which positively impacts myocardial function, providing further mechanistic insight for HNO as a therapeutic agent. ..
- Chen T, Illing M, Molday L, Hsu Y, Yau K, Molday R. Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation. Proc Natl Acad Sci U S A. 1994;91:11757-61 pubmed..These results together suggest that subunit 2b of the rod channel is a component of the 240-kDa protein and that it mediates the Ca(2+)-calmodulin modulation of the channel. ..
- Liu Y, Kranias E, Schneider M. Regulation of Ca2+ handling by phosphorylation status in mouse fast- and slow-twitch skeletal muscle fibers. Am J Physiol. 1997;273:C1915-24 pubmed
- Janssen P, Stull L, Marban E. Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat. Am J Physiol Heart Circ Physiol. 2002;282:H499-507 pubmed..We conclude that temperature independently affects contraction and relaxation, and cross-bridge cycling kinetics become rate limiting for cardiac relaxation under experimental conditions closest to those in vivo. ..
- Yang X, Wang W, Fan J, Lal A, Yang D, Cheng H, et al. Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. J Biol Chem. 2004;279:49298-306 pubmed..Collectively, our results indicate that PGA2 stabilizes the p21 mRNA through an ERK-independent increase in cytoplasmic HuR levels and an ERK-dependent association of HuR with the p21 mRNA. ..
- Petersen K, Dolan P, Kensler T, Peleg S, Posner G. Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation. J Med Chem. 2007;50:5824-32 pubmed..One of these three 23-oxa analogs has transcriptional potency almost as high as that of calcitriol, even though it binds to the human vitamin D receptor only about 1% as well as calcitriol. ..
- Sivakumaran V, Stanley B, Tocchetti C, Ballin J, Caceres V, Zhou L, et al. HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxid Redox Signal. 2013;19:1185-97 pubmed publisher..PLN remains physically associated with SERCA2a; however, less monomeric PLN is available resulting in decreased inhibition of the enzyme. These findings offer new avenues to improve Ca(2+) handling in failing hearts. ..
- Yanda M, Liu Q, Cebotaru V, Guggino W, Cebotaru L. Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease. J Biol Chem. 2017;292:17897-17908 pubmed publisher..We conclude that HDAC6 inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca2+ levels. Our results provide potential therapeutic targets that may be useful as treatments for ADPKD. ..
- Porter J, Minke B, Montell C. Calmodulin binding to Drosophila NinaC required for termination of phototransduction. EMBO J. 1995;14:4450-9 pubmed..These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction. ..
- Digel J, Abugo O, Kobayashi T, Gryczynski Z, Lakowicz J, Collins J. Calcium- and magnesium-dependent interactions between the C-terminus of troponin I and the N-terminal, regulatory domain of troponin C. Arch Biochem Biophys. 2001;387:243-9 pubmed..Our results provide the first indica- tion that the C-terminus of TnI may play an important role in the regulation of vertebrate striated muscle through Ca2+-dependent interactions with the regula- tory domain of TnC. ..
- Morris M, Coppin A, Tomavo S, Carruthers V. Functional analysis of Toxoplasma gondii protease inhibitor 1. J Biol Chem. 2002;277:45259-66 pubmed..TgPI-1 is the first anti-trypsin/chymotrypsin inhibitor to be identified in bradyzoites and sporozoites, stages of the parasite that would be exposed to proteolytic enzymes in the digestive tract of the host. ..
- Patterson R, van Rossum D, Ford D, Hurt K, Bae S, Suh P, et al. Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell. 2002;111:529-41 pubmed..Normal ACE was restored by transient expression of PLC-gamma2 or a lipase-inactive PLC-gamma2 mutant. The results indicate a lipase-independent role of PLC-gamma in the physiological agonist-induced activation of Ca2+ entry. ..
- Lamont C, Vial C, Evans R, Wier W. P2X1 receptors mediate sympathetic postjunctional Ca2+ transients in mesenteric small arteries. Am J Physiol Heart Circ Physiol. 2006;291:H3106-13 pubmed
- Dai T, Ramirez Correa G, Gao W. Apelin increases contractility in failing cardiac muscle. Eur J Pharmacol. 2006;553:222-8 pubmed..The increased force development is the result of increased [Ca(2+)](i) transients rather than changes in myofilament calcium responsiveness. ..
- Muend S, Rao R. Fungicidal activity of amiodarone is tightly coupled to calcium influx. FEMS Yeast Res. 2008;8:425-31 pubmed publisher..Our results support a model in which the fungicidal activity of amiodarone is mediated by Ca2+ stress, and highlight the pathway of Ca2+ mediated cell death as a promising target for antifungal drug development. ..
- Xu H, Weir M, Sun L. Calcium and phosphate ion releasing composite: effect of pH on release and mechanical properties. Dent Mater. 2009;25:535-42 pubmed publisher..This composite may have the potential to provide the necessary combination of load-bearing and caries-inhibiting capabilities. ..
- Bayer J, Narayan S, Lalani G, Trayanova N. Rate-dependent action potential alternans in human heart failure implicates abnormal intracellular calcium handling. Heart Rhythm. 2010;7:1093-101 pubmed publisher..Future studies should investigate whether APV-ALT at slow rates identifies patients with deranged calcium handing, including HF patients before decompensation or at risk for arrhythmias. ..
- Greenspon J, Li R, Xiao L, Rao J, Sun R, Strauch E, et al. Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. Dig Dis Sci. 2011;56:1342-53 pubmed publisher..These results indicate that S1P increases levels of E-cadherin, both in cellular amounts and at the cell-cell junctions, and leads to improved barrier integrity in cultured intestinal epithelial cells. ..
- Tison G, Blaha M, Budoff M, Katz R, Rivera J, Bertoni A, et al. The relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosis. Atherosclerosis. 2011;218:507-10 pubmed publisher..HOMA has a positive and graded association with ECC, but not independently of cardiovascular risk factors-particularly metabolic syndrome components. ..
- Zhang J. New insights into the contribution of arterial NCX to the regulation of myogenic tone and blood pressure. Adv Exp Med Biol. 2013;961:329-43 pubmed publisher..Arterial NCX expression and mechanisms that control the local (sub-plasma membrane) Na(+) gradient, including cation-selective receptor-operated channels containing TRPC6, regulate arterial Ca(2+) and constriction, and thus BP. ..
- Liao F, Shin H, Rhee S. Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells. Proc Natl Acad Sci U S A. 1992;89:3659-63 pubmed..Thus, Fc gamma RI and Fc gamma RII appear to be functionally coupled to a nonreceptor tyrosine kinase that phosphorylates PLC-gamma 1 after receptor cross-linking, thereby causing activation of PLC-gamma 1. ..
- Seminario M, Precht P, Bunnell S, Warren S, Morris C, Taub D, et al. PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt. Eur J Immunol. 2004;34:3165-75 pubmed..These results suggest that PTEN acts in T cells primarily to control basal PI-3,4,5-P3 levels, rather than opposing PI3K acutely during TCR stimulation. ..
- Wang W, Xu J, Kirsch T. Annexin V and terminal differentiation of growth plate chondrocytes. Exp Cell Res. 2005;305:156-65 pubmed..Overexpression of annexin V is sufficient to stimulate these terminal differentiation events in growth plate chondrocytes, whereas suppression of annexin V expression inhibits these events. ..
- Kossoff E, Rowley H, Sinha S, Vining E. A prospective study of the modified Atkins diet for intractable epilepsy in adults. Epilepsia. 2008;49:316-9 pubmed..Considering the rapid response in those who improved, but somewhat high discontinuation rate, a 2-month trial period may be adequate to assess for efficacy. ..
- Rojas C, Stathis M, Thomas A, Massuda E, Massuda E, Alt J, et al. Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg. 2008;107:469-78 pubmed publisher..However, these attributes alone are not sufficient to explain the results with palonosetron. We sought to elucidate additional differences among 5-HT(3)-RAs that could help explain the observations in the clinic...
- Linde C, Karashima E, Raina H, Zulian A, WIER W, Hamlyn J, et al. Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats. Am J Physiol Heart Circ Physiol. 2012;302:H611-20 pubmed publisher..These molecular and functional changes provide a mechanism for the increased peripheral vascular resistance (whole body autoregulation) that underlies the sustained hypertension. ..
- Yuan J, Kiselyov K, Shin D, Chen J, Shcheynikov N, Kang S, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-89 pubmed..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function. ..
- Ma H, Sumbilla C, Farrance I, Klein M, Inesi G. Cell-specific expression of SERCA, the exogenous Ca2+ transport ATPase, in cardiac myocytes. Am J Physiol Cell Physiol. 2004;286:C556-64 pubmed..We conclude that analysis of promoter efficiency and cell specificity is of definite advantage when cell-specific expression of exogenous SERCA is wanted in cardiac myocytes after cDNA delivery to mixed cell populations. ..
- Takimoto E, Soergel D, Janssen P, Stull L, Kass D, Murphy A. Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites. Circ Res. 2004;94:496-504 pubmed..These results have implications for cardiac failure in which force-frequency modulation is blunted and afterload relaxation sensitivity increased in association with diminished PKA TnI phosphorylation. ..
- Wang T, Xu H, Oberwinkler J, Gu Y, Hardie R, Montell C. Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX. Neuron. 2005;45:367-78 pubmed..These results illustrate the critical role of Ca(2+) for proper signaling and provide genetic evidence that Ca(2+) overload is responsible for a form of retinal degeneration resulting from defects in the TRP channel. ..
- Nunez J, McCarthy M. Evidence for an extended duration of GABA-mediated excitation in the developing male versus female hippocampus. Dev Neurobiol. 2007;67:1879-90 pubmed..This converging evidence infers that sex affects the duration of GABA(A) receptor-mediated excitation during normal hippocampal development, and provides a mechanism by which the effect is mediated. ..
- Lu W, Wang J, Shimoda L, Sylvester J. Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2008;295:L104-13 pubmed publisher..These results provide further support for the importance of SOCE in HPV and suggest that HPV is greater in distal than proximal PA because greater numbers and activation of SOCC in distal PASMC generate bigger increases in [Ca(2+)](i). ..
- Bruno R, Gover T, Burger A, Brodie A, Njar V. 17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response. Mol Cancer Ther. 2008;7:2828-36 pubmed publisher..Taken together, these findings show VN/124-1 is endowed with multiple anticancer properties that may contribute to its utility as a prostate cancer therapeutic. ..
- Zhang W, Linden D. Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude. J Neurosci. 2009;29:15586-94 pubmed publisher..These results suggest that boutons within brief segment of a single parallel fiber axon can have different sensitivities toward neuromodulators and may have different capacities for both short-term and long-term plasticities. ..
- Goss P, Hershman D, Cheung A, Ingle J, Khosla S, Stearns V, et al. Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a randomised controlled trial. Lancet Oncol. 2014;15:474-82 pubmed publisher..Canadian Cancer Society Research Institute, Pfizer, Canadian Institutes of Health Research. ..
- Yuan X, Tod M, Rubin L, Blaustein M. NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. Proc Natl Acad Sci U S A. 1996;93:10489-94 pubmed..The resulting membrane hyperpolarization, which lowers [Ca2+]i, is apparently one of the mechanisms by which NO induces pulmonary vasodilation. ..
- Breitwieser G, Gama L. Calcium-sensing receptor activation induces intracellular calcium oscillations. Am J Physiol Cell Physiol. 2001;280:C1412-21 pubmed..Serum Ca2+ concentrations thus chronically regulate cells expressing CaR, and small perturbations in extracellular Ca2+ alter both resting intracellular Ca2+ as well as Ca2+ dynamics...
- Song L, Guia A, Muth J, Rubio M, Wang S, Xiao R, et al. Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel. Circ Res. 2002;90:174-81 pubmed..These results also suggest that a modest but sustained increase in Ca(2+) influx triggers a coordinated remodeling of Ca(2+) handling to maintain Ca(2+) homeostasis. ..
- Lamont C, Wier W. Evoked and spontaneous purinergic junctional Ca2+ transients (jCaTs) in rat small arteries. Circ Res. 2002;91:454-6 pubmed..Visualization of sympathetic neurotransmission shows that purinergic components dominate at low frequencies of sympathetic nerve fiber activation. ..
- Oh E, Weinreich D. Bradykinin decreases K(+) and increases Cl(-) conductances in vagal afferent neurones of the guinea pig. J Physiol. 2004;558:513-26 pubmed..The BK-evoked Cl(-) conductance in NGNs may be the first demonstration of an inflammatory mediator exciting primary afferents via an anion channel. ..
- Yang X, Lin M, Yip K, Jeyakumar L, Fleischer S, Leung G, et al. Multiple ryanodine receptor subtypes and heterogeneous ryanodine receptor-gated Ca2+ stores in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2005;289:L338-48 pubmed
- White A, Ryoo S, Li D, Champion H, Steppan J, Wang D, et al. Knockdown of arginase I restores NO signaling in the vasculature of old rats. Hypertension. 2006;47:245-51 pubmed..AS oligonucleotides may, therefore, represent a novel therapeutic strategy against age-related vascular endothelial dysfunction. ..
- Manni S, Mauban J, Ward C, Bond M. Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells. J Biol Chem. 2008;283:24145-54 pubmed publisher..We conclude that RII phosphorylation regulates PKA-dependent substrate phosphorylation and may have significant implications for modulation of cardiac function. ..
- Wei A, Liu T, Winslow R, O ROURKE B. Dynamics of matrix-free Ca2+ in cardiac mitochondria: two components of Ca2+ uptake and role of phosphate buffering. J Gen Physiol. 2012;139:465-78 pubmed publisher..Interestingly, the trigger for PTP activation is unlikely to be [Ca(2+)](mito) itself but rather a downstream byproduct of total mitochondrial Ca(2+) loading. ..
- Maltsev V, Lakatta E. Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking. J Mol Cell Cardiol. 2013;59:181-95 pubmed publisher..It will also provide a conceptual basis for a general theory of robust, flexible, and energy-efficient pacemaking based on realistic components. ..
- Sirenko S, Maltsev V, Maltseva L, Yang D, Lukyanenko Y, Vinogradova T, et al. Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design. J Mol Cell Cardiol. 2014;66:106-15 pubmed publisher..This unleashed Ca(2+) clock that emerges in a physiological Ca(2+) milieu in VM has two faces, however: it can provoke ventricular arrhythmias; or if harnessed, can be an important feature of novel bio-pacemaker designs. ..
- Kofuji P, Hadley R, Kieval R, Lederer W, Schulze D. Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger. Am J Physiol. 1992;263:C1241-9 pubmed
- Murphy A, Kogler H, Georgakopoulos D, McDonough J, Kass D, Van Eyk J, et al. Transgenic mouse model of stunned myocardium. Science. 2000;287:488-91 pubmed..Proteolysis of troponin I also occurs in ischemic human cardiac muscle. Thus, troponin I proteolysis underlies the pathogenesis of a common acquired form of heart failure. ..
- Cavagna M, O Donnell J, Sumbilla C, Inesi G, Klein M. Exogenous Ca2+-ATPase isoform effects on Ca2+ transients of embryonic chicken and neonatal rat cardiac myocytes. J Physiol. 2000;528 Pt 1:53-63 pubmed..4. It is concluded that total SERCA transport velocity has a primary effect on the decay phase of transients. Transport velocity is affected by SERCA isoform turnover rate, temperature, and/or SERCA copy number. ..
- Murata M, Akao M, O ROURKE B, Marban E. Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection. Circ Res. 2001;89:891-8 pubmed..Furthermore, mitoK(ATP) channels and the MPT differentially affect mitochondrial calcium homeostasis: mitoK(ATP) channels suppress calcium accumulation during I/R, while the MPT comes into play only upon reperfusion. ..
- Zhou L, Burnett A, Huang P, Becker L, Kuppusamy P, Kass D, et al. Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle. Biochem Biophys Res Commun. 2002;294:1030-5 pubmed
- Hsu S, Levine M. Primary hyperparathyroidism in children and adolescents: the Johns Hopkins Children's Center experience 1984-2001. J Bone Miner Res. 2002;17 Suppl 2:N44-50 pubmed..In all cases, surgery was curative. These data suggest that PHPT in children is a more severe disease than in older adults, which may reflect a bias of ascertainment or a difference in fundamental parathyroid pathobiology. ..
- Undem B, Oh E, Lancaster E, Weinreich D. Effect of extracellular calcium on excitability of guinea pig airway vagal afferent nerves. J Neurophysiol. 2003;89:1196-204 pubmed
- Matthews T, Duncan R, Zidanic M, Michael T, Fuchs P. Cloning and characterization of SK2 channel from chicken short hair cells. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005;191:491-503 pubmed..These findings imply that the molecular mechanisms of inhibition are conserved in hair cells of all vertebrates. ..
- Xiong W, Tian Y, Disilvestre D, Tomaselli G. Transmural heterogeneity of Na+-Ca2+ exchange: evidence for differential expression in normal and failing hearts. Circ Res. 2005;97:207-9 pubmed..A selective upregulation of NCX expression in MID and ENDO in heart failure markedly redirects the orientation of the transmural functional gradient of NCX and may lead to enhanced vulnerability to cardiac arrhythmias. ..
- Takahashi S, Miriyala J, Tay L, Yue D, Colecraft H. A CaVbeta SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels. J Gen Physiol. 2005;126:365-77 pubmed..The results reveal that Ca(V)beta SH3 and GK domains function codependently to tune Ca(2+) channel trafficking and gating properties, and suggest new paradigms for physiological and therapeutic regulation of Ca(2+) channel activity. ..
- Liang L, MacDonald K, Schwiebert E, Zeitlin P, Guggino W. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am J Physiol Cell Physiol. 2009;296:C131-41 pubmed publisher..In conclusion, we have identified spiperone as a new therapeutic platform for correction of defective Cl(-) secretion in CF via a pathway independent of CFTR...
- ..These results suggest that short-term plasticity contributes to effective cholinergic inhibition of hair cells. ..
- Abud E, Maylor J, Undem C, Punjabi A, Zaiman A, Myers A, et al. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci U S A. 2012;109:1239-44 pubmed publisher..When started after pulmonary hypertension was established, digoxin attenuated the hypoxia-induced increases in RV pressure and PASMC pH and [Ca(2+)](i). These preclinical data support a role for HIF-1 inhibitors in the treatment of HPH. ..
- Khairallah R, Shi G, Sbrana F, Prosser B, Borroto C, Mazaitis M, et al. Microtubules underlie dysfunction in duchenne muscular dystrophy. Sci Signal. 2012;5:ra56 pubmed publisher..Together, these data show that microtubules are the proximate element responsible for the dysfunction in Ca(2+) and ROS signaling in DMD and could be effective therapeutic targets for intervention. ..
- Galvao T, Khairallah R, Dabkowski E, Brown B, Hecker P, O Connell K, et al. Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. Am J Physiol Heart Circ Physiol. 2013;304:H12-21 pubmed publisher..This suggest that greater susceptibility to MPT is not a contributor to cardiac pathology and poor survival in heart failure. ..
- Zacharia J, Mauban J, Raina H, Fisher S, WIER W. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via ?1A- and ?1D-adrenoceptor subtypes. PLoS ONE. 2013;8:e65969 pubmed publisher..p.) reduced basal tone by 90%. Tone of mouse femoral arteries in vivo is almost entirely sympathetic in origin. Activation of ?1A- and ?1D-adrenoceptors elevates [Ca(2+)]i and accounts for at least 55% of the tone. ..
- Zile M, Trayanova N. Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study. Prog Biophys Mol Biol. 2016;120:270-80 pubmed publisher..These findings provide important insight into the relationship between heart-failure-induced electrical and mechanical alternans and how they are altered by physiological conditions at near-resting heart rates. ..
- O Donnell J, Sumbilla C, Ma H, Farrance I, Cavagna M, Klein M, et al. Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes. Circ Res. 2001;88:415-21 pubmed..Expression of endogenous SERCA was unchanged, but expression of exogenous SERCA was higher in myocytes rendered hypertrophic by treatment with PHE than in nontreated controls. ..
- Camandola S, Cutler R, Gary D, Milhavet O, Mattson M. Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaB. J Biol Chem. 2005;280:22287-96 pubmed..These findings establish an ER calcium channel as a pivotal target for NF-kappaB-mediated cell survival signaling. ..