Genomes and Genes
Experts and Doctors on biological models in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Topic: biological models
Publications193 found, 100 shown here
- Cheng J, Cebotaru V, Cebotaru L, Guggino W. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell. 2010;21:1178-87 pubmed publisher..We have identified STX6 as a new component of the CAL complex that regulates the abundance and function of CFTR at the post-ER level. Our results suggest a therapeutic role of STX6 in enhancing rescued DeltaF508-CFTR. ..
- Ganapathy Kanniappan S, Vali M, Kunjithapatham R, Buijs M, Syed L, Rao P, et al. 3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy. Curr Pharm Biotechnol. 2010;11:510-7 pubmed..Therefore, these and other studies reveal the tremendous potential of 3-bromopyruvate as an anticancer agent. ..
- Ward C, Reiken S, Marks A, Marty I, Vassort G, Lacampagne A. Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats. FASEB J. 2003;17:1517-9 pubmed..The observed changes in Ca2+ signaling may contribute to defective excitation-contraction coupling in muscle that can contribute to the reduced exercise capacity in PMI, out of proportion to the degree of cardiac dysfunction. ..
- Zhang Y, Rao R. Global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone. J Biol Chem. 2007;282:37844-53 pubmed..Overall, the transcriptional responses to amiodarone revealed by this study were found to be distinct from other classes of antifungals, including the azole drugs, pointing toward a novel target pathway in combating fungal pathogenesis. ..
- Shaw J, Green R. Two distinct components of release factor function uncovered by nucleophile partitioning analysis. Mol Cell. 2007;28:458-67 pubmed..These data lead to a model where RFs make two distinct contributions to catalysis--a relatively nonspecific activation of the catalytic center and specific selection of water as a nucleophile facilitated by Q235. ..
- Jayanthi S, McCoy M, Beauvais G, Ladenheim B, Gilmore K, Wood W, et al. Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum. PLoS ONE. 2009;4:e6092 pubmed publisher..Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain. ..
- Ellison D, Munden A, Levchenko A. Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells. Mol Biosyst. 2009;5:1004-12 pubmed publisher..We suggest that the described computational/experimental platform can be used to identify and study specific factors and pathways involved in a wide variety of paracrine signaling systems. ..
- Xiong Y, Kabacoff C, Franca Koh J, Devreotes P, Robinson D, Iglesias P. Automated characterization of cell shape changes during amoeboid motility by skeletonization. BMC Syst Biol. 2010;4:33 pubmed publisher..Thus, the method provides a powerful tool for investigating amoeboid motility. ..
- Wolkow C. New haystacks reveal new needles: using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging. Interdiscip Top Gerontol. 2010;37:84-93 pubmed publisher..From this chapter, readers will develop a deeper understanding of the ways that C.elegans can be used for mechanistic gerontological studies. ..
- Earnshaw W, Cooke C. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. J Cell Sci. 1991;98 ( Pt 4):443-61 pubmed
- Mobley H, Garner R, Bauerfeind P. Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions. Mol Microbiol. 1995;16:97-109 pubmed..coli a high-affinity nickel-transport system (KT = 11.3 +/- 2.4 nM; Vmax = 1750 +/- 220 pmol Ni2+ min-1 10(-8) cells) and is necessary for expression of catalytically active urease, regardless of growth conditions...
- Miller R, Calhoun B, Young E. Discriminability of vowel representations in cat auditory-nerve fibers after acoustic trauma. J Acoust Soc Am. 1999;105:311-25 pubmed..However, information that could allow discrimination remains in the temporal (phase-locked) aspects of the responses. ..
- Iacobuzio Donahue C, Shuja S, Cai J, Peng P, Willett J, Murnane M. Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function. Int J Oncol. 2004;24:473-85 pubmed..Loss of cathepsin D protein may provide an advantage to colorectal tumors related to a loss of cathepsin D function in proapototic or antiangiogenic pathways while increased cathepsin D may promote cancer cell proliferation or invasion. ..
- Fiskum G, Rosenthal R, Vereczki V, Martin E, Hoffman G, Chinopoulos C, et al. Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress. J Bioenerg Biomembr. 2004;36:347-52 pubmed
- Wu G, Nie L, Zhang W. Relation between mRNA expression and sequence information in Desulfovibrio vulgaris: combinatorial contributions of upstream regulatory motifs and coding sequence features to variations in mRNA abundance. Biochem Biophys Res Commun. 2006;344:114-21 pubmed..This result demonstrates that upstream regulatory motifs and coding sequence information contribute to the overall mRNA expression in a combinatorial rather than an additive manner...
- Kallay L, McNickle A, Brennwald P, Hubbard A, Braiterman L. Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains. J Cell Biochem. 2006;99:647-64 pubmed..J. Cell. Biochem. 99: 647-664, 2006. (c) 2006 Wiley-Liss, Inc. ..
- Nakayama K, Nakayama N, Wang T, Shih I. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. Cancer Res. 2007;67:8058-64 pubmed..In summary, NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells. ..
- Khandelwal A, Gediya L, Njar V. MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN/66-1 in hormone-insensitive PC-3 prostate cancer cells and tumours. Br J Cancer. 2008;98:1234-43 pubmed publisher..In addition, the combination caused modulation and induction of apoptosis. These results suggest that VN/66-1 or its combination with MS-275 may be a novel therapy for the treatment of prostate carcinoma. ..
- Villa Abrille M, Sidor A, O ROURKE B. Insulin effects on cardiac Na+/Ca2+ exchanger activity: role of the cytoplasmic regulatory loop. J Biol Chem. 2008;283:16505-13 pubmed publisher..The finding that the 562-670 f-loop domain is implicated in both XIP and receptor-mediated modulation of NCX highlights its important role in acute physiological or pathophysiological regulation of Ca(2+) balance in the heart. ..
- Gallo C, Munro E, Rasoloson D, Merritt C, Seydoux G. Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos. Dev Biol. 2008;323:76-87 pubmed publisher..The maternal mRNA nos-2 is maintained in germ granules, but not in P-bodies. We conclude that P-bodies are distinct from germ granules, and represent a second class of RNA granules that behaves differently in somatic and germline cells. ..
- Robertson B, Chellaiah M. Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Exp Cell Res. 2010;316:1-11 pubmed publisher..This work describes an important aspect of cancer progression induced by OPN. ..
- Yu H, Smallwood P, Wang Y, Vidaltamayo R, Reed R, Nathans J. Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development. 2010;137:3707-17 pubmed publisher..These observations indicate that frizzled signaling is involved in diverse tissue closure processes, defects in which account for some of the most common congenital anomalies in humans...
- Kiselev A, Subramaniam S. Activation and regeneration of rhodopsin in the insect visual cycle. Science. 1994;266:1369-73 pubmed..The accumulation of inactive rhodopsin at higher light levels may represent a mechanism for gain regulation in the insect visual cycle. ..
- Shan X, Balakir R, Criado G, Wood J, Seminario M, Madrenas J, et al. Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation. Mol Cell Biol. 2001;21:7137-49 pubmed..These results demonstrate the existence of two pathways leading to TCR-stimulated Erk activation in Jurkat T cells: a ZAP-70-independent pathway requiring PKC and a ZAP-70-dependent pathway that is PKC independent. ..
- Evron Y, Johnson E, McCarty R. Regulation of proton flow and ATP synthesis in chloroplasts. J Bioenerg Biomembr. 2000;32:501-6 pubmed..It is concluded that the gamma and epsilon subunits of CF(1) play key roles in both regulation of activity and proton translocation. ..
- Paumi C, Menendez J, Arnoldo A, Engels K, Iyer K, Thaminy S, et al. Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis. Mol Cell. 2007;26:15-25 pubmed..Our study provides proof of principle that iMYTH is an ideal methodology to identify physiological interactors and regulators of ABC transporters and other yeast transmembrane proteins...
- Othman A, Tenero D, Boyle D, Eddington N, Fossler M. Population pharmacokinetics of S(-)-carvedilol in healthy volunteers after administration of the immediate-release (IR) and the new controlled-release (CR) dosage forms of the racemate. AAPS J. 2007;9:E208-18 pubmed..The model performed well in simulation and leverage analysis indicated its robustness. The model will be a useful tool for future simulation studies. ..
- Motegi F, Seydoux G. Revisiting the role of microtubules in C. elegans polarity. J Cell Biol. 2007;179:367-9 pubmed..One study (see Tsai and Ahringer on p. 397 of this issue) brings new light to this problem by demonstrating that severe loss of microtubules impairs polarity onset in C. elegans. ..
- Shin J, Kim Y, Linden D. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2008;105:746-50 pubmed publisher..These data suggest that Ca2+-dependent postsynaptic fusion of glutamate-loaded vesicles evokes a slow inward current produced by activation of postsynaptic mGluR1, thereby constituting a useful form of feedback regulation. ..
- Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson G, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008;68:3169-77 pubmed publisher..Thus, these novel human DNA ligase inhibitors will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents. ..
- Park S, Park J, Kim S, Kim J, Shepherd J, Smith Hicks C, et al. Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron. 2008;59:70-83 pubmed publisher..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD. ..
- Metzger M, Michaelis S. Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins. Mol Biol Cell. 2009;20:1006-19 pubmed publisher..Among these is RPN4, highlighting the importance of the Rpn4p-dependent response in tolerating UPR-M/C stress. Further analysis suggests the requirement for Rpn4p reflects severe impairment of the proteasome by UPR-M/C stress. ..
- Ravindran A, Kobrinsky E, Lao Q, Soldatov N. Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits. Channels (Austin). 2009;3:25-31 pubmed..2 channel. The data suggest a previously unknown action of CaM that in the presence of CaVbeta; translates into activation of the alpha2delta-deficient calcium channel and alteration of its properties. ..
- Ackermann M, Hu L, Bowman A, Bloch R, Kontrogianni Konstantopoulos A. Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Mol Biol Cell. 2009;20:2963-78 pubmed publisher..Collectively, our experiments identify a new ligand of obscurin at the M-band, MyBP-C slow variant-1 and suggest that their interaction contributes to the assembly of M- and A-bands. ..
- Sedaghat A, Siliciano R, Wilke C. Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. Antivir Ther. 2009;14:263-71 pubmed..Our results also highlight that the viral dynamics produced by different antiretroviral drugs should not be directly compared with each other. ..
- Loza M, Penn R. Regulation of T cells in airway disease by beta-agonist. Front Biosci (Schol Ed). 2010;2:969-79 pubmed..Here we provide a comprehensive review of the literature concerning beta-agonist effects on T cells, and discuss the relevance of emerging paradigms of beta-adrenergic receptor signaling to T cell function. ..
- Xie T, Spradling A. A niche maintaining germ line stem cells in the Drosophila ovary. Science. 2000;290:328-30 pubmed..Our studies implicate one of the somatic cell types, the cap cells, as a key niche component. ..
- Karson M, Whittington K, Alger B. Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. Neuropharmacology. 2008;54:117-28 pubmed..In summary, our data are compatible with the hypothesis that CCK has opposite actions on sIPSPs that originate from functionally distinct interneurons. ..
- Kim H, Kirsch T. Collagen/annexin V interactions regulate chondrocyte mineralization. J Biol Chem. 2008;283:10310-7 pubmed publisher..Because annexin V is up-regulated during pathological mineralization events of articular cartilage, it is possible that these interactions also regulate pathological mineralization. ..
- Raufman J, Samimi R, Shah N, Khurana S, Shant J, Drachenberg C, et al. Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res. 2008;68:3573-8 pubmed publisher..001). Compared with WT, azoxymethane-treated M(3)R-deficient mice have attenuated epithelial cell proliferation, tumor number, and size. M(3)R and post-M(3)R signaling are novel therapeutic targets for colon cancer. ..
- Huang H, Bader J. Precision and recall estimates for two-hybrid screens. Bioinformatics. 2009;25:372-8 pubmed publisher..All software (C source) and datasets are available as supplemental files and at http://www.baderzone.org under the Lesser GPL v. 3 license. ..
- Zhou W, Tu Y, Simpson P, Kuhajda F. Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells. Oncogene. 2009;28:2979-87 pubmed publisher..Taken together, these data indicate that MCD-induced cytotoxicity is likely mediated through malonyl-CoA metabolism. These findings support the hypothesis that MCD is a potential therapeutic target for cancer therapy. ..
- Gustafson T, He W, Craparo A, Schaub C, O Neill T. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol. 1995;15:2500-8 pubmed..The SAIN domain appears to represent a novel motif which is able to interact with autophosphorylated receptors such as the IR. ..
- Polli J, Ginski M. Human drug absorption kinetics and comparison to Caco-2 monolayer permeabilities. Pharm Res. 1998;15:47-52 pubmed
- Raines K, Cao G, Porsuphatana S, Tsai P, Rosen G, Shapiro P. Nitric oxide inhibition of ERK1/2 activity in cells expressing neuronal nitric-oxide synthase. J Biol Chem. 2004;279:3933-40 pubmed..These findings indicate that nNOS can differentially regulate the ERK signal transduction pathway in a manner dependent on the presence of l-arginine and the production of NO*. ..
- Nowak S, Corces V. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. 2004;20:214-20 pubmed..3 variant, which has a conserved N-terminal tail, can replace histone H3 at sites of active transcription, adds a new layer of complexity and possibilities to the regulation of transcription through changes in chromatin structure. ..
- Lee S, Montell C. Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr Biol. 2004;14:2076-85 pubmed..Our results support a model in which visual impairment caused by continuous illumination occurs through an arrestin-dependent pathway that promotes degradation of rhodopsin. ..
- Zhang Q, Adiseshaiah P, Kalvakolanu D, Reddy S. A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression. J Biol Chem. 2006;281:10174-81 pubmed
- Kim M, Chang X, Yamashita K, Nagpal J, Baek J, Wu G, et al. Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma. Oncogene. 2008;27:3624-34 pubmed publisher..Our data implicate DFNA5 as a novel tumor suppressor gene in CRC and a valuable molecular marker for human cancer. ..
- Juhaszova M, Wang S, Zorov D, Nuss H, Gleichmann M, Mattson M, et al. The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown. Ann N Y Acad Sci. 2008;1123:197-212 pubmed publisher..In this article we discuss the current state of knowledge and provide new data related to the MPT pore structure and regulation. ..
- Kamimura Y, Xiong Y, Iglesias P, Hoeller O, Bolourani P, Devreotes P. PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol. 2008;18:1034-43 pubmed publisher..These in turn phosphorylate a series of signaling and cytoskeletal proteins, thereby regulating directed migration. ..
- Qutub A, Popel A. Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting. BMC Syst Biol. 2009;3:13 pubmed publisher..model that bridges the gap between these two perspectives, and addresses a remaining question in angiogenic sprouting: how do the processes of endothelial cell elongation, migration and proliferation contribute to vessel formation?..
- Sun X, Werner D, Ghosh U. Modeling PCB mass transfer and bioaccumulation in a freshwater oligochaete before and after amendment of sediment with activated carbon. Environ Sci Technol. 2009;43:1115-21 pubmed
- Lee E, Kim H, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran S, et al. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 2010;17:732-9 pubmed publisher..Our findings indicate that FMRP represses translation by recruiting APP mRNA to processing bodies, whereas hnRNP C promotes APP translation by displacing FMRP, thereby relieving the translational block. ..
- Burdick M, Bochner B, Collins B, Schnaar R, Konstantopoulos K. Glycolipids support E-selectin-specific strong cell tethering under flow. Biochem Biophys Res Commun. 2001;284:42-9 pubmed..These findings indicate that glycosphingolipids expressing an appropriate oligosaccharide mediate cell tethering/rolling via E-selectin but not P-selectin. ..
- Thupari J, Pinn M, Kuhajda F. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001;285:217-23 pubmed..This study identifies CPT-1 and ACC as two new potential targets for cancer chemotherapy...
- Tam A, Schmidt W, Michaelis S. The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J Biol Chem. 2001;276:46798-806 pubmed..Importantly, this study is the first to directly demonstrate that a eukaryotic multispanning membrane protein can possess intrinsic proteolytic activity. ..
- D SOUZA V, Melamed J, Habib D, Pullen K, Wallace K, Summers M. Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition. J Mol Biol. 2001;314:217-32 pubmed..The present results indicate that MLV NC binds to a pocket or surface that only exists in the presence of all three stem loops. ..
- Boheler K, Czyz J, Tweedie D, Yang H, Anisimov S, Wobus A. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res. 2002;91:189-201 pubmed..This review summarizes the current state of ES cell-derived cardiogenesis and provides an overview of how genomic strategies coupled with this in vitro differentiation system can be applied to cardiac research. ..
- Moller D, Chen E. Genetic basis of remitting sarcoidosis: triumph of the trimolecular complex?. Am J Respir Cell Mol Biol. 2002;27:391-5 pubmed
- Esni F, Ghosh B, Biankin A, Lin J, Albert M, Yu X, et al. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development. 2004;131:4213-24 pubmed..These results define a normal inhibitory role for Notch in the regulation of exocrine pancreatic differentiation. ..
- Herndon T, Pirone D, Tsokos G, Chen C. T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho. Biochem Biophys Res Commun. 2005;332:1133-9 pubmed..Taken together, these results suggest that in addition to pathways stimulated by classical T cell-APC interactions, another signal arising from T cell clustering can enhance activation. ..
- Slawson C, Lakshmanan T, Knapp S, Hart G. A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell. 2008;19:4130-40 pubmed publisher..Together, these data demonstrate that the O-GlcNAc cycling enzymes associate with kinases and phosphatases at M phase to regulate the posttranslational status of vimentin. ..
- Kamimura Y, Tang M, Devreotes P. Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods Mol Biol. 2009;571:255-70 pubmed publisher..These studies help to link the signaling pathways to specific effectors and provide a more complete understanding of chemotaxis. ..
- Hoffman P. A conditioning lesion induces changes in gene expression and axonal transport that enhance regeneration by increasing the intrinsic growth state of axons. Exp Neurol. 2010;223:11-8 pubmed publisher..e., a peripheral nerve graft). This regeneration does not occur in the absence of a CL. We will examine how changes in gene expression and axonal transport induced by a CL may promote this regeneration. ..
- Wu F, Stefanini M, Mac Gabhann F, Popel A. Modeling of growth factor-receptor systems from molecular-level protein interaction networks to whole-body compartment models. Methods Enzymol. 2009;467:461-97 pubmed publisher..g., vascular permeability and lymphatic drainage). The given examples will demonstrate the utility of computational models in aiding both basic science and clinical research on VEGF systems biology. ..
- Calvi B, Spradling A. The nuclear location and chromatin organization of active chorion amplification origins. Chromosoma. 2001;110:159-72 pubmed..We discuss the implications of these results for understanding the role of higher order structure in amplification and chromosome duplication. ..
- Hadley G. Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells. Am J Transplant. 2004;4:1026-32 pubmed..The purpose of this communication is to review the known properties of the CD103 molecule and its postulated role in the efferent phase of renal allograft rejection. ..
- Martin E, Rosenthal R, Fiskum G. Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress. J Neurosci Res. 2005;79:240-7 pubmed
- Spassova M, Soboloff J, He L, Xu W, Dziadek M, Gill D. STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A. 2006;103:4040-5 pubmed..As a cell surface signaling protein, STIM1 represents a key pharmacological target to control fundamental Ca(2+)-regulated processes including secretion, contraction, metabolism, cell division, and apoptosis. ..
- Köttgen M. TRPP2 and autosomal dominant polycystic kidney disease. Biochim Biophys Acta. 2007;1772:836-50 pubmed..This review summarizes the known and emerging functions of TRPP2, focusing on the question of how channel function translates into complex morphogenetic programs regulating tubular structure. ..
- Poirier C, Iglesias P. An integrative approach to understanding mechanosensation. Brief Bioinform. 2007;8:258-65 pubmed..Multiscale modeling methods combined with experimental techniques in an integrative approach are suggested as ways of undertaking the study of such systems. ..
- Montell D. Morphogenetic cell movements: diversity from modular mechanical properties. Science. 2008;322:1502-5 pubmed publisher..A small number of properties used in combination could, in principle, generate a diverse array of cell shapes and arrangements and thus orchestrate the varied morphogenetic events observed during metazoan organ development. ..
- Tankersley C, Kleeberger S. Ozone-induced inflammation and altered ventilation in genetically susceptible mice: a comparison of acute and subacute exposures. Toxicol Lett. 1994;72:279-89 pubmed..Results imply that mechanisms that control susceptibility to the 2 exposures are not the same, and that one response is not necessarily predictive of the other. ..
- Reddi A. Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Rev. 1997;8:11-20 pubmed..The successful isolation of first mammalian morphogens has laid the foundation for the elucidation of molecular signalling during morphogenesis in bones and beyond. ..
- Nyska M, Parks B, Chu I, Myerson M. The contribution of the medial calcaneal osteotomy to the correction of flatfoot deformities. Foot Ankle Int. 2001;22:278-82 pubmed..The purpose of this study was twofold: 1) to define the contribution of the Achilles tendon to the flatfoot deformity, and 2) to define the effect of a calcaneal medial displacement osteotomy...
- Tang Q, Edidin M. Vesicle trafficking and cell surface membrane patchiness. Biophys J. 2001;81:196-203 pubmed..As predicted by the simulation, the apparent sizes of HLA patches increased, whereas their intensities decreased after endocytosis and vesicle trafficking were inhibited. ..
- Chellaiah M, Biswas R, Yuen D, Alvarez U, Hruska K. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem. 2001;276:47434-44 pubmed..Because both gelsolin deficiency and PI3K inhibition impair bone resorption, we conclude that phosphatidylinositol 3,4,5-trisphosphate-based protein interactions are critical for osteoclast function. ..
- Luk E, Culotta V. Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem. 2001;276:47556-62 pubmed..We propose a model in which Smf2p-containing vesicles play a central role in manganese trafficking to the mitochondria and other cellular sites as well. ..
- Frydman H, Spradling A. The receptor-like tyrosine phosphatase lar is required for epithelial planar polarity and for axis determination within drosophila ovarian follicles. Development. 2001;128:3209-20 pubmed..Our studies suggest that positional information can be stored transiently in the ECM. A major function of Lar may be to transduce such signals. ..
- Hurt K, Musicki B, Palese M, Crone J, Becker R, Moriarity J, et al. Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A. 2002;99:4061-6 pubmed..Our findings support a model in which rapid, brief activation of neuronal NOS initiates the erectile process, whereas PI3-kinase/Akt-dependent phosphorylation and activation of eNOS leads to sustained NO production and maximal erection. ..
- SANCHEZ ALVARADO A, Newmark P, Robb S, Juste R. The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development. 2002;129:5659-65 pubmed
- Malkiel E, Sheng J, Katz J, Strickler J. The three-dimensional flow field generated by a feeding calanoid copepod measured using digital holography. J Exp Biol. 2003;206:3657-66 pubmed..2x10(-9) N), its excess density (6.7 kg m(-3)) and the propulsive force generated by its feeding appendages (1.8x10(-8) N). ..
- Young E, Yu J, Reiss L. Non-linearities and the representation of auditory spectra. Int Rev Neurobiol. 2005;70:135-68 pubmed
- Kominsky S. Claudins: emerging targets for cancer therapy. Expert Rev Mol Med. 2006;8:1-11 pubmed..Further studies are needed to determine the potential systemic toxicity of this approach considering the ubiquitous expression of CLDNs in the body, but CLDN-targeted therapeutics appear to have promise in the treatment of cancer. ..
- Andersen J, Hassel B. The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe?. Cytokine Growth Factor Rev. 2006;17:411-21 pubmed..Here we review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis. ..
- Kato Y, Okollie B, Raman V, Vesuna F, Zhao M, Baker S, et al. Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models. Cancer Biol Ther. 2007;6:891-7 pubmed..The absence of these molecular responses to TMZ treatment in MCF-7 tumors in vivo supports the possibility that the onset of cancer drug resistance is associated with reduced PS, which can decrease delivery of the drug to cancer cells. ..
- Zou T, Liu L, Rao J, Marasa B, Chen J, Xiao L, et al. Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. Biochem J. 2008;409:389-98 pubmed