Genomes and Genes
Experts and Doctors on base sequence in Baltimore, Maryland, United States
Locale: Baltimore, Maryland, United States
Topic: base sequence
Publications376 found, 100 shown here
- McCann R, Craig S. The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals. Proc Natl Acad Sci U S A. 1997;94:5679-84 pubmed
- Watnick T, Piontek K, Cordal T, Weber H, Gandolph M, Qian F, et al. An unusual pattern of mutation in the duplicated portion of PKD1 is revealed by use of a novel strategy for mutation detection. Hum Mol Genet. 1997;6:1473-81 pubmed..This clustering of base pair substitutions is unusual and suggests that mutation may result from unique structural features of the PKD1 gene. ..
- Varney T, Casademunt E, Ho H, Petty C, Dolman J, Blumberg D. A novel Dictyostelium gene encoding multiple repeats of adhesion inhibitor-like domains has effects on cell-cell and cell-substrate adhesion. Dev Biol. 2002;243:226-48 pubmed..We propose that the AmpA protein functions as an anti-adhesive to limit cell-cell and cell-substrate adhesion during development and thus facilitates cell migration during morphogenesis. ..
- Radulovic S, Rahman M, Beier M, Azad A. Molecular and functional analysis of the Rickettsia typhi groESL operon. Gene. 2002;298:41-8 pubmed..Complementation assay by R. typhi groESL in a temperature sensitive Escherichia coli groEL mutant restored significant growth ability at non-permissive temperature...
- Simser J, Mulenga A, Macaluso K, Azad A. An immune responsive factor D-like serine proteinase homologue identified from the American dog tick, Dermacentor variabilis. Insect Mol Biol. 2004;13:25-35 pubmed..Additionally, an apparent orthologue of the D. variabilis clip-domain molecule was cloned, and expression detected, from a Dermacentor andersoni cell line indicating cross species conservation...
- Finzi S, Li Y, Mitchell T, Farr A, Maumenee I, Sallum J, et al. Posterior polar cataract: genetic analysis of a large family. Ophthalmic Genet. 2005;26:125-30 pubmed..The same mutation was recently identified in four families with congenital cataracts. This study provides further evidence of genetic heterogeneity of autosomal dominant posterior polar cataract. ..
- Cheong I, Huang X, Bettegowda C, Diaz L, Kinzler K, Zhou S, et al. A bacterial protein enhances the release and efficacy of liposomal cancer drugs. Science. 2006;314:1308-11 pubmed..This protein could potentially be incorporated into diverse experimental approaches for the specific delivery of chemotherapeutic agents to tumors. ..
- Wright E, Page S, Barber S, Clements J. Prep1/Pbx2 complexes regulate CCL2 expression through the -2578 guanine polymorphism. Genes Immun. 2008;9:419-30 pubmed publisher..Therefore, promoters that harbor the -2578 G allele undergo a higher fold induction and by extension, individuals homozygous for -2578 G would be expected to exhibit hyper-responsive CCL2 phenotypes during periods of inflammation. ..
- Hu G, Barnes B. IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway. J Biol Chem. 2009;284:2767-77 pubmed publisher..The results presented here identify IRF-5 as a new mediator of DR signaling and provides molecular insight into the mechanism of TRAIL-induced IRF-5 signaling. ..
- Liu Q, Pan C, Hishimoto A, Li C, Xi Z, Llorente Berzal A, et al. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. 2009;8:519-30 pubmed publisher..These results provide much improved information about CB2 gene structure and its human and rodent variants that should be considered in developing CB2-R-based therapeutic agents. ..
- Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, et al. Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. Int J Cancer. 2011;129:2134-46 pubmed publisher..8-71.5% of luciferase activity by degrading luciferase mRNA in HSA/c cells. In conclusion, PLK1 is post-transcriptionally regulated by miR-593* and could be a promising molecular target for EC treatment. ..
- Jiang Q, Turner T, Sosa M, Rakha A, Arnold S, Chakravarti A. Rapid and efficient human mutation detection using a bench-top next-generation DNA sequencer. Hum Mutat. 2012;33:281-9 pubmed publisher..We identified five missense mutations in these three genes that may potentially be involved in the pathogenesis of HSCR and need to be studied in larger patient samples. ..
- Müller G, Hansen U, Xu Z, Griswold B, Talan M, McDonnell N, et al. Allele-specific siRNA knockdown as a personalized treatment strategy for vascular Ehlers-Danlos syndrome in human fibroblasts. FASEB J. 2012;26:668-77 pubmed publisher..Thus, the application of allele-specific RNAi may be a promising direction for future personalized therapies to reduce the severity of vEDS. ..
- Cheng Y, Jin Z, Agarwal R, Ma K, Yang J, Ibrahim S, et al. LARP7 is a potential tumor suppressor gene in gastric cancer. Lab Invest. 2012;92:1013-9 pubmed publisher..001) relative to control siRNA transfection. Taken together, these findings suggest that LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation. ..
- Harduin Lepers A, Shaper N, Mahoney J, Shaper J. Murine beta 1,4-galactosyltransferase: round spermatid transcripts are characterized by an extended 5'-untranslated region. Glycobiology. 1992;2:361-8 pubmed..1 kb round spermatid beta 1,4-GT transcripts are distinguished by the presence of an additional 5'-untranslated sequence of approximately 560 bp that is absent in premeiotic germ cells and somatic cells.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Randall W. Cellular expression of a cloned, hydrophilic, murine acetylcholinesterase. Evidence of palmitoylated membrane-bound forms. J Biol Chem. 1994;269:12367-74 pubmed..Thus the membrane-bound AChE is palmitoylated, suggesting that fatty acylation may serve as an alternative mechanism for anchoring the hydrophilic polypeptide subunit of AChE to the external face of the plasma membrane. ..
- Nicholas J, Ruvolo V, Zong J, Ciufo D, Guo H, Reitz M, et al. A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. J Virol. 1997;71:1963-74 pubmed..We conclude that the DL-B locus of gammaherpesviruses displays considerably more variability that previously appreciated and that expression of many of these genes is likely to have important implications for HHV-8 biology and therapy. ..
- Lopez de Silanes I, Fan J, Yang X, Zonderman A, Potapova O, Pizer E, et al. Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene. 2003;22:7146-54 pubmed..We propose that HuR-regulated target mRNA expression contributes to colon cancer growth. Our results suggest a pivotal function for HuR in colon carcinogenesis. ..
- Chang T, Wentzel E, Kent O, Ramachandran K, Mullendore M, Lee K, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007;26:745-52 pubmed..Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53. ..
- Yamakuchi M, Ferlito M, Lowenstein C. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A. 2008;105:13421-6 pubmed publisher..Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway. ..
- Lin M, Tseng L, Kamiyama H, Kamiyama M, Lim P, Hidalgo M, et al. Quantifying the relative amount of mouse and human DNA in cancer xenografts using species-specific variation in gene length. Biotechniques. 2010;48:211-8 pubmed publisher..Finally, we discuss how contaminating mouse DNA affects next-generation DNA sequencing. ..
- Skibbens R, Corson L, Koshland D, Hieter P. Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev. 1999;13:307-19 pubmed..The analysis of Ctf7p also reveals an important connection between sister chromatid cohesion, spindle integrity and the spindle assembly checkpoint. ..
- Lu Y, Singh M, Cerny J. Canonical germinal center B cells may not dominate the memory response to antigenic challenge. Int Immunol. 2001;13:643-55 pubmed..2(+) cells. These data suggest that the late primary and secondary responses to a hapten may be born by different B cell lineages, and that some clonotypes may reach the memory pool without an extensive mutation and expansion. ..
- Hoffman S, Polack F, Hauer D, Griffin D. Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10. Viral Immunol. 2003;16:369-79 pubmed..Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression. ..
- Xie Y, Xu K, Dai B, Guo Z, Jiang T, Chen H, et al. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. Oncogene. 2006;25:70-8 pubmed..Our results suggest that these two isoforms of Pim-1 kinase may regulate distinct substrates and the 44 kDa Pim-1 may play a more prominent role in drug resistance in prostate cancer cells. ..
- Yeamans C, Wang D, Paz Priel I, Torbett B, Tenen D, Friedman A. C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood. 2007;110:3136-42 pubmed..1(+/+), PU.1(+/-), or PU.1(+/kd) marrow myeloid progenitors but induces granulocyte lineage commitment in PU.1(kd/kd) cells lacking the PU.1 distal enhancer and does not induce either lineage in PU.1(-/-) cells. ..
- Chen H, Zhang H, Lee J, Liang X, Wu X, Zhu T, et al. HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition. Cancer Res. 2007;67:8007-13 pubmed..These results strongly suggest that HOXA5 acts directly downstream of RARbeta and may contribute to retinoid-induced anticancer and chemopreventive effects. ..
- Yang M, Yao Y, Eades G, Zhang Y, Zhou Q. MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. Breast Cancer Res Treat. 2011;129:983-91 pubmed publisher..Our findings, that miR-28 targets the 3'UTR of Nrf2 mRNA and decreases Nrf2 expression, suggest that this miRNA is involved in the regulation of Nrf2 expression in breast epithelial cells. ..
- Feinstein P, Schrader K, Bakalyar H, Tang W, Krupinski J, Gilman A, et al. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A. 1991;88:10173-7 pubmed..The existence of multiple adenylyl cyclase enzymes may provide for complex and distinct modes of biochemical regulation of cAMP levels in the brain. ..
- Lee S. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proc Natl Acad Sci U S A. 1991;88:4250-4 pubmed..5 mouse embryos. The upstream open reading frame encodes a protein of unknown function containing multiple putative membrane-spanning domains. These findings raise the possibility that this mRNA may give rise to two different proteins. ..
- Fearon E, Cho K, Nigro J, Kern S, Simons J, Ruppert J, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990;247:49-56 pubmed..17-kb fragment immediately downstream of one of the exons. The DCC gene may play a role in the pathogenesis of human colorectal neoplasia, perhaps through alteration of the normal cell-cell interactions controlling growth. ..
- Lee B, Murakami A, Blake K, Lin S, Miller P. Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA. Biochemistry. 1988;27:3197-203 pubmed..Noncomplementary oligomers did not cross-link, and the extent of cross-linking of oligomers containing varying numbers of noncomplementary bases was greatly diminished or eliminated.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Papadopoulos N, Nicolaides N, Wei Y, Ruben S, Carter K, Rosen C, et al. Mutation of a mutL homolog in hereditary colon cancer. Science. 1994;263:1625-9 pubmed..These results suggest that defects in any of several mismatch repair genes can cause HNPCC. ..
- DiRuggiero J, Robb F, Jagus R, Klump H, Borges K, Kessel M, et al. Characterization, cloning, and in vitro expression of the extremely thermostable glutamate dehydrogenase from the hyperthermophilic Archaeon, ES4. J Biol Chem. 1993;268:17767-74 pubmed..difficile, and other Archaea. The gdhA gene of ES4 was expressed in vitro in a rabbit reticulocyte cell-free lysate, thus providing a system for structural studies of the mechanisms of thermostability in hyper-thermophilic proteins. ..
- Kuppers R, Hu Q, Rose N. Mouse thyroglobulin: conservation of sequence homology in C-terminal immunogenic regions of thyroglobulin. Autoimmunity. 1996;23:175-80 pubmed..These findings are consistent with our hypothesis that in murine experimental thyroiditis, the primary thyroiditogenic epitopes are encoded by mouse-specific regions of thyroglobulin. ..
- Wang H, Frelin L, Pevsner J. Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes. Gene. 1997;199:39-48 pubmed..In vitro binding studies reveal that syntaxin 7 binds alphaSNAP, a key regulator of transport vesicle fusion at multiple stages of the secretory pathway. ..
- Rørth P. Gal4 in the Drosophila female germline. Mech Dev. 1998;78:113-8 pubmed..FGF signaling guides tracheal cell migration in the embryo. However, misexpression of branchless in the ovary had no effect on border cell migration. Thus border cells and tracheal cells appear to be guided differently. ..
- Hollenbach A, Dickson K, Washabaugh M. Overexpression, purification, and characterization of the periplasmic space thiamin-binding protein of the thiamin traffic ATPase in Escherichia coli. Protein Expr Purif. 2002;25:508-18 pubmed
- Kim J, Zeller K, Wang Y, Jegga A, Aronow B, O Donnell K, et al. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol. 2004;24:5923-36 pubmed..In aggregate, these observations indicate that Myc is an important regulator of glycolytic genes, suggesting that MYC plays a key role in a switch to glycolytic metabolism during cell proliferation or tumorigenesis. ..
- Lo A, To K, Lo K, Lung R, Hui J, Liao G, et al. Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci U S A. 2007;104:16164-9 pubmed..The data provide insight into the discrepancy between LMP1 transcript and protein detection in NPC and highlight the role of the EBV miRNAs in regulating LMP1 downstream signaling to promote cancer development. ..
- Casolaro V, Fang X, Tancowny B, Fan J, Wu F, Srikantan S, et al. Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR. J Allergy Clin Immunol. 2008;121:853-9.e4 pubmed publisher..Mitogen-induced IL-13 expression involves changes in transcript turnover and a change in phosphorylation of HuR and its association with the mRNA 3'UTR. ..
- Chauhan S, Behrouzi R, Rangan P, Woodson S. Structural rearrangements linked to global folding pathways of the Azoarcus group I ribozyme. J Mol Biol. 2009;386:1167-78 pubmed publisher..The results show how small perturbations to the structure of the RNA, such as a nick in P9, populate kinetic folding intermediates that are not observed in the natural ribozyme...
- Gan Q, Chepelev I, Wei G, Tarayrah L, Cui K, Zhao K, et al. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Cell Res. 2010;20:763-83 pubmed publisher..The GEO accession number for the raw and analyzed RNA-seq data is GSE16960. ..
- Wang Y, Busin R, Reeves C, Bezman L, Raymond G, Toomer C, et al. X-linked adrenoleukodystrophy: ABCD1 de novo mutations and mosaicism. Mol Genet Metab. 2011;104:160-6 pubmed publisher..However, the residual maternal risk for having additional ovum carrying the mutant allele identified in an index case that appears to have a de novo mutation is at least 13%...
- Sarkar K, Cai Z, Gupta R, Parajuli N, Fox Talbot K, Darshan M, et al. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc Natl Acad Sci U S A. 2012;109:10504-9 pubmed publisher..Expression and dimerization of the HIF-1? and HIF-1? subunits is required, suggesting that the heterodimer is functioning as a transcriptional activator, despite the acute nature of the response. ..
- Resendiz M, SchOn A, Freire E, Greenberg M. Photochemical control of RNA structure by disrupting π-stacking. J Am Chem Soc. 2012;134:12478-81 pubmed publisher..Aryl sulfide 1 is a novel tool for modulating RNA structure, and formation of 5-methyluridine within a radical cage suggests that it will be useful in kinetic studies. ..
- Yu J, Walter K, Omura N, Hong S, Young A, Li A, et al. Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine. PLoS ONE. 2012;7:e43456 pubmed publisher..CAFs may also not be very responsive to therapeutic targeting with DNA methylation inhibitors. ..
- Gingras M, Covington K, Chang D, Donehower L, Gill A, Ittmann M, et al. Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation. Cell Rep. 2016;14:907-919 pubmed publisher..The high frequency of WNT pathway activating mutation, coupled with small-molecule inhibitors of Î²-catenin in clinical trials, suggests future treatment decisions for these patients may be guided by genomic analysis. ..
- Shaper J, Hollis G, Shaper N. Evidence for two forms of murine beta-1,4-galactosyltransferase based on cloning studies. Biochimie. 1988;70:1683-8 pubmed..The structural implications, topological distribution and potential biological significance of the 2 forms of the enzyme are discussed. ..
- Nucifora F, Li S, Danoff S, Ullrich A, Ross C. Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant. Brain Res Mol Brain Res. 1995;32:291-6 pubmed..The sequence of the longer form in human appears to create an additional consensus protein kinase C phosphorylation site. ..
- Walker N, Gastel J, Costa L, Clark G, Lucier G, Sutter T. Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. Carcinogenesis. 1995;16:1319-27 pubmed..In Sprague-Dawley rats, TCDD is a more potent hepatocarcinogen in females than in males. The induction of CYP1B1 in TCDD rat liver may be a contributing factor to the carcinogenic action of this persistent environmental pollutant. ..
- Lo A, Haass C, Wagner S, Teplow D, Sisodia S. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells. J Biol Chem. 1994;269:30966-73 pubmed..Finally, we demonstrate that A beta is secreted into the basolateral compartment of SWE cells and that the majority of these A beta-related species contains an amino-terminal aspartate residue (+1). ..
- Pietenpol J, Papadopoulos N, Markowitz S, Willson J, Kinzler K, Vogelstein B. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res. 1994;54:3714-7 pubmed..In contrast, a COOH-terminal deletion mutant of bcl2 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types. ..
- Kofuji P, Lederer W, Schulze D. Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger. J Biol Chem. 1994;269:5145-9 pubmed..This unusual arrangement of exons in the Na/Ca exchanger gene could allow for the generation of up to 32 different Na/Ca exchanger mRNAs and accounts for the isoforms identified to date. ..
- Reeder T, Schleif R. AraC protein can activate transcription from only one position and when pointed in only one direction. J Mol Biol. 1993;231:205-18 pubmed..In light of the strict spacing and orientation requirements for AraC activation, the interactions between AraC and RNA polymerase are likely to be specific and inflexible. ..
- Hu R, Lee M, Johnson L, Feinberg A. A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. Hum Mol Genet. 1996;5:1743-8 pubmed..hNAP2 diverges in its expression pattern from IGF2, H19, and p57KIP2, and it shows biallelic expression in all tissues tested. Thus, hNAP2 is functionally insulated from the imprinting domain of 11p15. ..
- Leshko Lindsay L, Corces V. The role of selectins in Drosophila eye and bristle development. Development. 1997;124:169-80 pubmed..The Fw protein is expressed in the larval imaginal discs where it might mediate carbohydrate-protein interactions necessary for proper development of a subset of adult sensory organs. ..
- Lijam N, Sussman D. Organization and promoter analysis of the mouse dishevelled-1 gene. Genome Res. 1995;5:116-24 pubmed..Multiple transcription initiation sites were mapped by primer extension analysis and confirmed by reporter gene assay. ..
- Pluta A, Earnshaw W, Goldberg I. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. J Cell Sci. 1998;111 ( Pt 14):2029-41 pubmed..We discuss the functional implications of the interphase-restricted association of HDaxx with centromeres. ..
- Dang D, Bachman K, Mahatan C, Dang L, Giardiello F, Yang V. Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. FEBS Lett. 2000;476:203-7 pubmed..Results indicate that the Gklf gene is not methylated in either normal or tumorous tissues. The findings of our study are therefore consistent with the potential role of GKLF as a negative growth regulator of gut epithelial cells. ..
- Wang Y, Devereux W, Woster P, Casero R. Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Biochem J. 2001;359:387-92 pubmed..Finally, the expression of mPMF-1 is induced when mouse M1 myeloid leukaemia cells are exposed to polyamine analogues, suggesting control similar to that observed for the hPMF-1...
- Ding C, Buckingham B, Levine M. Familial isolated hypoparathyroidism caused by a mutation in the gene for the transcription factor GCMB. J Clin Invest. 2001;108:1215-20 pubmed..We conclude that homozygous loss of function of the GCMB gene impairs normal parathyroid gland embryology and is responsible for isolated hypoparathyroidism in a subset of patients with this disease. ..
- Lee M, Gonzalez J, Robb F. Extremely thermostable glutamate dehydrogenase (GDH) from the freshwater archaeon Thermococcus waiotapuensis: cloning and comparison with two marine hyperthermophilic GDHs. Extremophiles. 2002;6:151-9 pubmed
- Tengs T, Bowers H, Glasgow H, Burkholder J, Oldach D. Identical ribosomal DNA sequence data from Pfiesteria piscicida (Dinophyceae) isolates with different toxicity phenotypes. Environ Res. 2003;93:88-91 pubmed..piscicida are linked to factors other than genetic strain variation detectable by ribosomal gene sequence analyses...
- Tiwari S, Zhang Y, Heller J, Abernethy D, Soldatov N. Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit. Proc Natl Acad Sci U S A. 2006;103:17024-9 pubmed..2alpha1 gene in the human artery that causes molecular and electrophysiological remodeling of Ca(v)1.2 calcium channels and possibly affects VSMC proliferation. ..
- Wang P, Rao J, Zou T, Liu L, Xiao L, Yu T, et al. Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis. Biochem J. 2010;426:293-306 pubmed publisher..Our findings indicate that MEK-1 is a key effector of the HuR-elicited anti-apoptotic programme in IECs. ..
- Stellato C, Gubin M, Magee J, Fang X, Fan J, Tartar D, et al. Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J Immunol. 2011;187:441-9 pubmed publisher..A better understanding of HuR-mediated control of Th2 polarization may have utility in altering allergic airway inflammation in human asthmatic patients. ..
- Jemc J, Milutinovich A, Weyers J, Takeda Y, Van Doren M. raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis. Dev Biol. 2012;367:114-25 pubmed publisher..Further, loss of raw results in mislocalization of ?-catenin away from the cell surface. Therefore, cadherin-based cell adhesion, likely at the level of ?-catenin, is a primary mechanism by which Raw regulates germline-soma interaction. ..
- Wang S, Adler R, Nathans J. A visual pigment from chicken that resembles rhodopsin: amino acid sequence, gene structure, and functional expression. Biochemistry. 1992;31:3309-15 pubmed..This sequence defines a new branch of the visual pigment gene family. ..
- Farber J. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci U S A. 1990;87:5238-42 pubmed..It is proposed that the gene encoding this protein be called mig, for monokine induced by gamma interferon. ..
- Lee S, Butler D, Kleckner N. Efficient Tn10 transposition into a DNA insertion hot spot in vivo requires the 5-methyl groups of symmetrically disposed thymines within the hot-spot consensus sequence. Proc Natl Acad Sci U S A. 1987;84:7876-80 pubmed
- Porter J, Minke B, Montell C. Calmodulin binding to Drosophila NinaC required for termination of phototransduction. EMBO J. 1995;14:4450-9 pubmed..These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction. ..
- Lu A, Tsai Wu J, Cillo J. DNA determinants and substrate specificities of Escherichia coli MutY. J Biol Chem. 1995;270:23582-8 pubmed..Taken together, our data suggest that DNA sequences proximal to and specific functional groups of mismatched bases are necessary for recognition and catalysis by MutY protein. ..
- Marble M, Geraghty M, de Franchis R, Kraus J, Valle D. Characterization of a cystathionine beta-synthase allele with three mutations in cis in a patient with B6 nonresponsive homocystinuria. Hum Mol Genet. 1994;3:1883-6 pubmed..The apparently simultaneous appearance of more than one mutation in a single exon suggests they may have arisen by a gene conversion event or by nonhomologous recombination...
- Surpin M, Moshiri F, Murphy A, Maier R. Genetic evidence for a fourth terminal oxidase in Bradyrhizobium japonicum. Gene. 1994;143:73-7 pubmed..This new oxidase exhibits greater homology to the Escherichia coli cytochrome o subunit I than any of the previously reported B. japonicum terminal oxidase genes. ..
- Abbott J, Beckett D. Cooperative binding of the Escherichia coli repressor of biotin biosynthesis to the biotin operator sequence. Biochemistry. 1993;32:9649-56 pubmed..Analysis of the data indicates that the binding process is best described by a cooperative model. An upper limit for the cooperative free energy is estimated to be between -2.0 and -3.0 kcal/mol. ..
- Wang L, Precht P, Balakir R, Horton W. Rat and chick cDNA clones encoding HMG-like proteins. Nucleic Acids Res. 1993;21:1493 pubmed
- Li X, Chen S, Wang Q, Zack D, Snyder S, Borjigin J. A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX. Proc Natl Acad Sci U S A. 1998;95:1876-81 pubmed..These data suggest that Crx may play a crucial role in regulating pineal gene expression through interactions with PIRE. ..
- Hamlington J, Clough M, Dunston J, McIntosh I. Deletion of a branch-point consensus sequence in the LMX1B gene causes exon skipping in a family with nail patella syndrome. Eur J Hum Genet. 2000;8:311-4 pubmed..RNA analysis demonstrated that deletion of the branchpoint sequence resulted in skipping of the downstream exon. A mechanism to explain this phenomenon is presented. ..
- Li X, Lu A. Intact MutY and its catalytic domain differentially contact with A/8-oxoG-containing DNA. Nucleic Acids Res. 2000;28:4593-603 pubmed..Overall, these results suggest that the C-terminal domain of MutY specifies additional contact sites on A/GO-containing DNA that are not found in MutY-A/G and M25-A/8-oxoG interactions. ..
- Heinbockel T, Heyward P, Conquet F, Ennis M. Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR1. J Neurophysiol. 2004;92:3085-96 pubmed..These findings suggest that endogenous glutamate tonically modulates MC excitability and responsiveness to olfactory nerve input, and hence the operation of the MOB circuitry, via activation of mGluR1. ..
- Seth M, Sumbilla C, Mullen S, Lewis D, Klein M, Hussain A, et al. Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes. Proc Natl Acad Sci U S A. 2004;101:16683-8 pubmed..The wide significance of this regulatory mechanism is related to its general involvement in Ca2+ signaling dynamics and in cardiac development and hypertrophy. ..
- Lohr J, Chen F, Hill R. Genomic analysis of bacteriophage PhiJL001: insights into its interaction with a sponge-associated alpha-proteobacterium. Appl Environ Microbiol. 2005;71:1598-609 pubmed..The unique marine phage-host system described here provides a model system for studying the role of phages in sponge microbial communities...
- Huang Y, Kim Y, Li Z, Fomenkov T, Fomenkov A, Ratovitski E. AEC-associated p63 mutations lead to alternative splicing/protein stabilization of p63 and modulation of Notch signaling. Cell Cycle. 2005;4:1440-7 pubmed..The truncated p63 failed to associate with the C-terminal domain of RNA polymerase II through SRA4 protein and, therefore affected keratinocyte proliferation, differentiation and survival and may strongly contribute to AEC phenotype. ..
- Zhelonkina A, O Hearn S, Law J, Cruz Reyes J, Huang C, Alatortsev V, et al. T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle. RNA. 2006;12:476-87 pubmed..Should such promiscuous TUTase action also occur in vivo, it could explain why editing utilizes substantially fewer U-deletional than U-insertional events and why partial editing appears preferential in U-deletion. ..
- Marti G, Mohebi P, Liu L, Wang J, Miyashita T, Harmon J. KGF-1 for wound healing in animal models. Methods Mol Biol. 2008;423:383-91 pubmed publisher..Considering these results, we believe we can further explore the treatment modalities for using the electroporation-assisted transfection of DNA plasmid expression vectors of growth factors to enhance cutaneous wound healing. ..
- McCully R, Pomerantz J. The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. Mol Cell Biol. 2008;28:5668-86 pubmed publisher..Using Bcl10- and MALT1-deficient cells, we show that CARD11 can recruit signaling cofactors independently of one another in a signal-inducible manner. ..
- Thio C, Astemborski J, Thomas R, Mosbruger T, Witt M, Goedert J, et al. Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. J Immunol. 2008;181:7944-7 pubmed
- Rajagopal D, Maul R, Ghosh A, Chakraborty T, Khamlichi A, Sen R, et al. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. J Exp Med. 2009;206:1237-44 pubmed publisher..We propose that altered DNA structure in the switch region pauses RNA polymerase II and limits access of DNA polymerase eta during hypermutation. ..