Experts and Doctors on apoptosis in Bethesda, Maryland, United States

Summary

Locale: Bethesda, Maryland, United States
Topic: apoptosis

Top Publications

  1. Pospisil R, Young Cooper G, Mage R. Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits. Proc Natl Acad Sci U S A. 1995;92:6961-5 pubmed
    ..These data suggest that "positive" selection of B lymphocytes through FR1 and FR3 VHa allotypic structures occurs during their development in the appendix. ..
  2. Santoni Rugiu E, Preisegger K, Kiss A, Audolfsson T, Shiota G, Schmidt E, et al. Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc Natl Acad Sci U S A. 1996;93:9577-82 pubmed
    ..The results indicate that HGF may function as a tumor suppressor during early stages of liver carcinogenesis, and suggest the possibility of therapeutic application for this cytokine. ..
  3. Wagner K, Claudio E, Rucker E, Riedlinger G, Broussard C, Schwartzberg P, et al. Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development. 2000;127:4949-58 pubmed
    ..Mice conditionally deficient in Bcl-x permitted us for the first time to study the effects of Bcl-x deficiency on cell proliferation, maturation and survival under physiological conditions in an adult animal. ..
  4. Koonin E, Aravind L. Origin and evolution of eukaryotic apoptosis: the bacterial connection. Cell Death Differ. 2002;9:394-404 pubmed
  5. Bleesing J, Janik J, Fleisher T. Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome. Br J Haematol. 2003;120:93-6 pubmed
    ..Altered O-glycosylation of the extracellular domains of CD45 may have consequences for this tyrosine phosphatase as a regulator of cell proliferation and survival. ..
  6. Kottilil S, Shin K, Jackson J, Reitano K, O Shea M, Yang J, et al. Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions. J Immunol. 2006;176:1107-14 pubmed
    ..Identification of specific surface receptors on NK cells that interact with HIV envelope proteins might explain how HIV is capable of circumventing innate immune defense mechanisms and establishing infection in susceptible individuals. ..
  7. Tominaga Y, Li C, Wang R, Deng C. Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci. 2006;2:161-70 pubmed
    ..These data provide in vivo evidence that mammalian Wee1 plays a critical role in maintaining genome integrity and is essential for embryonic survival at the pre-implantation stage of mouse development. ..
  8. Mukhopadhyay P, Bátkai S, Rajesh M, Czifra N, Harvey White J, Haskó G, et al. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol. 2007;50:528-36 pubmed
    ..These data suggest that CB1 antagonists may represent a new cardioprotective strategy against DOX-induced cardiotoxicity. ..
  9. Yang J, Qu X, Yu Y, Kohn E, Friedlander M. Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int J Cancer. 2008;123:258-263 pubmed publisher
    ..The antitumor effect is at least partly explained by G2/M cell cycle arrest and induction of apoptosis. These findings may have clinical implications directing clinical trials in selectively targeted patients with DNA MMR tumors. ..

More Information

Publications555 found, 100 shown here

  1. Pacak K, Sirova M, Giubellino A, Lencesova L, Csaderova L, Laukova M, et al. NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model. Int J Cancer. 2012;131:2445-55 pubmed publisher
  2. Park S, Ludes Meyers J, Zimonjic D, Durkin M, Popescu N, Aldaz C. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004;91:753-9 pubmed
    ..These results show that WWOX gene is frequently altered in HCC and raise the possibility that this gene is implicated in hepatocarcinogenesis. ..
  3. Kim S, Zhang Z, Hitomi E, Lee Y, Mukherjee A. Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL. Hum Mol Genet. 2006;15:1826-34 pubmed
    ..Our results provide insight into at least one of the molecular mechanisms of apoptosis in INCL and may allow the identification of potential targets for therapeutic intervention. ..
  4. Soung N, Kang Y, Kim K, Kamijo K, Yoon H, Seong Y, et al. Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol Cell Biol. 2006;26:8316-35 pubmed
    ..Our results further suggest that the anti-Odf2 immunoreactive centrosomal antigen previously detected in non-germ line cells is likely hCenexin1. ..
  5. Wang Q, Hanada K, Yang J. Characterization of a novel nonclassical T cell clone with broad reactivity against human renal cell carcinomas. J Immunol. 2008;181:3769-76 pubmed
    ..Our findings suggest that clone HC/2G-1 represents a novel type of CD4(+) cell that has broad TCR-mediated recognition of a determinant widely expressed by RCC. ..
  6. Kim M, Kang K, Kim C, Choi S. Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP. Biotechniques. 2008;45:331-4 pubmed publisher
    ..It could also facilitate study of the pathogenesis of apoptosis-related diseases. ..
  7. Chen J, Zhang M, Ju W, Waldmann T. Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25. Blood. 2009;113:1287-93 pubmed publisher
    ..001). The significantly improved therapeutic efficacy by combining depsipeptide with daclizumab supports a clinical trial of this combination in the treatment of ATL. ..
  8. Guirouilh Barbat J, Zhang Y, Pommier Y. Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin. Mol Cancer Ther. 2009;8:1985-94 pubmed publisher
    ..Together, our results indicate that brostallicin induces DNA double-strand breaks and suggest gamma-H2AX as a pharmacodynamic biomarker for brostallicin. ..
  9. Famakin B, Mou Y, Ruetzler C, Bembry J, Maric D, Hallenbeck J. Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia. Brain Res. 2011;1388:148-56 pubmed publisher
    ..4mm(3). These findings show that disruption of MyD88 or TRIF signaling does not confer protection in brain ischemia and suggests the possibility of additional or alternate downstream adaptors during TLR signaling in cerebral ischemia. ..
  10. Martin D, Zheng L, Siegel R, Huang B, Fisher G, Wang J, et al. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. Proc Natl Acad Sci U S A. 1999;96:4552-7 pubmed
    ..These data suggest that intracytoplasmic CD95 mutations in ALPS impair apoptosis chiefly by disrupting death-domain interactions with the signaling protein FADD/MORT1. ..
  11. Choi M, Anderson M, Zhang Z, Zimonjic D, Popescu N, Mukherjee A. Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. Gene. 2003;315:113-22 pubmed
    ..We propose that N-CDase is an essential component of an innate detoxifying mechanism to prevent ceramide-induced apoptosis. ..
  12. Walker D, Vacha S, Kirby M, Lo C. Connexin43 deficiency causes dysregulation of coronary vasculogenesis. Dev Biol. 2005;284:479-98 pubmed
  13. Kanungo J, Zheng Y, Mishra B, Pant H. Zebrafish Rohon-Beard neuron development: cdk5 in the midst. Neurochem Res. 2009;34:1129-37 pubmed publisher
    ..Based on ours studies and others', here we discuss possible mechanisms that may be involved in cdk5's role in RB neuron development and survival. ..
  14. Khatami M. Unresolved inflammation: 'immune tsunami' or erosion of integrity in immune-privileged and immune-responsive tissues and acute and chronic inflammatory diseases or cancer. Expert Opin Biol Ther. 2011;11:1419-32 pubmed publisher
  15. Knox S, Lombaert I, Haddox C, Abrams S, Cotrim A, Wilson A, et al. Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun. 2013;4:1494 pubmed publisher
    ..We propose that neurturin will protect the parasympathetic nerves from damage and improve organ regeneration. This concept may be applicable for other organs where parasympathetic innervation influences their function. ..
  16. Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez J, et al. Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. Cancer Res. 2017;77:5614-5627 pubmed publisher
    ..i>Cancer Res; 77(20); 5614-27. ©2017 AACR. ..
  17. Bry C, Maass K, Miyoshi K, Willecke K, Ott T, Robinson G, et al. Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development. Dev Biol. 2004;267:418-29 pubmed
    ..Cx26 is considered a tumor suppressor gene and Cx26-null mammary tissue was evaluated after five pregnancies. No hyperproliferation or hyperplasia was observed, suggesting that Cx26 does not function as a tumor suppressor. ..
  18. Moir S, Malaspina A, Pickeral O, Donoghue E, Vasquez J, Miller N, et al. Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J Exp Med. 2004;200:587-99 pubmed
  19. Petrovas C, Casazza J, Brenchley J, Price D, Gostick E, Adams W, et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med. 2006;203:2281-92 pubmed
  20. Krishnan K, Bruce B, Hewitt S, Thomas D, Khanna C, Helman L. Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway. Clin Exp Metastasis. 2006;23:227-36 pubmed
    ..These results, therefore, demonstrate that, in Ewing's sarcoma, the biology of ezrin is distinct from that described in other sarcomas. This study further validates ezrin as a potential therapeutic target. ..
  21. Yeow W, Baras A, Chua A, Nguyen D, Sehgal S, Schrump D, et al. Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. J Thorac Cardiovasc Surg. 2006;132:1356-62 pubmed
    ..This study provides evidence for the profound anticancer activity of this drug combination and should be further evaluated as a novel targeted molecular therapeutic for thoracic cancers. ..
  22. Ramaswamy M, Dumont C, Cruz A, Muppidi J, Gomez T, Billadeau D, et al. Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol. 2007;179:6384-8 pubmed
    ..Activating Rac signaling may be a novel way to sensitize chronically stimulated lymphocytes to Fas-induced apoptosis, an important goal in the treatment of autoimmune diseases. ..
  23. Jung K, Dasgupta A, Huang K, Jeong S, Pise Masison C, Gurova K, et al. Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells. J Virol. 2008;82:8537-47 pubmed publisher
    ..The fact that 9AA induces p53 and inhibits NF-kappaB suggests a promising strategy for the treatment of HTLV-1-transformed cells. ..
  24. Sarcon A, Desierto M, Zhou W, Visconte V, Gibellini F, Chen J, et al. Role of perforin-mediated cell apoptosis in murine models of infusion-induced bone marrow failure. Exp Hematol. 2009;37:477-86 pubmed publisher
    ..Perforin deficiency alters T-cell expansion but upregulates T-cell Fas ligand expression. Perforin-mediated cell death appears to play a minor role in mouse models of immune-mediated BM failure. ..
  25. Silver D, Watkins Chow D, Schreck K, Pierfelice T, Larson D, Burnetti A, et al. The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nat Neurosci. 2010;13:551-8 pubmed publisher
    ..Our results uncover requirements for the EJC in brain development, NSC maintenance and mitosis, thereby implicating this complex in the pathogenesis of microcephaly. ..
  26. Garimella S, Rocca A, Lipkowitz S. WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis. Mol Cancer Res. 2012;10:75-85 pubmed publisher
    ..Taken together, the data suggest that the combination of WEE1 inhibitor and TRAIL could provide a novel combination for the treatment of basal/triple-negative breast cancer. ..
  27. Peters N, Egen J, Secundino N, Debrabant A, Kimblin N, Kamhawi S, et al. In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science. 2008;321:970-4 pubmed publisher
    ..Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease...
  28. Klamt F, Zdanov S, Levine R, Pariser A, Zhang Y, Zhang B, et al. Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Nat Cell Biol. 2009;11:1241-6 pubmed publisher
    ..Exposure of cofilin to TnCl results in intramolecular disulphide bonding and oxidation of Met residues to Met sulphoxide, but only Cys oxidation causes cofilin to induce mitochondrial damage. ..
  29. Lo B, Ramaswamy M, Davis J, Price S, Rao V, Siegel R, et al. A rapid ex vivo clinical diagnostic assay for fas receptor-induced T lymphocyte apoptosis. J Clin Immunol. 2013;33:479-88 pubmed publisher
    ..Hence, this rapid apoptosis assay can expedite the diagnosis of new ALPS patients, including those with somatic mutations, and facilitate clinical and molecular investigation of these diseases. ..
  30. Yoshida A, Urasaki Y, Waltham M, Bergman A, Pourquier P, Rothwell D, et al. Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. J Biol Chem. 2003;278:37768-76 pubmed
    ..Thus, we propose that AN34 and Ape1 participate in the process of chromatin fragmentation during apoptosis. ..
  31. Zou B, Li Q, Zhao J, Li J, Cuff C, Reed E. ?-Elemene and taxanes synergistically induce cytotoxicity and inhibit proliferation in ovarian cancer and other tumor cells. Anticancer Res. 2013;33:929-40 pubmed
    ..This promising new therapeutic combination warrants further pre-clinical exploration for the treatment of chemoresistant ovarian cancer and other types of tumors. ..
  32. Taga K, Cherney B, Tosato G. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int Immunol. 1993;5:1599-608 pubmed
    ..Thus, another property of IL-10 is to promote the survival of IL-2-dependent T cells otherwise destined to die by apoptosis. ..
  33. Stewart J, Nguyen D, Chen G, Schrump D. Induction of apoptosis in malignant pleural mesothelioma cells by activation of the Fas (Apo-1/CD95) death-signal pathway. J Thorac Cardiovasc Surg. 2002;123:295-302 pubmed
    ..These preclinical data support further evaluation of strategies to enhance Fas-mediated apoptosis in mesotheliomas. ..
  34. Meng L, Kohn K, Pommier Y. Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene. 2007;26:4806-16 pubmed
  35. Neutzner M, Lopez T, Feng X, Bergmann Leitner E, Leitner W, Udey M. MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. Cancer Res. 2007;67:6777-85 pubmed
    ..MFG-E8 and its homologue Del1 may represent relevant targets in cancer and other diseases in which angiogenesis is prominent. ..
  36. Rajaraman P, Wang S, Rothman N, Brown M, Black P, Fine H, et al. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev. 2007;16:1655-61 pubmed
    ..Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways. ..
  37. Olivero O, Ming J, Das S, Vazquez I, Richardson D, Weston A, et al. Human inter-individual variability in metabolism and genotoxic response to zidovudine. Toxicol Appl Pharmacol. 2008;228:158-64 pubmed publisher
    ..These data suggest that variability in AZT-DNA incorporation may be modulated by inter-individual differences in the rate of induction of TK1 in response to AZT exposure...
  38. Mazar J, Thomas M, Bezrukov L, Chanturia A, Pekkurnaz G, Yin S, et al. Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cells. J Biol Chem. 2009;284:22022-8 pubmed publisher
  39. Pricola K, Kuhn N, Haleem Smith H, Song Y, Tuan R. Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem. 2009;108:577-88 pubmed publisher
  40. Watanabe H, Wells F, Major M. Clearance of hepatitis C in chimpanzees is associated with intrahepatic T-cell perforin expression during the late acute phase. J Viral Hepat. 2010;17:245-53 pubmed publisher
    ..There is a reduction in the numbers of intrahepatic T cells during the late acute phase in infections that become persistent with significantly fewer of these cells functional in clearing the virus by killing infected hepatocytes...
  41. Kemp C, Rao M, Xi S, Inchauste S, Mani H, Fetsch P, et al. Polycomb repressor complex-2 is a novel target for mesothelioma therapy. Clin Cancer Res. 2012;18:77-90 pubmed publisher
    ..Common as well as differential gene expression profiles were observed following knockdown of PRC-2 members or DZNep treatment. Pharmacologic inhibition of PRC-2 expression/activity is a novel strategy for mesothelioma therapy. ..
  42. Wan C, Oh J, Li P, West E, Wong E, Andraski A, et al. The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity. 2013;38:514-27 pubmed publisher
    ..Thus, IL-21 and GM-CSF exhibit cross-regulatory actions on gene regulation and apoptosis, regulating cDC numbers and thereby the magnitude of the immune response. ..
  43. Tian H, Lempicki R, King L, Donoghue E, Samelson L, Cohen D. HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation. Int Immunol. 1996;8:65-74 pubmed
  44. Orban Z, Mitsiades N, Burke T, Tsokos M, Chrousos G. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation. 2000;7:99-105 pubmed
    ..These findings may suggest that novel anti-inflammatory therapies can be based upon activation of NF-kappaB-mediated transcription of genes curbing the inflammatory response and that CAPE or its analogs hold therapeutic promise. ..
  45. Witta J, Baffi J, Palkovits M, Mezey E, Castillo S, Nikodem V. Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation. Brain Res Mol Brain Res. 2000;84:67-78 pubmed
    ..Our findings suggest that activation of Nurr1 might be therapeutically useful in Parkinson's disease. ..
  46. Blagosklonny M. Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. Leukemia. 2001;15:936-41 pubmed
    ..Clinical application of this approach may diminish the toxic side-effects of chemotherapy in patients with multidrug-resistant tumors. ..
  47. Ren M, Senatorov V, Chen R, Chuang D. Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proc Natl Acad Sci U S A. 2003;100:6210-5 pubmed
    ..Moreover, the heat shock response is likely to be involved in lithium's neuroprotective actions. Additionally, our studies indicate that lithium may have clinical utility for the treatment of patients with acute stroke. ..
  48. Lubet R, Christov K, Nunez N, Hursting S, Steele V, Juliana M, et al. Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis. Carcinogenesis. 2005;26:441-8 pubmed
    ..Determination of serum IGF1 levels showed that treatment of rats with highly effective doses of Targretin at 272 mg/kg diet or at 60 or 20 mg/kg body wt/day by gavage caused significantly decreased serum IGF1 levels. ..
  49. Han J, Yang L, Puri R. Analysis of target genes induced by IL-13 cytotoxin in human glioblastoma cells. J Neurooncol. 2005;72:35-46 pubmed
    ..On going studies will determine the role of associated genes and their products in the IL-13R functions in glioma cells. ..
  50. Nguyen D, Yeow W, Ziauddin M, Baras A, Tsai W, Reddy R, et al. The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell de. Cancer J. 2006;12:257-73 pubmed
    ..Furthermore, our data identify mitochondria as the direct target for the development of more refined strategies to enhance the therapeutic effect of Apo2L/TRAIL as an anticancer agent. ..
  51. Jobson A, Lountos G, Lorenzi P, Llamas J, Connelly J, Cerna D, et al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009;331:816-26 pubmed publisher
    ..These data indicate that PV1019 is a potent and selective inhibitor of Chk2 with chemotherapeutic and radiosensitization potential. ..
  52. Jun H, Lee Y, Cheung Y, McDermott D, Murphy P, De Ravin S, et al. Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome. Blood. 2010;116:2783-92 pubmed publisher
    ..The results establish that in nonapoptotic neutrophils, G6Pase-? is essential for normal energy homeostasis. A G6Pase-? deficiency prevents recycling of ER glucose to the cytoplasm, leading to neutrophil dysfunction. ..
  53. Gabay O, Zaal K, Sanchez C, Dvir Ginzberg M, Gagarina V, Song Y, et al. Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint Bone Spine. 2013;80:613-20 pubmed publisher
    ..The findings from this animal model demonstrated that Sirt1 KO mice presented an altered cartilage phenotype, with an elevated apoptotic process and a potential degradative cartilage process. ..
  54. Porter J, Fisher B, Baranello L, Liu J, Kambach D, Nie Z, et al. Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Mol Cell. 2017;67:1013-1025.e9 pubmed publisher
    ..Our study shows that global inhibition with specific activation of transcriptional pathways is important for the proper response to DNA damage; this mechanism may be a general principle used in many stress responses. ..
  55. Hsu Y, Wolter K, Youle R. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A. 1997;94:3668-72 pubmed
    ..These movements may represent an important step in the pathway by which members of this family regulate apoptosis. ..
  56. Yamanaka R, Zullo S, Tanaka R, Blaese M, Xanthopoulos K. Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki forest virus-mediated complementary DNA. J Neurosurg. 2001;94:474-81 pubmed
    ..Therapy with DCs that have been pulsed with SFV-mediated tumor cDNA may be an excellent procedure for the development of new cancer vaccines. ..
  57. Lahusen T, De Siervi A, Kunick C, Senderowicz A. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol Carcinog. 2003;36:183-94 pubmed
    ..Additional studies with paullones are warranted to further characterize their preclinical effects and to explore their potential use in the clinical setting. ..
  58. Gomez G, Sitkovsky M. Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo. Blood. 2003;102:4472-8 pubmed
    ..Thus, we demonstrate that A2a and A3 adenosine receptors are differentially utilized by inosine for the down-regulation of tissue damage under different inflammatory conditions in vivo. ..
  59. Zhang B, Zhang Y, Shacter E. Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75. Mol Cell Biol. 2004;24:6205-14 pubmed
    ..These findings define a mechanism by which active Rac1 promotes lymphoma cell survival and inhibits apoptosis in response to cancer chemotherapy drugs. ..
  60. Su H, Bidere N, Zheng L, Cubre A, Sakai K, Dale J, et al. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science. 2005;307:1465-8 pubmed
    ..These findings thus explain the paradoxical association of defective apoptosis and combined immunodeficiency in human CED. ..
  61. Cao L, Kim S, Xiao C, Wang R, Coumoul X, Wang X, et al. ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J. 2006;25:2167-77 pubmed
    ..Our data highlight how accurate maintenance of genomic integrity is critical for the suppression of both aging and malignancy, and provide a further link between aging and cancer. ..
  62. Moir S, Fauci A. Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease. J Allergy Clin Immunol. 2008;122:12-9; quiz 20-1 pubmed publisher
  63. Kim Y, Day R. Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPK?1/2 and Cdk4. Am J Physiol Lung Cell Mol Physiol. 2012;303:L228-38 pubmed publisher
    ..Together these findings illuminate a novel proapoptotic signaling pathway in endothelial cells, whereby Ang II triggers E2F1-mediated transcriptional upregulation of Bim via activation of AMPK?1/2 and Cdk4. ..
  64. Basanez G, Zimmerberg J. HIV and apoptosis death and the mitochondrion. J Exp Med. 2001;193:F11-4 pubmed
  65. Edsall L, Cuvillier O, Twitty S, Spiegel S, Milstien S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem. 2001;76:1573-84 pubmed
    ..Collectively, our results indicate that SPHK/SPP may play an important role in neuronal survival by regulating activation of SAPKs and caspases. ..
  66. Blagosklonny M, Dixon S, Robey R, Figg W. Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines. Int J Oncol. 2001;18:697-704 pubmed
    ..2 nM) and UCN-01. In PrEC, UCN-01 downregulated cyclin D1 and arrest growth with an IC50 less than 100 nM. We conclude that loss of sensitivity to either UCN-01 or PMA accompanies progression of prostate cancer. ..
  67. Becerra S, Amaral J. Erythropoietin--an endogenous retinal survival factor. N Engl J Med. 2002;347:1968-70 pubmed
  68. Liu K, McDuffie E, Abrams S. Exposure of human primary colon carcinoma cells to anti-Fas interactions influences the emergence of pre-existing Fas-resistant metastatic subpopulations. J Immunol. 2003;171:4164-74 pubmed
    ..Thus, Fas-based interactions may represent a novel mechanism for the biologic or immunologic selection of certain types of Fas-resistant neoplastic clones with enhanced metastatic ability. ..
  69. Crowder C, Dahle Ø, Davis R, Gabrielsen O, Rudikoff S. PML mediates IFN-alpha-induced apoptosis in myeloma by regulating TRAIL induction. Blood. 2005;105:1280-7 pubmed
    ..Identification of PML and PML NBs as effectors of IFN responses provides insights into mechanisms by which tumor cells exhibit resistance to this class of agents and may prove useful in assessing treatment regimens. ..
  70. Yamaguchi Y, Coelho S, Zmudzka B, Takahashi K, Beer J, Hearing V, et al. Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation. Exp Dermatol. 2008;17:916-24 pubmed publisher
    ..These results suggest that pigmentation induced in skin by repeated UV irradiation protects against subsequent UV-induced DNA damage but not as effectively as constitutive pigmentation. ..
  71. Solier S, Pommier Y. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell Cycle. 2009;8:1853-9 pubmed
    ..This signature ("phosphohistone 2 code") together with the gamma-H2AX ring provides a new feature to monitor and study apoptosis. ..
  72. Wang S, Pashtan I, Tsutsumi S, Xu W, Neckers L. Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors. Cell Cycle. 2009;8:2050-6 pubmed
    ..In contrast, Hsp90 inhibitors provide long-lasting suppression of c-Met-dependent signaling, and these drugs should be further evaluated in tumors driven by MET gene amplification. ..
  73. Xie Y, Tobin L, Camps J, Wangsa D, Yang J, Rao M, et al. MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells. Oncogene. 2013;32:2442-51 pubmed publisher
    ..In summary, our data suggest a novel mechanism by which miR-24 directly modulates XIAP expression level and consequently the apoptosis threshold in cancer cells. ..
  74. Chen J, Mikelis C, Zhang Y, Gutkind J, Zhang B. TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget. 2013;4:206-17 pubmed
    ..Our findings could have implications for the use of TRAIL receptor targeted therapies in the treatment of human OSCC tumors particularly the ones harboring constitutively active Ras mutant. ..
  75. Walton K, Wagner K, Rucker E, Shillingford J, Miyoshi K, Hennighausen L. Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation. Mech Dev. 2001;109:281-93 pubmed
    ..Concomitant deletion of the bax gene did not significantly modify the Bcl-x phenotype. Our results suggest that Bcl-x is not essential during mammopoiesis, but is critical for controlled apoptosis during the first phase of involution. ..
  76. Anderson H, Maylock C, Williams J, Paweletz C, Shu H, Shacter E. Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells. Nat Immunol. 2003;4:87-91 pubmed
    ..Protein S acted by binding to phosphatidylserine expressed on the apoptotic cell surface. Protein S is thus a multifunctional protein that can facilitate clearance of early apoptotic cells in addition to regulating blood coagulation. ..
  77. Beppu K, Jaboine J, Merchant M, Mackall C, Thiele C. Effect of imatinib mesylate on neuroblastoma tumorigenesis and vascular endothelial growth factor expression. J Natl Cancer Inst. 2004;96:46-55 pubmed
    ..001). Imatinib inhibited the growth of neuroblastoma cells in vitro and in vivo. This inhibition was associated with suppression of PDGFR and c-Kit phosphorylation and inhibition of VEGF expression. ..
  78. Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, et al. Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis. Am J Pathol. 2005;167:585-97 pubmed
    ..These results demonstrate that overexpression of CR-1 during pregnancy and lactation can lead to alterations in mammary gland development and to production of mammary tumors in multiparous mice. ..
  79. Muppidi J, Lobito A, Ramaswamy M, Yang J, Wang L, Wu H, et al. Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis. Cell Death Differ. 2006;13:1641-50 pubmed
  80. Robles A, Wright M, Gandhi B, Feis S, Hanigan C, Wiestner A, et al. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. Clin Cancer Res. 2006;12:6547-56 pubmed
  81. Wang X, Dakir E, Naizhen X, Jensen Taubman S, DeMayo F, Linnoila R. Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium. Lab Invest. 2007;87:527-39 pubmed
    ..The collective results suggest a novel model of BOA formation via hASH1-induced suppression of the apoptotic pathway. Our study yields a promising new preclinical tool for chemoprevention of peripheral lung carcinomas. ..
  82. Oliveira J, Bidere N, Niemela J, Zheng L, Sakai K, Nix C, et al. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 2007;104:8953-8 pubmed
    ..Our observations on the effects of NRAS activation indicate that RAS-inactivating drugs, such as farnesyltransferase inhibitors should be examined in human autoimmune and lymphocyte homeostasis disorders. ..
  83. Gills J, Castillo S, Zhang C, Petukhov P, Memmott R, Hollingshead M, et al. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. J Biol Chem. 2007;282:27020-9 pubmed
    ..Independent modulation of Akt and p38alpha could account for the profound cytotoxicity of PIAs. ..
  84. Furuya F, Lu C, Willingham M, Cheng S. Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. Carcinogenesis. 2007;28:2451-8 pubmed
    ..No significant adverse effects were observed for wild-type mice treated similarly with LY. The present study provides the first preclinical evidence for the in vivo efficacy for LY in the treatment of follicular thyroid cancer. ..
  85. Oh S, Perera L, Terabe M, Ni L, Waldmann T, Berzofsky J. IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proc Natl Acad Sci U S A. 2008;105:5201-6 pubmed publisher
    ..These findings suggest new vaccine strategies against infections and cancers, especially in individuals with CD4-deficiency. ..
  86. Muranski P, Restifo N. Adoptive immunotherapy of cancer using CD4(+) T cells. Curr Opin Immunol. 2009;21:200-8 pubmed publisher
  87. Huang B, Akbar M, Kevala K, Kim H. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011;192:979-92 pubmed publisher
    ..The novel molecular interaction mechanism for Akt activation suggests potential new targets for controlling Akt-dependent cell survival and proliferation. ..
  88. Kuehn H, Niemela J, Rangel Santos A, Zhang M, Pittaluga S, Stoddard J, et al. Loss-of-function of the protein kinase C ? (PKC?) causes a B-cell lymphoproliferative syndrome in humans. Blood. 2013;121:3117-25 pubmed publisher
    ..In summary, homozygous PRKCD mutation results in B-cell hyperproliferation and defective apoptosis with consequent lymphocyte accumulation and autoantibody production in humans, and disrupts natural killer cell function. ..
  89. Zhang G, He P, Gaedcke J, Ghadimi B, Ried T, Yfantis H, et al. FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer. Cancer Res. 2013;73:5416-25 pubmed publisher
    ..Taken together, our findings suggest that FOXL1 expression is a candidate predictor of clinical outcome in patients with resected PDAC and it plays an inhibitory role in pancreatic tumor progression. ..
  90. Lee Y, Kim K, Byrnes C, de Vasconcellos J, Noh S, Rabel A, et al. A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors. PLoS ONE. 2013;8:e68307 pubmed publisher
    ..Knockdown of beta-globin expression in cultured primary human erythroblasts provides a robust ex vivo model for beta-thalassemia. ..
  91. Gartner J, Parker S, Prickett T, Dutton Regester K, Stitzel M, Lin J, et al. Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma. Proc Natl Acad Sci U S A. 2013;110:13481-6 pubmed publisher
    ..Our data indicate that silent alterations have a role to play in human cancer, emphasizing the importance of their investigation in future cancer genome studies. ..
  92. Di X, Zhang G, Zhang Y, Takeda K, Rivera Rosado L, Zhang B. Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5. Oncotarget. 2013;4:1349-64 pubmed
    ..The results also provide a rationale for future non-clinical and clinical studies testing TRAIL agonists in combination with agents that directly inhibit autophagosome assembly. ..