Genomes and Genes
Experts and Doctors on animals in Rockville, Maryland, United States
Locale: Rockville, Maryland, United States
Publications403 found, 100 shown here
- del Castillo Olivares A, Kulkarni M, Smith H. Regulation of sperm gene expression by the GATA factor ELT-1. Dev Biol. 2009;333:397-408 pubmed publisher..This work demonstrates a role for the ELT-1 transcription factor in sperm, and provides a critical link between the germ line sex determination program and gamete-specific gene expression. ..
- Weiss G, Crompton P, Li S, Walsh L, Moir S, Traore B, et al. Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area. J Immunol. 2009;183:2176-82 pubmed publisher..This is the first description of an atypical MBC phenotype associated with malaria. Understanding the origin and function of these MBCs could be important in informing the design of malaria vaccines. ..
- Irons R, Tsuji P, Carlson B, Ouyang P, Yoo M, Xu X, et al. Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells. Cancer Prev Res (Phila). 2010;3:630-9 pubmed publisher..These data suggest tissue specificity in the cancer-protective effects of Sep15 downregulation, which are mediated, at least in part, by influencing the cell cycle. ..
- Radaev S, Zou Z, Tolar P, Nguyen K, Nguyen A, Krueger P, et al. Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. Structure. 2010;18:934-43 pubmed publisher..These studies provide the first structural model for understanding BCR function. ..
- Matyas G, Wieczorek L, Bansal D, Chenine A, Sanders Buell E, Tovanabutra S, et al. Inhibition of HIV-1 infection of peripheral blood mononuclear cells by a monoclonal antibody that binds to phosphoinositides and induces secretion of ?-chemokines. Biochem Biophys Res Commun. 2010;402:808-12 pubmed publisher
- Pepini T, Pulichino A, Carsillo T, Carlson A, Sari Sarraf F, Ramsauer K, et al. Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design. J Immunol. 2017;198:4012-4024 pubmed publisher..RNA sequence modification, delivery optimization, or concurrent use of appropriate compounds might be some of the strategies to finalize this aim. ..
- Dancey J. Clinical development of mammalian target of rapamycin inhibitors. Hematol Oncol Clin North Am. 2002;16:1101-14 pubmed..The challenge to investigators is to efficiently determine what role this class of agent will play in the treatment of cancer patients...
- Belkin A, Tsurupa G, Zemskov E, Veklich Y, Weisel J, Medved L. Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC domains promotes integrin-dependent cell adhesion and signaling. Blood. 2005;105:3561-8 pubmed..They also suggest a new role for transglutaminases in regulation of integrin-mediated adhesion and signaling via covalent modification of integrin ligands. ..
- Cao C, Lawrence D, Strickland D, Zhang L. A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics. Blood. 2005;106:3234-41 pubmed
- Protopopova M, Hanrahan C, Nikonenko B, Samala R, Chen P, Gearhart J, et al. Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines. J Antimicrob Chemother. 2005;56:968-74 pubmed..The aim of this study was to identify a candidate drug for clinical development from a previously synthesized combinatorial library based on the 1,2-ethylenediamine structure of ethambutol...
- Milner J. Preclinical perspectives on garlic and cancer. J Nutr. 2006;136:827S-831S pubmed publisher..Likewise, additional studies are needed that incorporate transgenic and knockout models to assist in the identification of molecular targets for garlic and its associated allyl sulfur components. ..
- Martinez M, Rathbone M, Burgess D, Huynh M. In vitro and in vivo considerations associated with parenteral sustained release products: a review based upon information presented and points expressed at the 2007 Controlled Release Society Annual Meeting. J Control Release. 2008;129:79-87 pubmed publisher
- Palachick B, Chen Y, Enoch A, Karlsson R, Mishina M, Holmes A. Role of major NMDA or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication. Alcohol Clin Exp Res. 2008;32:1479-92 pubmed publisher..Further work to elucidate the mechanisms underlying NMDAR x EtOH interactions could ultimately provide novel insight into the role of NMDARs in alcoholism and its treatment. ..
- Guo X, Silva J. Properties of non-coding DNA and identification of putative cis-regulatory elements in Theileria parva. BMC Genomics. 2008;9:582 pubmed publisher..Sequences similar to two of these Theileria motifs are conserved in Plasmodium hinting at the possibility of common regulatory machinery across the phylum Apicomplexa. ..
- Plassmeyer M, Reiter K, Shimp R, Kotova S, Smith P, Hurt D, et al. Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate. J Biol Chem. 2009;284:26951-63 pubmed publisher..5 nm in width. Thus native CSP appears as a glycosylphosphatidylinositol-anchored, flexible rod-like protein on the sporozoite surface. ..
- Li Z, Wang H, Xue L, Shin D, Roopenian D, Xu W, et al. Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood. 2009;114:4158-68 pubmed publisher..These results suggest that, in addition to constitutive activation of BCL10 in MZ B cells, other genetic factors or environmental influences are required for short latency oncogenic transformation. ..
- Major J, Cross A, Watters J, Hollenbeck A, Graubard B, Sinha R. Patterns of meat intake and risk of prostate cancer among African-Americans in a large prospective study. Cancer Causes Control. 2011;22:1691-8 pubmed publisher..02). No associations were observed for intake of other HCAs. Red meats cooked at high temperatures were positively associated with prostate cancer risk among African-American men. Further studies are needed to replicate these findings. ..
- Yuan W, Anderson K, Li S, Edwards J. Subsecond absolute quantitation of amine metabolites using isobaric tags for discovery of pathway activation in mammalian cells. Anal Chem. 2012;84:2892-9 pubmed publisher..Furthermore, even though we determined the absolute quantity of 32 metabolites here, the number of analytes that can be measured by this method is limited mainly by commercial availability of amine standards. ..
- Glass J. Synthetic genomics and the construction of a synthetic bacterial cell. Perspect Biol Med. 2012;55:473-89 pubmed publisher..The effort resulted in new synthetic genomics techniques called genome assembly and genome transplantation. The ability of scientists to design and build bacteria opens new possibilities for creating microbes to solve human problems. ..
- Modric S. Regulatory framework for the availability and use of animal drugs in the United States. Vet Clin North Am Small Anim Pract. 2013;43:1005-12 pubmed publisher..Only when buying approved animal drugs can clinicians be assured of product safety, effectiveness, and manufacturing to the strict standards for quality, purity, and potency, as well as truthful and complete labeling. ..
- Moore J, van Opstal E, Kolling G, Shin J, Bogatcheva E, Nikonenko B, et al. Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model. J Antimicrob Chemother. 2016;71:1300-6 pubmed publisher..difficile shedding and decreased toxin in faeces, were observed with SQ641 and vancomycin treatment. SQ641 is effective for CDI treatment with prevention of relapse in the murine model of CDI. ..
- Meerzaman D, Dunn B, Lee M, Chen Q, Yan C, Ross S. The promise of omics-based approaches to cancer prevention. Semin Oncol. 2016;43:36-48 pubmed publisher..In this article, we emphasize how the knowledge gained through large-scale omics-oriented approaches, with a focus on variations at the level of nucleic acids, can inform the field of chemoprevention. ..
- Spain L, Liu P. TCRbeta transmembrane tyrosines are required for pre-TCR function. J Immunol. 2002;168:127-33 pubmed..These data demonstrate that pre-TCR signaling pathways leading to proliferation and survival, differentiation, and allelic exclusion are differently sensitive to subtle mutation-induced alterations in pre-TCR structure. ..
- Stowers A, Chen Lh L, Zhang Y, Kennedy M, Zou L, Lambert L, et al. A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum. Proc Natl Acad Sci U S A. 2002;99:339-44 pubmed..This study demonstrates the potential for producing efficacious malarial vaccines in transgenic animals. ..
- Murthy M, Hamilton J, Greiner R, Moriguchi T, Salem N, Kim H. Differential effects of n-3 fatty acid deficiency on phospholipid molecular species composition in the rat hippocampus. J Lipid Res. 2002;43:611-7 pubmed..The observed decrease of 22:6n-3 species along with PS reduction may represent key biochemical changes underlying losses in brain-hippocampal function associated with n-3 deficiency. ..
- Hou Y, Hu W, Hirano T, Gu X. A new intra-NALT route elicits mucosal and systemic immunity against Moraxella catarrhalis in a mouse challenge model. Vaccine. 2002;20:2375-81 pubmed..This new route can be used as a model to study mucosal antigens or vaccine candidates for antigen activation and interaction with the NALT that is one of major inductive sites for common mucosal immune system. ..
- Gu X, Rudy S, Chu C, McCullagh L, Kim H, Chen J, et al. Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzae. Vaccine. 2003;21:2107-14 pubmed..The LOS-TT conjugate is well tolerant in adults and a Phase II evaluation of the conjugate in children is planned. ..
- Cherukuri A, Shoham T, Sohn H, Levy S, Brooks S, Carter R, et al. The tetraspanin CD81 is necessary for partitioning of coligated CD19/CD21-B cell antigen receptor complexes into signaling-active lipid rafts. J Immunol. 2004;172:370-80 pubmed..The requirement for CD81 to promote lipid raft association may define a novel mechanism by which tetraspanins function as molecular facilitators of signaling receptors. ..
- Xu X, Meier Schellersheim M, Jiao X, Nelson L, Jin T. Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell. 2005;16:676-88 pubmed..We propose a revised model of gradient sensing, suggesting an important role for locally controlled components that inhibit PI3Kinase activity. ..
- Davis T, Lennon G. Mice with a regenerative wound healing capacity and an SLE autoimmune phenotype contain elevated numbers of circulating and marrow-derived macrophage progenitor cells. Blood Cells Mol Dis. 2005;34:17-25 pubmed
- Drayton M, Noben Trauth K. Mapping quantitative trait loci for hearing loss in Black Swiss mice. Hear Res. 2006;212:128-39 pubmed..Haplotype analyses across the Cdh23 locus demonstrated the phylogenetic relationship between Black Swiss and common inbred strains. ..
- Fang J, Brzostowski J, Ou S, Isik N, Nair V, Jin T. A vesicle surface tyrosine kinase regulates phagosome maturation. J Cell Biol. 2007;178:411-23 pubmed..Our findings suggest that localized tyrosine kinase signaling on the surface of endosome/lysosomes represents a control mechanism for phagosome maturation. ..
- Isik N, Brzostowski J, Jin T. An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev Cell. 2008;15:590-602 pubmed publisher..Taken together, our data suggest that ElmoA modulates actin/myosin II at the cortex to prevent excessive F-actin polymerization around the cell periphery, thereby maintaining proper cell shape during phagocytosis and chemotaxis...
- ROSENBERG Y, Saxena A, Sun W, Jiang X, Chilukuri N, Luo C, et al. Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model. Chem Biol Interact. 2010;187:279-86 pubmed publisher..This homologous model can provide necessary preclinical protection data for the use of PEG-rHuBChE in humans and bodes well for a safe and efficacious CHO-derived rHuBChE therapeutic. ..
- Pushko P, Kort T, Nathan M, Pearce M, Smith G, Tumpey T. Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus. Vaccine. 2010;28:4771-6 pubmed publisher..Moreover, a single 15mug dose of H1N1 VLPs resulted in complete virus clearance in the ferret lung. These results provide support for the use of recombinant influenza VLP vaccine as an effective strategy against pandemic H1N1 virus. ..
- Nordstrom J, Gorlatov S, Zhang W, Yang Y, Huang L, Burke S, et al. Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fc? receptor binding properties. Breast Cancer Res. 2011;13:R123 pubmed publisher..The data support the clinical development of MGAH22, which may have utility in patients with low HER2 expressing tumors or carrying the CD16A low-binding allele. ..
- Xu X, Chang B, Mans B, Ribeiro J, Andersen J. Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi. Acta Crystallogr D Biol Crystallogr. 2013;69:105-13 pubmed publisher..The cavity contains significant additional volume, suggesting that this protein may have evolved from the related nitrophorin proteins, which bind a much larger heme ligand in the central cavity. ..
- Barouch D, Ghneim K, Bosche W, Li Y, Berkemeier B, Hull M, et al. Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys. Cell. 2016;165:656-67 pubmed publisher..These findings have important implications for the development of vaccines and other strategies to prevent infection. ..
- Madan B, Walker M, Young R, Quick L, Orgel K, Ryan M, et al. USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proc Natl Acad Sci U S A. 2016;113:E2945-54 pubmed publisher..Our study defines an additional route to ectopic Wnt pathway activation in human disease, and identifies a potential approach to modulate Wnt signaling for therapeutic benefit. ..
- Nelson M, Culhane M, Trovão N, Patnayak D, Halpin R, Lin X, et al. The emergence and evolution of influenza A (H1?) viruses in swine in Canada and the United States. J Gen Virol. 2017;98:2663-2675 pubmed publisher..The proliferation of novel H1?-3 viruses also highlights the need for expanded surveillance in a Canadian swine population that has long been overlooked, and may have implications for vaccine design...
- Roschke V, Sosnovtseva S, Ward C, Hong J, Smith R, Albert V, et al. BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol. 2002;169:4314-21 pubmed..These findings raise the possibility that active BLyS/APRIL heterotrimers may play a role in rheumatic and other autoimmune diseases and that other members of the TNF ligand superfamily may also form active soluble heterotrimers. ..
- Hirano T, Hou Y, Jiao X, Gu X. Intranasal immunization with a lipooligosaccharide-based conjugate vaccine from nontypeable Haemophilus influenzae enhances bacterial clearance in mouse nasopharynx. FEMS Immunol Med Microbiol. 2003;35:1-10 pubmed..Such a vaccine and vaccination regime may be applicable to humans with an appropriate formulation. ..
- Fiscella M, Perry J, Teng B, Bloom M, Zhang C, Leung K, et al. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. Nat Biotechnol. 2003;21:302-7 pubmed..Therefore, combining functional genomics with high-throughput cell-based screening is a valuable and efficient approach to identifying immunomodulatory activities for novel proteins. ..
- Sohn H, Gu H, Pierce S. Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med. 2003;197:1511-24 pubmed..Significantly, prolonged phosphorylation of Syk correlated with reduced ubiquitination of Syk indicating that Cbl-b negatively regulates BCR signaling by targeting Syk for ubiquitination. ..
- Saul A. Zooprophylaxis or zoopotentiation: the outcome of introducing animals on vector transmission is highly dependent on the mosquito mortality while searching. Malar J. 2003;2:32 pubmed..However, as the number of animals increases, improved availability of blood meals may increase mosquito survival, thereby countering the impact of diverting feeds...
- Dabdoub A, Jinks R, Wang Y, Battelle B, Payne R. Desensitization of the photoresponse in Limulus ventral photoreceptors by protein kinase C precedes rhabdomere disorganization and endocytosis. Vis Neurosci. 2003;20:241-8 pubmed..PKC-induced reduction in light sensitivity therefore precedes the detection of ultrastructural changes in the rhabdomeral membrane and is not due to a net loss of membrane. ..
- Belyantseva I, Boger E, Friedman T. Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle. Proc Natl Acad Sci U S A. 2003;100:13958-63 pubmed..We propose that myosin XVa is essential for the graded elongation of stereocilia during their functional maturation. ..
- Yepes M, Brown S, Moore E, Smith E, Lawrence D, Winkles J. A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. Am J Pathol. 2005;166:511-20 pubmed..We conclude that the cytokine TWEAK may play an important role in ischemia-induced brain injury and that inhibition of TWEAK expression or function in the brain may represent a novel neuroprotective strategy to treat ischemic stroke. ..
- Narum D, Ogun S, Batchelor A, Holder A. Passive immunization with a multicomponent vaccine against conserved domains of apical membrane antigen 1 and 235-kilodalton rhoptry proteins protects mice against Plasmodium yoelii blood-stage challenge infection. Infect Immun. 2006;74:5529-36 pubmed..These results support the concept of developing a multicomponent blood-stage vaccine and the inclusion of polymorphic targets such as AMA1, which these results suggest contain conserved domains recognized by inhibitory antibodies. ..
- Lin X, Takahashi K, Liu Y, Derrien A, Zamora P. A synthetic, bioactive PDGF mimetic with binding to both alpha-PDGF and beta-PDGF receptors. Growth Factors. 2007;25:87-93 pubmed..In these cell-based assays, PAB2-1c was effective at 1 microg/ml or lesser. The results support the hypothesis that PBA2-1c is a mimetic of PDGF, although it has a more promiscuous receptor interaction. ..
- Bok J, Brunet L, Howard O, Burton Q, Wu D. Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice. Dev Biol. 2007;311:69-78 pubmed..In addition, the size of the otic capsule is increased in Noggin -/- mutants, which most likely is due to unopposed BMP signaling for chondrogenesis in the peri-otic mesenchyme. ..
- Knight M, Raghavan N, Goodall C, Cousin C, Ittiprasert W, Sayed A, et al. Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation. Mol Biochem Parasitol. 2009;167:20-31 pubmed publisher..Enzymatic analysis of the purified, recombinant BgPrx4 revealed the snail sequence to function as Prx but with an unusual ability to use both thioredoxin and glutathione as substrates...
- Koo S, Hill J, Hwang C, Lin Z, Millen K, Wu D. Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear. Dev Biol. 2009;333:14-25 pubmed publisher..Furthermore, aberrant and ectopic sensory organs are observed; most striking among these is vestibular-like hair cells located in the cochlear duct. ..
- Leiby D. Transfusion-transmitted Babesia spp.: bull's-eye on Babesia microti. Clin Microbiol Rev. 2011;24:14-28 pubmed publisher..Despite current obstacles, continued discussion of TTB without proactive intervention is no longer a viable alternative...
- Kost G, Selvaraj S, Lee Y, Kim D, Ahn C, Singh B. Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking. Neurosci Lett. 2011;504:170-175 pubmed publisher..Overall, these data suggest that clavulanic acid enhances dopamine release in a mechanism involving Munc18-1 and Rab4 modulation and warrants further investigation of its therapeutic use in CNS disorders, such as depression. ..
- Molina Cruz A, DeJong R, Ortega C, Haile A, Abban E, Rodrigues J, et al. Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes. Proc Natl Acad Sci U S A. 2012;109:E1957-62 pubmed publisher..Evasion of the A. gambiae immune system by P. falciparum may be the result of parasite adaptation to sympatric mosquito vectors and may be an important factor driving malaria transmission. ..
- Goncalves R, Oliveira J, Oliveira G, Andersen J, Oliveira M, Oliveira P, et al. Mitochondrial reactive oxygen species modulate mosquito susceptibility to Plasmodium infection. PLoS ONE. 2012;7:e41083 pubmed publisher..gambiae susceptibility to Plasmodium infection. We provide direct experimental evidence indicating that ROS derived from mitochondria can modulate mosquito epithelial responses to Plasmodium infection. ..
- Korba B, Cote P, Hornbuckle W, Tennant B, Gerin J. Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans. Hepatology. 2000;31:1165-75 pubmed
- Korba B, Schinazi R, Cote P, Tennant B, Gerin J. Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks. Antimicrob Agents Chemother. 2000;44:1757-60 pubmed..No evidence of drug-related toxicity was observed in any of the animals treated. ..
- Xu W, Mimnaugh E, Rosser M, Nicchitta C, Marcu M, Yarden Y, et al. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem. 2001;276:3702-8 pubmed..These data suggest that Hsp90 uniquely stabilizes ErbB2 via interaction with its kinase domain and that GA stimulates ErbB2 degradation secondary to disruption of ErbB2/Hsp90 association. ..
- Kheirabadi B, Field Ridley A, Pearson R, MacPhee M, Drohan W, Tuthill D. Comparative study of the efficacy of the common topical hemostatic agents with fibrin sealant in a rabbit aortic anastomosis model. J Surg Res. 2002;106:99-107 pubmed..This high efficacy is in part attributed to the strong tissue adhesive property of this agent. FS application may potentially ease the anastomosis and shorten the duration of timely critical vascular procedures. ..
- Hou Y, Gu X. Development of peptide mimotopes of lipooligosaccharide from nontypeable Haemophilus influenzae as vaccine candidates. J Immunol. 2003;170:4373-9 pubmed..These data indicate that the peptide mimotopes of LOS that we have identified might be potential components of peptide vaccines against NTHi. ..
- Elam C, Hesson L, Vos M, Eckfeld K, Ellis C, Bell A, et al. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. Cancer Res. 2005;65:3117-25 pubmed..Thus, we identify a new member of the Ras superfamily that can serve as a potential tumor suppressor. ..
- Greeneltch K, Kelly Welch A, Shi Y, Keegan A. Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism. J Immunol. 2005;175:4999-5005 pubmed..These results suggest that morphine preferentially enhances Th2 cell differentiation via killing of Th1 cells in a Fas/FasL-dependent manner. ..
- Gopalakrishnan M, Suarez S, Hickey A, Gobburu J. Population pharmacokinetic-pharmacodynamic modeling of subcutaneous and pulmonary insulin in rats. J Pharmacokinet Pharmacodyn. 2005;32:485-500 pubmed..The proposed PKPD model satisfactorily describes insulin disposition and glucose concentrations across range of doses with and without HMAP. ..
- Norris H, Peterson M, Stebbins C, McConchie B, Bundoc V, Trivedi S, et al. Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation. J Leukoc Biol. 2007;82:1531-41 pubmed..Expression of gp49B was detected on peripheral eosinophils of control mice and on eosinophils from lungs of mice treated with RW, suggesting a role for gp49B on eosinophils in dampening allergic inflammatory responses. ..
- Neuwald A. Galpha Gbetagamma dissociation may be due to retraction of a buried lysine and disruption of an aromatic cluster by a GTP-sensing Arg Trp pair. Protein Sci. 2007;16:2570-7 pubmed..Other structural features associated with Galpha functional divergence further support the proposed mechanism. ..
- Lehmann T, Diabate A. The molecular forms of Anopheles gambiae: a phenotypic perspective. Infect Genet Evol. 2008;8:737-46 pubmed publisher..The implications of these results to disease transmission and control are discussed and many of the gaps in our understanding are highlighted. ..
- Thaler C, Koushik S, Puhl H, Blank P, Vogel S. Structural rearrangement of CaMKIIalpha catalytic domains encodes activation. Proc Natl Acad Sci U S A. 2009;106:6369-74 pubmed publisher..Our data support the existence of catalytic domain pairs, and glutamate receptor activation in neurons triggered an increase in anisotropy consistent with a structural transition from a paired to unpaired conformation. ..
- Ishmael N, Dunning Hotopp J, Ioannidis P, Biber S, Sakamoto J, Siozios S, et al. Extensive genomic diversity of closely related Wolbachia strains. Microbiology. 2009;155:2211-22 pubmed publisher..Overall, these insect-associated Wolbachia have highly mosaic genomes, with lateral gene transfer playing an important role in their diversity and evolution. ..
- Rehman A, Morell R, Belyantseva I, Khan S, Boger E, Shahzad M, et al. Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Am J Hum Genet. 2010;86:378-88 pubmed publisher..Although TPRN is expressed in many tissues, immunolocalization of the protein product in the mouse cochlea shows prominent expression in the taper region of hair cell stereocilia. Consequently, we named the protein taperin...
- Ostera G, Tokumasu F, Teixeira C, Collin N, Sa J, Hume J, et al. Plasmodium falciparum: nitric oxide modulates heme speciation in isolated food vacuoles. Exp Parasitol. 2011;127:1-8 pubmed publisher..The formation of heme nitrosyl complexes within the FV is a previously unrecognized factor that could affect the equilibrium between soluble and crystallized heme within the FV in vivo. ..
- Laassri M, Bidzhieva B, Speicher J, Pletnev A, Chumakov K. Microarray hybridization for assessment of the genetic stability of chimeric West Nile/dengue 4 virus. J Med Virol. 2011;83:910-20 pubmed publisher..The approach described in this article could be useful for monitoring the molecular consistency and quality control of vaccine strains. ..
- Gregori L, Yang H, Anderson S. Estimation of variant Creutzfeldt-Jakob disease infectivity titers in human blood. Transfusion. 2011;51:2596-602 pubmed publisher..The analysis supports continuing measures currently recommended to reduce the risk of TTvCJD. ..
- Wang X, Li Y, Yin Y, Mo M, Wang Q, Gao W, et al. Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc Natl Acad Sci U S A. 2011;108:15960-5 pubmed publisher..In addition, the CD4 mutants reported here constitute unique tools for probing the influence of CD4 affinity on T-cell activation and development. ..
- Kaleko M, Bristol J, Hubert S, PARSLEY T, Widmer G, Tzipori S, et al. Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection. Anaerobe. 2016;41:58-67 pubmed publisher..Phase I clinical studies demonstrated SYN-004 safety and tolerability. Phase 2 studies are in progress to assess the utility of SYN-004 for the prevention of antibiotic-associated diarrhea and Clostridium difficile disease. ..
- Ueki K, Muramatsu T, Kincaid R. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). Biochem Biophys Res Commun. 1992;187:537-43 pubmed..These data are consistent with the biological co-regulation of catalytic and regulatory subunits of a testis-specific isoenzyme during germ cell maturation. ..
- Yun Y, Casazza J, Sohn D, Veech R, Song B. Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet. Mol Pharmacol. 1992;41:474-9 pubmed..Our data thus indicated that P450IIE induction during the ketosis of a high fat feeding appears to be due to pretranslational activation and that is similar to the induction mechanism of fasted and diabetic animals. ..
- Pawlosky R, Denkins Y, Ward G, Salem N. Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil-based maternal diets. Am J Clin Nutr. 1997;65:465-72 pubmed..These findings suggest that in juvenile felines, maintenance of 22:6n-3 status in the nervous system is important for optimal retinal function. ..
- Yin D, Zhang L, Wang R, Radvanyi L, Haudenschild C, Fang Q, et al. Ligation of CD28 in vivo induces CD40 ligand expression and promotes B cell survival. J Immunol. 1999;163:4328-34 pubmed..Therefore, CD28-mediated expression of CD40L may play an important role in the regulation of lymphocyte homeostasis. ..
- Hu W, Chen J, McMichael J, Gu X. Functional characteristics of a protective monoclonal antibody against serotype A and C lipooligosaccharides from Moraxella catarrhalis. Infect Immun. 2001;69:1358-63 pubmed..catarrhalis clearance from lungs. These data suggest that MAb 8E7, which recognizes surface-exposed LOS of M. catarrhalis, is a protective antibody against M. catarrhalis. ..
- Ball L, Ball R, Pratt R. An assessment of thimerosal use in childhood vaccines. Pediatrics. 2001;107:1147-54 pubmed..Exposure of infants to mercury in vaccines can be reduced or eliminated by using products formulated without thimerosal as a preservative. ..
- Bunting K, Bradley H, Hawley T, Moriggl R, Sorrentino B, Ihle J. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood. 2002;99:479-87 pubmed..These results demonstrate that a significant proportion of the growth factor signals required for multilineage reconstitution potential of HSCs is STAT5 dependent...