Experts and Doctors on sindbis virus in Shreveport, Louisiana, United States
Locale: Shreveport, Louisiana, United States
Topic: sindbis virus
Klimstra W, Williams J, Ryman K, Heidner H. Targeting Sindbis virus-based vectors to Fc receptor-positive cell types. Virology. 2005;338:9-21 pubmed
..Specifically, ADE did not occur with FcgammaR-negative cells, did not require active complement proteins, and did not occur on FcgammaR-positive murine cell lines when virions were bound by murine IgG-derived F(ab')2 fragments...
Ryman K, Meier K, Gardner C, Adegboyega P, Klimstra W. Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons. Virology. 2007;368:273-85 pubmed
Zhang Y, Burke C, Ryman K, Klimstra W. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol. 2007;81:11246-55 pubmed
..However, ISG20 and ZAP potently inhibited SB replication in vitro, whereas and viperin, p56, and ISG15 exhibited modest replication inhibition in vitro. In contrast, p54 and p49 had little to no effect in any assay. ..
Ryman K, Meier K, Nangle E, Ragsdale S, Korneeva N, Rhoads R, et al
. Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells. J Virol. 2005;79:1487-99 pubmed
..Statistical analyses of gene array data identified 44 genes that met these criteria which are discussed...