Experts and Doctors on nucleic acid conformation in Baton Rouge, Louisiana, United States
Locale: Baton Rouge, Louisiana, United States
Topic: nucleic acid conformation
- Kim D, Shih D, Cho D, Swenson D. Helix-stabilizing compounds CC-1065 and U-71,184 bind to RNA-DNA and DNA-DNA duplexes containing modified internucleotide linkages and stabilize duplexes against thermal melting. Antisense Res Dev. 1995;5:49-57 pubmed..The results show that CC-1065 and U-71,184 are capable of binding and stabilizing a variety of nucleic acid duplexes. These agents or their analogs may become useful ligands for antisense oligonucleotide applications. ..
- Ghosh S, Grove A. The Deinococcus radiodurans-encoded HU protein has two DNA-binding domains. Biochemistry. 2006;45:1723-33 pubmed
- Bauerle K, Kamau E, Grove A. Interactions between N- and C-terminal domains of the Saccharomyces cerevisiae high-mobility group protein HMO1 are required for DNA bending. Biochemistry. 2006;45:3635-45 pubmed..Taken together, our data suggest that interactions between box A and the C-terminal tail induce a conformation that is required for DNA bending. ..
- Foltz D. An ancient repeat sequence in the ATP synthase beta-subunit gene of forcipulate sea stars. J Mol Evol. 2007;65:564-73 pubmed..In four species, the repeat in one or both introns has apparently experienced gene conversion. The two introns also show a correlated pattern of nucleotide substitutions, even after excluding the putative cases of gene conversion. ..
- Kim J, Kim J. In vivo YY1 knockdown effects on genomic imprinting. Hum Mol Genet. 2008;17:391-401 pubmed..In sum, these results demonstrate that YY1 indeed functions as a trans factor for transcriptional regulation and DNA methylation of these imprinted domains in vivo. ..
- Mukherjee A, Sokunbi A, Grove A. DNA protection by histone-like protein HU from the hyperthermophilic eubacterium Thermotoga maritima. Nucleic Acids Res. 2008;36:3956-68 pubmed publisher..We suggest that T. maritima HU serves an architectural function when associating with a single 35 bp site, but generates a very stable and compact aggregate at higher protein concentrations that organizes and protects the genomic DNA. ..
- Xiao L, Williams A, Grove A. The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending. Biochemistry. 2010;49:4051-9 pubmed publisher..This mode of binding is reminiscent of that proposed for the mammalian RNA polymerase I transcription factor UBF. ..